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https://www.readbyqxmd.com/read/27879343/strap-regulates-early-follicle-development-in-the-mouse-ovary
#1
Isam B Sharum, Sofia Granados-Aparici, Fiona C Warrander, Felicity P Tournant, Mark Fenwick
The molecular mechanisms involved in regulating the development of small, gonadotrophin-independent follicles are poorly understood; however, many studies have highlighted an essential role for TGFB ligands. Canonical TGFB signalling is dependent upon intracellular Smad proteins that regulate transcription. Strap has been identified in other tissues as an inhibitor of the TGFB-Smad signalling pathway. Therefore, in this study we aimed to determine the expression and role of Strap in the context of early follicle development...
November 22, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27859672/immune-activation-and-regulation-related-patterns-in-stable-hand-transplant-recipients
#2
Dorota Kamińska, Katarzyna Kościelska-Kasprzak, Magdalena Krajewska, Adam Chełmoński, Jerzy Jabłecki, Marcelina Żabińska, Marta Myszka, Mirosław Banasik, Maria Boratyńska, Agnieszka Gomółkiewicz, Piotr Dzięgiel, Marian Klinger
BACKGROUND: We assessed cell subsets and expression of a set of genes related to the T cell populations in peripheral blood mononuclear cells to elucidate whether immune status of stable hand transplant recipients (HTx) differs from stable kidney transplant recipients (KTx). MATERIAL AND METHODS: The study was conducted on 5 HTx 4.8 ± 1.7 years after transplantation and 30 stable KTx 7.9 ± 2.4 years after transplantation as well as 18 healthy volunteers. The research involved PBMC gene expression analysis of CD4, CD8, CTLA4, GZMB, FOXP3, IL10, IL4, ILR2A, NOTCH, PDCD1, PRF1, TGFB, TNFA genes on a custom designed low density array (TaqMan) as well as flow cytometry assessment of lymphocyte subpopulations...
November 9, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27827279/plasma-rich-in-growth-factors-promotes-dermal-fibroblast-proliferation-migration-and-biosynthetic-activity
#3
E Anitua, A Pino, G Orive
OBJECTIVE: The use of plasma rich in growth factors (PRGF) has gained importance in many medical fields due to its regenerative potential. The aim of this study is to evaluate the effects of PRGF on primary skin fibroblasts assessing cell proliferation, migration and secretion of growth factors. The age of the patients from who PRGF was prepared was also studied to determine whether it influenced the outcomes. METHOD: Human dermal fibroblasts were isolated from three healthy volunteers...
November 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27815749/co-expression-modules-identified-from-published-immune-signatures-reveal-five-distinct-immune-subtypes-in-breast-cancer
#4
Dominic Amara, Denise M Wolf, Laura van 't Veer, Laura Esserman, Michael Campbell, Christina Yau
PURPOSE: There is a growing body of literature demonstrating that immune-related expression signatures predict breast cancer prognosis and chemo-/targeted-therapy responsiveness. However, it is unclear whether these signatures correlate with each other or represent distinct immune-related signals. METHODS: We evaluated 57 published immune-related expression signatures in four public breast cancer datasets totaling 3295 samples. For each dataset, we used consensus clustering to group signatures together based on their co-expression pattern...
November 4, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27808102/bioinspired-seeding-of-biomaterials-using-three-dimensional-microtissues-induces-chondrogenic-stem-cell-differentiation-and-cartilage-formation-under-growth-factor-free-conditions
#5
J Leijten, L S Moreira Teixeira, J Bolander, W Ji, B Vanspauwen, J Lammertyn, J Schrooten, F P Luyten
Cell laden biomaterials are archetypically seeded with individual cells and steered into the desired behavior using exogenous stimuli to control growth and differentiation. In contrast, direct cell-cell contact is instructive and even essential for natural tissue formation. Namely, microaggregation and condensation of mesenchymal progenitor cells triggers chondrogenesis and thereby drives limb formation. Yet a biomimetic strategy translating this approach into a cell laden biomaterial-based therapy has remained largely unexplored...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806318/med12-mutations-in-breast-phyllodes-tumors-evidence-of-temporal-tumoral-heterogeneity-and-identification-of-associated-critical-signaling-pathways
#6
Marick Laé, Sophie Gardrat, Sophie Rondeau, Camille Richardot, Martial Caly, Walid Chemlali, Sophie Vacher, Jérôme Couturier, Odette Mariani, Philippe Terrier, Ivan Bièche
Exome sequencing has recently identified highly recurrent MED12 somatic mutations in fibroadenomas (FAs) and phyllodes tumors (PTs). In the present study, based on a large series, we confirmed the presence of MED12 exon 1 and 2 mutations in 49% (41/83) of PTs, 70% (7/10) of FAs and 9.1% (1/11) of fibromatoses. We show that MED12 mutations are associated with benign behavior of phyllodes tumors, as they are detected less frequently in malignant PTs (27.6%) compared to benign (58.3%) and borderline (63.3%) PTs, respectively (p = 0...
October 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27773809/transforming-growth-factor-%C3%AE-superfamily-signaling-in%C3%A2-development-of-colorectal-cancer
#7
REVIEW
Barbara Jung, Jonas J Staudacher, Daniel Beauchamp
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
October 20, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27769060/mir-185-akt-and-mir-29a-collagen-1a-pathways-are-activated-in-ipf-bal-cells
#8
Eliza Tsitoura, Athol U Wells, Kostantinos Karagiannis, Ismini Lasithiotaki, Eirini Vasarmidi, Eleni Bibaki, Chara Koutoulaki, Hiroe Sato, Demetrios A Spandidos, Nikolaos M Siafakas, George Sourvinos, Katerina M Antoniou
MicroRNA signatures of BAL cells and alveolar macrophages are currently lacking in IPF. Here we sought to investigate the expression of fibrosis-related microRNAs in the cellular component of the BAL in IPF. We thus focused on microRNAs previously associated with fibrosis (miR-29a, miR-29b, miR-29c, let-7d, and miR-21) and rapid IPF progression (miR-185, miR-210, miR-302c-3p miR-376c and miR-423-5p). Among the tested microRNAs miR-29a and miR-185 were found significantly downregulated in IPF while miR-302c-3p and miR-376c were not expressed by BAL cells...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27693511/infection-of-hepatocytes-with-hcv-increases-cell-surface-levels-of-heparan-sulfate-proteoglycans-uptake-of-cholesterol-and-lipoprotein-and-virus-entry-by-up-regulating-smad6-and-smad7
#9
Fang Zhang, Catherine Sodroski, Helen Cha, Qisheng Li, T Jake Liang
BACKGROUND & AIMS: The signaling molecule and transcriptional regulator SMAD6, which inhibits the transforming growth factor β signaling pathway, is required for infection of hepatocytes by hepatitis C virus (HCV). We investigated the mechanisms by which SMAD6, and another inhibitory SMAD (SMAD7), promote HCV infection in human hepatoma cells and hepatocytes. METHODS: We infected Huh7 and Huh7.5.1 cells and primary human hepatocytes with JFH1 HCVcc; we measured HCV binding, intracellular levels of HCV RNA, and expression of target genes...
September 30, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27683263/smad3-activation-a-converging-point-of-dysregulated-tgf-beta-superfamily-signaling-and-genetic-aberrations-in-granulosa-cell-tumor-development
#10
Xin Fang, Yang Gao, Qinglei Li
Ovarian granulosa cell tumors (GCTs) are rare gynecologic tumors in women. Due to the rarity and limited research efforts invested, the etiology of GCTs remains poorly defined. A landmark study has discovered the mutation of forkhead box L2 (FOXL2) as a genetic hallmark of adult GCTs in the human. However, our understanding of the role of cell signaling in GCT development is far from complete. Increasing lines of evidence highlight the importance of TGF-beta (TGFB) superfamily signaling in the pathogenesis of GCTs...
September 28, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27663597/identification-of-keratin19-positive-cancer-stem-cells-associating-human-hepatocellular-carcinoma-using-18f-fluorodeoxyglucose-positron-emission-tomography
#11
Takayuki Kawai, Kentaro Yasuchika, Satoru Seo, Tatsuya Higashi, Takamichi Ishii, Yuya Miyauchi, Hidenobu Kojima, Ryoya Yamaoka, Hokahiro Katayama, Elena Yukie Yoshitoshi, Satoshi Ogiso, Sadahiko Kita, Katsutaro Yasuda, Ken Fukumitsu, Yuji Nakamoto, Etsuro Hatano, Shinji Uemoto
Purpose The current lack of tools for easy assessment of cancer stem cells (CSCs) prevents the development of therapeutic strategies for hepatocellular carcinoma (HCC). We previously reported that keratin 19 (K19) is a novel HCC-CSC marker, and that positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) is an effective method for predicting postoperative outcome in HCC. Herein, we examined whether K19+ HCC-CSCs can be tracked using 18F-FDG-PET. Experimental Design K19 and glucose transporter-1 (GLUT1) expression was evaluated by immunohistochemistry in 98 HCC patients who underwent 18F-FDG-PET scans before primary tumor resection...
September 23, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27632054/hypoxia-increased-expression-of-genes-involved-in-inflammation-dedifferentiation-pro-fibrosis-and-extracellular-matrix-remodeling-of-human-bladder-smooth-muscle-cells
#12
Bridget Wiafe, Adetola Adesida, Thomas Churchill, Esther Ekpe Adewuyi, Zack Li, Peter Metcalfe
Partial bladder outlet obstruction (pBOO) is characterized by exaggerated stretch, hydrodynamic pressure, and inflammation which cause significant damage and fibrosis to the bladder wall. Several studies have implicated hypoxia in its pathophysiology. However, the isolated progressive effects of hypoxia on bladder cells are not yet defined. Sub-confluent normal human bladder smooth muscle cells (hbSMC) were cultured in 3% O2 tension for 2, 24, 48, and 72 h. RNA, cellular proteins, and secreted proteins were used for gene expression analysis, immunoblotting, and ELISA, respectively...
September 8, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27624535/hierarchical-heterogeneity-in-mammary-tumors-and-its-regulation-by-autophagy
#13
Syn Kok Yeo, Jun-Lin Guan
Intra-tumor heterogeneity can be attributed in part to the ability of tumor cells to acquire traits associated with less differentiated cells. In MMTV-PyMT mammary tumors, this hierarchical heterogeneity can be illustrated with the use of ITGB1/CD29(hi) ITGB3/CD61(+) markers to enrich for mammary stem-like cells and ALDH(+) to identify luminal progenitor-like cells. Macroautophagy/autophagy appears to be important for maintaining the cancer stem-like traits of both these populations. Interestingly, the regulation of these distinct cancer stem-like cells by autophagy occurs through EGFR-STAT3 and TGFB/TGF-β-SMAD pathways, respectively...
October 2, 2016: Autophagy
https://www.readbyqxmd.com/read/27609985/seminal-plasma-transforming-growth-factor-%C3%AE-activin-a-and-follistatin-fluctuate-within-men-over-time
#14
David J Sharkey, Kelton P Tremellen, Nancy E Briggs, Gustaaf A Dekker, Sarah A Robertson
STUDY QUESTION: Do seminal plasma transforming growth factor-β (TGFB) cytokines vary within individuals over time, and does this relate to sperm parameters, age or prior abstinence? SUMMARY ANSWER: Activin A and follistatin, and to a lesser extent TGFB1, TGFB2 and TGFB3, vary within individuals over time, in association with duration of abstinence. WHAT IS ALREADY KNOWN: Seminal plasma TGFB cytokines can influence sperm function and reproductive success through interactions with the female reproductive tract after coitus...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27603223/in-the-shadow-of-fibrosis-innate-immune-suppression-mediated-by-transforming-growth-factor-beta
#15
Belinda J Thomas, Keiko Kan-O, Kate Loveland, Jack A Elias, Philip G Bardin
Transforming growth factor beta (TGFB) regulates cell proliferation, differentiation, apoptosis and matrix homeostasis and is intimately involved in fibrosis. TGFB expression is increased in fibrotic lung diseases such as idiopathic pulmonary fibrosis (IPF) but also in chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD) and asthma. In addition to profibrotic activities, the molecule also exhibits profound immune-suppressive actions involving both innate and adaptive responses, but this aspect of TGFB biology is often overlooked...
September 7, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27581082/expressional-changes-of-amh-signaling-system-in-the-quail-testis-by-photoperiod
#16
Shigeo Otake, Min Kyun Park
Gonadal sex differentiation proceeds by interplay of various genes including the transcription factors and secretory factors in a complex network. The sex-differentiating genes are expressed not only during early sex differentiation but also throughout the gonadal development, and even in the adult gonads. In addition, the evidence that they actually function in the adult gonads have been accumulated from the studies using the conditional knockout mice. However, many previous studies were focused on one single gene though those genes function in a network...
August 31, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27527810/expression-of-several-cytokines-in-prostate-cancer-correlation-with-clinical-variables-of-patients-relationship-with-biochemical-progression-of-the-malignance
#17
Norelia Torrealba, Gonzalo Rodríguez-Berriguete, Benito Fraile, Gabriel Olmedilla, Pilar Martínez-Onsurbe, Manuel Guil-Cid, Ricardo Paniagua, Mar Royuela
BACKGROUND: This work is focused on finding new markers that complement or diagnoses currently used towards improving knowledge histological and statistical aspects that allow us to predict the local stage carcinomas and to identify and understand all the factors related to the progression of this disease. MATERIALS AND METHODS: Prostates were obtained from: normal prostates from 20 men, diagnosis of BPH (Benign Prostatic Hyperplasia) from 35 men and prostate cancer from 86 men...
August 12, 2016: Cytokine
https://www.readbyqxmd.com/read/27520733/biomaterials-influence-macrophage-mesenchymal-stem-cell-interaction-in-vitro
#18
Nienke Grotenhuis, Samantha F H De Witte, Gerjo J V M van Osch, Yves Bayon, Johan F Lange, Yvonne M Bastiaansen-Jenniskens
BACKGROUND: Macrophages and mesenchymal stem cells (MSCs) are important cells in wound healing. We hypothesized that the cross-talk between macrophages and adipose tissue-derived MSCs (ASCs) is biomaterial dependent, thereby influencing processes involved in wound healing. MATERIALS AND METHODS: The effect of macrophages cultured on polypropylene (PP) or polyethylene terephthalate coated with a collagen film (PET/Col) on ASCs in monolayer or on the same material was examined either through conditioned medium (CM) or in a direct coculture...
September 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27496032/expression-of-cytokine-genes-and-growth-factors-in-rat-lungs-and-kidneys-after-subtotal-hepatectomy
#19
A V Elchaninov, T Kh Fatkhudinov, N Yu Usman, I V Arutyunyan, A V Makarov, E Yu Kananykhina, V V Glinkina, G B Bolshakova, G T Sukhikh
Expression of il1b, il6, il10, tnfa, hgf, tgfb, vegf, and fgf2 genes in the lungs and kidneys was examined on rat model of liver regeneration after subtotal hepatectomy. Enhanced expression of il6, il10, tnfa, hgf, and fgf2 genes was detected at the early terms after 80% liver resection.
July 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27487644/loeys-dietz-syndrome-perioperative-anesthesia-considerations
#20
Judy G Johnson, Jacob P Bray, William H Risher, Alan David Kaye
Loeys-Dietz syndrome (LDS) is a rare autosomal dominant disease related to genetic mutations in receptors for the cytokine transforming growth factor-receptor type 1 (TGFB-R1) or 2 gene (TGFB-R2) on the cell surface. LDS results in abnormal protein synthesis and dysfunctional connective tissue, which can result in unique cardiovascular anesthesia challenges related to perioperative management. Patients with LDS may manifest hypertelorism, bifid uvula or cleft palate, and arterial tortuosity. Virtually all LDS patients show some type of abnormal skin findings and bleeding tendency...
June 2016: Middle East Journal of Anesthesiology
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