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https://www.readbyqxmd.com/read/29792307/putative-vaccine-candidates-and-drug-targets-identified-by-reverse-vaccinology-and-subtractive-genomics-approaches-to-control-haemophilus-ducreyi-the-causative-agent-of-chancroid
#1
Alissa de Sarom, Arun Kumar Jaiswal, Sandeep Tiwari, Letícia de Castro Oliveira, Debmalya Barh, Vasco Azevedo, Carlo Jose Oliveira, Siomar de Castro Soares
Chancroid is a sexually transmitted infection (STI) caused by the Gram-negative bacterium Haemophilus ducreyi The control of chancroid is difficult and the only current available treatment is antibiotic therapy; however, antibiotic resistance has been reported in endemic areas. Owing to recent outbreaks of STIs worldwide, it is important to keep searching for new treatment strategies and preventive measures. Here, we applied reverse vaccinology and subtractive genomic approaches for the in silico prediction of potential vaccine and drug targets against 28 strains of H...
May 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29749871/first-reported-case-of-chancroid-in-the-czech-republic
#2
Filip Rob, David Jilich, Šárka Lásiková, Veronika Křížková, Jana Hercogová
We describe the first case of chancroid seen in the Czech Republic, diagnosed in a 40-year-old heterosexual HIV-positive man. Despite genital localization of the ulcer, the transmission of Haemophilus ducreyi infection in our patient remains unclear, as he denied having sexual intercourse and he did not travel outside the Czech Republic for several months before the ulcer appeared. The correct diagnosis has been revealed by a multiplex nucleic acid amplification test. Physicians in countries in the eastern and central Europe region should be aware that chancroid can occur in their patients...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29720070/sexually-transmitted-infections-in-melbourne-australia-from-1918-to-2016-nearly-a-century-of-data
#3
Emile Jasek, Eric Pf Chow, Jason J Ong, Catriona S Bradshaw, Marcus Y Chen, Jane S Hocking, David Lee, Tiffany Phillips, Tiffany Phillips, Meredith Temple-Smith, Glenda Fehler, Christopher K Fairley
Introduction: Our aim was to describe trends in the number of bacterial sexually transmitted infections (STIs) diagnosed at Melbourne's sexual health clinic over a century. Methods: A retrospective analysis of STI diagnoses (gonorrhoea, infectious syphilis and chancroid) among individuals attending Melbourne's sexual health service over 99 years between 1918 and 2016. Results: Substantial increases in STI rates coincided with World War II, the 'Sexual Revolution of the 1960s and 1970s', and the last 10 years...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29652094/from-in-vivo-to-in-vitro-how-the-guatemala-std-experiments-transformed-bodies-into-biospecimens
#4
Kayte Spector-Bagdady, Paul A Lombardo
Policy Points: While most scholarship regarding the US Public Health Service's STD experiments in Guatemala during the 1940s has focused on the intentional exposure experiments, secondary research was also conducted on biospecimens collected from these subjects. These biospecimen experiments continued after the Guatemala grant ended, and the specimens were used in conjunction with those from the Tuskegee syphilis experiments for ongoing research. We argue there should be a public accounting of whether there are still biospecimens from the Guatemala and Tuskegee experiments held in US government biorepositories today...
April 13, 2018: Milbank Quarterly
https://www.readbyqxmd.com/read/29553314/direct-whole-genome-sequencing-of-cutaneous-strains-of-haemophilus-ducreyi
#5
Michael Marks, Maria Fookes, Josef Wagner, Rosanna Ghinai, Oliver Sokana, Yaw-Adu Sarkodie, Anthony W Solomon, David C W Mabey, Nicholas R Thomson
Haemophilus ducreyi, which causes chancroid, has emerged as a cause of pediatric skin disease. Isolation of H. ducreyi in low-income settings is challenging, limiting phylogenetic investigation. Next-generation sequencing demonstrates that cutaneous strains arise from class I and II H. ducreyi clades and that class II may represent a distinct subspecies.
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29240636/the-etiology-of-genital-ulcer-disease-and-coinfections-with-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-zimbabwe-results-from-the-zimbabwe-sti-etiology-study
#6
More Mungati, Anna Machiha, Owen Mugurungi, Mufuta Tshimanga, Peter H Kilmarx, Justice Nyakura, Gerald Shambira, Vitalis Kupara, David A Lewis, Elizabeth Gonese, Beth A Tippett Barr, H Hunter Handsfield, Cornelis A Rietmeijer
BACKGROUND: In many countries, sexually transmitted infections (STIs) are treated syndromically. Thus, patients diagnosed as having genital ulcer disease (GUD) in Zimbabwe receive a combination of antimicrobials to treat syphilis, chancroid, lymphogranuloma venereum (LGV), and genital herpes. Periodic studies are necessary to assess the current etiology of GUD and assure the appropriateness of current treatment guidelines. MATERIALS AND METHODS: We selected 6 geographically diverse clinics in Zimbabwe serving high numbers of STI cases to enroll men and women with STI syndromes, including GUD...
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29226307/macrolides-for-treatment-of-haemophilus-ducreyi-infection-in-sexually-active-adults
#7
REVIEW
Laura Romero, Cesar Huerfano, Carlos F Grillo-Ardila
BACKGROUND: Chancroid is a genital ulcerative disease caused by Haemophilus ducreyi. This microorganism is endemic in Africa, where it can cause up to 10% of genital ulcers. Macrolides may be an effective alternative to treat chancroid and, based on their oral administration and duration of therapy, could be considered as first line therapy. OBJECTIVES: To assess the effectiveness and safety of macrolides for treatment of H ducreyi infection in sexually active adults...
December 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28745556/gonorrhoea-in-greenland-incidence-and-previous-preventive-measures-a-review-to-improve-future-strategies
#8
REVIEW
Sine Berntsen, Anders Peder Højer Karlsen, Michael Lynge Pedersen, Gert Mulvad
Gonorrhoea continues to be a significant health challenge in Greenland. The aim of this study was to describe the development of gonorrhoea in Greenland through time including incidence rates and previous measures taken to address the challenge. A systematic literature search in PubMed, Embase and The Cochrane Library was conducted. Furthermore, local archives were searched in the Health Clinic in Nuuk for relevant literature. From the 1940s the incidence of gonorrhoea increased steadily with a steep incline around 1970, possibly as a consequence of changes in living conditions and urbanisation...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28470128/pseudoepitheliomatous-hyperplasia-causing-a-painful-plaque-in-a-hiv-infected-female
#9
Bianca F Parsons, N Ryder
Dermatological conditions are more common and can present atypically, in human immunodeficiency virus-infected individuals. This case report describes a 22-year-old human immunodeficiency virus-positive Caucasian female who presented with a vulval lesion eight weeks after starting antiretroviral treatment. Clinical examination revealed a 2 cm well-demarcated plaque on the outer aspect of the left labium minus. The lesion was tender, no contact bleeding or ulceration present. She was presumptively treated for chancroid and herpes simplex with 500 mg ceftriaxone IM stat, 1 g azithromycin PO stat, and valacyclovir 500 mg BD for five days...
June 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28406423/epidemiological-aspects-of-genital-ulcers-at-the-sti-center-of-the-national-institute-of-public-hygiene-abidjan-c%C3%A3-te-d-ivoire-2008-to-2010
#10
D Z Gakoué, I Tiembré
Genital ulcers are among the seven syndromes of sexually transmitted infections (STIs) identified in Côte d'Ivoire. Ulcerative STIs present a public health problem because of their frequency and their role in the spread of HIV. Our objective was to investigate the epidemiological characteristics of genital ulcers observed in the STI center of the National Institute of Public Hygiene in Abidjan. This cross-sectional, descriptive and analytical study examined cases seen at the center in 2008 through 2010. We retrospectively reviewed all files of clients aged 10 and older who sought care for the first time at the STI center and received a clinical diagnosis, confirmed by the laboratory, of a STI...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28397528/skin-diseases-of-the-vulva-infectious-diseases
#11
Freja Lærke Sand, Simon Francis Thomsen
A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area.
October 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28027326/haemophilus-ducreyi-cutaneous-ulcer-strains-diverged-from-both-class-i-and-class-ii-genital-ulcer-strains-implications-for-epidemiological-studies
#12
Dharanesh Gangaiah, Stanley M Spinola
BACKGROUND: Haemophilus ducreyi has emerged as a major cause of cutaneous ulcers (CU) in yaws-endemic regions of the tropics in the South Pacific, South East Asia and Africa. H. ducreyi was once thought only to cause the genital ulcer (GU) disease chancroid; GU strains belong to 2 distinct classes, class I and class II. Using whole-genome sequencing of 4 CU strains from Samoa, 1 from Vanuatu and 1 from Papua New Guinea, we showed that CU strains diverged from the class I strain 35000HP and that one CU strain expressed β-lactamase...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27818966/sexually-transmitted-infections-among-hospitalized-patients-with-human-immunodeficiency-virus-infection-and-acquired-immune-deficiency-syndrome-hiv-aids-in-zahedan-southeastern-iran
#13
Seyed Mohammad Hashemi-Shahri, Batool Sharifi-Mood, Hamid-Reza Kouhpayeh, Javad Moazen, Mohsen Farrokhian, Masoud Salehi
BACKGROUND: Studies show that nearly 40 million people are living with human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) around the world and since the beginning of the epidemic, about 35 million have died from AIDS. Heterosexual intercourse is the most common route for transmission of HIV infection (85%). People with a sexually transmitted infection (STI), such as syphilis, genital herpes, chancroid, or bacterial vaginosis, are more likely to obtain HIV infection during sex...
September 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27580336/sexually-transmitted-infections-case-notification-rates-in-the-kingdom-of-saudi-arabia-2005-2012
#14
Ziad A Memish, Sanaa M Filemban, Raafat F Al-Hakeem, Majdy H Hassan, Jaffar A Al-Tawfiq
INTRODUCTION: Sexually transmitted infections (STIs) are major public health concerns around the world. This study describes the epidemiology of reported STI cases from 2005 to 2012 in the Kingdom of Saudi Arabia. METHODOLOGY: The annual registry was the main source of data as reported by healthcare providers. Case definitions were based on positive human immunodeficiency virus (HIV) antibodies detectable by enzyme-linked immunosorbent assay (ELISA) and confirmed by western blot test for HIV cases...
August 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27389258/complete-genome-sequences-of-11-haemophilus-ducreyi-isolates-from-children-with-cutaneous-lesions-in-vanuatu-and-ghana
#15
Allan Pillay, Samantha S Katz, A Jeanine Abrams, Ronald C Ballard, Shirley V Simpson, Fasihah Taleo, Monica M Lahra, Dhwani Batra, Lori Rowe, David L Trees, Kingsley Asiedu, Cheng-Yen Chen
Haemophilus ducreyi causes chancroid and has recently been shown to be a significant cause of cutaneous lesions in tropical or subtropical regions where yaws is endemic. Here, we report the draft genome assemblies for 11 cutaneous strains of Haemophilus ducreyi, isolated from children in Vanuatu and Ghana.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27266230/prevalence-of-sexually-transmitted-infection-in-teenage-pregnancy-in-rajavithi-hospital-thailand
#16
Suvanna Asavapiriyanont, Udom Chaovarindr, Surasak Kaoien, Uraiwan Chotigeat, Ekachai Kovavisarach
BACKGROUND: Behavioral and social changes in the modern era have triggered an increase in the incidence of early sexual contact and teenage pregnancy. Since there is no routine Gonococcal & Chlamydial (GC & CT) screening in teens in antenatal clinics in Thailand, the present study was performed to find the prevalence of STI, especially Chlamydial infection, in teenage pregnancy. OBJECTIVE: To evaluate the prevalence of sexually transmitted infections (STIs), especially Chlamydial infection (CT), in teenage pregnancy and its related factors...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27107782/other-sexually-transmitted-diseases-chancroid-and-donovanosis
#17
REVIEW
Nathanial K Copeland, Catherine F Decker
No abstract text is available yet for this article.
August 2016: Disease-a-month: DM
https://www.readbyqxmd.com/read/26930707/haemophilus-ducreyi-seeks-alternative-carbon-sources-and-adapts-to-nutrient-stress-and-anaerobiosis-during-experimental-infection-of-human-volunteers
#18
Dharanesh Gangaiah, Xinjun Zhang, Beth Baker, Kate R Fortney, Hongyu Gao, Concerta L Holley, Robert S Munson, Yunlong Liu, Stanley M Spinola
Haemophilus ducreyi causes the sexually transmitted disease chancroid in adults and cutaneous ulcers in children. In humans, H. ducreyi resides in an abscess and must adapt to a variety of stresses. Previous studies (D. Gangaiah, M. Labandeira-Rey, X. Zhang, K. R. Fortney, S. Ellinger, B. Zwickl, B. Baker, Y. Liu, D. M. Janowicz, B. P. Katz, C. A. Brautigam, R. S. Munson, Jr., E. J. Hansen, and S. M. Spinola, mBio 5:e01081-13, 2014, http://dx.doi.org/10.1128/mBio.01081-13) suggested that H. ducreyi encounters growth conditions in human lesions resembling those found in stationary phase...
May 2016: Infection and Immunity
https://www.readbyqxmd.com/read/26812891/medical-examination-of-aliens-revisions-to-medical-screening-process-final-rule
#19
(no author information available yet)
The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS), is issuing this final rule (FR) to amend its regulations governing medical examinations that aliens must undergo before they may be admitted to the United States. Based on public comment received, HHS/CDC did not make changes from the NPRM published on June 23, 2015. Accordingly, this FR will: Revise the definition of communicable disease of public health significance by removing chancroid, granuloma inguinale, and lymphogranuloma venereum as inadmissible health-related conditions for aliens seeking admission to the United States; update the notification of the health-related grounds of inadmissibility to include proof of vaccinations to align with existing requirements established by the Immigration and Nationality Act (INA); revise the definitions and evaluation criteria for mental disorders, drug abuse and drug addiction; clarify and revise the evaluation requirements for tuberculosis; clarify and revise the process for the HHS/CDC-appointed medical review board that convenes to reexamine the determination of a Class A medical condition based on an appeal; and update the titles and designations of federal agencies within the text of the regulation...
January 26, 2016: Federal Register
https://www.readbyqxmd.com/read/26724885/indurative-edema-of-the-prepuce-mimicing-phimosis-an-atypical-manifestation-of-primary-syphilis
#20
LETTER
Mihai Dorin Vartolomei, Ovidiu Simion Cotoi, Mihail Alexandru Badea, Calin Bogdan Chibelean, Titiana Cotoi, Violeta Morariu, Cosmin Albu, Silviu Horia Morariu
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
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