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https://www.readbyqxmd.com/read/30322454/new-opioid-receptor-modulators-and-agonists
#1
REVIEW
Alan D Kaye, Elyse M Cornett, Shilpa S Patil, Sonja A Gennuso, Matthew M Colontonio, Dustin R Latimer, Aaron J Kaye, Richard D Urman, Nalini Vadivelu
There has been significant research to develop an ideal synthetic opioid. Opioids with variable properties possessing efficacy and with reduced side effects have been synthesized when compared to previously used agents. An opioid modulator is a drug that can produce both agonistic and antagonistic effects by binding to different opioid receptors and therefore cannot be classified as one or the other alone. These compounds can differ in their structures while still possessing opioid-mediated actions. This review will discuss TRV130 receptor modulators and other novel opioid receptor modulators, including Mitragyna "Kratom," Ignavine, Salvinorin-A, DPI-289, UFP-505, LP1, SKF-10,047, Cebranopadol, Naltrexone-14-O-sulfate, and Naloxegol...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322028/viral-persistence-and-chronicity-in-hepatitis-c-virus-infection-role-of-t-cell-apoptosis-senescence-and-exhaustion
#2
REVIEW
Muttiah Barathan, Rosmawati Mohamed, Yean K Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar
Hepatitis C virus (HCV) represents a challenging global health threat to ~200 million infected individuals. Clinical data suggest that only ~10⁻15% of acutely HCV-infected individuals will achieve spontaneous viral clearance despite exuberant virus-specific immune responses, which is largely attributed to difficulties in recognizing the pathognomonic symptoms during the initial stages of exposure to the virus. Given the paucity of a suitable small animal model, it is also equally challenging to study the early phases of viral establishment...
October 12, 2018: Cells
https://www.readbyqxmd.com/read/30321031/breaking-the-cycle-of-abusive-supervision-how-disidentification-and-moral-identity-help-the-trickle-down-change-course
#3
Shannon G Taylor, Matthew D Griffith, Abhijeet K Vadera, Robert Folger, Chaim R Letwin
Studies show that abusive leader behaviors "trickle down" to lower organizational levels, but this research ignores that many abused supervisors do not perpetuate abuse by harming their own subordinates. Drawing on social-cognitive theory and related research, we suggest abused supervisors might defy rather than emulate their managers' abusive behavior. Specifically, we predicted that some abused supervisors-namely, those with strong moral identities-might in effect "change course" by engaging in less abuse or demonstrating ethical leadership with their subordinates to the extent they disidentify with their abusive managers...
October 15, 2018: Journal of Applied Psychology
https://www.readbyqxmd.com/read/30316241/metrics-and-evaluation-tools-for-patient-engagement-in-healthcare-organization-and-system-level-decision-making-a-systematic-review
#4
Vadim Dukhanin, Rachel Topazian, Matthew DeCamp
BACKGROUND: Patient, public, consumer, and community (P2C2) engagement in organization-, community-, and systemlevel healthcare decision-making is increasing globally, but its formal evaluation remains challenging. To define a taxonomy of possible P2C2 engagement metrics and compare existing evaluation tools against this taxonomy, we conducted a systematic review. METHODS: A broad search strategy was developed for English language publications available from January 1962 through April 2015 in PubMed, Embase, Sociological Abstracts, PsycINFO, EconLit, and the gray literature...
May 16, 2018: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/30315917/pre-ventricular-assist-device-palliative-care-consultation-a-qualitative-analysis
#5
Sarah Chuzi, Sarah Hale, Jason Arnold, Amy Zhou, Rebecca Harap, Kathleen L Grady, Jonathan D Rich, Clyde W Yancy, Adeboye Ogunseitan, Eytan Szmuilowicz, Jane E Wilcox
INTRODUCTION: In 2013 the Centers for Medicare and Medicaid Services (CMS) issued a mandate requiring that all patients undergoing destination therapy ventricular assist device (DT VAD) implantation have access to a palliative care team prior to surgery. Subsequently, many VAD programs implemented a mandatory pre-implantation palliative care consultation for patients considering DT VAD. However, little is known about the quality of these consults. METHODS: All patients undergoing DT VAD at Northwestern Memorial Hospital from October 30, 2013 (the CMS decision date) through March 1, 2018 were included...
October 10, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/30314394/modification-of-the-ceramic-implant-surfaces-from-zirconia-by-the-magnetron-sputtering-of-different-calcium-phosphate-targets-a-comparative-study
#6
Anna I Kozelskaya, Evgeny N Bolbasov, Alexey S Golovkin, Alexander I Mishanin, Alice N Viknianshchuk, Evgeny V Shesterikov, Аndrey Ashrafov, Vadim A Novikov, Alexander Y Fedotkin, Igor A Khlusov, Sergey I Tverdokhlebov
In this study, thin calcium phosphate (Ca-P) coatings were deposited on zirconia substrates by radiofrequency (RF) magnetron sputtering using different calcium phosphate targets (calcium phosphate tribasic (CPT), hydroxyapatite (HA), calcium phosphate monobasic, calcium phosphate dibasic dehydrate (DCPD) and calcium pyrophosphate (CPP) powders). The sputtering of calcium phosphate monobasic and DCPD powders was carried out without an inert gas in the self-sustaining plasma mode. The physico-chemical, mechanical and biological properties of the coatings were investigated...
October 11, 2018: Materials
https://www.readbyqxmd.com/read/30313854/three-new-taxa-of-the-genus-cechetra-zolotuhin-ryabov-2012-lepidoptera-sphingidae-from-south-east-asia-with-notes-on-other-species-of-the-genus
#7
Nikolay Ivshin, Vadim Krutov, Denis Romanov
Two new species and one subspecies of the genus Cechetra Zolotuhin Ryabov, 2012 are described from South-East Asia. Cechetra bryki sp.n. is described from Nepal, Myanmar (Burma), southwestern China and northern Vietnam. This species is most closely related in habitus, male genitalia morphology and COI mtDNA to the sympatric species, C. lineosa (Walker, 1856) and C. scotti (Rothschild, 1920) in habitus, male genitalia morphology and COI mtDNA. Cechetra inconspicua sp.n. is described from Peninsular Malaysia, Borneo and Sumatra...
July 23, 2018: Zootaxa
https://www.readbyqxmd.com/read/30313495/five-new-species-of-the-genus-ernolatia-walker-1862-lepidoptera-bombycidae-from-islands-of-malesia
#8
Vadim V Zolotuhin, Vladislav A Dolgunov
Five new species of the genus Ernolatia Walker, 1862 are described from the islands of Malesia. They are E. adrasteia sp. nov. (type locality: Philippinen, Negros occ., Mt. Kanlaon, 600-800 m, W-Route via Mambucal), E. invicema sp. nov. (type locality: S. Sulawesi, Puncak, Palopo, 2°55'S, 120°05'E), E. callirhoe sp. nov. (type locality: S. Sulawesi, Mt. Sampuraga, 2°10'S, 120°45'E), E. fumidiflora sp. nov. (type locality: Indonesia, N. Tengg. Timur, Flores, 9 km S Ruteng Golo Luseng) and E. doris sp. nov...
May 24, 2018: Zootaxa
https://www.readbyqxmd.com/read/30313471/a-new-species-of-the-genus-phyllodesma-phyllodesma-h%C3%A3-bner-1820-1816-from-southern-china-lepidoptera-lasiocampidae
#9
Aidas Saldaitis, Vadim V Zolotuhin
A new species, Phyllodesma kopetzi sp. nov. (type locality: China, W. Sichuan, Road Daocheng/Litang, 4100 m, N29°36.788', E100°19.825'), is described from the southwestern part of China's Sichuan Province. The holotype is deposited in the World Insect Gallery (Joniškis, Lithuania) collection. It is compared with the poorly known Phyllodesma sinina (Grum-Grshimailo, 1891) described from Sinin-Shan [Qinghai, China].
May 29, 2018: Zootaxa
https://www.readbyqxmd.com/read/30313413/nomenclature-and-synonymic-remarks-on-two-species-of-eupterotidae-lepidoptera-described-by-johan-christian-fabricius-and-notes-on-related-species
#10
Vadim V Zolotuhin
Types of two species of monkey moths (Eupterotidae, Lepidoptera) described by Johan Christian Fabricius were located and are here figured for the first time, and lectotypes are designated for both species. The lectotype of Bombyx hibisci Fabricius 1775 is a male from the Hunterian Museum (Glasgow). The lectotype of Bombyx orientalis Fabricius 1793, originally listed from "Dom. Lund" was found in the Zoological Museum-University of Copenhagen (as temporarily loan from the Zoological Museum of Kiel University) with an old incorrect identification label...
September 5, 2018: Zootaxa
https://www.readbyqxmd.com/read/30312379/impact-of-13-pneumococcal-conjugate-vaccine-among-adults-a-systematic-review-and-meta-analysis
#11
Nirma Khatri Vadlamudi, Anna Chen, Fawziah Marra
BACKGROUND: A notable reduction of pneumococcal disease burden among adults was observed after introduction of 7 valent- pneumococcal conjugate vaccine in childhood immunization programs. In 2010, 13 valent-pneumococcal conjugate vaccine (PCV13) replaced PCV7 in many jurisdictions; a comparative assessment of PCV13's impact has not yet been performed. OBJECTIVE: To summarize available data and assess the change in the incidence of invasive pneumococcal disease (IPD) in adults after the introduction of PCV13 in childhood immunization programs...
October 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30312217/diagnostic-and-prognostic-value-of-18f-fdg-pet-ct-imaging-in-suspected-recurrence-of-male-breast-cancer
#12
Shelvin K Vadi, Bhagwant R Mittal, Ashwani Sood, Gurpreet Singh, Amanjit Bal, Ashwin S Parihar, Anish Bhattacharya, Rajender K Basher, Rakesh Kapoor
PURPOSE: Male breast cancer (MBC) is a rare malignancy, with recurrence being one of the main adverse predictors for prognosis. The aim of the study was to evaluate the diagnostic and predictive value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in the setting of suspected recurrence of MBC. PATIENTS AND METHODS: Retrospective analysis of PET/CT findings was performed in 23 previously treated, histologically proven patients with MBC (mean age: 59.3±10.9 years; range: 36-79 years) with suspected recurrence...
October 11, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30311082/the-self-disproportionation-of-enantiomers-sde-of-%C3%AE-amino-acid-derivatives-facets-of-steric-and-electronic-properties
#13
Takuma Hosaka, Tomomi Imai, Alicja Wzorek, Magdalena Marcinkowska, Anna Kolbus, Osamu Kitagawa, Vadim A Soloshonok, Karel D Klika
α-Amino acids (α-AAs) are in extremely high demand in nearly every sector of the food and health-related chemical industries and continue to be the subject of intense multidisciplinary research. The self-disproportionation of enantiomers (SDE) is an emerging and one of the least studied areas of α-AA or enantiomeric properties, critically important for their production and application. In the present work, we report a detailed study of the SDE via achiral, gravity-driven column chromatography for a set of N-acylated, N-carbonylated, N-fluoroacylated, and N-thioacylated α-amino acid esters...
October 11, 2018: Amino Acids
https://www.readbyqxmd.com/read/30311037/role-of-closed-drain-after-multi-level-posterior-spinal-surgery-in-adults-a-randomised-open-label-superiority-trial
#14
Alexander Vadimovich Gubin, Oksana Germanovna Prudnikova, Koushik Narayan Subramanyam, Alexander Vladimirovich Burtsev, Maxim Viktorovich Khomchenkov, Abhishek Vasant Mundargi
PURPOSE: To explore the role of closed suction drain in multi-level posterior spinal surgery. METHODS: We performed prospective, open-label, randomised control, superiority trial with parallel design and 1:1 allocation. A total of 161 patients undergoing posterior spinal surgery involving more than one motion segment at a dedicated spine surgery department were randomly allocated into "drain" or "no-drain" groups, based on which surgical drain was employed at the end of surgery...
October 11, 2018: European Spine Journal
https://www.readbyqxmd.com/read/30310827/-vernonia-amygdalina-delile-exhibits-a-potential-for-the-treatment-of-acute-promyelocytic-leukemia
#15
Clement G Yedjou, Jennifer N Sims, Sylvianne Njiki, Nole Tsabang, Ifedayo V Ogungbe, Paul B Tchounwou
The World Health Organization (WHO) has been on front line to encourage developing countries to identify medicinal plants that are safe and easily available to patients. Traditional medicine represents the first-treatment choice for the healthcare of approximately 80% of people living in developing countries. Also, its use in the United States has increased by 38% during within the last decade of the 20th century alone. Therefore, the aim of the present study was to explore the efficacy of a medicinal plant, Vernonia amygdalina Delile (VAD), as a new targeted therapy for the management of acute promyelocytic leukemia (APL), using HL-60 cells as a test model...
August 2018: Global journal of advanced engineering technologies and sciences
https://www.readbyqxmd.com/read/30310034/-implantable-ventricular-assist-device
#16
Kan Nawata, Minoru Ono
For patients with "stage D refractory heart failure" as stated by the The Japanese Circulation Society (JCS) 2017/The Japanese Heart Failure Society (JHFS) 2017 Guidelines for Diagnosis and Treatment of Acute and Chronic Heart Failure, extensive therapeutic methods including implantation of ventricular assist device (VAD) and/or heart transplantation, as well as terminal care. An implantable VAD is a device designed to support patients for a long term of several years. This device has its most part buried in the body with its driveline penetrated out through the skin to connect with a controller and butteries...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/30309393/sepsis-related-deaths-in-the-at-risk-population-on-the-wards-attributable-fraction-of-mortality-in-a-large-point-prevalence-study
#17
Maja Kopczynska, Ben Sharif, Sian Cleaver, Naomi Spencer, Amit Kurani, Camilla Lee, Jessica Davis, Carys Durie, Jude Joseph-Gubral, Angelica Sharma, Lucy Allen, Billie Atkins, Alex Gordon, Llewelyn Jones, Amy Noble, Matthew Bradley, Henry Atkinson, Joy Inns, Harriet Penney, Carys Gilbert, Rebecca Walford, Louise Pike, Ross Edwards, Robyn Howcroft, Hazel Preston, Jennifer Gee, Nicholas Doyle, Charlotte Maden, Claire Smith, Nik Syakirah Nik Azis, Navrhinaa Vadivale, Tamas Szakmany
OBJECTIVE: Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. RESULTS: 839 patients were recruited over the two 24-h periods in 2016 and 2017...
October 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30308249/better-with-time-an-economic-assessment-of-long-term-mechanical-circulatory-support-in-a-population-surviving-at-least-one-year-with-a-left-ventricular-assist-device
#18
Jennifer J Chung, Robert Stetson, Jonathan Gordon, Carol W Chen, Ann C Gaffey, J Eduardo Rame, Michael Acker, Pavan Atluri
OBJECTIVE: This study aims to identify the major components of left ventricular assist device (LVAD) -related costs in a population on long term mechanical circulatory support to gain insight into opportunities for improvements in quality, safety, and efficiency of care for end stage heart failure patients. METHODS: This was a single institution, retrospective cost analysis of patients who received a Heartmate II or HeartWare LVAD between November 2005 - October 2015...
October 8, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30307122/optimising-first-line-seven-day-standard-triple-therapy-for-h-pylori-eradication-prolonging-treatment-or-adding-bismuth-which-is-better
#19
Alex Hwong-Ruey Leow, Ahmad Najib Azmi, Mun-Fai Loke, Jamuna Vadivelu, David Y Graham, Khean-Lee Goh
OBJECTIVE: The 7-day standard triple therapy (STT) gives unacceptable low eradication rates. We sought to determine if extending the STT from 7 days to 14 days or adding a bismuth compound to the one week STT would result in a better eradication rates. METHODS: H. pylori positive patients were assigned to: Group A- (7-day STT) rabeprazole(Pariet) 20mg b.i.d., amoxicillin(Ospamox) 1g b.i.d. and clarithromycin(Klacid) 500mg b.i.d. for 7 days, Group B- (7 day STT with bismuth) rabeprazole (Pariet) 20mg b...
October 11, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/30306218/latarjet-procedure-versus-open-capsuloplasty-in-traumatic-anterior-shoulder-dislocation-long-term-clinical-and-functional-results
#20
Angelo De Carli, Antonio Vadalà, Lorenzo Proietti, Antonio Ponzo, Davide Desideri, Andrea Ferretti
PURPOSE: To compare the results of two different open surgical techniques (open capsuloplasty and Bristow-Latarjet procedure) at a mid- to long-term follow-up (6 years) in patients with recurrent traumatic anterior shoulder dislocations. METHODS: Seventy-three patients (73 shoulders, 48 males; 25 females) fulfilled inclusion and exclusion criteria. Patients were classified as group A if operated on with a Bristow-Latarjet procedure (40 patients, 24 males; 16 females) or group B if operated on with an open capsuloplasty (33 patients, 24 males; 9 females)...
October 10, 2018: International Orthopaedics
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