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https://www.readbyqxmd.com/read/29778594/differential-toxin-profiles-of-ciguatoxins-in-marine-organisms-chemistry-fate-and-global-distribution
#1
REVIEW
Lucía Soliño, Pedro Reis Costa
Ciguatoxins (CTXs) are fish metabolism products and a result of biotransformation of precursor gambiertoxins produced, in the first instance, by benthic dinoflagellates Gambierdiscus and Fukuyoa. Ciguatoxins are potent neurotoxins that selectively open voltage gated sodium channels in excitable cells causing the human food poisoning known as Ciguatera (CFP). Endemic from tropical areas in central Pacific and West Indian Ocean, and the Caribbean Sea, CTX may affect up to 500,000 people annually due to fish consumption...
August 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28527331/analysis-of-zip-zrt-irt-related-protein-transporter-gene-expression-in-murine-neural-stem-progenitor-cells
#2
Mayu Nishikawa, Hideki Mori, Masayuki Hara
Zinc plays important roles for brain development. Zrt-, Irt-related protein (ZIP) is a major transporter family to regulate the intracellular zinc levels. Neural stem/progenitor cells (NSPCs) are more sensitive than their differentiated progeny (neural/glial cells) to zinc in vitro (Nishikawa et al., 2015). We analyzed relative gene expression of 14 different ZIPs in murine NSPCs and differentiated cells by real-time polymerase chain reaction technique. Expression of Zip4 and that of Zip12 drastically increased, while that of Zip8 clearly decreased after differentiation of NSPCs...
July 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27729641/intracellular-localization-of-saffold-virus-leader-l-protein-differs-in-vero-and-hep-2-cells
#3
Yishi Xu, Carla Bianca Luena Victorio, Qimei Ng, Mookkan Prabakaran, Yee-Joo Tan, Kaw Bing Chua
The Saffold virus (SAFV) genome is translated as a single long polyprotein precursor and co-translationally cleaved to yield 12 separate viral proteins. Little is known about the activities of SAFV proteins although their homologs in other picornaviruses have already been described. To further support research on functions and activities of respective viral proteins, we investigated the spatio-temporal distribution of SAFV proteins in Vero and HEp-2 cells that had been either transfected with plasmids that express individual viral proteins or infected with live SAFV...
October 12, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/25333857/sox2-promotes-tumorigenicity-and-inhibits-the-differentiation-of-i-type-neuroblastoma-cells
#4
Shaobo Yang, Jicui Zheng, Xianmin Xiao, Ting Xu, Weitao Tang, Haitao Zhu, Lin Yang, Shan Zheng, Kuiran Dong, Guomin Zhou, Yang Wang
SOX2 is a transcription factor associated with the pluripotency, proliferative potential, and self-renewing properties observed with embryonic stem cells and germ cells. SOX2 expression has been reported in several cancers and is implicated in tumorigenesis. We previously found that SOX2 expression was correlated to the clinical stage of neuroblastoma. Recently, we found that SOX2 overexpression occurs in I-type neuroblastoma cells (BE(2)-C cells). To elucidate the tumorigenic function of SOX2, we established a SOX2 overexpressed BE(2)-C cell line...
January 2015: International Journal of Oncology
https://www.readbyqxmd.com/read/23904362/salidroside-attenuates-lps-stimulated-activation-of-thp-1-cell-derived-macrophages-through-down-regulation-of-mapk-nf-kb-signaling-pathways
#5
Hong-Wu Wang, Ting Wu, Jun-Ying Qi, Ya-Qi Wang, Xiao-Ping Luo, Qin Ning
Excessive activation of macrophages is implicated in various inflammatory injuries. Salidroside (Sal), one of the main bioactive components of Rhodiola Sachalinensis, has been reported to possess anti-inflammatory activities. This study aimed to examine the effect of Sal on the activation of macrophages and the possible mechanism. The lipopolysaccharide (LPS)-stimulated phrobol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were established. The changes in the inflammatory profiles of THP-1-derived macrophages were determined...
August 2013: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/23115524/from-genotype-%C3%A3-environment-interaction-to-gene-%C3%A3-environment-interaction
#6
Jose Crossa
Historically in plant breeding a large number of statistical models has been developed and used for studying genotype × environment interaction. These models have helped plant breeders to assess the stability of economically important traits and to predict the performance of newly developed genotypes evaluated under varying environmental conditions. In the last decade, the use of relatively low numbers of markers has facilitated the mapping of chromosome regions associated with phenotypic variability (e.g...
May 2012: Current Genomics
https://www.readbyqxmd.com/read/22826717/multiple-aplasia-cutis-congenita-lesions-located-along-blaschko-s-lines-in-a-patient-with-tetralogy-of-fallot-a
#7
Daiki Rokunohe, Eijiro Akasaka, Akiko Rokunohe, Takahide Kaneko, Yasushi Matsuzaki, Noriko Takiyoshi, Takayuki Aizu, Hajime Nakano, Daisuke Sawamura
BACKGROUND: Aplasia cutis congenita (ACC) is a congenital absence of skin, and a single alopecic lesion on the scalp is the most common form. MAIN OBSERVATION: We present a case of ACC with tetralogy of Fallot-A. Differetial diagnosis included Adams-Oliver syndrome and nevus psiloliparus. Interestingly, our patient showed multiple ACC lesions, which were located along Blaschko's lines. CONCLUSIONS: As far as we know, our case is the third case of ACC with tetralogy of Fallot-A...
June 30, 2012: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/22635083/combined-octreotide-and-peptide-receptor-radionuclide-therapy-90-y-dota-tate-in-case-of-malignant-insulinoma
#8
Jakub Fischbach, Paweł Gut, Magdalena Matysiak-Grześ, Aleksandra Klimowicz, Maria Gryczyńska, Ryszard Waśko, Marek Ruchała
BACKGROUND: Insulinomas are the most common functioning neuroendocrine tumours of the pancreas. Hypoglycemia due to excessive production of insulin is a main feature of this disease. Usually these neoplasms are benign and single with surgical excision as a treatment of choice. About 10% are malignant with tendency to form metastases especially to the liver then therapy requires various medical technics. CASE REPORT: 43 years old female with reccurent syncopies in course of hypoglycemia was admitted to the hospital to be diagnosed...
2012: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/19761124/clinicopathological-implications-of-inactivation-of-rassf1a-in-serous-epithelial-ovarian-cancers
#9
L Ma, Q Guo, Y Ma, F R Liu, X Y Shen
OBJECTIVE: To investigate the frequency of promoter hypermethylation of RASSF1A gene in ovarian cancers and its correlations to gene expression and clinicopathological characters in the Chinese population. METHODS: In this study, we detected the frequency of promoter hypermethylation of the RASSF1A gene in 60 patients with primary serous epithelial ovarian carcinomas (SEOCs) using Methylation-Specific PCR (MSP). The gene expression of mRNA and protein was examined by RT-PCR and Western blot...
2009: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/19412574/the-differentiation-of-human-placenta-derived-mesenchymal-stem-cells-into-dopaminergic-cells-in-vitro
#10
Li Chen, Dong-Mei He, Yuan Zhang
Mesenchymal stem cells (MSCs) constitute an interesting cellular source to promote brain regeneration after Parkinson's disease. MSCs have significant advantages over other stem cell types, and greater potential for immediate clinical application. The aim of this study was to investigate whether MSCs from the human placenta could be induced to differentiate into dopaminergic cells. MSCs from the human placenta were isolated by digestion and density gradient fractionation, and their cell surface glycoproteins were analyzed by flow cytometry...
2009: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/19267617/mitochondria-are-more-numerous-and-smaller-in-pink-eyed-dilution-melanoblasts-and-melanocytes-than-in-wild-type-melanocytes-in-the-neonatal-mouse-epidermis
#11
Tomohisa Hirobe, Kenji Ishizuka, Shigeru Ogawa, Hiroyuki Abe
Abstract The mouse pink-eyed dilution (p) locus is known to control the melanin content in melanocytes. However, it was not known whether the p gene is involved in regulating the proliferation and differentation of melanocytes during development, especially the biogenesis of melanosomes and other organelles. Epidermal cell suspensions of neonatal dorsal skin derived from mice wild type for the p locus (black, C57BL/10JHir-P/P) and their congenic mutant phenotype (pink-eyed dilution, C57BL/10JHir-p/p) were cultured in serum-free melanocyte-proliferation medium (MDMD)...
November 2008: Zoological Science
https://www.readbyqxmd.com/read/18616104/-emphysematous-giant-bulla-that-was-difficult-to-differetiated-from-pneumothorax
#12
S Niimi, B Satou, M Asaoka
We experienced 2 patients who admitted to our hospital becaus of acute onset of dyspnea and chest pain. Chest X-ray and chest computed tomography showed severe atelectasisi of hemilateral lung. After intathoracic drainage under local anesthesia, we diagnosed a emphysematous giant bulla. We resected the giant bulla.
July 2008: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/17579196/risk-factors-for-hypospadias-in-the-estrogen-receptor-2-gene
#13
COMPARATIVE STUDY
Ana Beleza-Meireles, Ingrid Kockum, Fredrik Lundberg, Cilla Söderhäll, Agneta Nordenskjöld
CONTEXT: Hypospadias is a common inborn error of the male genitalia of complex, and still elusive, etiology. The presence of active estrogen receptors (ESRs) in the developing male urethra, predominantly the ESR2, has suggested a role of estrogens in the otherwise androgen-dependent male genital differetiation. Moreover, imbalances between these two steroid hormones have been suggested to disturb the external genital development. This has been supported by the association between longer (CA)n variants in the ESR2 gene with lower androgen levels as well as with hypospadias...
September 2007: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/16501472/-intrahepatic-cholestasis-clinical-and-nosological-classification-critical-survey-of-personal-experience
#14
A Reggiani, P Dizioli, D Quattrocchi, M Quinzani, A Marelli, P Bodini
We reviewed 20 patients (16 females and 4 males) with intrahepatic cholestasis and recognised the following miscellaneous disorders: 12 primary biliary cirrhosis (PBC), 3 primary sclerosing cholangitis (PSC), 1 immune cholangiopathy (IC), 3 liver sarcoidosis and 1 cholestasis with Horton's arteritis. The aim of the study was to identify potentially differetiating clinical and biochemical findings in intrahepatic cholestasis. Sixty females were affected with changes reflecting a cholestatic pattern including an elevated alkaline phosphatasis and gammaglutamyltransferase level...
June 1997: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/15159803/-clinical-analysis-of-40-cases-of-malignant-tumor-of-the-floor-of-the-mouth
#15
Y L Cai, Z H Wang
This is a retrospective review for 40 patients with malignant tumour of the floor of mouth.In the group,squamous carinoma is 62.5%.adenoid cystic carcinoma is 22.5%.Both of them are the major type,stage III.IV were 72.5%,Generally ipsilateral;radical mandibular and neck dissection was performed sellectively.65% of patient were given preoprative chemotherapy.Total 5 years survival rate was 50%,for stage I-III were 78.6%.Although preoperative chemotherapy was given that the group of lower pathological differetiation was still in lower survival rate,higher recurrence and mortality than those given surgery alone...
December 1993: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/12508641/-effects-of-retinoid-ro-40-8757-on-human-cancer-cell-lines-in-vitro
#16
Jing Lu, Jin-dan Song
BACKGROUND & OBJECTIVES: The retinoids are potent anti-tumor drugs affecting cellular proliferation and inducing cell differetiation or apoptosis. This study was designed to investigate the anti-proliferative effect of a new-developed retinoid, Ro 40-8757, on cell structure, cell cycle and cell cycle proteins of four human cancer cell lines in vitro in order to reveal its probable mechanism. METHODS: MTT assay was used to determine the anti-proliferative effects of Ro 40-8757 on human cancer cell lines CCL-187, CCL-229, JF-305, and ASPC-1...
October 2002: Ai Zheng, Aizheng, Chinese Journal of Cancer
https://www.readbyqxmd.com/read/12478897/-expression-and-significance-of-beta-catenin-in-esophageal-carcinoma
#17
Xiao-bo Zhou, Ning Lu, Wei Zhang, Lan-ping Quan, Dong-mei Lin, Quan-hong Wang, Ya-ling Li, Ning-zhi Xu
BACKGROUND & OBJECTIVE: Many reports have characterized the aberrant expression of beta-catenin in diverse types of human cancer. To determine whether beta-catenin has possible roles in esophageal carcinogensis, we designed this study to detect the expression pattern of beta-catenin in normal esophageal epithelium and esophageal cancer tissue, then to study the relevance of its expression and localization to tumor differetiation degree and lymph node metastasis. METHODS: By using immunohistochemical staining(SP method), the expression of beta-catenin was detected in 22 normal esophageal tissue slides and 52 esophageal carcinomas...
August 2002: Ai Zheng, Aizheng, Chinese Journal of Cancer
https://www.readbyqxmd.com/read/11542373/comparison-of-excitability-parameters-and-sodium-channel-behavior-of-fast-and-slow-twitch-rat-skeletal-muscles-for-the-study-of-the-effects-of-hindlimb-suspension-a-model-of-hypogravity
#18
COMPARATIVE STUDY
J F Desaphy, S Pierno, A Liantonio, A De Luca, C Leoty, D Conte Camerino
When mammals are constrained to hypogravity, their neuromuscular apparatus undergoes modifications which rend difficult postural maintenance and muscular activity upon the return to normal gravitational conditions. Muscle atrophy and differetial gene expression are particularly evident in slow-twitch antigravity muscles such as the soleus. During hypogravity, most of the metabolic and contractile properties characteristic of slow-twitch muscles shift toward to those of fast-twitch muscles. For example, the expression of the fast isoforms of both the myosin heavy-chain and the sarcoplasmic reticulum calcium pump increases in slow-twitch muscle during hypogravity...
July 1998: Journal of Gravitational Physiology: a Journal of the International Society for Gravitational Physiology
https://www.readbyqxmd.com/read/11320653/id-gene-expression-varies-with-lineage-during-differentiation-of-pluripotential-male-germ-cell-tumor-cell-lines
#19
J Houldsworth, V E Reuter, G J Bosl, R S Chaganti
Human male germ cell tumors (GCTs) comprise an excellent model system for understanding the molecular events controlling cellular differentiation and lineage decision. Pluripotential embryonal carcinoma cell lines derived from GCTs can be induced to undergo terminal differentiation along specific lineages dependent upon the differentiating agent. We report here that one such cell line, NTera2/clone D1 (NT2/D1), previously shown to undergo differentiation along a neuronal lineage by all-trans-retinoic acid (RA), can be induced along a distinct non-neuronal lineage by the mammalian morphogens, bone morphogenetic proteins-2 and -4 (BMP-2 and -4)...
March 2001: Cell and Tissue Research
https://www.readbyqxmd.com/read/9812860/-in-vitro-growth-characteristics-of-ril3-stimulated-megakaryocytic-progenitor-cells-cfu-mk-of-fetal-liver
#20
D C Ma, Y H Sun, K Z Chang
In this study, plasma clot and methycellulose semi-solid and liquid culture technigues were employed to observe the in vitro growth characteristics of proliferation and differetiation of 4-5 months fetal liver and adult bone marrow CFU-MKs. Fetal liver MK colonies in plasma clot in the presence of rIL3 or Meg-CSA were larger (usually with > 50 cells/colony) than that of the adult (usually with < 50 cells/colony). The number (36.40 +/- 16.60/1 x 10(5) cells) of fetal liver Mk colonies in presence of 2 ng/ml rIL3 was larger than that (10...
April 1997: Sheng Li Xue Bao: [Acta Physiologica Sinica]
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