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Hatem Jaber, Everett Lohman, Noha Daher, Gurinder Bains, Abhay Nagaraj, Prajakta Mayekar, Manali Shanbhag, Mansoor Alameri
BACKGROUND/PURPOSE: Ankle sprains are common and potentially disabling musculoskeletal injuries that often lead to chronic ankle instability (CAI). CAI has been linked to impairments in postural and neuromuscular control; however, inconsistent findings have been reported. Individuals who experience a lateral ankle sprain, but do not develop instability, termed copers, may adapt different neuromuscular control strategies after injury. This study aimed to compare postural control and electromyographic (EMG) activity of hip and ankle muscles during the performance of the Star Excursion Balance Test (SEBT) in subjects with and without CAI...
2018: PloS One
Ibnouf Sulieman, Ahmed Mahfouz, Einas AlKuwari, Lajos Szabados, Walid Elmoghazy, Ahmed Elaffandi, Hatem Khalaf
INTRODUCTION: Most patients with pancreatic masses pose a diagnostic challenge when a benign lesion is suspected, and often, resection is needed before a benign diagnosis is confirmed. PRESENTATION OF CASE: A 57 years old male patient presented with a pancreatic head mass, obstructive jaundice and submandibular lymph node enlargement. He also had a history of recurrent eye pain and redness, skin lesions, and benign prostatic hypertrophy. MRI showed a pancreatic head mass with double duct sign, aortic thickening, bilateral renal lesions, diffuse lymph node enlargement, and prostatic enlargement...
July 31, 2018: International Journal of Surgery Case Reports
Ali H Eid, Ahmed F El-Yazbi, Fouad Zouein, Abdelilah Arredouani, Allal Ouhtit, Md M Rahman, Hatem Zayed, Gianfranco Pintus, Haissam Abou-Saleh
Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function together with an alteration in vascular smooth muscle cells (VSMCs) calcium homeostasis leading to increased myogenic tone. Changes in free intracellular calcium levels ([Ca2+ ] i ) are mediated either by the influx of Ca2+ from the extracellular space or release of Ca2+ from intracellular stores, mainly the sarcoplasmic reticulum (SR)...
2018: Frontiers in Physiology
Aida Mossaad, Amr Kotb, Moustapha Abdelrahaman, Hatem Al Ahmady
BACKGROUND: Postoperative scarring is a common cause of patients dissatisfaction. Several modalities have been developed to overcome such a problem following surgical repair. Despite precise surgical technique, still, some scars would remain over the time, mostly due to the weak formation or inadequately replaced collagen fibres in the underneath dermis especially those following unilateral or bilateral cleft lip repair surgery. AIM: of this study is to evaluate whether a 10,600 nm fractional ablative carbon dioxide (CO2 ) used early during the healing period would result in better postoperative scars...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
Mamdouh El-Nahas, Shaimaa El-Shazly, Fayrouz El-Gamel, Mohamed Motawea, Fady Kyrillos, Hatem Idrees
OBJECTIVE: Increased skin temperature at the plantar aspect of the foot can predict foot ulceration. However its relation to plantar pressure overload is unknown. The aim of this study was to assess the ability of 'smart socks', monitoring plantar temperature under real-life conditions, to predict plantar pressure distribution. METHOD: The 'smart socks' have seven thermal sensors woven into the fabric of the sock to measure the temperature beneath the foot in real-life conditions...
August 2, 2018: Journal of Wound Care
[Objective: To present the activities that facilitate the development of a public policy by public health and higher and university education ministry stakeholders – based on a common vision of nurses and midwives training in Democratic Republic of the Congo (DRC).Methods: An operational research using different methods applied by experts called “policy brokers” according to a framework covering the advocacy mechanisms (Advocacy Coalition Framework) designed to promote the development of a public policy. The population comprised 2 types of common interest groups (coalitions), derived from 3 systems (sociocultural-legal, educational, professional), involved in the choice of the “secondary AND higher” or “secondary OR higher“ training profile for the concerned professionals. The methods comprised: workshops (discussion, training, restitution, validation, negotiation, scientific, reflection group meetings), training activities (programme development, training of nursing and midwives trainers-supervisors) and a variety of media coverage and marketing activities.Results: The nurses and midwives profiles required in the DRC have been established. The levels required for their training have been validated and defined by a common vision of the two ministries concerned. A formal consultation framework was set up to launch the required reform for the review of these two professional’s profiles.Conclusion: The public policy experts’ activities based on the advocacy framework are complex, lengthy and time-consuming. In DRC, a Ministerial decree is currently being finalized to address the creation of a formal consultation framework concerning the training and utilisation of human health resources].
Marie Hatem, Hana Halabi-Nassif, Marie Maroun
OBJECTIVE: To present the activities that facilitate the development of a public policy by public health and higher and university education ministry stakeholders - based on a common vision of nurses and midwives training in Democratic Republic of the Congo (DRC). METHODS: An operational research using different methods applied by experts called ?policy brokers? according to a framework covering the advocacy mechanisms (Advocacy Coalition Framework) designed to promote the development of a public policy...
March 3, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Marie Hatem, Hana Halabi-Nassif, Marie Maroun
INTRODUCTION: The quality of mother and child healthcare remains a challenge for low and middle income countries. Quality interventions that allow a reduction of maternal and infantile mortality require the services of qualified personnel. The objective of this study is to present the results of analysis of the status of human healthcare resources and the quality of healthcare (technical, interpersonal, organisational) they provide to mothers and neonates in Guinea and Togo. METHODS: Data were derived from Guinea and Togo case studies with embedded levels of analysis...
March 3, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Radwa Barakat, Po-Ching Lin, Chan Jin Park, Catherine Best-Popescu, Hatem H Bakry, Mohamed E Abosalem, Nabila M Abdelaleem, Jodi A Flaws, CheMyong Ko
No abstract text is available yet for this article.
August 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Janick Selves, Benoit Terris, Dominique Cazals-Hatem, Jean-François Fléjou
The therapeutic management of malignant colorectal polyp with endoscopic resection is mainly based on specific histopathological criteria. The quality of these criteria is strongly linked to the management of the endoscopic specimen. The French Pathology Society drafted a standardized pathological report with guidelines for the macroscopic management of the endoscopic specimen and explanatory notes for each histopathological criteria. These guidelines are based on the TNM AJCC/UICC classification, 8th edition and the WHO 2010 classification of colorectal tumors, the recommendations of the French Society of Digestive Endoscopy, the synthesis of the literature and on international consensus for prognostic criteria...
July 26, 2018: Annales de Pathologie
Sabine Kuss, Hatem Magdy Abdelhalim Amin, Richard G Compton
Bacterial infections represent one of the leading causes of mortality worldwide, nevertheless the design and development of rapid, cost-efficient and reliable detection methods for pathogens remains challenging. In recent years, electrochemical sensing methods have gained increasing attention for the detection of pathogenic bacteria, due to their increasingly competitive sensitivity. However, combining sensitivity with cost efficiency, high selectivity and a facile working procedure in a portable device is difficult...
July 27, 2018: Chemistry, An Asian Journal
Abderrahmane Hamdi, Christine Enjalbal, Hervé Drobecq, Rabah Boukherroub, Oleg Melnyk, Hatem Ezzaouia, Yannick Coffinier
RATIONALE: Many important biological processes rely on specific biomarkers (such as metabolites, drugs, proteins or peptides, carbohydrates, lipids, ...) that need to be monitored in various fluids (blood, plasma, urine, cell cultures, tissue homogenates, …). Although mass spectrometry (MS) hyphenated to liquid chromatography (LC) is widely accepted as a 'gold-standard' method for identifying such synthetic chemicals or biological products, their robust fast sensitive detection from complex matrices still constitutes a highly challenging matter...
July 26, 2018: Rapid Communications in Mass Spectrometry: RCM
Hatem Zayed, Ussama M Abdel Motal, Akila Gopalakrishnan, Chinnayan Ponnuraja, C George Priya Doss, Nasser Rizk, Fatma M Shebl
AIMS: To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. METHODS: We systematically searched 4 different literature databases (PubMed, Science Direct, Web of Science and Embase), from the date of inception until December 2017, to collect all the information about patients with T1D who developed retinopathy complications; for statistical analysis, we used MetaXL to evaluate the pooled prevalence estimate and the subgroup prevalence estimates employing double arcsine transformation and inverse variance heterogeneity models...
July 25, 2018: Ophthalmic Research
Zeinab A Muhammad, Mohamed A A Radwan, Thoraya A Farghaly, Hatem M Gaber, Mahmuod M Elaasser
BACKGROUND: Several biologically active indole alkaloids have been isolated from marine organisms over the previous few years. Many scientsts interested in synthesis of the marine azepino-indole alkaloids due to their wide range of bioliogical activies. OBJECTIVE: We interested herein to synthesize a new series of some analogues of new naturally occurring azepinoindole alkaloids. METHOD: A novel series of [1,2,4,5]tetrazepino[6,7-b]indoles, Marine natural product Hyrtioreticuline C and D analogues, were synthesized via the reaction of 3-hydrazonoindolin-2-one with hydrzaonoyl chlorides in basic medium...
July 23, 2018: Mini Reviews in Medicinal Chemistry
Rania El Botty, Florence Coussy, Rana Hatem, Franck Assayag, Sophie Chateau-Joubert, Jean-Luc Servely, Sophie Leboucher, Charles Fouillade, Sophie Vacher, Bérengère Ouine, Aurélie Cartier, Leanne de Koning, Paul Cottu, Ivan Bièche, Elisabetta Marangoni
Breast cancer is a complex disease in which each patient could present several genetic alterations that are therapeutically relevant in cancers. Here we explored the therapeutic benefit of combining PARP and mTOR inhibitors in a context of DNA repair deficiency and PI3K pathway activation. The combination of everolimus and olaparib was tested in BRCA2-mutated patient-derived xenografts (PDX) carrying alterations in the PI3K/AKT/mTOR pathway. An RPPA analysis of different signalling pathways was performed in untreated and treated xenografts...
July 3, 2018: Oncotarget
Mariem Itaimi Dammak, Ibtissem Chakroun, Zeineb Mzoughi, Sawsen Amamou, Hedi Ben Mansour, Didier Le Cerf, Hatem Majdoub
Prunus amygdalus is used in the folk medicine that proved the interest of this plant which cures many diseases. Many researchers are interested to valorize almond waste (hull and shell) and to evaluate their biological and pharmacological activities. In this work, polysaccharides from Prunus amygdalus shell were extracted sequentially by water, ammonium oxalate and hydrochloric acid. The monosaccharide composition of polysaccharides fractions was performed by GC-MS. Water-soluble polysaccharide was found to be the most effective extracting agent with an extracted yield of 9%...
July 20, 2018: International Journal of Biological Macromolecules
Violette Said Hanna, Azza Gawish, Marwa Abou El-Dahab, Hatem Tallima, Rashika El Ridi
Schistosoma mansoni and Schistosoma haematobium are intravascular, parasitic flatworms that infect >250 million people in 70 developing countries, yet not all people of the same community and household are afflicted. Regarding laboratory rodents, mice but not rats are susceptible to infection with S. mansoni and hamsters but not mice are entirely permissive to infection with S. haematobium . A recent Brazilian publication has demonstrated that resistance of the water-rat, Nectomys squamipes to S. mansoni infection might be ascribed to stores of arachidonic acid (ARA)-rich lipids in liver...
May 2018: Journal of Advanced Research
Hatem Tallima, Rashika El Ridi
It is time to shift the arachidonic acid (ARA) paradigm from a harm-generating molecule to its status of polyunsaturated fatty acid essential for normal health. ARA is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility, so necessary for the function of all cells, especially in nervous system, skeletal muscle, and immune system. Arachidonic acid is obtained from food or by desaturation and chain elongation of the plant-rich essential fatty acid, linoleic acid. Free ARA modulates the function of ion channels, several receptors and enzymes, via activation as well as inhibition...
May 2018: Journal of Advanced Research
Inmaculada Riquelme, Carlyne Arnould, Samar M Hatem, Yannick Bleyenheuft
BACKGROUND: Tools to assess bimanual coordination are scant. We aimed to: 1) provide normative data of maturation of bimanual coordination in tipically developing (TD) children measured by the Two Arm Coordination Test (TACT), and 2) validate the TACT as an instrument to specifically discriminate impairment of bimanual coordination in children with unilateral cerebral palsy (UCP). PROCEDURE: Cross-sectional observational study. 252 TD children and 26 children with UCP performed 8 trials of TACT (following a star pattern with a pointer steered by coordinated movements of both arms)...
July 19, 2018: Developmental Neurorehabilitation
Ezzeldin Ibrahim, Wesameldin Sultan, Saffa Helal, Hatem Abo-Elwafa, Ahmed Abdelaziz
BACKGROUND: Conscious sedation is usually required during flexible bronchoscopy. Sedation should be achieved without respiratory depression or loss of consciousness. The present study was designed to evaluate the effect of pregabalin pre-medication on reducing the amount of sedatives and to show its advantages for patients undergoing flexible bronchoscopy with dexmedetomidine. METHODS: Seventy patients undergoing elective flexible bronchoscopy were randomly divided into two groups of 35 patients each...
July 18, 2018: Minerva Anestesiologica
Giorgia Zampardi, Jorg Thöming, Hendrik Naatz, Hatem M A Amin, Suman Pokhrel, Lutz Mädler, Richard G Compton
The electrochemical behavior of copper oxide nanoparticles is investigated at both the single particle and at the ensemble level in neutral aqueous solutions through the electrode-particle collision method and cyclic voltammetry, respectively. The influence of Cl- and NO3 - anions on the electrochemical processes occurring at the nanoparticles is further evaluated. The electroactivity of CuO nanoparticles is found to differ between the two types of experiments. At the single-particle scale, the reduction of the CuO nanoparticles proceeds to a higher extent in the presence of chloride ion than of nitrate ion containing solutions...
July 17, 2018: Small
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