Sarah Alice Long, Virginia S Muir, Britta E Jones, Valerie Z Wall, Alyssa Ylescupidez, Anne M Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Alexander T Heubeck, Troy R Torgerson, Adam K Savage, Michael A Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S Linsley, Jane H Buckner
Exhausted CD8 T cells (TEX ) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+ KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we found that the frequency of TIGIT+ KLRG1+ TEX is stable within an individual but differs across individuals in both T1D and healthy control (HC) cohorts. This TIGIT+ KLRG1+ CD8 TEX population shares an exhaustion-associated EOMES gene signature in HC, T1D, rheumatoid arthritis (RA), and cancer subjects, expresses multiple inhibitory receptors, and is hyporesponsive in vitro , together suggesting co-expression of TIGIT and KLRG1 may broadly define human peripheral exhausted cells...
2024: Frontiers in Immunology