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Alamira Marzouk Fouad, Hatem Soliman, Ebtsam S H Abdallah, Sherif Ibrahim, Mansour El-Matbouli, Ahmad A Elkamel
Spring viremia of carp, a fatal viral disease, is caused by the spring viremia of carp virus (SVCV) and can result in up to 70% mortalities in common carps and significant economic losses in several other cyprinid aquaculture. The present study aimed to investigate the possible control of SVCV replication in Epithelioma papulosum cyprini (EPC) cells using the RNA interference technology targeting the RNA-dependent RNA polymerase (L) gene of the SVCV that is essential for its replication. Three stealth small interfering RNA (siRNA) sequences were designed to target three different regions on the SVCV-L gene...
October 15, 2018: Journal of Virological Methods
Matteo Lambertini, Samuel Martel, Christine Campbell, Sébastien Guillaume, Florentine S Hilbers, Uwe Schuehly, Larissa Korde, Hatem A Azim, Serena Di Cosimo, Richard C Tenglin, Jens Huober, José Baselga, Alvaro Moreno-Aspitia, Martine Piccart-Gebhart, Richard D Gelber, Evandro de Azambuja, Michail Ignatiadis
BACKGROUND: Limited data exist on the safety of using anti-human epidermal growth factor receptor 2 (HER2) targeted agents during pregnancy. To date, only retrospective studies have assessed the prognosis of patients with a pregnancy after prior early breast cancer, with no data in HER2-positive patients. METHODS: The Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimization (NeoALTTO) trial and the Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization (ALTTO) trial were randomized phase 3 trials for patients with HER2-positive early breast cancer...
October 18, 2018: Cancer
Altaf A Kondkar, Tahira Sultan, Faisal A Almobarak, Hatem Kalantan, Khaled K Abu-Amero, Saleh A Al-Obeidan
OBJECTIVE: Plexin domain containing 2 (PLXDC2), a cell surface transmembrane protein receptor for pigment epithelium derived factor, is expressed in many tissues including the eye. Polymorphism rs7081455 flanking PLXDC2 has been associated with primary open angle glaucoma (POAG) and its clinical phenotypes and may have a role in POAG. Rs7081455 was genotyped in POAG cases (n = 188) and non-glaucomatous controls (n = 164) of Saudi origin using Taq-Man® to determine any association of this variant with POAG and its endophenotypes...
October 16, 2018: BMC Research Notes
Rim Ben Abdelaziz, Hela Hajji, Hela Boudabous, Amel Ben Chehida, Sonia Mrad-Mazigh, Hatem Azzouz, Neji Tebib
BACKGROUND: The use of the pedagogic tool Patient-Management Problem (PMP) for medical teaching and evaluation remains limited in Tunisia. AIM: to evaluate the value of PMP learning sessions in pediatrics and students' perception of the use of PMP for learning and evaluation. METHODS: We conducted a cross-sectional evaluative study in four pediatric departments in Tunis. Students had a learning session with an electronic PMP. Their knowledge was assessed using a pre-test and a post-test...
January 2018: La Tunisie Médicale
Nils Große Hokamp, Nuran Abdullayev, Thorsten Persigehl, Max Schlaak, Christian Wybranski, Jasmin A Holz, Thomas Streichert, Hatem Alkadhi, David Maintz, Stefan Haneder
OBJECTIVE: To comprehensively assess precision, reproducibility, and repeatability of iodine maps from spectral detector CT (SDCT) in a phantom and in patients with repetitive examination of the abdomen. METHODS: Seventy-seven patients who underwent examination two (n = 52) or three (n = 25) times according to clinical indications were included in this IRB-approved, retrospective study. The anthropomorphic liver phantom and all patients were scanned with a standardized protocol (SSDE in patients 15...
October 15, 2018: European Radiology
Abdelkarim Mahdhi, Nadia Leban, Ibtissem Chakroun, Sihem Bayar, Kacem Mahdouani, Hatem Majdoub, Bochra Kouidhi
The overuse of antibiotics and biofilm formation ability has led to the emergence of resistant bacterial strains. The combined use of several antibiotics has been an efficient strategy to overcome this resistance. In this study, two exopolysaccharides (EPS) obtained from Lactobacillus plantarum (EPS-Lp) and Bacillus spp. (EPS-B), isolated from a traditional Tunisian food "ricotta cheese" and hypersaline environment respectively, were used to counteract the biofilm formation and efflux pumps activities in Escherichia coli ATCC35218...
October 10, 2018: Microbial Pathogenesis
Ehab Abdelbaki Hussin, Asim Aldaheri, Hatem Alharbi, Hazem A Farouk
Purpose: This study compared the accessory anteromedial portal (AAMP) and the modified transtibial technique (MTTT)" for single-bundle anterior cruciate ligament (ACL) reconstruction. Patients and methods: Sixty active adult patients with ACL tear were randomly assigned into two equal groups who were treated surgically. One group was operated on using AAMP and the other group through MTTT. Both the groups had the same postoperative course and were followed for 1 year after surgery...
2018: Open Access Journal of Sports Medicine
Amel Ben Chehida, Sana Ben Messaoud, Rim Ben Abdelaziz, Nadia Ben Ali, Hela Boudabous, Ines Ben Abdelaziz, Zeineb Ben Ameur, Yosra Sassi, Neziha Kaabachi, Sonia Abdelhak, Mohamed Slim Abdelmoula, Mohamed Fradj, Hatem Azzouz, Neji Tebib
BACKGROUND:  Our aim was to describe the natural history of neuromuscular involvement (NMI) in glycogen storage disease type III (GSDIII). METHODS:  We conducted a longitudinal study of 50 Tunisian patients, 9.87 years old in average. RESULTS:  NMI was diagnosed at an average age of 2.66 years and was clinically overt in 85% of patients. Patients with clinical features were older ( p  = 0.001). Complaints were dominated by exercise intolerance (80%), noticed at 5...
October 11, 2018: Neuropediatrics
Innocent Safeukui, Pierre A Buffet, Guillaume Deplaine, Sylvie Perrot, Valentine Brousse, Alain Sauvanet, Beatrice Aussilhou, Safi Dokmak, Anne Couvelard, Dominique Cazals-Hatem, Odile Mercereau-Puijalon, Geneviève Milon, Peter H David, Narla Mohandas
The current paradigm in the pathogenesis of several hemolytic red blood cell disorders is that reduced cellular deformability is a key determinant of splenic sequestration of affected red cells. Three distinct features regulate cellular deformability: membrane deformability, surface area-to-volume ratio (cell sphericity), and cytoplasmic viscosity. By perfusing normal human spleens ex vivo, we had previously showed that red cells with increased sphericity are rapidly sequestered by the spleen. Here, we assessed the retention kinetics of red cells with decreased membrane deformability but without marked shape changes...
October 23, 2018: Blood Advances
Mohamed A Akl, Hatem R Ismael, Fathy I Abd Allah, Alla A Kassem, Ahmed M Samy
Tolmetin sodium (TS) is a non-steroidal anti-inflammatory drug (NSAID) indicated for treatment of musculoskeletal issues. As other NSAID, TS displays a marked side effects on the gastro-intestinal (GI) tract after oral administration. Tradational solid suppositories can cause pain and discomfort for patients, may reach the end of the colon; consequently, the drug can undergo the first-pass effect. TS liquid suppository (TS-LS ) was developed to enhance patient compliance and rectal mucosal safety in high-risk patients receiving highly NSAID therapy...
October 10, 2018: Drug Development and Industrial Pharmacy
Guillaume Le Baut, Claire O'Brien, Paul Pavli, Maryline Roy, Philippe Seksik, Xavier Tréton, Stéphane Nancey, Nicolas Barnich, Madeleine Bezault, Claire Auzolle, Dominique Cazals-Hatem, Jérome Viala, Matthieu Allez, Jean-Pierre Hugot, Anne Dumay
Yersinia are common contaminants of food products, but their prevalence in the human gut is poorly documented. Yersinia have been implicated in Crohn's Disease (CD, an inflammatory bowel disease) however their role in CD is controversial. We performed highly sensitive PCR assays of specific sequences for the gyrB gene of Y. aldovae, Y. bercovieri, Y. enterocolitica, Y. intermedia, Y. mollaretii and the inv gene of Y. pseudotuberculosis . We analyzed a total of 470 ileal samples taken from 338 participants (262 CD patients and 76 controls) belonging to three independent cohorts...
2018: Frontiers in Cellular and Infection Microbiology
Khaoula Bouazizi, Amer Rahhal, Slawomir Kusmia, Morgane Evin, Carine Defrance, Philippe Cluzel, Myriam Berthet, Fabrice Atassi, Pascal Leprince, Guillaume Lebreton, Nadjia Kachenoura, Stéphane N Hatem, Alban Redheuil
BACKGROUND: Atrial fibrillation is associated with an atrial cardiomyopathy composed mainly of fibrosis and adipose tissue accumulation. We hypothesized that MRI, when used in an optimal ex vivo setting allowing high spatial resolution without motion artifacts, can help characterizing the complex 3D left atrial (LA) wall composition in human myocardial samples, as compared to histology. METHODS: This prospective case-control study was approved by the institutional review board...
2018: PloS One
Manal F Elkhadragy, Rami B Kassab, Dina M Metwally, Rafa Almeer, Rewaida Abdel-Gaber, Ebtesam M Al-Olayan, Ehab A Essawy, Hatem K Amin, Ahmed E Abdel Moneim
Cadmium (Cd) is a common environmental toxicant that has harmful effects on plants, animals, and humans. This study evaluated the protective effects of Fragaria ananassa methanolic extract (SME) on cadmium chloride (CdCl2 )-induced neuronal toxicity in rats. Male albino rats were intraperitoneally injected with CdCl2 (6.5 mg/kg) for 5 days with or without the SME (250 mg/kg). We measured the levels of Cd, lipid peroxidation, nitric oxide, glutathione, and oxidative enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase, and glutathione reductase in the whole brain homogenate...
October 5, 2018: Bioscience Reports
Hatem A Wafa, Charles D A Wolfe, Anthony Rudd, Yanzhong Wang
BACKGROUND: As the average life expectancy increases, more people are predicted to have strokes. Recent studies have shown an increasing incidence in certain types of cerebral infarction. We aimed to estimate time trends in incidence, prior risk factors, and use of preventive treatments for ischaemic stroke (IS) aetiological subtypes and to ascertain any demographic disparities. METHODS AND FINDINGS: Population-based data from the South London Stroke Register (SLSR) between 2000 and 2015 were studied...
October 2018: PLoS Medicine
Duong Thi Bich Thuan, Hatem Zayed, Ali H Eid, Haissam Abou-Saleh, Gheyath K Nasrallah, Arduino A Mangoni, Gianfranco Pintus
Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, digestive system, kidneys, muscles, joints, and nervous system. These abnormalities are associated with altered secretion of growth factor and profibrotic cytokines, such as transforming growth factor-beta (TGF-β), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective-tissue growth factor (CTGF)...
2018: Frontiers in Immunology
D Thirumal Kumar, Maryam Umer Niazullah, Sadia Tasneem, E Judith, B Susmita, C George Priya Doss, E Selvarajan, Hatem Zayed
Pompe disease is an autosomal recessive lysosomal storage disease caused by acid α-glucosidase (GAA) deficiency, resulting in intralysosomal accumulation of glycogen, including cardiac, skeletal, and smooth muscle cells. The GAA gene is located on chromosome 17 (17q25.3), the GAA protein consists of 952 amino acids; of which 378 amino acids (347-726) falls within the catalytic domain of the protein and comprises of active sites (518 and 521) and binding sites (404, 600, 616, and 674). In this study, we used several computational tools to classify the missense mutations in the catalytic domain of GAA for their pathogenicity and stability...
October 3, 2018: Journal of Cellular Biochemistry
Zexin Yu, Hatem Moussa, Yangzhou Ma, Meimei Liu, Bilel Chouchene, Raphaël Schneider, Michel Moliere, Hanlin Liao
The deposition of oxygen-defective ZnO films exhibiting varied nanostructures via Solution Precursor Plasma Spray (SPPS) route, a one-step, minute-scaled duration and large scale method, is reported. The in situ formation of oxygen vacancies in ZnO films was confirmed by UV-Visible, Raman and photoluminescence (PL) spectroscopy and the as-prepared samples exhibit a bandgap as low as 3.02 eV. Density functional theory (DFT) simulation demonstrates that the polarization of ZnO is enhanced by the created oxygen vacancies, leading to substantially improved photocatalytic activity...
September 19, 2018: Journal of Colloid and Interface Science
Batuhan Kara, Hatem Hakan Selcuk, Aysun Erbahceci Salik, Hasanagha Zalov, Omer Yildiz, Gunay Gul, Bedih Balkan
BACKGROUND: Tigertriever (Rapid Medical, Yoqneam, Israel) is a new design of stent retriever. PURPOSE: To evaluate the feasibility, safety, and efficacy of the Tigertriever in patients with acute ischemic stroke who have undergone mechanical thrombectomy. MATERIALS AND METHODS: Two different techniques-namely, standard unsheathing (SUT) and repetitive inflation-deflation (RID) techniques, were used. Modified Thrombolysis in Cerebral Infarction (mTICI) scores of 2b and 3 were considered as successful recanalization...
September 27, 2018: Journal of Neurointerventional Surgery
Dabor Résière, Claude Olive, Hatem Kallel, André Cabié, Rémi Névière, Bruno Mégarbane, José María Gutiérrez, Hossein Mehdaoui
In Martinique, Bothrops lanceolatus snakebite, although relatively uncommon (~30 cases/year), may result in serious complications such as systemic thrombosis and local infections. Infections have been hypothesized to be related to bacteria present in the snake's oral cavity. In this investigation, we isolated, identified, and studied the susceptibility to beta-lactams of bacteria sampled from the oral cavity of twenty-six B. lanceolatus specimens collected from various areas in Martinique. Microbiota from B...
September 27, 2018: International Journal of Environmental Research and Public Health
Mohamed Aymen Chaouch, Khaoula Mkhadmini Hammi, Manel Dhahri, Mohamed Ben Mansour, Mounir Raoui Maaroufi, Didier Le Cerf, Hatem Majdoub
In order to develop new and low cost anticoagulants as potential heparin alternatives, sulfation of a pectin-like polysaccharide from Opuntia ficus indica cladodes using SO3 -DMF complex was performed with a significant sulfate content (7%). FTIR and NMR assays indicated that the sulfation reaction had occurred. In addition, GC-MS analyses demonstrated that sulfation was carried out on the arabinose units of native polysaccharide. Moreover, Physico-chemical characterization indicated an evident decrease of the average molecular weight (Mw ) and sugar rates after sulfation...
September 24, 2018: International Journal of Biological Macromolecules
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