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Melatonin and muscle

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https://www.readbyqxmd.com/read/30335670/melatonin-enhances-atherosclerotic-plaque-stability-by-inducing-prolyl-4-hydroxylase-%C3%AE-1-expression
#1
Hongxuan Li, Jingyuan Li, Xiuxin Jiang, Shangming Liu, Yan Liu, Weiqian Chen, Jianmin Yang, Cheng Zhang, Wencheng Zhang
OBJECTIVE: Melatonin, an endogenous neurohormone secreted predominately by the pineal gland, has a variety of physiological functions. However, its protective role in atherosclerosis is not clear. In this study, we sought to investigate the potential effects of melatonin in modulating atherosclerotic plaque stability in apolipoprotein E knockout (ApoE) mice. METHOD AND RESULTS: Smooth muscle cells were treated with melatonin, which significantly increased mRNA and protein levels of a key intracellular enzyme essential for collagen maturation and secretion, prolyl-4-hydroxylase α1 (P4Hα1)...
October 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30321542/melatonin-promotes-reduction-in-tnf-levels-and-improves-the-lipid-profile-and-insulin-sensitivity-in-pinealectomized-rats-with-periodontal-disease
#2
Rodrigo Martins Dos Santos, Fernando Marani, Fernando Yamamoto Chiba, Maria Sara de Lima Coutinho Mattera, Thais Verônica Saori Tsosura, Gestter Willian Lattari Tessarin, Renato Felipe Pereira, Bianca Elvira Belardi, Beatriz Costa E Silva Pinheiro, Doris Hissako Sumida
AIM: This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD). MAIN METHODS: One hundred and forty-four rats (age = 40 days) were distributed into 8 groups: 1) control (CN); 2) PD only; 3) PNX only; 4) PNX and PD (PNXPD); 5) CN treated with ME (CNM); 6) PD treated with ME (PDM); 7) PNX treated with ME(PNXM); 8) PNX and PD treated with ME(PNXPDM)...
October 12, 2018: Life Sciences
https://www.readbyqxmd.com/read/30315933/the-multiple-protective-roles-and-molecular-mechanisms-of-melatonin-and-its-precursor-n-acetylserotonin-in-targeting-brain-injury-and-liver-damage-and-in-maintaining-bone-health
#3
REVIEW
Chengliang Luo, Qiang Yang, Yuancai Liu, Shuanhu Zhou, Jiying Jiang, Russel J Reiter, Pallab Bhattacharya, Yongchun Cui, Hongwei Yang, He Ma, Jiemin Yao, Sean E Lawler, Xinmu Zhang, Jianfang Fu, Renato Rozental, Hany Aly, Mark D Johnson, E Antonio Chiocca, Xin Wang
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly produced by the pineal gland in animals. Numerous physiological functions of melatonin have been demonstrated including anti-inflammation, suppressing neoplastic growth, circadian and endocrine rhythm regulation, and its potent antioxidant activity as well as its role in regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. In this review, we summarize the recent advances related to the multiple protective roles of melatonin receptor agonists, melatonin and N-acetylserotonin (NAS) in brain injury, liver damage, and bone health...
October 10, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30166643/hydrogen-peroxide-promotes-gastric-motility-in-the-newborn-rat
#4
Andre Felipe Fajardo, Curtis Sobchak, Yulia Shifrin, Jingyi Pan, Tanja Gonska, Jaques Belik
BACKGROUND: When compared with infant formula, human milk enhances gastric emptying in preterm infants. Hydrogen peroxide (H2 O2 ) is present in large quantities in human milk that has an antimicrobial role for the mother and infant. In vitro adult rat studies suggest that H2 O2 facilitates gastric motor contraction. Hypothesizing that H2 O2 enhances gastric motility, we investigated its effects on the newborn rat stomach tissue. METHODS: Rat newborn and adult gastric fundic segments, or their smooth muscle cells, were used to evaluate the muscle response to H2 O2 exposure...
August 24, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30166532/rem-sleep-behaviour-disorder
#5
REVIEW
Yves Dauvilliers, Carlos H Schenck, Ronald B Postuma, Alex Iranzo, Pierre-Herve Luppi, Giuseppe Plazzi, Jacques Montplaisir, Bradley Boeve
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia that is characterized by loss of muscle atonia during REM sleep (known as REM sleep without atonia, or RSWA) and abnormal behaviours occurring during REM sleep, often as dream enactments that can cause injury. RBD is categorized as either idiopathic RBD or symptomatic (also known as secondary) RBD; the latter is associated with antidepressant use or with neurological diseases, especially α-synucleinopathies (such as Parkinson disease, dementia with Lewy bodies and multiple system atrophy) but also narcolepsy type 1...
August 30, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/30086243/effects-of-melatonin-on-low-dose-lipopolysaccharide-induced-oxidative-stress-in-the-mouse-liver-muscle-and-kidney
#6
Natalia Kurhaluk, Arkadiusz Szarmach, Olga V Zaitseva, Alina Sliuta, Svitlana Kyriienko, Pawel J Winklewski
Lipopolysaccharide (LPS) administration in an in vivo experimental mice model causes oxidative damage in the liver, muscle and kidney. We aimed to determine specific mechanisms underlying melatonin's antioxidant protective role. Assays were carried out in quadruplicate in the control, melatonin (10 mg/kg, 10 days), acute LPS administration (once 150 μg) and LPS plus melatonin groups. LPS stimulated lipid peroxidation processes (dienes and malondialdehyde) and antioxidant enzyme concentrations (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) were assessed in all investigated tissues...
August 7, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30081859/results-of-a-randomized-double-blind-placebo-controlled-crossover-trial-of-melatonin-for-treatment-of-nocturia-in-adults-with-multiple-sclerosis-menims
#7
Marcus J Drake, Luke Canham, Nikki Cotterill, Debbie Delgado, Jenny Homewood, Kirsty Inglis, Lyndsey Johnson, Mary C Kisanga, Denise Owen, Paul White, David Cottrell
BACKGROUND: Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in the bladder. There is limited evidence supporting use of melatonin to alleviate urinary frequency at night in the treatment of nocturia. The aim of this study was to evaluate the effect of melatonin on the mean number of nocturia episodes per night in patients with MS...
August 6, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29921483/melatonin-attenuates-chronic-immobilization-stress-induced-muscle-atrophy-in-rats-influence-on-lactate-to-pyruvate-ratios-and-na-k-atpase-activity
#8
Eman S H Abd Allah, Ahmed M Mahmoud
This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobilization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90 min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA levels. An increase in the serum lactate-to-pyruvate ratio and the oxidative stress accompanied by a reduction of Na+ /K+ ATPase activity could be responsible for these changes...
June 16, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29895193/melatonin-promotes-cashmere-goat-capra-hircus-secondary-hair-follicle-growth-a-view-from-integrated-analysis-of-long-non-coding-and-coding-rnas
#9
Wei Ge, Shan-He Wang, Bing Sun, Yue-Lang Zhang, Wei Shen, Hasan Khatib, Xin Wang
The role of melatonin in promoting the yield of Cashmere goat wool has been demonstrated for decades though there remains a lack of knowledge regarding melatonin mediated hair follicle growth. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are widely transcribed in the genome and play ubiquitous roles in regulating biological processes. However, the role of lncRNAs in regulating melatonin mediated hair follicle growth remains unclear. In this study, we established an in vitro Cashmere goat secondary hair follicle culture system, and demonstrated that 500 ng/L melatonin exposure promoted hair follicle fiber growth...
2018: Cell Cycle
https://www.readbyqxmd.com/read/29892224/melatonin-attenuates-dysregulation-of-the-circadian-clock-pathway-in-mice-with-ccl-4-induced-fibrosis-and-human-hepatic-stellate-cells
#10
Bárbara González-Fernández, Diana I Sánchez, Irene Crespo, Beatriz San-Miguel, Juan Ortiz de Urbina, Javier González-Gallego, María J Tuñón
Dysregulation of the circadian clock machinery is a critical mechanism in the pathogenesis of fibrosis. This study aimed to investigate whether the antifibrotic effect of melatonin is associated with attenuation of circadian clock pathway disturbances in mice treated with carbon tetrachloride (CCl4 ) and in human hepatic stellate cells line LX2. Mice received CCl4 5 μL/g body weight i.p. twice a week for 4 or 6 weeks. Melatonin was given at 5 or 10 mg/kg/day i.p., beginning 2 weeks after the start of CCl4 administration...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29882895/effect-of-melatonin-on-rat-heart-mitochondria-in-acute-heart-failure-in-aged-rats
#11
Irina Odinokova, Yulia Baburina, Alexey Kruglov, Irina Fadeeva, Alena Zvyagina, Linda Sotnikova, Vladimir Akatov, Olga Krestinina
Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonselective mitochondrial permeability transition pore are important factors that promote cardiac pathologies and dysfunction. The hormone melatonin (MEL) is known to improve the functional state of mitochondria via an antioxidant effect. Here, the effect of MEL administration on heart mitochondria from aged rats with acute cardiac failure caused by isoprenaline hydrochloride (ISO) was studied. A histological analysis revealed that chronic intake of MEL diminished the age-dependent changes in the structure of muscle fibers of the left ventricle, muscle fiber swelling, and injury zones characteristic of acute cardiac failure caused by ISO...
May 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29846091/melatonin-ingestion-after-exhaustive-late-evening-exercise-improves-sleep-quality-and-quantity-and-short-term-performances-in-teenage-athletes
#12
Mohamed Cheikh, Omar Hammouda, Nawel Gaamouri, Tarak Driss, Karim Chamari, Ridha Ben Cheikh, Mohamed Dogui, Nizar Souissi
The present study aimed to explore the effects of a single 10-mg dose of melatonin (MEL) administration after exhaustive late-evening exercise on sleep quality and quantity, and short-term physical and cognitive performances in healthy teenagers. Ten male adolescent athletes (mean ± SD, age = 15.4 ± 0.3 years, body-mass = 60.68 ± 5.7 kg, height = 167.9 ± 6.9 cm and BMI = 21.21 ± 2.5) performed two test sessions separated by at least one week. During each session, participants completed the Yo-Yo intermittent-recovery-test level-1 (YYIRT-1) at ~20:00 h...
May 30, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29843047/melatonin-ameliorates-bisphenol-a-induced-perturbations-of-the-prostate-gland-of-adult-wistar-rats
#13
Samuel Gbadebo Olukole, Samuel Olumide Ajani, Eunice Olufunke Ola-Davies, Damilare Olaniyi Lanipekun, Oluwasanmi Olayinka Aina, Matthew Olugbenga Oyeyemi, Bankole Olusiji Oke
Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that has been demonstrated to induce alterations in reproductive organs while melatonin (ML), an antioxidant, present in plants and animals, is capable of protecting against EDC-induced alterations. Adult male Wistar rats (average weight, 240 + 10 g) were divided into four groups of ten animals each: Rats in group I (control) received oral 0.2 ml 1% dimethyl sulfoxide (DMSO)/99% canola oil as vehicle; group II received intra-peritoneal 10 mg/kg BW/day ML...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29618988/the-hyperglycemic-effect-of-melatonin-in-the-chinese-mitten-crab-eriocheir-sinensis
#14
Xiaozhen Yang, Minjie Xu, Genyong Huang, Cong Zhang, Yangyang Pang, Zhigang Yang, Yongxu Cheng
Melatonin has been identified in a variety of invertebrate species, but its function is not as well understood as in crustaceans. The effects of melatonin on hemolymph glucose levels and tissue carbohydrate metabolism in the Chinese mitten crab, Eriocheir sinensis , were fully investigated in this study. Moreover, whether the eyestalk (an important endocrine center in invertebrate species) involves in this process or not, also were clarified. Analysis revealed that eyestalk ablation, especially bilateral, caused a significant decrease in the hemolymph glucose level...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29607540/melatonin-improves-insulin-resistance-and-hepatic-steatosis-through-attenuation-of-alpha-2-hs-glycoprotein
#15
Jee-In Heo, Dae Wui Yoon, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim
Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be associated with insulin resistance and type 2 diabetes. The aim of this study was to determine whether melatonin improves hepatic insulin resistance and hepatic steatosis in a FETUA-dependent manner...
September 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29562315/the-protective-effect-of-melatonin-against-age-associated-sarcopenia-dependent-tubular-aggregate-formation-lactate-depletion-and-mitochondrial-changes
#16
Ramy K A Sayed, Marisol Fernández-Ortiz, María E Diaz-Casado, Iryna Rusanova, Ibtissem Rahim, Germaine Escames, Luis C López, Doaa M Mokhtar, Darío Acuña-Castroviejo
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild-type C57BL/6J female mice were examined by magnetic resonance and microscopy. Locomotor activity, lactate production, and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 months of age, with reduction of muscle fiber number, muscle weight/body weight ratio, lactate, and locomotor activity...
September 11, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29506623/the-effects-of-zinc-and-melatonin-on-muscle-ischaemi-reperfusion-injury-in-rat
#17
Mehmet Celer, Rasim Mogulkoc, Abdulkerim Kasim Baltaci, Dervis Dasdelen
Ischemia-reperfusion leads to damage in cell or tissue due to insufficient blood flow. The aim of present study was to determine the effect of zinc, melatonin and zinc + melatonin supplementations during 3 weeks on muscle tissue and plasma MDA and GSH levels. This study was performed on 38 male Wistar-Albino rats. Experiments groups were designed as sham-control, ischemia-reperfusion (I/R), zinc + I/R, melatonin + I/R and zinc + melatonin + I/R Ischemia-reperfusion was induced by left femoral artery occlusion (1 hour) and reopening (1 hour)...
February 28, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29497878/spasticity-treatment-ameliorates-the-efficacy-of-melatonin-therapy-in-experimental-autoimmune-encephalomyelitis-eae-mouse-model-of-multiple-sclerosis
#18
Majid Ghareghani, Kazem Zibara, Hossein Sadeghi, Naser Farhadi
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease in the central nervous system (CNS). Melatonin is an effective treatment in MS patients and experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Melatonin secretion peaks at 2 AM, concomitant with the time at which the muscles are resting and the body is exerting its antioxidant activity. The current study was designed to investigate combination treatment of baclofen, a muscle relaxant drug, and melatonin in EAE mice...
July 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29480949/role-of-melatonin-receptor-1a-and-pituitary-homeobox-1-coexpression-in-protecting-tubular-epithelial-cells-in-membranous-nephropathy
#19
Yen-Sung Huang, Kuo-Cheng Lu, Tai-Kuang Chao, Jin-Shuen Chen, Ann Chen, Cheng-Yi Guo, Hsin-Yi Hsieh, Hsiu-Ming Shih, Huey-Kang Sytwu, Chia-Chao Wu
Membranous nephropathy (MN), a type of glomerular nephritis, is one of the most common causes of nephrotic syndrome in adults. Although it is known that melatonin plays a protective role in MN, the role of melatonin receptors in the pathophysiology of MN is unclear. Using an experimental MN model and clinical MN specimens, we studied melatonin receptor expression and found that melatonin receptor 1A (MTNR1A) expression was significantly downregulated in renal tubular epithelial cells. Molecular studies showed that the transcription factor pituitary homeobox-1 (PITX1) promoted MTNR1A expression via direct binding to its promoter...
August 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29356345/four-days-of-simulated-shift-work-reduces-insulin-sensitivity-in-humans
#20
R Bescos, M J Boden, M L Jackson, A J Trewin, E C Marin, I Levinger, A Garnham, D S Hiam, F Falcao-Tebas, F Conte, J A Owens, D J Kennaway, G K McConell
AIM: The aim of this study was to investigate the effects of 4 consecutive simulated night shifts on glucose homeostasis, mitochondrial function and central and peripheral rhythmicities compared with a simulated day shift schedule. METHODS: Seventeen healthy adults (8M:9F) matched for sleep, physical activity and dietary/fat intake participated in this study (night shift work n = 9; day shift work n = 8). Glucose tolerance and insulin sensitivity before and after 4 nights of shift work were measured by an intravenous glucose tolerance test and a hyperinsulinaemic euglycaemic clamp respectively...
June 2018: Acta Physiologica
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