keyword
https://read.qxmd.com/read/38058259/akkermansia-muciniphila-might-improve-anti-pd-1-therapy-against-hcc-by-changing-host-bile-acid-metabolism
#21
JOURNAL ARTICLE
Xiucai Lan, Jiaming Ma, Zhipeng Huang, Yuzhen Xu, Yaomin Hu
PD-1 monoclonal antibodies (mAb) have demonstrated remarkable efficacy in a variety of cancers, including Hepatocellular carcinoma (HCC). However, the patient response rates remain suboptimal, and a significant proportion of initial responders may develop resistance to this therapeutic approach. Akkermansia muciniphila (AKK), a microorganism implicated in multiple human diseases, has been reported to be more abundant in patients who exhibit favorable responses to PD-1mAb. However, the underlying mechanism has yet to be elucidated...
December 7, 2023: Journal of Gene Medicine
https://read.qxmd.com/read/38053196/a-randomized-double-blind-clinical-trial-on-safety-and-efficacy-of-tauroursodeoxycholic-acid-tudca-as-add-on-treatment-in-patients-affected-by-amyotrophic-lateral-sclerosis-als-the-statistical-analysis-plan-of-tudca-als-trial
#22
RANDOMIZED CONTROLLED TRIAL
Flavia L Lombardo, Stefania Spila Alegiani, Flavia Mayer, Marta Cipriani, Maria Lo Giudice, Albert Christian Ludolph, Christopher J McDermott, Philippe Corcia, Philip Van Damme, Leonard H Van den Berg, Orla Hardiman, Gabriele Nicolini, Nicola Vanacore, Brian Dickie, Alberto Albanese, Maria Puopolo
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have been no significant improvements in therapeutic options for ALS patients in recent years. Currently, there is no cure for ALS, and the only approved treatment in Europe is riluzole, which has been shown to slow the disease progression and prolong survival by approximately 3 months. Recently, tauroursodeoxycholic acid (TUDCA) has emerged as a promising and effective treatment for neurodegenerative diseases due to its neuroprotective activities...
December 5, 2023: Trials
https://read.qxmd.com/read/38015303/tauroursodeoxycholic-acid-inhibited-apoptosis-and-oxidative-stress-in-h-2-o-2-induced-bmsc-death-via-modulating-the-nrf-2-signaling-pathway-the-therapeutic-implications-in-a-rat-model-of-spinal-cord-injury
#23
JOURNAL ARTICLE
Jiaxian Weng, Le Wang, Kai Wang, Haitao Su, Dan Luo, Haimei Yang, Yaqian Wen, Qiduan Wu, Xing Li
Spinal cord injury (SCI) is a prevalent and significant injury to the central nervous system, resulting in severe consequences. This injury is characterized by motor, sensory, and excretory dysfunctions below the affected spinal segment. Transplantation of bone marrow mesenchymal stem cells (BMSCs) has emerged as a potential treatment for SCI. However, the low survival as well as the differentiation rates of BMSCs within the spinal cord microenvironment significantly limit their therapeutic efficiency. Tauroursodeoxycholic acid (TUDCA), an active ingredient found in bear bile, has demonstrated its neuroprotective, antioxidant, and antiapoptotic effects on SCI...
November 28, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37981257/glycyrrhetinic-acid-attenuates-endoplasmic-reticulum-stress-induced-hepatocyte-apoptosis-via-chop-dr5-caspase-8-pathway-in-cholestasis
#24
JOURNAL ARTICLE
Bin Zou, Zhang Shuang, Jing Zhao, Guochao Song, Fengyi Weng, Xiaoqing Xu, Fengling Li, Jingyi Jin, Dongming Yan, Kai Huang, Chenghai Liu, Yue Li, Furong Qiu
Bile acid (BA)-induced apoptosis is a common pathologic feature of cholestatic liver injury. Glycyrrhetinic acid (GA) is the hepatoprotective constituent of licorice. In the present study, the anti-apoptotic potential of GA was investigated in wild type and macrophage-depleted C57BL/6 mice challenged with alpha-naphthyl isothiocyanate (ANIT), and hepatocytes stimulated with Taurocholic acid (TCA) or Tumor necrosis factor alpha (TNF-α). Apoptosis was determined by TUNEL positive cells and expression of executioner caspases...
November 17, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37973672/tauro-urso-deoxycholic-acid-trials-in-amyotrophic-lateral-sclerosis-what-is-achieved-and-what-to-expect
#25
REVIEW
Maria Lo Giudice, Antoniangela Cocco, Giorgio Reggiardo, Stefania Lalli, Alberto Albanese
Phase II studies on tauro-urso-deoxycholic acid (TUDCA) raised the promise of safety and efficacy in patients with amyotrophic lateral sclerosis, a currently incurable and devastating disease. We review the available evidence on the efficacy and safety of TUDCA, administered alone or in combination, by analyzing and comparing published and ongoing studies on amyotrophic lateral sclerosis. Two independent phase II studies (using TUDCA solo or combined with sodium phenylbutyrate) showed similar efficacy in slowing disease progression measured by functional scales...
November 16, 2023: Clinical Drug Investigation
https://read.qxmd.com/read/37943350/extracorporeal-adsorption-of-protective-and-toxic-bile-acids-and-bilirubin-in-patients-with-cholestatic-liver-dysfunction-a-prospective-study
#26
JOURNAL ARTICLE
Antonia Greimel, Katharina Habler, Caroline Gräfe, Nils Maciuga, Clara Isabell Brozat, Michael Vogeser, Michael Zoller, Felix L Happich, Uwe Liebchen, Sandra Frank, Michael Paal, Christina Scharf
BACKGROUND: The release of toxic bile acids (BAs) in the blood of critically ill patients with cholestatic liver dysfunction might lead to the damage of various organs. Their extracorporeal elimination using the cytokine adsorber Cytosorb® (CS) (adsorption of especially hydrophobic molecules < 60 kDa) might be promising, but data proving a potential adsorption are missing so far. METHODS: The prospective Cyto-SOVLE study (NCT04913298) included 20 intensive care patients with cholestatic liver dysfunction, continuous kidney replacement therapy, total bilirubin concentration > 10 mg/dl and the application of CS into the dialysis circuit...
November 9, 2023: Annals of Intensive Care
https://read.qxmd.com/read/37918087/hyperandrogenism-drives-ovarian-inflammation-and-pyroptosis-a-possible-pathogenesis-of-pcos-follicular-dysplasia
#27
JOURNAL ARTICLE
Yu Xiang, Hua Wang, Huimin Ding, Tianyue Xu, Xiu Liu, Zichao Huang, Honghui Wu, Hongshan Ge
Hyperandrogenemia and persistent chronic inflammation, two main striking features of polycystic ovary syndrome (PCOS), have been proven involved in follicular dysgenesis in PCOS. However, the association between hyperandrogenism and inflammation activation in PCOS is not fully understood. Excess testosterone(T) induces inflammation and pyroptosis activation in a mouse model of PCOS, leading to ovarian dysfunction and fibrosis. Excessive endoplasmic reticulum (ER) stress is present in ovarian granulosa cells (GCs), testosterone-induced PCOS mouse and cellular models...
October 31, 2023: International Immunopharmacology
https://read.qxmd.com/read/37880338/activation-of-the-perk-chop-signaling-pathway-during-endoplasmic-reticulum-stress-contributes-to-olanzapine-induced-dyslipidemia
#28
JOURNAL ARTICLE
Lu Liu, Lei Tang, Jia-Ming Luo, Si-Yu Chen, Chun-Yan Yi, Xue-Mei Liu, Chang-Hua Hu
Olanzapine (OLZ) is a widely prescribed antipsychotic drug with a relatively ideal effect in the treatment of schizophrenia (SCZ). However, its severe metabolic side effects often deteriorate clinical therapeutic compliance and mental rehabilitation. The peripheral mechanism of OLZ-induced metabolic disorders remains abstruse for its muti-target activities. Endoplasmic reticulum (ER) stress is implicated in cellular energy metabolism and the progression of psychiatric disorders. In this study, we investigated the role of ER stress in the development of OLZ-induced dyslipidemia...
October 25, 2023: Acta Pharmacologica Sinica
https://read.qxmd.com/read/37874230/cellular-senescence-contributes-to-the-progression-of-hyperoxic-bronchopulmonary-dysplasia
#29
JOURNAL ARTICLE
Xigang Jing, Shuang Jia, Maggie Teng, Billy W Day, Adeleye J Afolayan, Jason A Jarzembowski, Chien-Wei Lin, Martin J Hessner, Kirkwood A Pritchard, Stephen Naylor, G Ganesh Konduri, Ru-Jeng Teng
Oxidative stress (OS), inflammation, and endoplasmic reticulum (ER) stress sequentially occur in bronchopulmonary dysplasia (BPD), and all result in DNA damage. When DNA damage becomes irreparable, tumor suppressors increase, followed by apoptosis or senescence. Although cellular senescence contributes to wound healing, its persistence inhibits growth. Therefore, we hypothesized that cellular senescence contributes to BPD progression. Human autopsy lungs were obtained. Sprague-Dawley rat pups exposed to 95% oxygen between postnatal day 1 (P1) to P10 were used as the BPD phenotype...
October 24, 2023: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/37852571/can-endoplasmic-reticulum-stress-observed-in-the-ptz-kindling-model-seizures-be-prevented-with-tudca-and-4-pba
#30
JOURNAL ARTICLE
Züleyha Doğanyiğit, Aslı Okan, Enes Akyüz, Seher Yılmaz, Şükrü Ateş, Serpil Taheri, Zeynep Yılmaz, Mohd Farooq Shaikh
Epilepsy is a chronic neurological disease with recurrent seizures. Increasing evidence suggests that endoplasmic reticulum (ER) stress may play a role in the pathogenesis of epilepsy. We aimed to investigate the effects of Tauroursodeoxycholic acid (TUDCA) and 4-phenyl-butyric acid (4-PBA), which are known to suppress ER stress, on developed seizures in terms of markers of ER stress, oxidative stress, and apoptosis. The pentylenetetrazole (PTZ) kindling model was induced in Wistar albino rats (n = 48) by administering 35 mg/kg PTZ intraperitoneally (I...
October 16, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37842553/effect-of-tauroursodeoxycholic-acid-on-survival-and-safety-in-amyotrophic-lateral-sclerosis-a-retrospective-population-based-cohort-study
#31
JOURNAL ARTICLE
Elisabetta Zucchi, Umberto Maria Musazzi, Guido Fedele, Ilaria Martinelli, Giulia Gianferrari, Cecilia Simonini, Nicola Fini, Andrea Ghezzi, Maria Caputo, Elisabetta Sette, Veria Vacchiano, Lucia Zinno, Pietro Anceschi, Elena Canali, Marco Vinceti, Salvatore Ferro, Jessica Mandrioli
BACKGROUND: Oral tauroursodeoxycholic acid (TUDCA) is a commercial drug currently tested in patients with amyotrophic lateral sclerosis (ALS) both singly and combined with sodium phenylbutyrate. This retrospective study aimed to investigate, in a real-world setting, whether TUDCA had an impact on the overall survival of patients with ALS who were treated with this drug compared to those patients who received standard care only. METHODS: This propensity score-matched study was conducted in the Emilia Romagna Region (Italy), which has had an ALS regional registry since 2009...
November 2023: EClinicalMedicine
https://read.qxmd.com/read/37821059/clinical-prediction-of-hbv-associated-cirrhosis-using-machine-learning-based-on-platelet-and-bile-acids
#32
JOURNAL ARTICLE
Zhenpeng Wang, Aimin Zhang, Yue Yin, Jiashu Tian, Xialin Wang, Zhihong Yue, Lin Pei, Li Qin, Mei Jia, Hui Wang, Lin-Lin Cao
OBJECTIVES: The present study was conducted to evaluate the performance of serum bile acids in the prediction of cirrhosis in chronic hepatitis B (CHB) population. METHODS: Dysregulated metabolites were explored using untargeted and targeted metabolomic analyses. A machine learning model based on platelet (PLT) and several bile acids was constructed using light gradient boosting machine (LightGBM), to differentiate HBV-associated cirrhosis (BAC) from CHB patients...
November 1, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/37797890/targeted-echogenic-and-anti-inflammatory-polymeric-prodrug-nanoparticles-for-the-management-of-renal-ischemia-reperfusion-injury
#33
JOURNAL ARTICLE
Sooyeon Kim, Hanui Jo, Suyeon Lee, Manseok Yang, Hayoung Jun, Youngjong Lee, Giwook Kim, Dongwon Lee
Ischemia/reperfusion (IR) injury is an inevitable pathological event occurring when blood is resupplied to the tissues after a period of ischemia. One of major causes of IR injury is the overproduction of reactive oxygen species (ROS) including hydrogen peroxide (H2 O2 ), which mediates the expression of various inflammatory cytokines to exacerbate tissue damages. The overproduced H2 O2 could therefore serve as a diagnostic and therapeutic biomarker of IR injury. In this study, poly(boronated methacrylate) (pBMA) nanoparticles were developed as nanotheranostic agents for renal IR injury, which not only generate CO2 bubbles to enhance the ultrasound contrast but also provide potent preventive effects in a H2 O2 -triggered manner...
October 3, 2023: Journal of Controlled Release
https://read.qxmd.com/read/37793463/er-stress-modulated-klotho-restoration-a-prophylactic-therapeutic-strategy-against-acute-kidney-injury-diabetes-comorbidity
#34
JOURNAL ARTICLE
Ajinath Kale, Vishwadeep Shelke, Tahib Habshi, Neha Dagar, Anil Bhanudas Gaikwad
Klotho is a renoprotective factor that is at the forefront of research as a potential therapeutic agent and biomarker of acute kidney injury (AKI). Endoplasmic reticulum (ER) stress and Klotho downregulation are the critical hallmarks of AKI progression. Importantly, the crosstalk between ER and Klotho is still elusive in AKI under diabetic condition. Therefore, this study aimed to elucidate the affiliation between ER stress and Klotho regulation by using the ischemia-reperfusion renal injury (IRI) model based on male Wistar rats and the hypoxia-reperfusion injury (HRI) using NRK52E cells...
October 2, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/37762363/tauroursodeoxycholic-acid-supplementation-in-in-vitro-culture-of-indicine-bovine-embryos-molecular-and-cellular-effects-on-the-in-vitro-cryotolerance
#35
JOURNAL ARTICLE
Elisa Mariano Pioltine, Camila Bortoliero Costa, Fernanda Fagali Franchi, Priscila Helena Dos Santos, Marcelo Fábio Gouveia Nogueira
During embryo development, the endoplasmic reticulum (ER) acts as an important site for protein biosynthesis; however, in vitro culture (IVC) can negatively affect ER homeostasis. Therefore, the aim of our study was to evaluate the effects of the supplementation of tauroursodeoxycholic acid (TUDCA), an ER stress inhibitor, in the IVC of bovine embryos. Two experiments were carried out: Exp. 1: an evaluation of blastocyst rate, hatching kinetics, and gene expression of hatched embryos after being treated with different concentrations of TUDCA (50, 200, or 1000 μM) in the IVC; Exp...
September 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37749820/tauroursodeoxycholic-acid-protects-schwann-cells-from-high-glucose-induced-cytotoxicity-by-targeting-nlrp3-to-regulate-cell-migration-and-pyroptosis
#36
JOURNAL ARTICLE
Qiuyue Wang, Wen Li, Xiaozhuo Zhang, Shuet Ling Chung, Jinling Dai, Zhu Jin
Diabetic peripheral neuropathy (DPN) is the most prevalent complication of type 2 diabetes mellitus (T2DM), and it seriously affects the quality of life of patients. Tauroursodeoxycholic acid (TUDCA) is a bile acid that plays a protective role against various diseases. However, the function of TUDCA in DPN progression needs to be elucidated. Hence, this study clarified the action of TUDCA on DPN development and explored its mechanism of action. Fecal samples were collected from 50 patients with T2DM or DPN...
September 25, 2023: Biotechnology and Applied Biochemistry
https://read.qxmd.com/read/37740611/identification-of-a-human-blood-biomarker-of-pharmacological-11%C3%AE-hydroxysteroid-dehydrogenase-1-inhibition
#37
JOURNAL ARTICLE
Cristina Gómez, Zerin Alimajstorovic, Nantia Othonos, Denise V Winter, Sarah White, Gareth G Lavery, Jeremy W Tomlinson, Alexandra J Sinclair, Alex Odermatt
BACKGROUND AND PURPOSE: 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the oxoreduction of cortisone to cortisol, thereby amplifying levels of active glucocorticoids. It is considered a pharmaceutical target in metabolic disease and cognitive impairments. 11β-HSD1 also converts some 7oxo-steroids to their 7β-hydroxy forms. A recent study in mice described the ratio of tauroursodeoxycholic acid (TUDCA)/tauro-7oxolithocholic acid (T7oxoLCA) as a biomarker for decreased 11β-HSD1 oxoreductase activity...
September 23, 2023: British Journal of Pharmacology
https://read.qxmd.com/read/37691227/neuroprotective-effect-of-tauroursodeoxycholic-acid-tudca-on-in-vitro-and-in-vivo-models-of-retinal-disorders-a-systematic-review
#38
JOURNAL ARTICLE
Jiaxian Li, Ziyang Huang, Yu Jin, Lina Liang, Yamin Li, Kai Xu, Wei Zhou, Xiaoyu Li
BACKGROUND: Tauroursodeoxycholic acid (TUDCA) is a naturally produced hydrophilic bile acid that has been used for centuries in Chinese medicine. Numerous recent in vitro and in vivo studies have shown that TUDCA has neuroprotective action in various models of retinal disorders. OBJECTIVE: To systematically review the scientific literature and provide a comprehensive summary on the neuroprotective action and the mechanisms involved in the cytoprotective effects of TUDCA...
September 7, 2023: Current Neuropharmacology
https://read.qxmd.com/read/37687178/metabolomics-and-lipidomics-study-unveils-the-impact-of-tauroursodeoxycholic-acid-on-hyperlipidemic-mice
#39
JOURNAL ARTICLE
Na Cui, Wensen Zhang, Fazhi Su, Zhihong Zhang, Weijie Qiao, Yanping Sun, Bingyou Yang, Haixue Kuang, Qiuhong Wang
Bear bile powder is an essential, traditional and valuable Chinese herbal medicine that clears heat, calms the liver, and improves eyesight. Early studies have shown that bear bile powder has lipid-lowering activity, but due to the scarcity of natural bear bile powder resources, it has yet to be used on a large scale. Researchers have found that tauroursodeoxycholic acid (TUDCA) is the primary characteristic bioactive substance of bear bile powder. This study aimed to investigate the therapeutic effect of TUDCA on high-fat diet (HFD)-induced hyperlipidemia...
August 30, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37664919/ampk-mediates-early-activation-of-the-unfolded-protein-response-through-a-positive-feedback-loop-in-palmitate-treated-muscle-cells
#40
JOURNAL ARTICLE
Jing Gong, Lu Wang, Wuchen Tao, Xiangsheng Pang, Zonghan Liu, Shiming Li, Wenjiong Li, Xiaoping Chen, Peng Zhang
BACKGROUND: Activation of the unfolded protein response (UPR) is closely related to the pathogenesis of many metabolic disorders. Accumulating evidence also shows that UPR and metabolic signaling pathways are interdependent. The AMP-activated protein kinase (AMPK) signal pathway controls the energy balance of eukaryotes. The aim of this study was therefore to investigate the possible interaction between AMPK signaling and UPR in muscle cells exposed to saturated fatty acids, as well as the potential mechanism...
August 7, 2023: Frontiers in Bioscience (Landmark Edition)
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