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Ulcer Bleed

Amol Agarwal, Petros Benias, Olaya I Brewer Gutierrez, Vivien Wong, Yuri Hanada, Juliana Yang, Vipin Villgran, Vivek Kumbhari, Anthony Kalloo, Mouen A Khashab, Philip Chiu, Saowanee Ngamruengphong
Background and study aims  Acute non-variceal upper gastrointestinal bleeding (UGIB) due to peptic ulcer disease (PUD) remains a common and challenging emergency managed by gastroenterologists. The proper role of endoscopic suturing on the management of PUD-related UGIB is unknown. Patients and methods  This is an international case series of patients who underwent endoscopic suturing for bleeding PUD. Primary outcome was rate of immediate hemostasis and rate of early rebleeding (within 72 hours). Secondary outcomes included technical success, delayed rebleeding (> 72 hours), and rate of adverse events (AEs)...
December 2018: Endoscopy International Open
Lao-Tzu Allan-Blitz, Omer E Beaird, Sarah M Dry, Marc Kaneshiro, Jeffrey D Klausner
The incidence of syphilis is increasing. Syphilitic proctitis involving the rectal mucosa often presents with pain on defecation, rectal bleeding, or ulceration. We present a case of asymptomatic syphilitic proctitis diagnosed upon a routine screening colonoscopy.
December 3, 2018: Sexually Transmitted Diseases
Manish P Shrestha, Sasha Taleban
The incidence rate of ulcerative colitis (UC) in older patients is rising. Diagnosis of UC may be difficult in older patients as several common gastrointestinal disorders can mimic UC in these patients. Compared with younger adults, left-sided colitis is more common in older-onset UC, while rectal bleeding, abdominal pain, and extraintestinal manifestations are less common. The disease course of older-onset UC may be similar to that of adult-onset UC. The management of UC in older patients includes medical and surgical options...
December 4, 2018: Drugs & Aging
Karsten Bernerth, Ingolf Schiefke, Karin Liebscher, Susanne Raczynski, Tanja Kottmann, Niels Teich
OBJECTIVE: Coagulation factor XIII plays a key role in fibrin clot stabilization and epithelial healing. Under chronic inflammatory conditions involving bleeding and an activation of the coagulation cascade, the FXIIIa inversely correlate with disease activity. We assumed that FXIIIa could be a predictor of severity in patients with ulcerative colitis (UC). Here, we evaluated the course of plasma activity of FXIIIa in 49 patients with mild to moderate UC and active rectal bleeding. Patients with a partial Mayo bleeding subscore > 2 were eligible to participate in our prospective observational study in an outpatient setting...
December 4, 2018: BMC Research Notes
Atli Steinn Valgardsson, Sigurbergur Karason, Elin Laxdal, Kristin Huld Haraldsdottir
Arterial cannulation is a common procedure in critically ill patients, as it facilitates continuous monitoring of blood pressure, titration of inotropes, vasopressors and fluids and is also used for blood sampling. Serious complications from arterial lines are very rare, permanent ischemic damage occurs in less than 0,1% of patients. We report the case of a 60-year-old woman in septic shock caused by a perforated duodenal ulcer which was treated with emergent laparoscopic repair. She required high doses of vasopressors and received several arterial lines, including lines in both the ulnar and the radial arteries of the left arm...
December 2018: Læknablađiđ
Diego García-Compeán, Alan R Jiménez-Rodríguez, Ángel N Del Cueto-Aguilera, Gilberto Herrera-Quiñones, José A González-González, Héctor J Maldonado-Garza
BACKGROUND: Meckel's diverticulum (MD) occurs predominantly in children and adolescents. It is rarely diagnosed in adults. Preoperative diagnosis is difficult due to low sensitivity of the radiological imaging studies. The role of video capsule endoscopy (VCE) in the diagnosis of MD is unknown, and the endoscopic patterns are not defined. We will describe four of our cases of MD evaluated with VCE and make a review of the literature focusing on the endoscopic characteristics. CASE SUMMARY: We present four cases of MD confirmed by surgery...
November 26, 2018: World Journal of Clinical Cases
Sung Hee Youn, Hyun Lim, Yeonmi Ju, Jae Seung Soh, Ji Won Park, Ho Suk Kang, Sung Eun Kim, Sung Hoon Moon, Jong Hyeok Kim, Choong Kee Park, Seung In Seo, Woon Geon Shin
OBJECTIVES: Direct oral anticoagulants (DOACs) are effective in the prevention and treatment of thromboembolism; however, they are associated with upper gastrointestinal bleeding (UGIB). In this study, we evaluated the efficacy of gastroprotective agents (GPAs) in reducing the risk of UGIB in patients receiving DOACs. METHODS: We retrospectively reviewed the medical records of 2076 patients who received DOACs for the prevention or treatment of thromboembolic events between January 2008 and July 2016...
December 3, 2018: Scandinavian Journal of Gastroenterology
P Kasper, U Janssens, G Michels
No abstract text is available yet for this article.
November 30, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Xin Tun, Keiji Yasukawa, Ken-Ichi Yamada
Ulcerative colitis is characterized by colonic mucosal bleeding and ulceration, often with repeated active and remission stages. One factor in ulcerative colitis development is increased susceptibility to commensal bacteria and lipopolysaccharide (LPS). LPS activates macrophages to release nitric oxide (NO) through Toll-like receptor 4 (TLR4) signaling. However, whether NO is beneficial or detrimental to colitis remains controversial. In this study, we investigated whether NO enhances the development of colitis in mice treated with dextran sulfate sodium (DSS) and inflammation in cells treated with low-dose LPS...
2018: Biological & Pharmaceutical Bulletin
Eduardo Anitua, Paquita Nurden, Roberto Prado, Alan T Nurden, Sabino Padilla
The healing of vascularized mammalian tissue injuries initiate with hemostasis and clotting as part of biological defense system leading to the formation of a fibrin clot in which activated platelets are trapped to quickly stop bleeding and destroy microbials. In order to harness the therapeutic potential of biomolecules secreted by platelets and stemmed from plasma, blood deconstruction has allowed to yield autologous platelet-and plasma-derived protein fibrin scaffold. The autologous growth factors and microparticles stemmed from platelets and plasma, interact with fibrin, extracellular matrix, and tissue cells in a combinatorial, synergistic, and multidirectional way on mechanisms governing tissue repair...
November 21, 2018: Biomaterials
Konstantinos Argyriou, Sunil Samuel, Gordon W Moran
BACKGROUND: Mesalazine-refractory ulcerative proctitis is common, with a significant proportion of the patients requiring escalation to immunomodulators or biological therapy. Three small preliminary cohort studies suggested good clinical efficacy for the organic arsenic derivative acetarsol in the management of proctitis. Our aim was to describe our experience on the use of acetarsol in proctitis and to review all existing evidence on its safety and efficacy. PATIENTS AND METHODS: We retrospectively reviewed clinical records of all ulcerative colitis patients exposed to acetarsol at Nottingham University Hospitals since 2012...
November 29, 2018: European Journal of Gastroenterology & Hepatology
Rashmi Laddha, Monica Mahajania, Amruta Khadse, Rajat Bajaj, Rashmi Jawade, Shashwati Choube
AIM: Periodontitis is considered as infection in periodontal supporting structure leading to tooth mobility and ulcerated periodontal pockets. The present study was conducted to assess Sirtuin 3 (SIRT 3) and SIRT 4 level in patients with diabetes mellitus (DM) and periodontitis. MATERIALS AND METHODS: The present study was conducted on 60 subjects. Subjects were divided into four groups, groups I to IV. Each group comprised of 15 subjects. In all subjects, fasting blood glucose level was assessed...
October 1, 2018: Journal of Contemporary Dental Practice
Vicente Lorenzo-Zúñiga, Vicente Moreno de Vega, Ramón Bartolí, Ingrid Marín, Noemí Caballero, Ignacio Bon, Jaume Boix
AIM: To prospectively evaluate the efficacy of submucosal injection of platelet-rich plasma (PRP) on endoscopic resection of large sessile lesions. METHODS: Eleven patients were submitted to endoscopic mucosal resection (EMR) with prior injection of PRP, obtained at the time of endoscopy. Patients were followed during 1 mo. The incidence of adverse events (delayed bleeding or perforation) and the percentage of mucosal healing (MHR) after 4 wk were registered. RESULTS: EMR was performed in 11 lesions (46...
November 16, 2018: World Journal of Gastrointestinal Endoscopy
Takefumi Mori, Shinichi Sato, Ikuko Oba-Yabana, Takuo Hirose, Satoshi Kinugasa, Yoshikazu Muroya, Kohei Ota, Shingo Nakayama, Hannah Nakamura, Junichi Tani, Chika Takahashi, Sadayoshi Ito
Exit-site infection poses a risk for peritonitis and can shorten peritoneal dialysis (PD) vintage. A loose fit of the skin around the catheter at the exit site can push bacteria surrounding the catheter into the subcutaneous tunnel. Negative-pressure wound therapy (NPWT) has been used to hasten healing of the wound after an operation or to treat pressure ulcers. We hypothesized that NPWT could speed the healing of the exit site and tighten the fit of the skin around the catheter. Using a V.A.C. Therapy system [vacuum-assisted closure (KCI, San Antonio, TX, U...
November 2018: Advances in Peritoneal Dialysis
Andrzej S Tarnawski, Amrita Ahluwalia
In this editorial we comment on the article by Fukushi K et al published in the recent issue of the World Journal of Gastroenterology 2018; 24(34): 3908-3918. We focus specifically on the mechanisms of the anti-thrombotic action of aspirin, gastric mucosal injury and aging-related increased susceptibility of gastric mucosa to injury. Aspirin is widely used not only for the management of acute and chronic pain and arthritis, but also importantly for the primary and secondary prevention of cardiovascular events such as myocardial infarcts and strokes...
November 14, 2018: World Journal of Gastroenterology: WJG
Maryam M Binabaj, Fereshteh Asgharzadeh, Amir Avan, Farzad Rahmani, Atena Soleimani, Mohammad R Parizadeh, Gordon A Ferns, Mikhail Ryzhikov, Majid Khazaei, Seyed M Hassanian
EW-7197 is a transforming growth factor-β type I receptor kinase inhibitor with potential anti-inflammatory and antifibrotic properties. Here, we investigate the potential therapeutic effects of EW-7197 in a murine model of ulcerative colitis. EW-7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW-7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation...
November 27, 2018: Journal of Cellular Physiology
Marin J de Jong, Danielle Roosen, Juliette H R J Degens, Tim R A van den Heuvel, Marielle Romberg, W Hameeteman, Alexander G L Bodelier, Igor Romanko, Milan Lukas, Bjorn Winkens, Tineke Markus, Ad A M Masclee, Astrid van Tubergen, Daisy M A E Jonkers, Marie J Pierik
BACKGROUND & AIMS: Patient-reported outcome measures (PROMs) assessing inflammatory bowel disease (IBD) activity are of interest for monitoring in clinical practice, telemedicine systems or trials. Different PROMs for follow-up of disease activity are available; however, none was developed with endoscopy as golden standard. The objective of this study was to develop and validate a PROM to predict endoscopic disease activity following the recommendations of the Food and Drug Administration...
November 24, 2018: Journal of Crohn's & Colitis
Ya-Wen Du, Qun Liu, Xiao-Cui Luo, Dong-Xiao Zhao, Jian-Bo Xue, Pu Feng, Robert F Margolskee, Hong Wang, Liquan Huang
Inflammatory bowel disease (IBD) is one of the immune-related gastrointestinal disorders, including ulcerative colitis and Crohn's disease, that affects the life quality of millions of people worldwide. IBD symptoms include abdominal pain, diarrhea, and rectal bleeding, which may result from the interactions among gut microbiota, food components, intestinal epithelial cells, and immune cells. It is of particular importance to assess how each key gene expressed in intestinal epithelial and immune cells affects inflammation in the colon...
November 9, 2018: Journal of Visualized Experiments: JoVE
Zhaohui Bai, Xiaozhong Guo, Xiaodong Shao, Yingying Li, Qianqian Li, Xiangbo Xu, Zhendong Liang, Jiao Deng, Xia Zhang, Hongyu Li, Xingshun Qi
Esophageal variceal bleeding is a common lethal complication of cirrhosis. Endoscopic injection sclerotherapy (EIS) is one of the major endoscopic approaches for treating esophageal variceal bleeding. However, complications may occur after EIS, which mainly include retrosternal discomfort/pain, dysphagia, re-bleeding, esophageal ulcer, esophageal strictures, and esophageal perforation, etc. In this article, we reported a 36-year-old male who developed esophageal ulcer related bleeding after EIS. Currently, there is no consensus on the treatment strategy for esophageal ulcer-related bleeding after EIS...
2018: Drug Discoveries & Therapeutics
Xing-Jie Shen, Liang Liu, Jing-Yu Zhu
RATIONALE: Radiation enteritis (RE) is one of the serious complications caused by the radiotherapy and it can occur in any segment of the intestine, including small intestine, colon, and rectum. It can cause a number of serious problems of the intestine, such as chronic ulcers, bleeding, intestinal stenosis, intestinal fistula, and perforation. At present, there is no standard treatment guideline for the RE. PATIENT CONCERNS: A 54-year-old male patient received surgery and chemotherapy for rectal cancer and radiofrequency ablation (RFA) for a single metastatic carcinoma of the liver...
November 2018: Medicine (Baltimore)
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