Zheyu Shen, Ting Liu, Yan Li, Joseph Lau, Zhen Yang, Wenpei Fan, Zijian Zhou, Changrong Shi, Chaomin Ke, Vladimir I Bregadze, Swadhin K Mandal, Yijing Liu, Zihou Li, Ting Xue, Guizhi Zhu, Jeeva Munasinghe, Gang Niu, Aiguo Wu, Xiaoyuan Chen
Cancer is one of the leading causes of morbidity and mortality in the world, but more cancer therapies are needed to complement existing regimens due to problems of existing cancer therapies. Herein, we term ferroptosis therapy (FT) as a form of cancer therapy and hypothesize that the FT efficacy can be significantly improved via accelerating the Fenton reaction by simultaneously increasing the local concentrations of all reactants (Fe2+ , Fe3+ , and H2 O2 ) in cancer cells. Thus, Fenton-reaction-acceleratable magnetic nanoparticles, i...
November 27, 2018: ACS Nano