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Sirine Lajili, Hiba Hadj Ammar, Zeineb Mzoughi, Haifa Bel Haj Amor, Christian D Muller, Hatem Majdoub, Abderrahman Bouraoui
This study was designed to characterize the physico-chemical properties of the sulfated polysaccharide (SP) isolated from the red alga Laurencia obtusa and to evaluate its apoptotic, gastroprotective and antioxidant activities. The different macromolecular characteristics of SP were determined by size exclusion chromatography combined with multi-angle laser light-scattering detection (SEC-MALLS), Fourier transform infrared spectroscopy (FTIR) analysis and nuclear magnetic resonance spectroscopy (1 H NMR and 13 C NMR)...
December 10, 2018: International Journal of Biological Macromolecules
Hyung L Kim, Ping Li, Huei-Chung Huang, Samineh Deheshi, Tara Marti, Beatrice Knudsen, Hatem Abou-Ouf, Ridwan Alam, Tamara L Lotan, Lucia L C Lam, Marguerite du Plessis, Elai Davicioni, Neil Fleshner, Brian R Lane, Ashley E Ross, John W Davis, James L Mohler, Bruce J Trock, Eric A Klein, Jeffrey J Tosoian, M Eric Hyndman, Tarek A Bismar
ABSTACT: BACKGROUND: Many men diagnosed with prostate cancer are active surveillance (AS) candidates. However, AS may be associated with increased risk of disease progression and metastasis due to delayed therapy. Genomic classifiers, e.g., Decipher, may allow better risk-stratify newly diagnosed prostate cancers for AS. METHODS: Decipher was initially assessed in a prospective cohort of prostatectomies to explore the correlation with clinically meaningful biologic characteristics and then assessed in diagnostic biopsies from a retrospective multicenter cohort of 266 men with National Comprehensive Cancer Network (NCCN) very low/low and favorable-intermediate risk prostate cancer...
December 12, 2018: Prostate Cancer and Prostatic Diseases
Hatem A Awaga, Julia K Bosdou, Dimitrios G Goulis, Katerina Chatzimeletiou, Mohamed Salem, Salah Roshdy, Grigoris Grimbizis, Basil C Tarlatzis, Efstratios M Kolibianakis
The use of testicular spermatozoa in men without azoospermia has been proposed as a means to increase the chances of pregnancy following assisted reproductive treatment. The purpose of this systematic review is to assess whether clinical outcomes are better when testicular rather than ejaculated spermatozoa are used for intracytoplasmic sperm injection in patients with abnormal semen parameters without azoospermia. A literature search identified four eligible studies out of 757 initially found. In a prospective study in men with high DNA fragmentation index (DFI) and oligozoospermia, the probability of live birth was significantly higher with testicular compared to ejaculated spermatozoa (risk ratio [RR]: 1...
November 2018: Reproductive Biomedicine Online
Alexandre Nuzzo, Leon Maggiori, Catherine Paugam-Burtz, Dominique Cazals-Hatem, Maxime Ronot, Audrey Huguet, Aymeric Becq, Yves Castier, Emmanuel Weiss, Aurélie Plessier, Alexy Tran-Dinh, Francisca Joly, Yves Panis, Yoram Bouhnik, Nathalie Gault, Olivier Corcos
OBJECTIVES: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI). METHODS: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. RESULTS: Between 2009 and 2015, 67 patients with AMI were included. ITIN occurred in 34% of patients and mortality was 13%. Oral antibiotics was independently associated with a decreased risk of ITIN (HR: 0...
December 11, 2018: American Journal of Gastroenterology
Moureq R Alotaibi, Amal J Fatani, Ahmed T Almnaizel, Mohammed M Ahmed, Hatem M Abuohashish, Salim S Al-Rejaie
OBJECTIVE: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. MATERIALS AND METHODS: Streptozotocin (STZ)-induced diabetic animals were orally treated with GLI and/or LT 5 and 25 mg/kg respectively for 4 weeks...
December 10, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Rashad Al-Salahi, Moustapha E Moustapha, Hatem A Abuelizz, Abdulrahman I Alharthi, Khalid A Alburikan, Ismail T Ibrahim, Mohamed Marzouk, Mohamed A Motaleb
3-Benzyl-2-((3-methoxybenzyl)thio)benzo[ g ]quinazolin-4(3 H )-one was previously synthesized and proved by physicochemical analyses (HRMS, 1 H and 13 C NMR). The target compound was examined for its radioactivity and the results showed that benzo[ g ]quinazoline was successfully labeled with radioactive iodine using NBS via an electrophilic substitution reaction. The reaction parameters that affected the labeling yield such as concentration, pH and time were studied to optimize the labeling conditions. The radiochemical yield was 91...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Ahmed E Khodir, Eman Said, Hoda Atif, Hassan A ElKashef, Hatem A Salem
Ulcerative colitis (UC) is usually a mildly active disease; however, it can be associated with serious systemic complications. The current study was undertaken to evaluate the anti-ulcerogenic and coloprotective properties of crocin; the major biologically active ingredient of saffron against experimentally-induced UC, by intracolonic instillation of AA (AA). Rats received either felodipine (3 mg/kg) or crocin (20 mg/kg) orally for 8 successive days as protective and curative therapies. Either as a protective or as a curative remedy, crocin significantly reversed AA-induced colonic damage...
December 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hatem Rekik, Nadia Zaraî Jaouadi, Khelifa Bouacem, Bilal Zenati, Sidali Kourdali, Abdelmalek Badis, Rachid Annane, Amel Bouanane-Darenfed, Samir Bejar, Bassem Jaouadi
A new manganese peroxidase-producing white-rot basidiomycete fungus was isolated from symptomatic wood of the camphor trees Cinnamomum camphora (L.) at the Hamma Botanical Garden (Algeria) and identified as Trametes pubescens strain i8. The enzyme was purified (MnP TP55) to apparent electrophoretic homogeneity and biochemically characterized. The specific activity and Reinheitzahl value of the purified enzyme were 221 U/mg and 2.25, respectively. MALDI-TOF/MS analysis revealed that the purified enzyme was a monomer with a molecular mass of 55...
December 6, 2018: International Journal of Biological Macromolecules
Hatem I Mokhtar, Randa A Abdel-Salam, Ghada M Hadad
Sulfonamides and trimethoprim combinations have been used extensively as antimicrobial agents for prevention and treatment of human and animal infections. Although many microextraction methods were developed for monitoring their residues in environmental water, none of these methods applied liquid-liquid microextraction for this purpose. This work presents for the first time a simultaneous Salt Assisted Liquid-Liquid Microextraction SALLME coupled with HPLC-UV for determination of trimethoprim and six common sulfonamide residues (sulfathiazole, sulfadiazine, sulfadmidine, sulfamethoxazole sulfadoxine and sulfaquinoxaline) in water samples...
December 3, 2018: Journal of Chromatography. A
Mohamed Waseem Osman, Mintu Nath, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
AIM: To assess the changes in haemodynamics amongst pregnant women who were screened for gestational diabetes mellitus (GDM) in comparison to low-risk healthy pregnant controls. METHODOLOGY: A total of 120 pregnant women of mean (standard deviation) age 31.03 (5.41) years who attended their oral glucose tolerance test as part of the national screening for GDM (study), and 60 low-risk healthy pregnant women (control) of mean age 29.71 (5.33) years, were invited to participate in this study...
October 2018: Pregnancy Hypertension
Hany S Ibrahim, Wagdy M Eldehna, Anna Lucia Fallacara, Esam R Ahmed, Hazem A Ghabbour, Mahmoud M Elaasser, Maurizio Botta, Sahar M Abou-Seri, Hatem A Abdel-Aziz
AIM: Inhibition of P53-mdm2 interaction will lead to cancer cell apoptosis. This strategy was achieved by reported spiro-oxindole derivatives. MATERIALS & METHODS: Spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitrile derivatives (4a-i and 9a, b) were synthesized and screened for their in vitro anticancer activity. The most active compounds were subjected to P53-MDM2 inhibitory activity, apoptotic and molecular docking studies. RESULTS & DISCUSSION: Compound 4d exhibited potent and broad spectrum of antiproliferative activity with full panel GI50 (MG-MID) value of 3...
December 10, 2018: Future Medicinal Chemistry
Timothee Bonifay, Christelle Prince, Clarisse Neyra, Magalie Demar, Dominique Rousset, Hatem Kallel, Mathieu Nacher, Félix Djossou, Loïc Epelboin
BACKGROUND: French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients. MATERIALS AND METHODS: A monocentric retrospective study was conducted in Cayenne hospital, the main city and the main hospital in FG, from March 1st 2014 to August 31st 2015...
2018: PloS One
Sarah Ahmed Mohamed Mahmoud, Hatem Wael Amer, Sally Ibrahim Mohamed
Ameloblastic carcinoma (AC) is an extremely rare malignant odontogenic tumour arising from odontogenic epithelium. It was classified into primary type and secondary type. A previous study revealed that primary ameloblastic carcinoma cases were associated with more favourable prognosis than secondary cases. The aim of the present work was: to report the clinical, histopathological, immunohistochemical, and ploidy status, and therapeutic details of four cases of primary AC, and to review the literature with regard to clinical, follow-up, prognosis, histopathological, and immunohistochemical information of primary AC...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Jesmar Buttigieg, Hatem Ali, Ajay Sharma, Ahmed Halawa
The presence of pre-formed donor-specific antibodies (DSAs) in kidney transplantation is associated with worse overall outcomes compared with DSA-negative transplantation. A positive complement-dependant cytotoxic crossmatch presents a high immunological risk, while a negative flow cytometry crossmatch is at the lower end of the risk spectrum. Yet, the presence of low-level DSA detected by Luminex alone, that is, positive Luminex and negative flow (PLNF) cytometry crossmatch lacks robust scientific exploration...
November 30, 2018: Nephrology, Dialysis, Transplantation
Nour Eissa, Hatem Kittana, João Carlos Gomes-Neto, Hayam Hussein
Chronic enteropathy (CE) in dogs is a chronic and relapsing immunopathology, of unknown etiology, that usually manifests with a plethora of clinical signs reflecting the underlying heterogeneity in its pathogenesis. Alterations of the mucosal immune responses and the gut microbiota composition are thought to play an essential role in CE. Similar to humans, it is hypothesized that the breakdown in mucosal tolerance leads to aberrant and pathological immune responses toward the gut microbiota, that in turn, may contribute to the severity of disease, at least for certain CE subsets...
November 24, 2018: Research in Veterinary Science
Sara Pakseresht, Ahmed Waleed Majeed Alogaili, Hatem Akbulut, Daniela Placha, Erich Pazdziora, Diana Klushina, Zuzana Konvičková, Gabriela Kratošová, Sylva Holešová, Gražyna Simha Martynková
Medical devices have an essential part in healthcare system in recent years, such as usage of heart valves, several types of stents and implants devices in patients. However, bacterial infection of medical devices causes critical issues for patients due to attachment of bacteria and formation of biofilm onto the medical devices. Therefore, finding an effective antibacterial coating to prevent biofilm formation and infection is our goal. In this study, we developed silver/chitosan nanocomposites for antimicrobial coating system by chemical and green methods using sodium borohydride and linden extract, respectively...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Gražyna Simha Martynková, Fatih Becerik, Daniela Plachá, Jinbo Pang, Hatem Akbulut, Alicja Bachmatiuk, Mark H Rummeli
Mechanical treatment of graphite silver mixture followed by heat treatment showed morphology and structure changes of both components. Silver is being distributed over graphite flakes randomly with higher concentration on the edges and nanometric size, which was observed using scanning and transmission electron microscopy. The annealing temperature 1300 °C is higher than melting temperature of silver (961.8 °C) and base on phase diagram C-Ag (C. L. Chen, et al., Appl. Phys. Lett. 96, 253104 (2010) .) silver is being transferred from liquid phase to solid phase at rapid cooling, which is giving various crystallinity...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Matthew T Finn, Darshan Doshi, Jacob Cleman, Lei Song, Akiko Maehara, Raja Hatem, Björn Redfors, Sanjog Kalra, Justin A Fried, Ming Liao, Candido Batres, Jeffery W Moses, Manish A Parikh, Michael B Collins, Tamim M Nazif, Khady N Fall, Phillip Green, Ajay J Kirtane, Ziad A Ali, Martin B Leon, Gary S Mintz, Dimitri Karmpaliotis
OBJECTIVES: We sought to determine the 1-year outcomes of patients receiving successful chronic total occlusion (CTO) percutaneous coronary intervention (PCI) procedures comparing subintimal versus intraplaque wire tracking patterns. BACKGROUND: CTO PCI utilizes both intraluminal and subintimal wire tracking to achieve successful percutaneous revascularization. Intravascular ultrasound (IVUS) can be used to precisely determine the path of wire tracking. METHODS: From 2014 to 2016, data from patients undergoing CTO PCI were collected in a single-center database...
November 29, 2018: Catheterization and Cardiovascular Interventions
Mahmoud El-Bendary, Mustafa Neamatallah, Hatem Elalfy, Tarek Besheer, Maged El-Setouhy, Nihal Kasim, Noha T Abou El-Khier, Emily Kamel, Abdel-Hamid Eladl, Ahmad El-Waseef, Abdel-Aziz F Abdel-Aziz, Gamal Esmat
Background and Aim: Polymorphisms in some genes may influence the persistence of hepatitis C virus (HCV) infection, clinical outcome, HCV replication, and liver damage. This study was conducted to investigate the role of the interferon gamma (IFN-γ) gene at (+874 T/A, -764 G/C, -179 C/A) single-nucleotide polymorphisms (SNPs) and its receptor (IFN-γR2) at (rs 2786067 A/C) SNP in the susceptibility of Egyptian families to HCV infection with high-resolution techniques. Methods: In total, 517 Egyptian families, with 2246 subjects, were recruited to this study from the Upper and Lower Egypt governorates and were classified into three groups: 1034 patients with chronic hepatitis C virus, 108 subjects with spontaneous virus clearance (SVC), and 1104 subjects as a healthy control group...
December 2017: JGH open: an open access journal of gastroenterology and hepatology
Zexin Yu, Hatem Moussa, Bilel Chouchene, Meimei Liu, Raphaël Schneider, Weize Wang, Michel Moliere, Hanlin Liao
Binary spinel-type metal oxides (AB2 O4 ) related materials, including ferrites (AFe2 O4 ), are attractive photocatalysts thanks to their excellent visible light response for the photodegradation of organic pollutants. Currently, these materials are synthesized via conventional chemical routes suffering from long preparation duration and multistep. Moreover, the photocatalysts are obtained as nano-powders from conventional chemical routes would introduce another drawback for their recycling and reuse. From an industrial perspective, it is desirable to develop an efficient and facile synthesis process to produce photocatalysts in a non-dispersible form...
January 25, 2019: Nanotechnology
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