Xigang Jing, Shuang Jia, Maggie Teng, Billy W Day, Adeleye J Afolayan, Jason A Jarzembowski, Chien-Wei Lin, Martin J Hessner, Kirkwood A Pritchard, Stephen Naylor, G Ganesh Konduri, Ru-Jeng Teng
Oxidative stress (OS), inflammation, and endoplasmic reticulum (ER) stress sequentially occur in bronchopulmonary dysplasia (BPD), and all result in DNA damage. When DNA damage becomes irreparable, tumor suppressors increase, followed by apoptosis or senescence. Although cellular senescence contributes to wound healing, its persistence inhibits growth. Therefore, we hypothesized that cellular senescence contributes to BPD progression. Human autopsy lungs were obtained. Sprague-Dawley rat pups exposed to 95% oxygen between postnatal day 1 (P1) to P10 were used as the BPD phenotype...
October 24, 2023: American Journal of Respiratory Cell and Molecular Biology