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https://www.readbyqxmd.com/read/30323651/stereotactic-radiotherapy-of-pancreatic-cancer-a-systematic-review-on-pain-relief
#1
REVIEW
Milly Buwenge, Gabriella Macchia, Alessandra Arcelli, Rezarta Frakulli, Lorenzo Fuccio, Sara Guerri, Elisa Grassi, Silvia Cammelli, Francesco Cellini, Alessio G Morganti
Locally advanced pancreatic carcinoma (LAPC) has a poor prognosis and the purpose of treatment is survival prolongation and symptom palliation. Radiotherapy has been reported to reduce pain in LAPC. Stereotactic RT (SBRT) is considered as an emerging radiotherapy technique able to achieve high local control rates with acceptable toxicity. However, its role in pain palliation is not clear. To review the impact on pain relief with SBRT in LAPC patients, a literature search was performed on PubMed, Scopus, and Embase (January 2000-December 2017) for prospective and retrospective articles published in English...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/30319652/immune-stimulation-using-a-gut-microbe-based-immunotherapy-reduces-disease-pathology-and-improves-barrier-function-in-ulcerative-colitis
#2
Ho Pan Sham, Mark Bazett, Momir Bosiljcic, Hyungjun Yang, Beryl Luk, Hong T Law, Vijay Morampudi, Hong B Yu, Jim Pankovich, Simon Sutcliffe, Brian Bressler, John K Marshall, Richard N Fedorak, Jenny Chen, Michelle Jones, Hal Gunn, Shirin Kalyan, Bruce A Vallance
Background: Current ulcerative colitis (UC) treatments are focused on symptom management primarily via immune suppression. Despite the current arsenal of immunosuppressant treatments, the majority of patients with UC still experience disease progression. Importantly, aggressive long-term inhibition of immune function comes with consequent risk, such as serious infections and malignancy. There is thus a recognized need for new, safe and effective treatment strategies for people living with UC that work upstream of managing the symptoms of the disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30319608/-in-vivo-evidence-for-partial-activation-of-eosinophils-via-the-histamine-h-4-receptor-adoptive-transfer-experiments-using-eosinophils-from-h-4-r-and-h-4-r-mice
#3
Bastian Schirmer, Luisa Bringmann, Roland Seifert, Detlef Neumann
Our previous in vitro studies revealed that histamine via histamine the H4 -receptors (H4 R), as compared to other stimuli, such as eotaxin or formylpeptides, rather partially activates eosinophilic granulocytes (eosinophils). In order to evaluate the H4 R-mediated activation of eosinophils in vivo , we employed dextran sodium sulfate (DSS)-induced colitis in mice, closely resembling human ulcerative colitis (UC), which is largely characterized by a local eosinophilic infiltration of the colon. IL-5-deficient BALB/c mice served as a model with reduced endogenous numbers of eosinophils, in which wild-type (H4 R+/+ ) or H4 R-deficient (H4 R-/- ) eosinophils were adoptively transferred during the course of DSS-induced colitis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30317488/multimodal-postoperative-pain-control-is-effective-and-reduces-opioid-use-after-laparoscopic-roux-en-y-gastric-bypass
#4
Ryan D Horsley, Ellen D Vogels, Daaron A P McField, David M Parker, Charles Medico, James Dove, Marcus Fluck, Jon D Gabrielsen, Michael R Gionfriddo, Anthony T Petrick
BACKGROUND: Opioids have been the mainstay for postoperative pain relief for many decades. Recently, opioid-related adverse events and death have been linked to postoperative dependency. Multimodal approaches to postoperative pain control may be part of the solution to this health care crisis. The safety and effectiveness of multimodal pain control regimens after laparoscopic Roux-en-Y gastric bypass (LRYGB) has not been well studied. The primary aim of our study was to determine if an evidence-based, multimodal pain regimen during hospitalization could decrease the total oral morphine equivalent (TME) use after LRYGB...
October 13, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30313113/successful-azathioprine-treatment-in-an-adolescent-with-chronic-enteropathy-associated-with-slco2a1-gene-a-case-report
#5
Keisuke Eda, Tatsuki Mizuochi, Yugo Takaki, Kosuke Ushijima, Junji Umeno, Yushiro Yamashita
INTRODUCTION: Chronic nonspecific multiple ulcers of the small intestine (CNSU), an entity with female preponderance and manifestations including anemia and hypoproteinemia reflecting persistent gastrointestinal bleeding and intestinal protein loss, has been considered idiopathic. Umeno et al recently reported that CNSU is caused by loss-of-function mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) encoding a prostaglandin transporter, renaming the disorder "chronic enteropathy associated with SLCO2A1 gene mutation" (CEAS)...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30301333/medication-non-adherence-in-inflammatory-bowel-diseases-is-associated-with-disability
#6
Jonathan Perry, Andy Chen, Viraj Kariyawasam, Glen Collins, Chee Choong, Wei Ling Teh, Nikola Mitrev, Friedbert Kohler, Rupert Wing Loong Leong
Background/Aims: Medication non-adherence is common in inflammatory bowel diseases (IBD). The short-term consequences of non-adherence include increased disease relapse but the long-term impact upon patients in terms of daily functional impairment are less well characterized. Identifying negative outcomes, such as disability, may encourage adherence. Methods: Consecutive ambulatory IBD subjects completed the Medication Adherence Rating Scale (MARS; non-adherence defined as ≤16), Inflammatory Bowel Diseases Disability Index (IBD-DI; disability: <3...
October 10, 2018: Intestinal Research
https://www.readbyqxmd.com/read/30298318/talimogene-laherparepvec-tvec-for-the-treatment-of-advanced-melanoma-a-single-institution-experience
#7
Matthew C Perez, John T Miura, Syeda Mahrukh Hussnain Naqvi, Youngchul Kim, Amanda Holstein, Daniel Lee, Amod A Sarnaik, Jonathan S Zager
BACKGROUND: Talimogene laherparepvec (TVEC) is an oncolytic herpes virus used as intralesional therapy for patients with unresectable stage IIIB through IV melanoma. We reviewed the standard of care treatment of TVEC at a single institution. METHODS: All patients treated with TVEC for advanced melanoma were retrospectively evaluated from 2015 to 2018. Patient demographics, clinicopathologic characteristics, treatment response, and toxicity were reviewed. RESULTS: Twenty-seven patients underwent therapy with TVEC...
October 8, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30298109/hemophilia-a-complicated-by-ulcerative-colitis
#8
Maxim Olivier, Mario Madruga, S J Carlan, Li Ge
Background: Hemophilia A is an X-linked recessive disorder characterized by defective synthesis of Factor VIII protein. Depending on the level of FVIII activity, patients may present with easy bruising, inadequate clotting of traumatic or mild injury, or in severe hemophilia, spontaneous hemorrhage. Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that is reported to have a decreased frequency of occurrence in subjects with coagulation disorders. Case: A 26-year-old white male with Hemophilia A was admitted for one month of rectal bleeding...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/30295105/proton-pump-inhibitors-use-and-misuse-in-the-clinical-setting
#9
Vincenzo Savarino, Elisa Marabotto, Patrizia Zentilin, Manuele Furnari, Giorgia Bodini, Costanza De Maria, Gaia Pellegatta, Claudia Coppo, Edoardo Savarino
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach to acid-related diseases for their efficacy and safety. Areas Covered: The following evidence-based indications for PPI use are acknowledged by many scientific societies: treatment of the various forms and complications of gastroesophageal reflux disease, eradication of H. pylori infection in combination with two or more antibiotics, short- and long-term therapy of H. pylori-negative peptic ulcers, healing, and prevention of NSAID/COXIB-associated gastric ulcers, co-therapy with endoscopic procedures to control upper digestive bleeding and medical treatment of Zollinger Ellison syndrome...
October 8, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/30291716/peptic-ulcer-is-the-most-common-cause-of-non-variceal-upper-gastrointestinal-bleeding-nvugib-in-china
#10
Mingliang Lu, Gang Sun, Xiao-Mei Zhang, You-Qing Xv, Shi-Yao Chen, Ying Song, Xue-Liang Li, Bin Lv, Jian-Lin Ren, Xue-Qing Chen, Hui Zhang, Chen Mo, Yan-Zhi Wang, Yun-Sheng Yang
BACKGROUND This study aimed to discover the common cause of non-variceal upper-gastrointestinal bleeding (NVUGIB) by conducting a multi-center retrospective study from 2008 to 2012. MATERIAL AND METHODS Hospitalized patients ages ≥18 years old, from 8 hospitals in China, diagnosed with NVUGIB by endoscopy from 1 January 2008 to 31 December 2012 were enrolled. Questionnaires were developed and a data-entry graphical user interface was designed by using EpiData software. RESULTS Total of 2977 hospitalized patients from 8 medical centers were included...
October 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30285104/deep-remission-with-vedolizumab-in-patients-with-moderately-to-severely-active-ulcerative-colitis-a-gemini-1-post-hoc-analysis
#11
William J Sandborn, Jean-Frédéric Colombel, Remo Panaccione, Parambir S Dulai, Maria Rosario, Charlie Cao, Morris Barocas, Karen Lasch
Background and Aims: This GEMINI 1 post hoc analysis evaluated vedolizumab efficacy for inducing deep remission in patients with ulcerative colitis and correlation between vedolizumab trough concentrations and deep remission rates. Methods: Week 6 vedolizumab responders were re-randomised to placebo or vedolizumab every 8 or 4 weeks. Deep remission at Week 52 was measured using 4 different definitions (from most to least stringent): (1) Mayo Clinic endoscopic score=0, rectal bleeding score=0 and decrease or no change from baseline in stool frequency score; (2) endoscopic score ≤1, rectal bleeding score=0 and stool frequency score=0; (3) endoscopic score ≤1, rectal bleeding score=0, decrease or no change from baseline stool frequency score, and total score [endoscopic score + rectal bleeding score + stool frequency score] ≤1; (4) endoscopic score ≤1, rectal bleeding score=0 and stool frequency score ≤1...
October 4, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/30283281/lethal-bleeding-from-a-duodenal-cancerous-ulcer-communicating-with-the-superior-mesenteric-artery-in-a-patient-with-pancreatic-head-cancer
#12
Yoshifumi Morita, Takanori Sakaguchi, Ryo Kitajima, Satoru Furuhashi, Ryota Kiuchi, Makoto Takeda, Takanori Hiraide, Yasushi Shibasaki, Hirotoshi Kikuchi, Yuji Suzuki, Kei Tsukamoto, Tomoharu Matsuura, Hiroya Takeuchi
Pancreatic cancer often invades the duodenum and causes obstruction, but rarely causes massive duodenal bleeding. A 68-year-old male was admitted to our hospital because of vomiting. Enhanced abdominal CT showed a hypovascular tumor with air bubbles in the uncinate process of the pancreas. The tumor invaded the duodenum and metastasized to the liver and peritoneum. The main trunk of the superior mesenteric artery (SMA) was circumferentially involved. After admission, he had hematemesis and melena. Emergency gastroduodenoscopy revealed pulsating vessels in the third portion of the duodenum and he eventually experienced hemorrhagic shock...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/30283227/secretory-carcinoma-of-the-breast-in-a-20-year-old-male-case-report-and-review-of-literature
#13
Abdurrahman Abba Sheshe, Mohammed Ibrahim Imam
Secretory breast carcinoma (SBC) is a very rare low-grade subtype of breast carcinoma. It was initially termed "juvenile breast cancer," but it is now known to occur in adults of both sexes, and only few male cases have been reported in the literature. SBC is of importance because of its unique morphology and excellent prognosis. We report here a case in a 20-year-old male presenting with right pedunculated and ulcerated breast mass with associated contact bleeding. Histopathology was performed and it revealed a secretory carcinoma...
July 2018: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/30282931/glycogen-storage-disease-ib-and-severe-periodontal-destruction-a-case-report
#14
Rui Ma, Fardad Moein Vaziri, Gregory J Sabino, Nima D Sarmast, Steven M Zove, Vincent J Iacono, Julio A Carrion
Background : Glycogen storage diseases (GSDs) are genetic disorders that result from defects in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. It also manifests with impaired neutrophil chemotaxis and neutropenic episodes which results in severe destruction of the supporting dental tissues, namely the periodontium. Although GSD Type Ib cannot be cured, associated symptoms and debilitating oral manifestations of the disease can be managed through collaborative medical and dental care where early detection and intervention is of key importance...
October 3, 2018: Dentistry journal
https://www.readbyqxmd.com/read/30282412/national-perioperative-outcomes-of-flap-coverage-for-pressure-ulcers-from-2005-to-2015-using-american-college-of-surgeons-national-surgical-quality-improvement-program
#15
Bao Ngoc N Tran, Austin D Chen, Parisa Kamali, Dhruv Singhal, Bernard T Lee, Eugene Y Fukudome
BACKGROUND: Complication rates after flap coverage for pressure ulcers have been high historically. These patients have multiple risk factors associated with poor wound healing and complications including marginal nutritional status, prolonged immobilization, and a high comorbidities index. This study utilizes the National Surgical Quality Improvement Program (NSQIP) to examine perioperative outcomes of flap coverage for pressure ulcers. METHODS: Data from the NSQIP database (2005-2015) for patient undergoing flap coverage for pressure ulcers was identified...
September 2018: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/30280108/endoscopic-doppler-probe-in-the-diagnosis-and-management-of-upper-gastrointestinal-hemorrhage
#16
Sagarika Satyavada, Perica Davitkov, Meer Akbar Ali, Gregory Cooper, Richard C K Wong, Amitabh Chak
Through-the-scope (TTS) endoscopic Doppler ultrasound probe technology is a tool that has garnered interest for the evaluation of variceal and non-variceal bleeding. In previous studies, this technology has been proposed as a more objective method of identifying the bleeding subsurface blood vessel in peptic ulcer hemorrhage. We describe 3 cases where the use of an endoscopic Doppler probe guided the diagnosis and management of upper gastrointestinal (GI) hemorrhage due to causes other than peptic ulcer disease...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/30275795/metastatic-renal-cell-carcinoma-presenting-as-a-bleeding-gastric-polyp
#17
Muhammad F Mubarak, Ebubekir S Daglilar, Thom Smilari, Arnab Ray
Background: Renal cell carcinoma (RCC) is responsible for nearly 13,000 deaths in the United States every year, predominantly because of metastasis to other bodily organs. However, metastasis of RCC to the stomach occurs rarely; it presents as solitary or multiple polyps or as ulcers concerning for primary gastric carcinoma. Bleeding from metastasis to the stomach is a rare and underrecognized cause of gastrointestinal bleeding. We describe a case of gastrointestinal bleeding in an elderly female who was found to have a gastric polyp of RCC origin...
2018: Ochsner Journal
https://www.readbyqxmd.com/read/30268131/comparison-of-outcomes-between-vertical-and-transverse-skin-incisions-in-percutaneous-tracheostomy-for-critically-ill-patients-a-retrospective-cohort-study
#18
Sung Yoon Lim, Won Gun Kwack, Youlim Kim, Yeon Joo Lee, Jong Sun Park, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Young-Jae Cho
BACKGROUND: Percutaneous tracheostomy (PT) is a common procedure in critical care medicine. No definite clinical practice guidelines recommended on the choice of the direction of skin incision, vertical or transverse for tracheostomy in critically ill patients. The objective of this retrospective study was to compare the outcomes associated with vertical and transverse skin incisions in patients undergoing PT. METHODS: Patients who underwent PT between March 2011 and December 2015 in the intensive care unit (ICU) of a tertiary hospital were retrospectively included...
September 30, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30266650/senescence-marker-protein-30-protects-intestinal-epithelial-cells-against-inflammation-induced-cell-death-by-enhancing-nrf2-activity
#19
Jieun Choo, Gwangbeom Heo, Su Jin Kim, Yunna Lee, Akihito Ishigami, Naoki Maruyama, Hae Young Chung, Eunok Im
Senescence marker protein 30 (SMP30) is a calcium-binding protein whose expression decreases during senescence. SMP30 deficiency increases susceptibility to cytokine-induced apoptosis in the liver and to radiation-induced apoptosis in the small intestine. Furthermore, colonic epithelial cell death is associated with the severity of colitis. Therefore, in the present study, we investigated the function of SMP30 during intestinal inflammation. In SMP30 deficient mice, colitis was significantly exacerbated as demonstrated by increased mortality (p = 0...
September 26, 2018: Biochimica et biophysica acta. Molecular basis of disease
https://www.readbyqxmd.com/read/30264579/developing-and-testing-a-chart-abstraction-tool-for-icu-quality-measurement
#20
Jarone Lee, J Matthew Austin, Jungyeon Kim, Paola D Miralles, Haytham M A Kaafarani, Peter J Pronovost, Vipra Ghimire, Sean M Berenholtz, Karen Donelan, Elizabeth Martinez
Quality measures are increasingly used to measure the performance of providers, hospitals, and health care systems. Intensive care units (ICUs) are an important clinical area in hospitals, given that they generate high costs and present high risks to patients. Yet, currently, few valid and clinically significant ICU-specific outcome measures are reported nationally. This study reports on the creation and evaluation of new abstraction tools that evaluate ICU patients for the following clinically important outcomes: central line-associated bloodstream infection, methicillin-resistant Staphylococcus aureus, gastrointestinal bleed, and pressure ulcer...
September 28, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
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