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Endobronchial tumors

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https://www.readbyqxmd.com/read/30310038/-bronchoscopy-and-interventional-pulmonology
#1
Takahiro Nakajima, Ichiro Yoshino
Recent advance in bronchology and interventional pulmonology contributes to improve the quality of patient care in thoracic surgery. Narrow band imaging (NBI) combined with high definition bronchoscopy clearly visualize the aberrant tumor vessels on the mucosa of endobronchial malignancy. It helps the preoperative surgical planning for the clear bronchial margin during the surgery. The index of hemoglobin (IHb) show the approximate amount of hemoglobin within the mucosal surface and we use the IHb for the evaluation of local circulation of bronchial anastomosis after bronchoplasty...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/30302308/a-unique-case-report-of-endobronchial-cryptococcosis-and-review-of-the-literature
#2
Shi-Yuan Shuai, Liang Xiong, Xin-Liang He, Fan Yu, Qin Xia, Qiong Zhou
Cryptococcosis is an infection caused by the yeast-like fungus Cryptococcus neoformans . Pulmonary cryptococcosis is typically identified as a single mass or as multiple nodules, while endobronchial lesions are quite rare. Here we report an uncommon case of pulmonary cryptococcosis presenting as endobronchial lesion in an immunocompetent patient. A 49-year-old male patient complained of intermittent cough with hemoptysis for two years. Computerized tomography of the chest showed a filling defect in the basal segment of the right lower lobe bronchus...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30276554/molecular-testing-in-ebus-tbna-specimens-of-lung-adenocarcinoma-a-study-of-concordance-between-cell-block-method-and-liquid-based-cytology-in-appraising-sample-cellularity-and-egfr-mutations
#3
Daniele Magnini, Leonello Fuso, Francesco Varone, Ettore D'Argento, Maurizio Martini, Antonietta Pecoriello, Vincenzo Di Noia, Damiano Arciuolo, Guido Fadda, Guido Rindi, Luca Richeldi
PURPOSE: Cytological endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimens of mediastinal lymph node metastasis are frequently used to perform concomitant diagnosis, staging and genetic testing in non-small-cell lung cancer (NSCLC). The purposes of this single-center retrospective study were to evaluate EBUS-TBNA samples' adequacy for molecular testing of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), and to analyze the concordance between the cell block method and liquid-based cytology (LBC) in appraising the sample cellularity and in detecting EGFR mutation...
October 1, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/30253411/endoscopic-ultrasound-with-bronchoscope-guided-fine-needle-aspiration-for-the-diagnosis-of-paraesophageally-located-lung-lesions
#4
Ida Skovgaard Christiansen, Jolanda Corina Kuijvenhoven, Uffe Bodtger, Therese Maria Henriette Naur, Khaliq Ahmad, Jatinder Singh Sidhu, Rafi Nessar, Goran Nadir Salih, Asbjørn Høegholm, Jouke Tabe Annema, Paul Frost Clementsen
BACKGROUND: Diagnosing centrally located lung tumors without endobronchial abnormalities and not located near the major airways is a diagnostic challenge. Tumors near or adjacent to the esophagus can be aspirated and detected with esophageal ultrasound (EUS) using gastrointestinal endoscopes. OBJECTIVE: To assess the feasibility and diagnostic yield of endoscopic ultrasound with bronchoscope-guided fine needle aspiration (EUS-B-FNA) in paraesophageally located lung tumors and its added value to bronchoscopy and endobronchial ultrasound (EBUS)...
September 25, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30227375/conversion-to-thoracotomy-during-vats-segmentectomy-for-treatment-of-symptomatic-endobronchial-hamartoma
#5
Dario Amore, Pasquale Imitazione, Albina Palma, Dino Casazza, Roberto Scaramuzzi, Davide Di Natale, Antonio Molino, Carlo Curcio
INTRODUCTION: Most hamartomas are located peripherally in the lung parenchyma and are rarely identified as an endobronchial lesion. Clinically patients with an endobronchial hamartoma are often symptomatic and may present with various symptoms including: fever, wheezing, hemoptysis and obstructive pneumonia. CASE PRESENTATION: A 68-year-old man presented with complaints of fever and cough for 1 month. Chest X-ray revealed a right infrahilar density, which on chest CT was found to be a lesion obstructing the superior segmental bronchus of the right lower lobe and extending outside of the bronchus...
September 12, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30220948/adenocarcinoma-of-lung-and-bronchial-carcinoid-presenting-as-double-synchronous-primary-lung-cancer-a-case-report-and-review-of-literature
#6
Lakshmi Saladi, Sai Mounica Maddu, Masooma Niazi, Ajsza Matela
Recent advances in imaging techniques led to an increase in the incidence of synchronous and metachronous primary lung cancers due to early detection. Management of these patients is challenging and prognosis depends on the stage of the tumor at initial diagnosis and histological type. A 68-year-old African American male patient with medical history of hypertension and diabetes mellitus presented to our emergency department with right sided chest pain, worsening dyspnea and dry cough of 2-week duration. He also reported significant weight loss and was a smoker with 25 pack-years smoking history...
August 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/30175037/a-rare-case-of-endobronchial-mucoepidermoid-carcinoma-of-the-lung-presenting-as-non-resolving-pneumonia
#7
Toolsie Omesh, Ranjan Gupta, Anjali Saqi, Joshua Burack, Misbahuddin Khaja
Background: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, and MECs of the lung are rare, accounting for 0.1-0.2% of malignant lung tumors. Pulmonary MECs are commonly found in the segmental or lobar bronchi, rarely presenting as endobronchial lesions. Case presentation: Here we describe the case of a 21-year-old female with no comorbid conditions who presented at the emergency room with a cough, yellow phlegm, pleuritic chest pain, and a subjective fever...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30174918/endobronchial-ultrasound-guided-fine-needle-aspiration-for-pulmonary-carcinomas-genotyping-experience-with-398-cases-including-rapid-egfr-kras-analysis-in-43-cases
#8
Maria-Rosa Ghigna, Adrian Crutu, Valentina Florea, Séverine Feuillet-Soummer, Pierre Baldeyrou, Julien Adam, Ludovic Lacroix, Benjamin Besse, Olaf Mercier, Elie Fadel, Peter Dorfmuller, Rida El Ayoubi, Vincent Thomas de Montpréville
Background: Endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) of mediastinal lymph nodes is a minimally invasive and efficient tool for both diagnosis and staging of lung cancer. EBUS-FNA also permits tumor genotyping. However this critical datum for the therapeutic management is often long to obtain for metastatic patients with short life expectancy. Methods: From May 2011 to December 2017, 398 lung cancer patients underwent a genetic analysis based on EBUS-FNA samples...
July 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30168461/multimodality-multistaged-management-of-large-endobronchial-carcinoid-causing-respiratory-failure-a-case-report-with-review-of-literature
#9
Abhijeet Singh, Sivaramakrishnan Mahadevan, Vallandramam R Pattabhiraman, Arjun Srinivasan
We report the case of a 58-year-old female presenting with central airway obstruction leading to airway compromise thrice, first two times from endobronchial growth of typical carcinoid tissue and subsequently from granulation tissue at anastomotic site after left carinal pneumonectomy. Bronchoscopic resection of carcinoid tumor and granulation tissue was performed successfully with electrosurgical snaring through rigid bronchoscope. Cryodebridement using flexible cryoprobe of the tumor was done postembolization and of the remnant granulation tissue without any complication...
September 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/30117519/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-the-diagnosis-of-hilar-and-mediastinal-lymph-node-metastases-of-melanoma
#10
José-Fernando Val-Bernal, María Martino, Elena Yllera, Félix Romay, María Sánchez-Ares, Ihab Abdulkader Nallib
OBJECTIVE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique for investigating hilar and mediastinal lymphadenopathy. This study reports eleven cases in which EBUS-TBNA was used to assess mediastinal and hilar lymph nodes for the presence of metastatic melanoma. MATERIAL AND METHOD: A retrospective study was performed of all patients who had a history of melanoma and underwent EBUS-TBNA to assess hilar or mediastinal lymphadenopathy for the presence of metastatic melanoma...
August 17, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/30089578/the-role-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-stereotactic-body-radiation-therapy-for-non-small-cell-lung-cancer
#11
Kohei Hashimoto, Niccolò Daddi, Meredith Giuliani, Andrew Hope, Lisa W Le, Kasia Czarnecka, Marcelo Cypel, Andrew Pierre, Marc de Perrot, Gail Darling, Thomas K Waddell, Shaf Keshavjee, Kazuhiro Yasufuku
OBJECTIVE: To evaluate the diagnostic value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in stereotactic body radiation therapy (SBRT) candidates and compare with computed tomography (CT) and positron emission tomography (PET). METHODS: Inclusion criteria for this single institutional retrospective study were 1) biopsy-proven or suspicious NSCLC with diameter <6 cm; 2) no distant metastasis; 3) EBUS-TBNA staging between April 2008 and November 2014; 4) SBRT eligible...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30059678/comparison-of-programmed-death-ligand-1-immunohistochemical-staining-between-endobronchial-ultrasound-transbronchial-needle-aspiration-and-resected-lung-cancer-specimens
#12
Kenneth K Sakata, David E Midthun, John J Mullon, Ryan M Kern, Darlene R Nelson, Eric S Edell, Dante N Schiavo, James R Jett, Marie Christine Aubry
BACKGROUND: In advanced non-small cell lung cancer (NSCLC), small biopsy specimens from endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are often the only available material from cancer tissue for the analysis of programmed death ligand-1 (PD-L1) expression. We aim to assess the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PD-L1 expression at ≥ 1% and ≥ 50% on EBUS-TBNA samples compared with their corresponding surgically resected tumor...
October 2018: Chest
https://www.readbyqxmd.com/read/30048419/endobronchial-myxoma-an-uncommon-entity
#13
Arindam Mukherjee, Ritesh Agarwal, Sahajal Dhooria, Pawan Singh, Amanjit Bal, Harkant Singh, Inderpaul S Sehgal
A 31-year-old woman presented with progressive breathlessness since 1 year. Flexible bronchoscopy revealed a vascular tumor completely occluding the right main bronchus. A diagnosis of primary endobronchial myxoma was made. Tumor debulking was performed using rigid bronchoscopy. This enabled right lower lobectomy. A literature search yielded 12 cases of primary pulmonary myxoma, and only 2 previous reports of endobronchial myxoma. Most tumors were incidentally detected and were cured surgically. Endobronchial myxomas are rare and are usually asymptomatic...
July 25, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/30021251/endobronchial-smooth-muscle-tumors-a-series-of-five-cases-highlighting-pitfalls-in-diagnosis
#14
Tripti Nakra, Aanchal Kakkar, Shipra Agarwal, Karan Madan, Suresh C Sharma, Deepali Jain
Background: Primary endobronchial smooth muscle tumors (SMTs), which are extremely rare, include endobronchial leiomyomas and leiomyosarcomas. Clinically, SMTs present with signs and symptoms of bronchial obstruction, and lack specific radiological findings. Thus, histopathological examination is required for accurate diagnosis as well as for tumor grading. We examined the histomorphological and immunohistochemical features of endobronchial SMTs and highlighted pitfalls in diagnosis, particularly when using small biopsies...
July 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/30015588/non-small-cell-lung-cancer-with-resistance-to-egfr-tki-therapy-ct-characteristics-of-t790m-mutation-positive-cancer
#15
Hyun Jung Koo, Mi Young Kim, Sojung Park, Han Na Lee, Hwa Jung Kim, Jae Cheol Lee, Sang-We Kim, Dae Ho Lee, Chang-Min Choi
Purpose To evaluate the clinical and CT characteristics of T790M mutation-positive non-small cell lung cancer (NSCLC) after epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy failure. Materials and Methods A retrospective study of 304 patients with NSCLC who underwent rebiopsy after first-line EGFR-TKI therapy was conducted. Rebiopsy methods included CT- or fluoroscopy-guided lung biopsies (n = 105), endobronchial US- or bronchofibroscopy-guided biopsies (n = 66), pleural fluid analysis (n = 47), other solid organ biopsies (n = 43), US-guided axillary or supraclavicular lymph node biopsies (n = 31), and cerebrospinal fluid analysis (n = 12)...
October 2018: Radiology
https://www.readbyqxmd.com/read/29987577/epithelial-myoepithelial-carcinoma-of-the-lung-a-case-report
#16
Yasuhiro Nakashima, Riichiro Morita, Akiko Ui, Kuniko Iihara, Takuya Yazawa
BACKGROUND: Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is a rare subset of salivary gland-type tumors of the lung. Because of its rarity and unproven malignant potential, the optimal therapy for P-EMC has not been defined. Here, we report a typical case of P-EMC and a review of the literature to consider appropriate treatment. CASE PRESENTATION: A 54-year-old woman presented with an abnormal lung shadow on a routine chest X-ray. A chest computed tomography (CT) scan verified an 18-mm endobronchial nodule on the middle lobe...
July 9, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29983103/giant-intercostal-nerve-schwannoma-in-a-patient-with-neurofibromatosis-type-2
#17
Luca Ampollini, Luigi Ventura, Letizia Gnetti, Paolo Carbognani, Enrico Maria Silini, Michele Rusca
PURPOSE: To describe a case of giant intercostal nerve schwannoma successfully resected in a patient with neurofibromatosis type 2. METHODS: A 44-year-old woman, with a history of neurofibromatosis type 2, presented with chest discomfort and mild dyspnea. She had undergone a recent resection of a large frontal parasagittal benign meningioma. Radiologic examinations showed a large lesion (9×12×9 cm) of the left hemithorax causing a complete atelectasis of left upper lobe...
June 1, 2018: Tumori
https://www.readbyqxmd.com/read/29977787/organized-blood-clot-masquerading-as-endobronchial-tumor-a-review-of-management-and-recent-advances
#18
Lakshmi Saladi, Dmitry Lvovsky
Central airway obstruction, a frequently encountered emergency, is usually associated with blood clots, tumors, foreign bodies or mucus plugs. Airway obstruction due to blood clots can be seen as a complication of lung malignancies, infections, bronchiectasis, arteriovenous malformations or pulmonary infarction. In patients with long standing blood clots, the thrombus gets organized and firmly adherent to the airway. The diagnosis is often misleading as these clots mimic tumors clinically and on imaging. Hemoptysis is the most common presenting symptom though many patients can be asymptomatic...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29977779/massive-hemorrhage-after-inspection-bronchoscopy-for-carcinoid-tumor
#19
Mirna Ayache, Christopher Donatelli, Kara Roncin, Kianoush AnsariGilani, Michael Yang, Jihane Faress, Catalina Teba
Carcinoid tumor is a neuroendocrine tumor that can arise in the bronchial tree and can be hypervascular. Here we describe a case of bronchial carcinoid tumor in a 34-year-old previously healthy male who presented with hemoptysis and right lung mass. Inspection bronchoscopy revealed bronchus intermedius endobronchial lesion and was complicated by urgent intubation and placement of endobronchial blocker for massive hemorrhage. Subsequent angiography with embolization of the bronchial artery supplying the mass resulted in control of bleeding...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29977775/a-unique-case-of-a-huge-mixed-squamous-cell-and-glandular-papilloma-of-non-endobronchial-origin-with-a-peripheral-growth
#20
Kei Yabuki, Atsuji Matsuyama, Kosho Obara, Masaru Takenaka, Fumihiro Tanaka, Yukio Nakatani, Masanori Hisaoka
We report a case of a huge solitary non-endobronchial pulmonary tumor in a 76-year-old male smoker. The tumor measured 11 × 10 × 8 cm. It was ill-defined, and it was located periphery of the right lower lobe with the subpleural cystic spaces. He underwent right lower lobectomy with mediastinal lymph node dissection and is free from tumor 30 months after surgery. Microscopically, it was composed of a proliferation of squamous and ciliated columnar epithelial cells with a few mucous cells. These cells were arranged in a papillary growth fashion extending along the fibrously thickened alveolar septa together with metaplastic bronchiolar and squamous epithelia displaying an usual interstitial pneumonia-pattern...
2018: Respiratory Medicine Case Reports
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