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Maryam Roham, Mahnoush Momeni, Mohsen Saberi, Rahil Kheirkhah, Ali Jafarian, Hossein Rahbar
Background and Objectives: Currently, there are no well-defined guidelines or criteria for catheter-site care in burn patients, and there is little information about the epidemiology of central vein catheter (CVC) infection in such patients. This study aimed at addressing the epidemiological aspect of CVC infection in a sample of Iranian burn patients admitted to the largest referral burn center in Iran, Motahari Burn Center. Materials and Methods: A total of 191 burn patients were eligible for the study...
October 2017: Iranian Journal of Microbiology
Cong Liu, Jiawei Huang, Hong Li, Zhangyou Yang, Yiping Zeng, Jing Liu, Yuhui Hao, Rong Li
The therapeutic effect of ghrelin on wound healing was assessed using a rat model of combined radiation and burn injury (CRBI). Rat ghrelin, anti-rat tumor necrosis factor (TNF) α polyclonal antibody (PcAb), or selective antagonists of p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), and growth hormone secretagogue receptor (GHS-R) 1a (SB203580, SP600125, and [D-Lys3]-GHRP-6, respectively), were administered for seven consecutive days. Levels of various signaling molecules were assessed in isolated rat peritoneal macrophages...
2016: Scientific Reports
Wenqing Liu, Damien West, Liang He, Yongbing Xu, Jun Liu, Kejie Wang, Yong Wang, Gerrit van der Laan, Rong Zhang, Shengbai Zhang, Kang L Wang
Magnetic doping is the most common method for breaking time-reversal-symmetry surface states of topological insulators (TIs) to realize novel physical phenomena and to create beneficial technological applications. Here we present a study of the magnetic coupling of a prototype magnetic TI, that is, Cr-doped Bi2Se3, in its ultrathin limit which is expected to give rise to quantum anomalous Hall (QAH) effect. The high quality Bi2-xCrxSe3 epitaxial thin film was prepared using molecular beam epitaxy (MBE), characterized with scanning transimission electron microscopy (STEM), electrical magnetotransport, and X-ray magnetic circularly dichroism (XMCD) techniques, and the results were simulated using density functional theory (DFT) with spin-orbit coupling (SOC)...
October 27, 2015: ACS Nano
A Mirijello, M Impagnatiello, V Zaccone, G Ventura, L Pompa, G Addolorato, R Landolfi
Catheter-related bloodstream infections (CRBI) represent a frequent complication of immune-compromised hosts with a high mortality rate. In this setting, opportunistic pathogens can create a biofilm on implanted devices, being the source of infection. We provide a mini-review of the literature, starting from the description of two cases of CRBI by opportunistic pathogens in poly-morbid patients, successfully treated by antibiotic lock-therapy.
July 2015: European Review for Medical and Pharmacological Sciences
Ali Dahhan, William R Maddox, Siva Krothapalli, Matthew Farmer, Amit Shah, Benjamin Ford, Marc Rhodes, Laurie Matthews, Vernon A Barnes, Gyanendra K Sharma
BACKGROUND: Cardiac rehabilitation (CR) is an effective preventive measure that remains underutilised in the United States. The study aimed to determine the CR referral rate (RR) after percutaneous coronary intervention (PCI) at an academic tertiary care centre, identify barriers to referral, and evaluate awareness of CR benefits and indications (CRBI) among cardiologists. Subsequently, it aimed to evaluate if an intervention consisting of physicians' education about CRBI and implementation of a formal CR referral system could improve RR and consequently participation rate (PR)...
August 2015: Heart, Lung & Circulation
Sachin S Jadhav, Christopher J Meeks, Nicholas M Mordwinkin, Theresa B Espinoza, Stan G Louie, Gere S diZerega, Kathleen E Rodgers
In the event of a nuclear disaster, the individuals proximal to the source of radiation will be exposed to combined radiation injury. As irradiation delays cutaneous repair, the purpose of this study was to elucidate the effect of combined radiation and burn injury (CRBI) on apoptosis and inflammation at the site of skin injury. Male C57Bl/6 mice were exposed to no injury, thermal injury only, radiation only (1 and 6 Gy) and CRBI (1 and 6 Gy) and euthanized at various times after for skin collection. TUNEL staining revealed that the CRBI 6 Gy group had a delayed and increased apoptotic response...
July 2015: Apoptosis: An International Journal on Programmed Cell Death
M J Artacho-Reinoso, P Olbrich, P Solano-Paéz, P Ybot-Gonzalez, J A Lepe, O Neth, J Aznar
We present the case of a 6-year-old boy diagnosed with stage III mediastinal Non Hodgkin Lymphoblastic T cell Lymphoma who suffered from catheter-related bloodstream infection (CRBI) due to Mycobacterium fortuitum whilst receiving chemotherapy. Isolation of this rare pathogen was done directly from blood culture and identification was made rapidly within 48 h using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectro-metry as well as specific polymerase chain reaction (PCR)-reverse hybridization method...
April 2014: Klinische Pädiatrie
Sachin S Jadhav, Natasha Sharma, Christopher J Meeks, Nicholas M Mordwinkin, Theresa B Espinoza, Norma R Roda, Gere S DiZerega, Colin K Hill, Stan G Louie, Kathleen E Rodgers
The renin-angiotensin system (RAS) plays an important role in wound repair; however, little is known pertaining to RAS expression in response to thermal injury and the combination of radiation plus burn injury (CRBI). The purpose of this study was to test the hypothesis that thermal injury modifies expression of RAS components and CRBI delayed this up-regulation of RAS. Skin from uninjured mice was compared with mice receiving local thermal injury or CRBI (injury site). Skin was analyzed for gene and protein expression of RAS components...
January 2013: Wound Repair and Regeneration
J L Del Pozo, R Rodil, A Aguinaga, J R Yuste, C Bustos, A Montero, G Espinosa, N García-Fernández
INTRODUCTION: To evaluate the efficacy of Daptomycin (DPT) lock therapy in the treatment of Grampositive long-term catheter-related bloodstream infections (LT-CRBI). PATIENTS AND METHODS: A retrospective review of all patients receiving DPT lock therapy for the treatment of LT-CRBI from December 2009 to May 2010 was conducted. The primary endpoint used in this study was failure to cure the episode of LT-CRBI. Cure was defined as fever disappearance, negative blood cultures within 1 month after the end of treatment, and catheter salvage...
March 2012: International Journal of Clinical Practice
Roser Terradas, Marta Riu, Marcel Segura, Xavier Castells, Mónica Lacambra, Juan Carlos Alvarez, Agia Segura, Estela Membrilla, Luís Grande, Gemma Segura, Hernando Knobel
OBJECTIVE: To evaluate a multidisciplinary and multifocal intervention in order to reduce catheter related bloodstream infections (CRBI), based on previously identified risk factors in non-critical patients. METHODS: A pre-post-intervention study, 2004-2006. POPULATION: patients with a central venous catheter (CVC). The primary endpoint was the CRBI. Other studied variables were patient characteristics, insertion, maintenance and removal of the catheter...
January 2011: Enfermedades Infecciosas y Microbiología Clínica
Ana Isabel Casanegra, Scott Brannan, Ramona Dadu, Philip Ong, Mitchell Berner, Kristopher Spinning, Terence Hughes, Greg Marrinan, Kenneth Zinn, Constantine Manthous
BACKGROUND: Experts and national regulatory bodies have deemed femoral vein catheterization (FVC) unsafe, and recommend avoiding it whenever possible. OBJECTIVE: To assess rates of catheter-related bloodstream infections (CRBI) and deep venous thrombosis (DVT) complicating FVC. DESIGN: Prospective observational cohort study. SETTING: Medical intensive care unit (MICU) of a 350-bed community teaching hospital. PATIENTS: Consecutive admissions to the MICU during 7 months...
January 2011: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
J García-Rodríguez, M de Pablos, A Gutiérrez
Different multicentre epidemiological studies such as ENVIN-HELICS or EPINE, have remarked that catheter related bloodstream infection (CRBI) is an increasingly condition in hospital environment. The microbiologist plays a major role in the diagnosis, either by recommending what type of catheter must be considered for confirmatory diagnosis, when these samples must be sent for culture, when is indicated to perform surveillance studies of the catheter and what results are clinically significant to be informed...
June 2010: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Joan Robinson
Catheter-related bloodstream infections (CRBIs) are a common problem in paediatrics. Sterile insertion and proper care of the catheter is likely more important than the type of catheter in determining the rate of CRBIs. The accuracy of the diagnosis of CRBIs can be improved by comparing the time to positivity or the concentration of organisms in blood drawn through the catheter with blood drawn from other sites, or by changing the catheter over a guidewire and culturing the removed catheter. When a CRBI is suspected, the catheter should be removed if it is no longer required, the child is hemodynamically unstable, there are metastatic foci of infection, the infecting organism is Candida or a mycobacterium, or there is a tunnel infection...
October 2005: Paediatrics & Child Health
A L Buchman, J Spapperi, P Leopold
OBJECTIVE: Catheter-related blood stream infection (CRBI) is a major cause of morbidity and mortality, and is a source of significant healthcare expenditures in patients that require central venous catheters for intravenous nutrition, chemotherapy, and other products. The source of many catheter-related infections is contamination of the catheter hub. Herein an antimicrobial catheter cap, the AB Cap is described. METHODS: The AB Cap device is a catheter cleaning device designed to keep needleless luer valves clean by encapsulating them in a cleaning solution...
January 2009: Journal of Vascular Access
S Mandolfo, S Borlandelli, A Elli
In recent years, the number of patients on hemodialysis (HD) with central vascular catheters (CVCs) has grown. However, CVC use is often associated with an important risk for catheter related bloodstream infections (CR-BI) and inadequate dialysis due to flow problems. In this study, we reviewed alternative solutions to heparin for locking HD CVCs. Several experiences have demonstrated that trisodium citrate (TSC) (30-47%), citrate (4%) and taurolidine (1.35%) solutions are effective and safe for the prevention of CRBI, while heparin stimulates biofilm formation...
July 2006: Journal of Vascular Access
Josep-Maria Sirvent, Loreto Vidaur, María García, Patricia Ortiz, Jordi de Batlle, Montserrat Motjé, Alfons Bonet
OBJECTIVE: To analyze the colonization of each lumen and the risk factors for triple-lumen central venous catheter-related bloodstream infection (CRBI). DESIGN AND SETTING: Prospective, observational study in the medical-surgical intensive care unit (ICU) of a teaching hospital. PATIENTS: A total of 120 patients requiring the insertion of a triple-lumen catheter. INTERVENTIONS: Cultures of the catheter. MEASUREMENTS AND RESULTS: The catheters were removed when CRBI was suspected or at discharge from ICU...
September 2006: Intensive Care Medicine
A Abdelkefi, W Achour, L Torjman, T Ben Othman, S Ladeb, A Lakhal, H Allouche, A Ben Hassen, A Ben Abdeladhim
In patients with central venous catheters (CVCs), catheter-related bloodstream infections (CRBI) are a prominent cause of morbidity, excess hospital costs, and in some cases mortality. The aim of this prospective study was to assess the validity of the Gram stain-acridine orange leukocyte cytospin (AOLC) test for the diagnosis of CRBI in hematopoietic stem cell transplant (HSCT) recipients with nontunnelled CVCs, using the differential-time-to-positivity (DTP)/clinical criteria as the criterion standard to define CRBIs...
March 2006: Bone Marrow Transplantation
A David, D C Risitano, G Mazzeo, L Sinardi, F S Venuti, A U Sinardi
The indications to the positioning of central venous catheters (CVCs) are various: parenteral nutrition, chemotherapy, infusion of large amount of fluids or blood products, chronic access for hemodialysis, invasive measurement of hemodynamic variables. Infection is the most important clinical complication associated with the use of CVC, both in terms of incidence and of gravity. Despite the efforts for the optimization of the materials that are more and more biocompatible, the presence of a foreign body in the organism is an ideal substratum for the microbial colonization...
September 2005: Minerva Anestesiologica
A L Christensen
My work in Neurotraumatology was initiated in 1961, when I as a neuropsychologist got a position in a neurosurgical University department. The tasks were to evaluate the mental state of patients, give advices to family members regarding the mental and social prognosis of the patients and to support nurses in the initial care of the patients. Initially the methods that were made use of were tests developed by the German neurologist Kurt Goldstein and traditional psychometric tests, but it was not until the theories of A...
2005: Acta Neurochirurgica. Supplement
Ioannis Germanakis, Athanasia Christidou, Emmanouil Galanakis, Iraklis Kyriakakis, Yiannis Tselentis, Maria Kalmanti
BACKGROUND: Paired quantitative and qualitative blood cultures have been introduced for the diagnosis of catheter-related bloodstream infections (CRBI) with the catheter in situ. The aim of the study was to compare the diagnostic performance and the prognostic value of the two methods in the evaluation of febrile episodes without an apparent source in children with cancer. PROCEDURE: During a 4-year period, in every febrile episode without an apparent focus, blood was drawn simultaneously from the catheter lumen and a peripheral vein in order to perform paired quantitative (Isolator) as well as qualitative (BacT/Alert) blood cultures...
December 2005: Pediatric Blood & Cancer
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