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Melatonin and muscle

Wen-Lai Guo, Zhi-Ping Qi, Li Yu, Tian-Wen Sun, Wen-Rui Qu, Qian-Qian Liu, Zhe Zhu, Rui Li
After nerve-root avulsion injury of the brachial plexus, oxidative damage, inflammatory reaction, and glial scar formation can affect nerve regeneration and functional recovery. Melatonin (MT) has been shown to have good anti-inflammatory, antioxidant, and neuroprotective effects. Chondroitin sulfate ABC (ChABC) has been shown to metabolize chondroitin sulfate proteoglycans and can reduce colloidal scar formation. However, the effect of any of these drugs alone in the recovery of nerve function after injury is not completely satisfactory...
February 2019: Neural Regeneration Research
Cristian Augusto Ostjen, Carlos Gustavo Sakuno Rosa, Renata Minuzzo Hartmann, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares, Norma Possa Marroni
In recent decades, the number of people who practice sports has grown exponentially, increasing the number of muscular injuries. Trauma injury occurs when the muscle is exposed to a sudden compression force. Melatonin (MLT) has often been cited in the literature as a potent antioxidant and anti-inflammatory agent. This study was designed to evaluate MLT action on muscle tissue in Wistar rats in an experimental model of muscle trauma. Twenty-eight Wistar rats were used, divided into four groups: CO (Control), CO + MLT (Control + Melatonin), T (Trauma) and T + MLT (Trauma + Melatonin)...
December 3, 2018: Experimental and Molecular Pathology
Yasemin Behram Kandemir, Ünal Guntekin, Veysel Tosun, Necmettin Korucuk, Mehmet Nuri Bozdemir
The aim of the present study is to investigate if the melatonin has any protective effect on diabetic cardiomyopathy and antioxidant enzymes via phosphorylation of vascular endothelial growth factor-A (VEGF-A). A total of 40 male Wistar rats were enrolled in the study. Rats were divided into four groups: group 1 (control, n=10), group 2 (DM, n=10), group 3 (melatonin, n=10), and group 4 (melatonin+DM, n=10). Melatonin was injected intraperitoneally at a dose of 50 mg/kg/day for 56 days to group 3 and group 4...
November 30, 2018: Cellular and Molecular Biology
Silvia Bona, Graziella Rodrigues, Andrea J Moreira, Fábio C Di Naso, Alexandre S Dias, Thêmis R Da Silveira, Claudio A Marroni, Norma P Marroni
Background and Aim: Liver diseases are a major public health problem, accounting for a significant number of hospital visits and admissions and an increasing mortality rate. Melatonin (MLT) is a powerful antioxidant molecule that has been shown to be beneficial under various conditions. The objective was to evaluate the effect of MLT on experimental liver cirrhosis induced by carbon tetrachloride (CCl4 ) in rats. Methods: Twenty male Wistar rats (230-250 g) were divided into four groups...
August 2018: JGH open: an open access journal of gastroenterology and hepatology
Dušan T Sokolović, Ljubiša Lilić, Vesko Milenković, Rade Stefanović, Tatjana Popović Ilić, Branimir Mekić, Igor Ilić, Nikola M Stojanović, Ivan R Ilić
Animal models demonstrating skeletal muscle (SM) disorders are rarely investigated, although these disorders accompany liver disorders and can occur during prolonged exercise/training. In cases of SM disorders exogenous antioxidants, such as melatonin, could help by generally improving tissues antioxidant capacities. We aimed to analyze the potential of melatonin in preventing biochemical and structural changes in rat biceps muscle (BM) occurring after an acute exposure to carbon tetrachloride (CCl4 ). Biceps muscles obtained from male Wistar rats belonging to different experimental groups were biochemically (determination of tissue MDA, total antioxidant capacity, GSH, CAT, SOD and GPx activities) and pathologically analyzed...
November 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Jennifer E Hewitt, Amelia K Pollard, Leila Lesanpezeshki, Colleen S Deane, Christopher J Gaffney, Timothy Etheridge, Nathaniel J Szewczyk, Siva A Vanapalli
Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies including Duchenne and Becker muscular dystrophies. Although Caenorhabditis elegans is an established genetic model for studying mechanisms and treatments of muscular dystrophies, analogous strength-based measurements in this disease model are lacking. Here we describe the first demonstration of the direct measurement of muscular strength in dystrophin-deficient C. elegans mutants using a micropillar-based force measurement system called NemaFlex...
November 5, 2018: Disease Models & Mechanisms
Zhaoxia Xu, Ying Wu, Yanyan Zhang, Huirong Zhang, Lijun Shi
The pineal hormone melatonin is a neuroendocrine hormone with high membrane permeability that is involved in regulation of circadian rhythm of several biological functions. Large-conductance Ca2+ -activated K+ (BKCa ) channels are abundantly expressed in vascular smooth muscle cells and play an important role in vascular tone regulation. We investigated the mechanisms through which myocyte BKCa channels mediate effects of melatonin on cerebral arteries (CAs). Arterial contractility measurements showed that melatonin alone did not change vascular tone in CAs; however, it induced concentration-dependent vasodilation of phenylephrine-induced contraction in CAs...
October 26, 2018: European Journal of Pharmacology
Hongxuan Li, Jingyuan Li, Xiuxin Jiang, Shangming Liu, Yan Liu, Weiqian Chen, Jianmin Yang, Cheng Zhang, Wencheng Zhang
OBJECTIVE: Melatonin, an endogenous neurohormone secreted predominately by the pineal gland, has a variety of physiological functions. However, its protective role in atherosclerosis is not clear. In this study, we sought to investigate the potential effects of melatonin in modulating atherosclerotic plaque stability in apolipoprotein E knockout (ApoE) mice. METHOD AND RESULTS: Smooth muscle cells were treated with melatonin, which significantly increased mRNA and protein levels of a key intracellular enzyme essential for collagen maturation and secretion, prolyl-4-hydroxylase α1 (P4Hα1)...
October 17, 2018: Journal of Hypertension
Rodrigo Martins Dos Santos, Fernando Marani, Fernando Yamamoto Chiba, Maria Sara de Lima Coutinho Mattera, Thais Verônica Saori Tsosura, Gestter Willian Lattari Tessarin, Renato Felipe Pereira, Bianca Elvira Belardi, Beatriz Costa E Silva Pinheiro, Doris Hissako Sumida
AIM: This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD). MAIN METHODS: One hundred and forty-four rats (age = 40 days) were distributed into 8 groups: 1) control (CN); 2) PD only; 3) PNX only; 4) PNX and PD (PNXPD); 5) CN treated with ME (CNM); 6) PD treated with ME (PDM); 7) PNX treated with ME(PNXM); 8) PNX and PD treated with ME(PNXPDM)...
October 12, 2018: Life Sciences
Chengliang Luo, Qiang Yang, Yuancai Liu, Shuanhu Zhou, Jiying Jiang, Russel J Reiter, Pallab Bhattacharya, Yongchun Cui, Hongwei Yang, He Ma, Jiemin Yao, Sean E Lawler, Xinmu Zhang, Jianfang Fu, Renato Rozental, Hany Aly, Mark D Johnson, E Antonio Chiocca, Xin Wang
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly produced by the pineal gland. Numerous physiological functions of melatonin have been demonstrated including anti-inflammation, suppressing neoplastic growth, circadian and endocrine rhythm regulation, and its potent antioxidant activity as well as its role in regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. In this review, we summarize the recent advances related to the multiple protective roles of melatonin receptor agonists, melatonin and N-acetylserotonin (NAS), in brain injury, liver damage, and bone health...
October 11, 2018: Free Radical Biology & Medicine
Andre Felipe Fajardo, Curtis Sobchak, Yulia Shifrin, Jingyi Pan, Tanja Gonska, Jaques Belik
BACKGROUND: When compared with infant formula, human milk enhances gastric emptying in preterm infants. Hydrogen peroxide (H2 O2 ) is present in large quantities in human milk that has an antimicrobial role for the mother and infant. In vitro adult rat studies suggest that H2 O2 facilitates gastric motor contraction. Hypothesizing that H2 O2 enhances gastric motility, we investigated its effects on the newborn rat stomach tissue. METHODS: Rat newborn and adult gastric fundic segments, or their smooth muscle cells, were used to evaluate the muscle response to H2 O2 exposure...
August 24, 2018: Pediatric Research
Yves Dauvilliers, Carlos H Schenck, Ronald B Postuma, Alex Iranzo, Pierre-Herve Luppi, Giuseppe Plazzi, Jacques Montplaisir, Bradley Boeve
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia that is characterized by loss of muscle atonia during REM sleep (known as REM sleep without atonia, or RSWA) and abnormal behaviours occurring during REM sleep, often as dream enactments that can cause injury. RBD is categorized as either idiopathic RBD or symptomatic (also known as secondary) RBD; the latter is associated with antidepressant use or with neurological diseases, especially α-synucleinopathies (such as Parkinson disease, dementia with Lewy bodies and multiple system atrophy) but also narcolepsy type 1...
August 30, 2018: Nature Reviews. Disease Primers
Natalia Kurhaluk, Arkadiusz Szarmach, Olga V Zaitseva, Alina Sliuta, Svitlana Kyriienko, Pawel J Winklewski
Lipopolysaccharide (LPS) administration in an in vivo experimental mice model causes oxidative damage in the liver, muscle, and kidney. We aimed to determine specific mechanisms underlying melatonin's antioxidant protective role. Assays were carried out in quadruplicate in the control, melatonin (10 mg/kg, 10 days), acute LPS administration (once 150 μg), and LPS + melatonin groups. LPS stimulated lipid peroxidation processes (dienes and malondialdehyde) and antioxidant enzyme concentrations (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) were assessed in all investigated tissues...
November 2018: Canadian Journal of Physiology and Pharmacology
Marcus J Drake, Luke Canham, Nikki Cotterill, Debbie Delgado, Jenny Homewood, Kirsty Inglis, Lyndsey Johnson, Mary C Kisanga, Denise Owen, Paul White, David Cottrell
BACKGROUND: Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in the bladder. There is limited evidence supporting use of melatonin to alleviate urinary frequency at night in the treatment of nocturia. The aim of this study was to evaluate the effect of melatonin on the mean number of nocturia episodes per night in patients with MS...
August 6, 2018: BMC Neurology
Eman S H Abd Allah, Ahmed M Mahmoud
This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobilization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90 min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA levels. An increase in the serum lactate-to-pyruvate ratio and the oxidative stress accompanied by a reduction of Na+ /K+ ATPase activity could be responsible for these changes...
June 16, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Wei Ge, Shan-He Wang, Bing Sun, Yue-Lang Zhang, Wei Shen, Hasan Khatib, Xin Wang
The role of melatonin in promoting the yield of Cashmere goat wool has been demonstrated for decades though there remains a lack of knowledge regarding melatonin mediated hair follicle growth. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are widely transcribed in the genome and play ubiquitous roles in regulating biological processes. However, the role of lncRNAs in regulating melatonin mediated hair follicle growth remains unclear. In this study, we established an in vitro Cashmere goat secondary hair follicle culture system, and demonstrated that 500 ng/L melatonin exposure promoted hair follicle fiber growth...
2018: Cell Cycle
Bárbara González-Fernández, Diana I Sánchez, Irene Crespo, Beatriz San-Miguel, Juan Ortiz de Urbina, Javier González-Gallego, María J Tuñón
Dysregulation of the circadian clock machinery is a critical mechanism in the pathogenesis of fibrosis. This study aimed to investigate whether the antifibrotic effect of melatonin is associated with attenuation of circadian clock pathway disturbances in mice treated with carbon tetrachloride (CCl4 ) and in human hepatic stellate cells line LX2. Mice received CCl4 5 μL/g body weight i.p. twice a week for 4 or 6 weeks. Melatonin was given at 5 or 10 mg/kg/day i.p., beginning 2 weeks after the start of CCl4 administration...
2018: Frontiers in Pharmacology
Irina Odinokova, Yulia Baburina, Alexey Kruglov, Irina Fadeeva, Alena Zvyagina, Linda Sotnikova, Vladimir Akatov, Olga Krestinina
Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonselective mitochondrial permeability transition pore are important factors that promote cardiac pathologies and dysfunction. The hormone melatonin (MEL) is known to improve the functional state of mitochondria via an antioxidant effect. Here, the effect of MEL administration on heart mitochondria from aged rats with acute cardiac failure caused by isoprenaline hydrochloride (ISO) was studied. A histological analysis revealed that chronic intake of MEL diminished the age-dependent changes in the structure of muscle fibers of the left ventricle, muscle fiber swelling, and injury zones characteristic of acute cardiac failure caused by ISO...
May 23, 2018: International Journal of Molecular Sciences
Mohamed Cheikh, Omar Hammouda, Nawel Gaamouri, Tarak Driss, Karim Chamari, Ridha Ben Cheikh, Mohamed Dogui, Nizar Souissi
The present study aimed to explore the effects of a single 10-mg dose of melatonin (MEL) administration after exhaustive late-evening exercise on sleep quality and quantity, and short-term physical and cognitive performances in healthy teenagers. Ten male adolescent athletes (mean ± SD, age = 15.4 ± 0.3 years, body-mass = 60.68 ± 5.7 kg, height = 167.9 ± 6.9 cm and BMI = 21.21 ± 2.5) performed two test sessions separated by at least one week. During each session, participants completed the Yo-Yo intermittent-recovery-test level-1 (YYIRT-1) at ~20:00 h...
September 2018: Chronobiology International
Samuel Gbadebo Olukole, Samuel Olumide Ajani, Eunice Olufunke Ola-Davies, Damilare Olaniyi Lanipekun, Oluwasanmi Olayinka Aina, Matthew Olugbenga Oyeyemi, Bankole Olusiji Oke
Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that has been demonstrated to induce alterations in reproductive organs while melatonin (ML), an antioxidant, present in plants and animals, is capable of protecting against EDC-induced alterations. Adult male Wistar rats (average weight, 240 + 10 g) were divided into four groups of ten animals each: Rats in group I (control) received oral 0.2 ml 1% dimethyl sulfoxide (DMSO)/99% canola oil as vehicle; group II received intra-peritoneal 10 mg/kg BW/day ML...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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