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Dharanesh Gangaiah, Stanley M Spinola
BACKGROUND: Haemophilus ducreyi has emerged as a major cause of cutaneous ulcers (CU) in yaws-endemic regions of the tropics in the South Pacific, South East Asia and Africa. H. ducreyi was once thought only to cause the genital ulcer (GU) disease chancroid; GU strains belong to 2 distinct classes, class I and class II. Using whole-genome sequencing of 4 CU strains from Samoa, 1 from Vanuatu and 1 from Papua New Guinea, we showed that CU strains diverged from the class I strain 35000HP and that one CU strain expressed β-lactamase...
December 2016: PLoS Neglected Tropical Diseases
Seyed Mohammad Hashemi-Shahri, Batool Sharifi-Mood, Hamid-Reza Kouhpayeh, Javad Moazen, Mohsen Farrokhian, Masoud Salehi
BACKGROUND: Studies show that nearly 40 million people are living with human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) around the world and since the beginning of the epidemic, about 35 million have died from AIDS. Heterosexual intercourse is the most common route for transmission of HIV infection (85%). People with a sexually transmitted infection (STI), such as syphilis, genital herpes, chancroid, or bacterial vaginosis, are more likely to obtain HIV infection during sex...
September 2016: International Journal of High Risk Behaviors & Addiction
Ziad A Memish, Sanaa M Filemban, Raafat F Al-Hakeem, Majdy H Hassan, Jaffar A Al-Tawfiq
INTRODUCTION: Sexually transmitted infections (STIs) are major public health concerns around the world. This study describes the epidemiology of reported STI cases from 2005 to 2012 in the Kingdom of Saudi Arabia. METHODOLOGY: The annual registry was the main source of data as reported by healthcare providers. Case definitions were based on positive human immunodeficiency virus (HIV) antibodies detectable by enzyme-linked immunosorbent assay (ELISA) and confirmed by western blot test for HIV cases...
August 31, 2016: Journal of Infection in Developing Countries
Allan Pillay, Samantha S Katz, A Jeanine Abrams, Ronald C Ballard, Shirley V Simpson, Fasihah Taleo, Monica M Lahra, Dhwani Batra, Lori Rowe, David L Trees, Kingsley Asiedu, Cheng-Yen Chen
Haemophilus ducreyi causes chancroid and has recently been shown to be a significant cause of cutaneous lesions in tropical or subtropical regions where yaws is endemic. Here, we report the draft genome assemblies for 11 cutaneous strains of Haemophilus ducreyi, isolated from children in Vanuatu and Ghana.
2016: Genome Announcements
Suvanna Asavapiriyanont, Udom Chaovarindr, Surasak Kaoien, Uraiwan Chotigeat, Ekachai Kovavisarach
BACKGROUND: Behavioral and social changes in the modern era have triggered an increase in the incidence of early sexual contact and teenage pregnancy. Since there is no routine Gonococcal & Chlamydial (GC & CT) screening in teens in antenatal clinics in Thailand, the present study was performed to find the prevalence of STI, especially Chlamydial infection, in teenage pregnancy. OBJECTIVE: To evaluate the prevalence of sexually transmitted infections (STIs), especially Chlamydial infection (CT), in teenage pregnancy and its related factors...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Nathanial K Copeland, Catherine F Decker
No abstract text is available yet for this article.
August 2016: Disease-a-month: DM
Dharanesh Gangaiah, Xinjun Zhang, Beth Baker, Kate R Fortney, Hongyu Gao, Concerta L Holley, Robert S Munson, Yunlong Liu, Stanley M Spinola
Haemophilus ducreyi causes the sexually transmitted disease chancroid in adults and cutaneous ulcers in children. In humans, H. ducreyi resides in an abscess and must adapt to a variety of stresses. Previous studies (D. Gangaiah, M. Labandeira-Rey, X. Zhang, K. R. Fortney, S. Ellinger, B. Zwickl, B. Baker, Y. Liu, D. M. Janowicz, B. P. Katz, C. A. Brautigam, R. S. Munson, Jr., E. J. Hansen, and S. M. Spinola, mBio 5:e01081-13, 2014, suggested that H. ducreyi encounters growth conditions in human lesions resembling those found in stationary phase...
May 2016: Infection and Immunity
(no author information available yet)
The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS), is issuing this final rule (FR) to amend its regulations governing medical examinations that aliens must undergo before they may be admitted to the United States. Based on public comment received, HHS/CDC did not make changes from the NPRM published on June 23, 2015. Accordingly, this FR will: Revise the definition of communicable disease of public health significance by removing chancroid, granuloma inguinale, and lymphogranuloma venereum as inadmissible health-related conditions for aliens seeking admission to the United States; update the notification of the health-related grounds of inadmissibility to include proof of vaccinations to align with existing requirements established by the Immigration and Nationality Act (INA); revise the definitions and evaluation criteria for mental disorders, drug abuse and drug addiction; clarify and revise the evaluation requirements for tuberculosis; clarify and revise the process for the HHS/CDC-appointed medical review board that convenes to reexamine the determination of a Class A medical condition based on an appeal; and update the titles and designations of federal agencies within the text of the regulation...
January 26, 2016: Federal Register
Mihai Dorin Vartolomei, Ovidiu Simion Cotoi, Mihail Alexandru Badea, Calin Bogdan Chibelean, Titiana Cotoi, Violeta Morariu, Cosmin Albu, Silviu Horia Morariu
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
David A Lewis, Oriol Mitjà
PURPOSE OF REVIEW: This article provides an overview of the biology, epidemiology, clinical features, diagnostic tests, and treatment of Haemophilus ducreyi infection, with special reference to the decline of chancroid and the recent emergence of H. ducreyi as a pathogen responsible for chronic limb ulceration clinically similar to yaws. RECENT FINDINGS: Chancroid has declined in importance as a sexually transmitted infection in most countries where it was previously endemic...
February 2016: Current Opinion in Infectious Diseases
Sarup Tayal, Fadlo Shaban, Kaushik Dasgupta, Mohamed A Tabaqchali
INTRODUCTION: Condylata lata in secondary syphilis is well known presentation and needs to be considered in differential diagnosis of perianal lesions. In England between 2013 and 2014 the overall incidence of infectious syphilis increased by 33% and is mainly seen in men who have sex with men. PRESENTATION OF CASE: We report the management of a 49-years-old Caucasian homosexual man with perianal lesions that were suspicious of malignancy. After biopsies, colonoscopy, staging with computed tomography, magnetic resonance imaging and syphilis serology anal cancer was excluded and a diagnosis of syphilis was confirmed...
2015: International Journal of Surgery Case Reports
Iffat Hassan, Parvaiz Anwar, Shagufta Rather, Farah Sameem, Imran Majid, Yasmeen Jabeen, Syed Mubashir, Nuzhatun Nisa, Qazi Masood
BACKGROUND: Changing trends of sexually transmitted infections (STI) and HIV/AIDS has been noted in the literature over years, depending to some extent on the geographical and cultural factors of the region. In Kashmir Valley also, the pattern of STI may be different from the rest of the country. AIMS OF THE STUDY: The aim was to present the experience with patterns of STI in Kashmir. MATERIALS AND METHODS: Retrospective hospital-based study carried out by detailed analysis of case records of 5-year period...
January 2015: Indian Journal of Sexually Transmitted Diseases
Sébastien Fouéré, François Lassau, Clotilde Rousseau, Martine Bagot, Michel Janier
We report the first case of chancroid seen at our clinic in 14 years. It was diagnosed by nuclear acid amplification test in a male patient returning from Madagascar. Although the disease is considered on the verge of disappearance even in tropical countries, its real potential for reemergence - due to new strains of Haemophilus ducreyi, underreporting and a lack of widespread use of molecular testing - could be underestimated.
August 2016: International Journal of STD & AIDS
Virginia Homfray, Clare Tanton, Robert F Miller, Simon Beddows, Nigel Field, Pam Sonnenberg, Kaye Wellings, Kavita Panwar, Anne M Johnson, Catherine H Mercer
BACKGROUND: It is well-established that male circumcision reduces acquisition of HIV, herpes simplex virus 2, chancroid, and syphilis. However, the effect on the acquisition of non-ulcerative sexually transmitted infections (STIs) remains unclear. We examined the relationship between circumcision and biological measures of three STIs: human papillomavirus (HPV), Chlamydia trachomatis and Mycoplasma genitalium. METHODS: A probability sample survey of 15,162 men and women aged 16-74 years (including 4,060 men aged 16-44 years) was carried out in Britain between 2010 and 2012...
2015: PloS One
William G Fusco, Neelima R Choudhary, Shelley M Stewart, S Munir Alam, Gregory D Sempowski, Christopher Elkins, Isabelle Leduc
Haemophilus ducreyi is the causative agent of the sexually transmitted genital ulcer disease chancroid. Strains of H. ducreyi are grouped in two classes (I and II) based on genotypic and phenotypic differences, including those found in DsrA, an outer membrane protein belonging to the family of multifunctional trimeric autotransporter adhesins. DsrA is a key serum resistance factor of H. ducreyi that prevents binding of natural IgM at the bacterial surface and functions as an adhesin to fibronectin, fibrinogen, vitronectin, and human keratinocytes...
April 2015: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Jordan R Gaston, Sally A Roberts, Tricia L Humphreys
Haemophilus ducreyi, the etiologic agent of chancroid, has been previously reported to show genetic variance in several key virulence factors, placing strains of the bacterium into two genetically distinct classes. Recent studies done in yaws-endemic areas of the South Pacific have shown that H. ducreyi is also a major cause of cutaneous limb ulcers (CLU) that are not sexually transmitted. To genetically assess CLU strains relative to the previously described class I, class II phylogenetic hierarchy, we examined nucleotide sequence diversity at 11 H...
2015: PloS One
Syed Kamran Amir Razvi, Shahzad Najeeb, Hassan Shahzad Nazar
BACKGROUND: Sexually transmitted diseases are present in all societies across the globe. Different cultures and societies show a different spectrum of these diseases. The last study conducted in Hazara division was back in 1995. We have conducted this study to see the recent trends and patterns of sexually transmitted diseases in the region. METHODS: This cross-sectional study was conducted in Ayub Teaching Hospital, Abbottabad and included patients over a five year period from January 2010 till December 2014...
October 2014: Journal of Ayub Medical College, Abbottabad: JAMC
B Degboé, F Atadokpèdé, H Adégbidi, B Saka, F Akpadjan, C d'Almeïda, C Hounkpè Mélomè, S Sèmikenké, H Yédomon, F do-Ango Padonou
OBJECTIVE: The aim of this study was to document the epidemiological and clinical characteristics of anogenital dermatoses (AGDs) in Cotonou, Benin. METHOD: This retrospective, descriptive study, conducted in the Department of Dermatology-Venereology at the National University Hospital of Cotonou, examined medical records of admissions and outpatient consultations for the 5-year period 2005-2009 and included the records of all patients with a clinical diagnosis of AGD...
October 2014: Médecine et Santé Tropicales
H Schöfer
BACKGROUND: In May 2012 a German regional court (Cologne) declared circumcision on religious grounds in minor boys an illegitimate bodily harm. This led to substantial political and religious discussions, because Jews as well as Muslims consider circumcision as an indispensable element of their religion. Still in 2012 a "circumcision law" was passed by the Federal Council of Germany, which continues to allow circumcision in boys "performed under strict medical conditions". OBJECTIVE: How male circumcision is assessed in terms of infectiology (pros and cons)? METHOD: Electronic databases were searched for articles about the infection risks of foreskin surgery, and the efficacy of circumcision in reducing the risks of sexual transmission of HIV, herpes viruses, HPV, treponema pallidum, chlamydia, hemophilus ducrey and Neisseria gonorrhoeae...
January 2015: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Pranav Tripathi, Ritu Chaudhary, Ajeet Singh
Conventionally, drugs are discovered by testing chemically synthesized compounds against a battery of in vivo biological screens. Information technology and Omic science enabled us for high throughput screening of compound libraries against biological targets and hits are then tested for efficacy in cells or animals. Chancroid, caused by Haemophilus ducreyi is a public health problem and has been recognized as a cofactor for Human Immunodeficiency Virus (HIV) transmission. It facilitates HIV transmission by providing an accessible portal entry, promoting viral shedding, and recruiting macrophages as well as CD4 cells to the skin...
2014: Bioinformation
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