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Endobronchial tumors

Kohei Hashimoto, Niccolò Daddi, Meredith Giuliani, Andrew Hope, Lisa W Le, Kasia Czarnecka, Marcelo Cypel, Andrew Pierre, Marc de Perrot, Gail Darling, Thomas K Waddell, Shaf Keshavjee, Kazuhiro Yasufuku
OBJECTIVE: To evaluate the diagnostic value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in stereotactic body radiation therapy (SBRT) candidates and compare with computed tomography (CT) and positron emission tomography (PET). METHODS: Inclusion criteria for this single institutional retrospective study were 1) biopsy-proven or suspicious NSCLC with diameter <6 cm; 2) no distant metastasis; 3) EBUS-TBNA staging between April 2008 and November 2014; 4) SBRT eligible...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Kenneth K Sakata, David E Midthun, John J Mullon, Ryan M Kern, Darlene R Nelson, Eric S Edell, Dante N Schiavo, James R Jett, Marie Christine Aubry
BACKGROUND: In advanced non-small cell lung cancer (NSCLC), small biopsy specimens from endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are often the only available material from cancer tissue for the analysis of programmed death ligand-1 (PD-L1) expression. We aim to assess the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PD-L1 expression at ≥1% and ≥50% on EBUS-TBNA samples compared with their corresponding surgically resected tumor...
July 27, 2018: Chest
Arindam Mukherjee, Ritesh Agarwal, Sahajal Dhooria, Pawan Singh, Amanjit Bal, Harkant Singh, Inderpaul S Sehgal
A 31-year-old woman presented with progressive breathlessness since 1 year. Flexible bronchoscopy revealed a vascular tumor completely occluding the right main bronchus. A diagnosis of primary endobronchial myxoma was made. Tumor debulking was performed using rigid bronchoscopy. This enabled right lower lobectomy. A literature search yielded 12 cases of primary pulmonary myxoma, and only 2 previous reports of endobronchial myxoma. Most tumors were incidentally detected and were cured surgically. Endobronchial myxomas are rare and are usually asymptomatic...
July 25, 2018: Journal of Bronchology & Interventional Pulmonology
Tripti Nakra, Aanchal Kakkar, Shipra Agarwal, Karan Madan, Suresh C Sharma, Deepali Jain
Background: Primary endobronchial smooth muscle tumors (SMTs), which are extremely rare, include endobronchial leiomyomas and leiomyosarcomas. Clinically, SMTs present with signs and symptoms of bronchial obstruction, and lack specific radiological findings. Thus, histopathological examination is required for accurate diagnosis as well as for tumor grading. We examined the histomorphological and immunohistochemical features of endobronchial SMTs and highlighted pitfalls in diagnosis, particularly when using small biopsies...
July 2018: Journal of Pathology and Translational Medicine
Hyun Jung Koo, Mi Young Kim, Sojung Park, Han Na Lee, Hwa Jung Kim, Jae Cheol Lee, Sang-We Kim, Dae Ho Lee, Chang-Min Choi
Purpose To evaluate the clinical and CT characteristics of T790M mutation-positive non-small cell lung cancer (NSCLC) after epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy failure. Materials and Methods A retrospective study of 304 patients with NSCLC who underwent rebiopsy after first-line EGFR-TKI therapy was conducted. Rebiopsy methods included CT- or fluoroscopy-guided lung biopsies (n = 105), endobronchial US- or bronchofibroscopy-guided biopsies (n = 66), pleural fluid analysis (n = 47), other solid organ biopsies (n = 43), US-guided axillary or supraclavicular lymph node biopsies (n = 31), and cerebrospinal fluid analysis (n = 12)...
July 17, 2018: Radiology
Yasuhiro Nakashima, Riichiro Morita, Akiko Ui, Kuniko Iihara, Takuya Yazawa
BACKGROUND: Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is a rare subset of salivary gland-type tumors of the lung. Because of its rarity and unproven malignant potential, the optimal therapy for P-EMC has not been defined. Here, we report a typical case of P-EMC and a review of the literature to consider appropriate treatment. CASE PRESENTATION: A 54-year-old woman presented with an abnormal lung shadow on a routine chest X-ray. A chest computed tomography (CT) scan verified an 18-mm endobronchial nodule on the middle lobe...
July 9, 2018: Surgical Case Reports
Luca Ampollini, Luigi Ventura, Letizia Gnetti, Paolo Carbognani, Enrico Maria Silini, Michele Rusca
PURPOSE: To describe a case of giant intercostal nerve schwannoma successfully resected in a patient with neurofibromatosis type 2. METHODS: A 44-year-old woman, with a history of neurofibromatosis type 2, presented with chest discomfort and mild dyspnea. She had undergone a recent resection of a large frontal parasagittal benign meningioma. Radiologic examinations showed a large lesion (9×12×9 cm) of the left hemithorax causing a complete atelectasis of left upper lobe...
June 1, 2018: Tumori
Lakshmi Saladi, Dmitry Lvovsky
Central airway obstruction, a frequently encountered emergency, is usually associated with blood clots, tumors, foreign bodies or mucus plugs. Airway obstruction due to blood clots can be seen as a complication of lung malignancies, infections, bronchiectasis, arteriovenous malformations or pulmonary infarction. In patients with long standing blood clots, the thrombus gets organized and firmly adherent to the airway. The diagnosis is often misleading as these clots mimic tumors clinically and on imaging. Hemoptysis is the most common presenting symptom though many patients can be asymptomatic...
2018: Respiratory Medicine Case Reports
Mirna Ayache, Christopher Donatelli, Kara Roncin, Kianoush AnsariGilani, Michael Yang, Jihane Faress, Catalina Teba
Carcinoid tumor is a neuroendocrine tumor that can arise in the bronchial tree and can be hypervascular. Here we describe a case of bronchial carcinoid tumor in a 34-year-old previously healthy male who presented with hemoptysis and right lung mass. Inspection bronchoscopy revealed bronchus intermedius endobronchial lesion and was complicated by urgent intubation and placement of endobronchial blocker for massive hemorrhage. Subsequent angiography with embolization of the bronchial artery supplying the mass resulted in control of bleeding...
2018: Respiratory Medicine Case Reports
Kei Yabuki, Atsuji Matsuyama, Kosho Obara, Masaru Takenaka, Fumihiro Tanaka, Yukio Nakatani, Masanori Hisaoka
We report a case of a huge solitary non-endobronchial pulmonary tumor in a 76-year-old male smoker. The tumor measured 11 × 10 × 8 cm. It was ill-defined, and it was located periphery of the right lower lobe with the subpleural cystic spaces. He underwent right lower lobectomy with mediastinal lymph node dissection and is free from tumor 30 months after surgery. Microscopically, it was composed of a proliferation of squamous and ciliated columnar epithelial cells with a few mucous cells. These cells were arranged in a papillary growth fashion extending along the fibrously thickened alveolar septa together with metaplastic bronchiolar and squamous epithelia displaying an usual interstitial pneumonia-pattern...
2018: Respiratory Medicine Case Reports
Paul Zarogoulidis, Stella Laskou, Athanasios Katsaounis, Efstathios Pavlidis, Dimitrios Giannakidis, Charilaos Koulouris, Stylianos Mantalovas, Ioanna Kougioumtzi, Nikolaos Katsikogiannis, Fotis Konstantinou, Wolfgang Hohenforst-Schmidt, Haidong Huang, Chong Bai, Alkis Euthimiou, Dimitris Hatzibougas, Iota Fitili, Chrysanthi Sardeli, Aggeliki Rapti, Isaak Kesisoglou, Konstantinos Sapalidis
Esophageal lyomyoma are rare benign tumors of the esophagus and they remain usually undiagnosed until local compression symptoms occur in the esophagus. Gastroscopy or esophageal ultrasonography (EUS) are usually the methods of choice for diagnosis. Moreover; surgery is the solution for this entity. In our case we present diagnosis of esophageal lyomyoma using convex probe endobronchial ultrasound (EBUS) with a fine needle aspiration of 22G.
2018: Respiratory Medicine Case Reports
Yuanshun Liu, Hua Jiang, Qiuran Xu, Hongbin Zhou, Yaqing Li
Liposarcoma is the most common type of soft-tissue sarcoma, and predominantly originates from the extremities and retroperitoneal cavity. However, primary endobronchial liposarcoma is extremely rare. The present study reports on the case of a 54-year-old man, a smoker, diagnosed with primary endobronchial atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLS), which was successfully resected via bronchoscopy. Chest computed tomography (CT) revealed a neoplasm in the left main bronchus measuring 12...
July 2018: Oncology Letters
Carlos Perez, Fayez Kheir, Marianne Barry, Yaron Gesthalther, Adnan Majid
No abstract text is available yet for this article.
July 2018: Journal of Bronchology & Interventional Pulmonology
Irfan I Ayub, Dhanasekar Thangaswamy, Leena D Joseph, Manickavasagam Meenakshisundaram
Ovarian cancer is the seventh most common cancer in women and the eighth most common cause of cancer death in the world with an overall 5-year survival rate of <50%. (1) The most common age of presentation is at the perimenopausal age group and two-thirds of them present with advanced stage of disease. (2) Thoracic metastases occur in up to 50% of patients. Pleural effusion is the most common presentation of thoracic metastases in these patients, whereas pulmonary parenchymal metastases, lymphangitis, and nodal involvement are less commonly reported...
July 2018: Journal of Bronchology & Interventional Pulmonology
A Christine Argento, Daniel L Gilstrap, Scott Shofer, Kamran Mahmood, Kimberly Blackwell, Momen M Wahidi
BACKGROUND: Metastasis of breast cancer to mediastinal lymph nodes is common and biopsy of suspicious lesions can have important diagnostic, prognostic, and therapeutic implications, particularly with respect to tumor receptor status. Our aim was to show that endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be used for the diagnosis of metastatic breast cancer and demonstrate reliable receptor evaluation that can result in change of therapy. METHODS: A retrospective review of consecutive adult patients undergoing EBUS-TBNA from May 2007 to September 2012 was performed...
July 2018: Journal of Bronchology & Interventional Pulmonology
Adnan Majid, Atul Palkar, Fayez Kheir, Daniel Alape, Sebastian Fernandez-Bussy, Joseph Aronovitz, Jorge Guerrero, Sidhu Gangadharan, Michael Kent, Richard Whyte, Erik Folch
BACKGROUND: Stereotactic body radiotherapy (SBRT) had become a therapeutic modality in patients with primary tumors, locally recurrent as well as oligometastasis involving the lung. Some modalities of SBRT require fiducial marker (FM) for dynamic tumor tracking. Previous studies have focused on evaluating bronchoscopic-guided FM placement for peripheral lung nodules. We describe the safety and feasibility of placing FM using real-time convex probe endobronchial ultrasound (CP-EBUS) for SBRT in patients with centrally located hilar/mediastinal masses or lymph nodes...
June 22, 2018: Journal of Bronchology & Interventional Pulmonology
Deepali Jain, K S Supraja, Anant Mohan, V K Iyer
OBJECTIVE: PD-L1 immunohistochemistry (IHC) is essential in patients of advanced non-small-cell-lung cancer (NSCLC) to determine eligibility for immunotherapy. PD-L1 IHC assays have been clinically validated only on FFPE tissue; however, lung cancer is frequently diagnosed on cytology. PD-L1 immunocytochemistry (ICC) has shown high concordance of immunoexpression between cytology samples and paired small biopsies. Feasibility of liquid-based cytology (LBC) smears for PD-L1 ICC has not been analyzed previously...
June 25, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Adam R Dyas, Robert W King, Asem F Ghanim, Robert J Cerfolio
BACKGROUND: Our objective is to compare the clinical to the pathologic stage in patients with non-small cell lung cancer (NSCLC). METHODS: Review of a prospective database from one surgeon. Patients had NSCLC, chest tomography (CT) and most had positron emissions tomography (PET). Those with suggested N1, N2, central tumors and/or tumors > 5 cm underwent mediastinoscopy and/or endobronchial ultrasound and, if N2 negative, underwent resection with complete thoracic lymphadenectomy...
June 14, 2018: Annals of Thoracic Surgery
José-Fernando Val-Bernal, María Martino, Félix Romay, Elena Yllera
Evaluation of mediastinal lymphadenopathy in patients with a previous diagnosis of renal cell carcinoma (RCC) is critical for the determination of further treatment. A minimally invasive method of cytology sampling of mediastinal lymph nodes using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a useful tool in diagnosis. Between January 2010 and April 2018, we performed 1744 EBUS-TBNA studies of mediastinal and hilar lymph nodes for a variety of clinical indications including mediastinal malignancy...
July 2018: Pathology, Research and Practice
L Eickhoff, H Golpon, P Zardo, H Suhling, T Welte, D Jonigk, J Gottlieb, T Fuehner
BACKGROUND:  Endobronchial ultrasound (EBUS) bronchoscopy with transbronchial needle aspiration (TBNA) is a well-established tool in mediastinal staging in lung cancer and gains importance in exploration of non-malignant lymphadenopathy. The aim of this study was to evaluate the role of EBUS-TBNA in suspected non-malignant diseases. METHODS:  A retrospective, single-center, observation analysis of endobronchial ultrasound bronchoscopy procedures was performed in a university medical center between March 2013 and July 2015...
May 22, 2018: Pneumologie
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