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https://www.readbyqxmd.com/read/30526160/emerging-cellular-therapies-for-cancer
#1
Sonia Guedan, Marco Ruella, Carl H June
Genetically engineered T cells are powerful new medicines, offering hope for curative responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were recently approved by the US Food and Drug Administration and are poised to enter the practice of medicine for leukemia and lymphoma, demonstrating that engineered immune cells can serve as a powerful new class of cancer therapeutics. The emergence of synthetic biology approaches for cellular engineering provides a broadly expanded set of tools for programming immune cells for enhanced function...
December 10, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/30523731/managing-pulmonary-complications-in-allogeneic-hematopoietic-stem-cell-transplantation
#2
Louise Bondeelle, Anne Bergeron
Progress in allogeneic hematopoietic stem cell transplantation (HSCT) procedures have been associated with improved survival in HSCT recipients. However, they have also brought to light organ-specific complications, especially pulmonary complications. In this setting, pulmonary complications are consistently associated with poor outcomes, and improved management of these complications is required. Areas covered: We review the multiple infectious and noninfectious lung complications that occur both early and late after allogeneic HSCT...
December 7, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/30464643/prevalence-of-extrapulmonary-tuberculosis-among-people-living-with-hiv-aids-in-sub-saharan-africa-a-systemic-review-and-meta-analysis
#3
REVIEW
Hussen Mohammed, Nega Assefa, Bezatu Mengistie
Background: The double burden of infectious diseases such as tuberculosis (TB) and HIV disproportionately affects Africa. Our objective was to summarize the prevalence of extrapulmonary TB (EPTB) among people living with HIV/AIDS (PLWHA) in sub-Saharan Africa (SSA). Methods: We searched PubMed and Google Scholar for studies done on the prevalence of EPTB among PLWHA which published in English from 1990 to 2017. We also searched bibliographic indices and browsed through reference lists of articles and journals...
2018: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/30459850/a-comprehensive-review-of-skull-base-osteomyelitis-diagnostic-and-therapeutic-challenges-among-various-presentations
#4
REVIEW
Muhammad Adnan Khan, Syed Abdul Qader Quadri, Abdulmuqueeth Syed Kazmi, Vishal Kwatra, Anirudh Ramachandran, Aaron Gustin, Mudassir Farooqui, Sajid Sattar Suriya, Atif Zafar
Skull base osteomyelitis (SBO) is a complex and fatal clinical entity that is often misdiagnosed for malignancy. SBO is commonly a direct complication of otogenic, sinogenic, odontogenic, and rhinogenic infections and can present as central, atypical, or pediatric clival SBO. This review describes the clinical profile, investigational approach, and management techniques for these variants. A comprehensive literature review was performed in PubMed, MEDLINE, Research Gate, EMBASE, Wiley Online Library, and various Neurosurgical and Neurology journals with the keywords including: SBO, central or atypical SBO, fungal osteomyelitis, malignant otitis externa, temporal bone osteomyelitis, and clival osteomyelitis...
October 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/30446431/fogarty-international-center-collaborative-networks-in-infectious-disease-modeling-lessons-learnt-in-research-and-capacity-building
#5
REVIEW
Martha I Nelson, James O Lloyd-Smith, Lone Simonsen, Andrew Rambaut, Edward C Holmes, Gerardo Chowell, Mark A Miller, David J Spiro, Bryan Grenfell, Cécile Viboud
Due to a combination of ecological, political, and demographic factors, the emergence of novel pathogens has been increasingly observed in animals and humans in recent decades. Enhancing global capacity to study and interpret infectious disease surveillance data, and to develop data-driven computational models to guide policy, represents one of the most cost-effective, and yet overlooked, ways to prepare for the next pandemic. Epidemiological and behavioral data from recent pandemics and historic scourges have provided rich opportunities for validation of computational models, while new sequencing technologies and the 'big data' revolution present new tools for studying the epidemiology of outbreaks in real time...
October 23, 2018: Epidemics
https://www.readbyqxmd.com/read/30409221/global-output-of-research-on-the-health-of-international-migrant-workers-from-2000-to-2017
#6
Waleed M Sweileh
BACKGROUND: Approximately 150 million international migrant workers work under conditions that increase their risk of illness and injuries. The current study aimed to assess and analyze the global output of research on the health of international migrant workers to promote national and international policies that could help improve the health of international migrant workers. METHODS: A bibliometric methodology was implemented using Scopus database after retrieving documents relevant to the health of migrant workers during the study period from 2000 to 2017...
November 8, 2018: Globalization and Health
https://www.readbyqxmd.com/read/30403551/the-global-landscape-of-tuberculosis-therapeutics
#7
Jeffrey A Tornheim, Kelly E Dooley
Tuberculosis (TB) is one of the oldest infections afflicting humans yet remains the number one infectious disease killer worldwide. Despite decades of experience treating this disease, TB regimens require months of multidrug therapy, even for latent infections. There have been important recent advances in treatment options across the spectrum of TB, from latent infection to extensively drug-resistant (XDR) TB disease. In addition, new, potent drugs are emerging out of the development pipeline and are being tested in novel regimens in multiple currently enrolling trials...
November 7, 2018: Annual Review of Medicine
https://www.readbyqxmd.com/read/30390630/zoonotic-disease-research-in-east-africa
#8
Naomi Kemunto, Eddy Mogoa, Eric Osoro, Austin Bitek, M Kariuki Njenga, S M Thumbi
BACKGROUND: The East African region is endemic with multiple zoonotic diseases and is one of the hotspots for emerging infectious zoonotic diseases with reported multiple outbreaks of epidemic diseases such as Ebola, Marburg and Rift Valley Fever. Here we present a systematic assessment of published research on zoonotic diseases in the region and thesis research in Kenya to understand the regional research focus and trends in publications, and estimate proportion of theses research transitioning to peer-reviewed journal publications...
November 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30386419/bibliometric-analysis-of-peer-reviewed-literature-on-syrian-refugees-and-displaced-people-2011-2017
#9
Waleed M Sweileh
Background: The Syrian conflict has created the worst humanitarian crisis of our time with approximately half of Syria's pre-war population killed or forced to flee their homes. The current study aimed to analyze peer-reviewed literature published on Syrian refugees and displaced people. Methods: A bibliometric methodology was implemented using Scopus database after retrieving documents relevant to Syrian refugees and displaced people. Findings: In total, 323 documents were retrieved...
2018: Conflict and Health
https://www.readbyqxmd.com/read/30365414/incidence-of-infectious-adverse-events-in-patients-with-rheumatoid-arthritis-and-spondyloarthritis-on-biologic-drugs-data-from-the-brazilian-registry-for-biologics-monitoring
#10
Mariana Cecconi, Roberto Ranza, David C Titton, Júlio C B Moraes, Manoel Bertolo, Washington Bianchi, Claiton Brenol, Hellen M Carvalho, Glaucio R W de Castro, Izaias P Costa, Maria F L Cunha, Ângela Duarte, Vander Fernandes, Marlene Freire, Paulo Louzada-Junior, José C Macieira, José R S Miranda, Ivanio A Pereira, Geraldo R C Pinheiro, Barbara Stadler, Roberto A Toledo, Valeria Valim, Miguel A Descalzo, Rogerio M C Pinto, Ieda Laurindo
BACKGROUND: The safety profile of biologic drugs might present substantial regional differences. Since 2009, the Brazilian Society of Rheumatology has maintained BIOBADABRASIL (Brazilian Registry for Biologic Drugs), a registry for monitoring of biologic therapies in rheumatic diseases. OBJECTIVES: The aim of this study was to verify the incidence rate (IR) of serious infections in rheumatoid arthritis (RA) and spondyloarthritis (SpA) patients on biologic drugs...
October 25, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/30355154/clinical-metagenomic-next-generation-sequencing-for-pathogen-detection
#11
Wei Gu, Steve Miller, Charles Y Chiu
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach for pathogen detection. The cost of high-throughput or next-generation sequencing has been reduced by several orders of magnitude since its advent in 2004, and it has emerged as an enabling technological platform for the detection and taxonomic characterization of microorganisms in clinical samples from patients. This review focuses on the application of untargeted metagenomic next-generation sequencing to the clinical diagnosis of infectious diseases, particularly in areas in which conventional diagnostic approaches have limitations...
October 24, 2018: Annual Review of Pathology
https://www.readbyqxmd.com/read/30355153/modeling-disease-with-inducible-pluripotent-stem-cells
#12
Rodrigo Grandy, Rute Tomaz, Ludovic Vallier
Understanding the physiopathology of disease remains an essential step in developing novel therapeutics. Although animal models have certainly contributed to advancing this enterprise, their limitation in modeling all the aspects of complex human disorders is one of the major challenges faced by the biomedical research field. Human induced pluripotent stem cells (hiPSCs) derived from patients represent a great opportunity to overcome this deficiency because these cells cover the genetic diversity needed to fully model human diseases...
October 24, 2018: Annual Review of Pathology
https://www.readbyqxmd.com/read/30355150/cellular-and-molecular-mechanisms-of-prion-disease
#13
Christina J Sigurdson, Jason C Bartz, Markus Glatzel
Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably, these infectious proteins have been responsible for widespread disease epidemics, including kuru in humans, bovine spongiform encephalopathy in cattle, and chronic wasting disease in cervids, the latter of which has spread across North America and recently appeared in Norway and Finland. The hallmark histopathological features include widespread spongiform encephalopathy, neuronal loss, gliosis, and deposits of variably sized aggregated prion protein, ranging from small, soluble oligomers to long, thin, unbranched fibrils, depending on the disease...
October 24, 2018: Annual Review of Pathology
https://www.readbyqxmd.com/read/30332777/climate-change-health-and-existential-risks-to-civilization-a-comprehensive-review-1989%C3%A2-2013
#14
REVIEW
Colin D Butler
Background: Anthropogenic global warming, interacting with social and other environmental determinants, constitutes a profound health risk. This paper reports a comprehensive literature review for 1989⁻2013 (inclusive), the first 25 years in which this topic appeared in scientific journals. It explores the extent to which articles have identified potentially catastrophic, civilization-endangering health risks associated with climate change. Methods: PubMed and Google Scholar were primarily used to identify articles which were then ranked on a three-point scale...
October 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30317761/-dynamic-analysis-of-the-academic-influence-in-chinese-journal-of-hepatology-from-2010-to-2016
#15
Z Peng, Y H Sun, H M Zhu, M Gui, L Du, D Z Zhang, H Ren
Objective: To dynamically analyze the discipline status, influence factors and key issues of Chinese Journal of Hepatology from 2010 to 2016 and explore the development rules of citation indexes. Methods: We collected information published by the China Institute of Scientific and Technological Information [China Science and Technology Journal Citation Report (Core Edition)] and Wanfang Database Periodicals statistical analysis platform from 2010 to 2016. A bibliometric analyses on article volume, citation frequency, citation rate, h-index, ratio of fund-aided papers, periodical influence, key number published period, number of relevant articles, and so on were analyzed for annual's impact factor...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30278054/leprosy-in-children-under-15-years-of-age-in-brazil-a-systematic-review-of-the-literature
#16
Michelle Christini Araújo Vieira, Joilda Silva Nery, Enny S Paixão, Kaio Vinicius Freitas de Andrade, Gerson Oliveira Penna, Maria Glória Teixeira
BACKGROUND: Leprosy is a chronic infectious disease neglected, caused by Mycobacterium leprae, considered a public health problem because may cause permanent physical disabilities and deformities, leading to severe limitations. This review presents an overview of the results of epidemiological studies on leprosy occurrence in childhood in Brazil, aiming to alert health planners and managers to the actual need to institute special control strategies. METHODOLOGY/PRINCIPAL FINDINGS: Data collection consisted of an electronic search for publications in eight databases: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), PuBMed, Biblioteca Virtual em Saúde (BVS), SciVerse Scopus (Scopus), CAPES theses database, CAPES journals database and Web of Science of papers published up to 2016...
October 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30275432/polymerase-chain-reaction-pcr-as-a-potential-point-of-care-laboratory-test-for-leprosy-diagnosis-a-systematic-review
#17
REVIEW
Sushma Tatipally, Aparna Srikantam, Sanjay Kasetty
Leprosy is an infectious disease caused by Mycobacterium leprae and mainly affects skin, peripheral nerves, and eyes. Suitable tools for providing bacteriological evidence of leprosy are needed for early case detection and appropriate therapeutic management. Ideally these tools are applicable at all health care levels for the effective control of leprosy. This paper presents a systematic review analysis in order to investigate the performance of polymerase chain reaction (PCR) vis-à-vis slit skin smears (SSS) in various clinical settings and its potential usefulness as a routine lab test for leprosy diagnosis...
October 1, 2018: Tropical Medicine and Infectious Disease
https://www.readbyqxmd.com/read/30270581/journal-metrics-of-infection-chemotherapy-and-current-scholarly-journal-publication-issues
#18
Sun Huh
BACKGROUND: In 2013, Infection & Chemotherapy changed the main language of its articles to English so that they could be submitted to PubMed Central. This study presents the recent status of journal metrics for Infection & Chemotherapy and introduces scholarly journal publishing policies or guidelines that have recently appeared. MATERIALS AND METHODS: A variety of journal metrics were analyzed based on the Web of Science Core Collection, including the nationality of authors the proportion of funded articles to Journal Articles , manually calculated impact factor, the titles of journals in which articles were cited", and the Hirsch index...
September 2018: Infection & Chemotherapy
https://www.readbyqxmd.com/read/30269306/chinese-clinical-practice-guidelines-for-acute-infectious-diarrhea-in-children
#19
Jie Chen, Chao-Min Wan, Si-Tang Gong, Feng Fang, Mei Sun, Yuan Qian, Ying Huang, Bao-Xi Wang, Chun-Di Xu, Li-Yan Ye, Mei Dong, Yu Jin, Zhi-Hua Huang, Qin-Bing Wu, Chao-Min Zhu, You-Hong Fang, Qi-Rong Zhu, Yong-Sui Dong
BACKGROUND: The guidelines addressed the evidence-based indications for the management of children with acute infectious diarrhea in Chinese pediatric population. DATA SOURCES: The experts group of evidence development put forward clinical problems, collects evidence, forms preliminary recommendations, and then uses open-ended discussions to form recommendations. The literature review was done for developing this guideline in databases including PubMed, Cochrane, EMBASE, China Biomedical Database, and Chinese Journal Full-text Database up to June 2013...
October 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/30265310/model-selection-and-parameter-estimation-for-dynamic-epidemic-models-via-iterated-filtering-application-to-rotavirus-in-germany
#20
Theresa Stocks, Tom Britton, Michael Höhle
Despite the wide application of dynamic models in infectious disease epidemiology, the particular modeling of variability in the different model components is often subjective rather than the result of a thorough model selection process. This is in part because inference for a stochastic transmission model can be difficult since the likelihood is often intractable due to partial observability. In this work, we address the question of adequate inclusion of variability by demonstrating a systematic approach for model selection and parameter inference for dynamic epidemic models...
September 27, 2018: Biostatistics
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