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Transport Nano particle

Orane Lorton, Jean-Noël Hyacinthe, Stéphane Desgranges, Laura Gui, Antoine Klauser, Zarko Celicanin, Lindsey A Crowe, François Lazeyras, Eric Allémann, Nicolas Taulier, Christiane Contino-Pépin, Rares Salomir
OBJECTIVE: Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging contrast agents, or as delivery vectors for pharmaceuticals. They also demonstrated capability to enhance the efficiency of high intensity focused ultrasound thermo-therapy. In the context of new biomedical applications we investigated perfluorooctyl bromide (PFOB) theranostic droplets using 19 F NMR. Each droplet contains biocompatible fluorinated surfactants composed of a polar Tris(hydroxymethyl)aminomethane head unit and hydrophobic perfluorinated tail (abbreviated as F-TAC)...
August 2, 2018: Journal of Magnetic Resonance
Ana Mateos-Maroto, Andrés Guerrero-Martínez, Ramon Gonzalez Rubio, Francisco Ortega, Fernando Martinez-Pedrero
Some biological microorganisms can crawl or swim due to coordinated motions of their cytoskeleton or the flagella located inside their bodies, which push the cells forward through intracellular forces. To date, there is no demonstration of a biomimetic self-propelled swimmer operating at a low Reynolds number due to internal movements within an enclosing membrane. Here, we report lipid vesicles and other more complex self-assembled biohybrid structures able to propel due to the advection flows generated by the actuated rotation of the superparamagnetic particles they contain...
August 8, 2018: ACS Applied Materials & Interfaces
Leila Pourtalebi Jahromi, Soliman Mohammadi-Samani, Reza Heidari, Amir Azadi
PURPOSE: Although it passes through blood-brain barrier (BBB) very poorly, methotrexate (MTX) is an important therapeutic in the treatment of many central nervous system malignancies. Accordingly, intranasal (IN) administration accompanied with a muco-adhesive chitosan-based nanoformulation is expected to overcome this problem. METHODS: Nanogel containing MTX was prepared through an ionic gelation method and then characterized in terms of particle size, morphology, zeta potential, drug loading and drug release behavior...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Jarol E Molina, Alejandro Vasquez Echeverri, David C Schwartz, Juan P Hernandez-Ortiz
Electrostatic forces greatly affect the overall dynamics and diffusional activities of suspended charged particles in crowded environments. Accordingly, the concentration of counter-, or co-ions in a fluid -- ``the salt" -- determines the range, strength and order of electrostatic interactions between particles. This environment fosters engineering routes for controlling directed assembly of particles at both the micro- and nano-scale. Here, we analyzed two computational modeling schemes that considered salt within suspensions of charged particles, or polyelectrolytes: discrete and continuum...
July 25, 2018: Journal of Chemical Theory and Computation
Kittima Amornwachirabodee, Supaporn Khramchantuk, Prompong Pienpinijtham, Nipan Israsena, Tanapat Palaga, Supason Wanichwecharungruang
Uses of micro-/nano-sized particles to deliver biologically active entities into cells are common for medical therapeutics and prophylactics and also for cellular experiments. Enhancing cellular uptake and avoiding destruction by lysosomes are desirable for general particulate drug delivery systems. Here, we show that the relatively nontoxic, negatively charged oxidized carbon black particles (OCBs) can enhance cellular penetration of micro- and nano-particles. Experiments with retinal-grafted chitosan particles (PRPs) with hydrodynamic sizes of 1200 ± 51...
June 30, 2018: ACS Omega
Sesi Li, Yunhao Zhao, Zhengwang Liu, Liting Yang, Jie Zhang, Min Wang, Renchao Che
The ingenious design of a freestanding flexible electrode brings the possibility for power sources in emerging wearable electronic devices. Here, reduced graphene oxide (rGO) wraps carbon nanotubes (CNTs) and rGO tightly surrounded by MnO2 nanosheets, forming a 3D multilevel porous conductive structure via vacuum freeze-drying. The sandwich-like architecture possesses multiple functions as a flexible anode for lithium-ion batteries. Micrometer-sized pores among the continuously waved rGO layers could extraordinarily improve ion diffusion...
July 15, 2018: Small
Tatiana Borisova
Nerve cells take a special place among other cells in organisms because of their unique function mechanism. The plasma membrane of nerve cells from the one hand performs a classical barrier function, thereby being foremost targeted during contact with micro- and nano-sized particles, and from the other hand it is very intensively involved in nerve signal transmission, i.e., depolarization-induced calcium-dependent compound exocytosis realized via vesicle fusion following by their retrieval and calcium-independent permanent neurotransmitter turnover via plasma membrane neurotransmitter transporters that utilize Na+ /K+ electrochemical gradient as a driving force...
2018: Frontiers in Physiology
Yu-Peng Yan, Ya-Dong Tang, Biao Wan, Xiao-Ming Wang, Fan Liu, Xiong-Han Feng
With the rapid development of nanotechnology, the environmental behavior and ecological effect of nanoparticles (NPs) are receiving more and more attention. As an important environmental component, metal oxide NPs occur widely in nature, such as in water bodies, air, soils, and sediments. They have a large surface area and high surface activity, allowing them to control and affect the speciation, migration, transformation, and bioavailability of some contaminants and nutrients in the environment. The nano-size is a unique property of nanoparticles...
June 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
Hen Markovich, Ivan I Shishkin, Netta Hendler, Pavel Ginzburg
The ability to manipulate small objects with focused laser beams opens a broad spectrum of opportunities in fundamental and applied studies, for which precise control over mechanical path and stability is required. Although conventional optical tweezers are based on refractive optics, the development of compact trapping devices that could be integrated within fluid cells is in high demand. Here, a plasmonic polarization-sensitive metasurface-based lens, embedded within a fluid, is demonstrated to provide several stable trapping centers along the optical axis...
July 2, 2018: Nano Letters
Lanxiang Shi, Jiajun Chen, Qingwei Wang, Xinran Song
The delivery of nano-zerovalent iron (nZVI) as a remediation agent to targeted areas in soil was studied using different carriers. Among water, surfactant solution, and surfactant foam, the nZVI transport and carrying abilities followed the order of surfactant foam > surfactant solution > water. The nZVI migration was also facilitated by increased soil particle size and high surfactant concentration. Batch experiments probed the remediation of dichlorodiphenyltrichloroethane (DDT)-contaminated sand under different conditions...
June 19, 2018: Chemosphere
Meirav Cohen, Noam Weisbrod
In field applications, mostly in porous media, transport of stabilized nano zerovalent iron particles (nZVI) has never exceeded a few meters in range. In the present study, the transport of Carbo-Iron Colloids (CIC), a composite material of activated carbon as a carrier for nZVI stabilized by carboxymethyl cellulose (CMC), was tested under field conditions. The field site lies within a fractured chalk aquitard characterized by moderately saline (∼13 mS) groundwater. A forced gradient tracer test was conducted where one borehole was pumped at a rate of 8 L/min and CMC-stabilized CIC was introduced at an injection borehole 47 m up-gradient...
July 17, 2018: Environmental Science & Technology
Alireza Rahnama, Hiren Kotadia, Samuel Clark, Vit Janik, Seetharaman Sridhar
High Al Low-density steels could have a transformative effect on the light-weighting of steel structures for transportation. They can achieve the desired properties with the minimum amount of Ni, and thus are of great interest from an economic perspective. In this study, the mechanical properties of two duplex low-density steels, Fe-15Mn-10Al-0.8C-5Ni and Fe-15Mn-10Al-0.8 C (wt.%) were investigated through nano-indentation and simulation through utilization of ab-initio formalisms in Density Functional Theory (DFT) in order to establish the hardness resulting from two critical structural features (κ-carbides and B2 intermetallic) as a function of annealing temperature (500-1050 °C) and the addition of Ni...
June 13, 2018: Scientific Reports
Cynthia Hajal, Marco Campisi, Clara Mattu, Valeria Chiono, Roger D Kamm
The blood-brain barrier (BBB) is the tightest endothelial barrier in humans. Characterized by the presence of tight endothelial junctions and adherens junctions, the primary function of the BBB is to maintain brain homeostasis through the control of solute transit across the barrier. The specific features of this barrier make for unique modes of transport of solutes, nanoparticles, and cells across the BBB. Understanding the different routes of traffic adopted by each of these is therefore critical in the development of targeted therapies...
July 2018: Biomicrofluidics
O V Angelsky, A Ya Bekshaev, P P Maksimyak, A P Maksimyak, S G Hanson
A method is described for the generation of micrometer-sized vapor-gas bubbles in a water suspension containing absorptive pigment nanoparticles. The diluted suspension (mean interparticle distance 20 μm) absorbs the continuous laser radiation (wavelength 808 nm), and each particle in the best illuminated volume (~10 × 10 × 200 μm3 ) serves as a bubble-nucleation center. The suspension heating is inessential (several degrees above the room temperature) and the bubbles are formed mainly of the air gases dissolved in water...
May 28, 2018: Optics Express
Mark Epshtein, Netanel Korin
Intracranial side aneurysms (IA) are pathological blood-filled bulges in cerebral blood vessels. Unlike healthy blood vessels where mass transport is dominated by convection, both diffusion and convection can play an active role in aneurysm sites. Here, we study via dye washout experiments and numerical simulations, the transport characteristics of particles (1 micron) and small molecules (300 Da) into simplified side aneurysms models following bolus injection. Time-lapse fluorescent microscopy imaging performed in our idealized aneurysm models showed that the parent artery geometry (located on the inner vs...
June 4, 2018: Scientific Reports
Wenrong Zhao, Hong Sun, Yitong Wang, Julian Eastoe, Shuli Dong, Jingcheng Hao
Developing nontoxic artificial carriers for stimuli-responsive capture, transport, and delivery of biomolecules is of immense scientific interest. Herein, for the first time, we synthesize a double-tailed cationic surfactant, (C16 H33 )2 (CH3 )2 N+ [FeCl3 Br]- , which possesses magnetic properties [magnetic surfactants (Mag-Surfs)]. The time-dependent formation of virus-shaped hybrid mixed assemblies of polyoxometalates (POMs) {Mo72 Fe30 }/Mag-Surf with hollow-shell structures is followed. These structures serve well as robust high-surface-area shuttles, which can be manipulated with applied magnetic fields...
June 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Zihan Huang, Pengyu Chen, Guolong Zhu, Ye Yang, Ziyang Xu, Li-Tang Yan
In the development of biocompatible nano-/micromotors for drug and cargo delivery, motile bacteria represent an excellent energy source for biomedical applications. Despite intense research of the fabrication of bacteria-based motors, how to effectively utilize the instinctive responses of bacteria to environmental stimuli in the fabrication process, particularly, chemotaxis, remains an urgent and critical issue. Here, by developing a molecular-dynamics model of bacterial chemotaxis, we present an investigation of the transport of a bacteria-activated Janus particle driven by chemotaxis...
July 24, 2018: ACS Nano
Jian Zhang, Han Song, Zhi Chen, Shasha Liu, Yali Wei, Jingyi Huang, Chuling Guo, Zhi Dang, Zhang Lin
Current studies reveal that the biomineralization of U(VI) by anaerobes normally produces nano-sized U(IV) minerals that can easily re-migrate/re-oxidize, while the biomineralization of U(VI) by aerobes has been constrained because the general mechanism has not yet been fully characterized. The biomineralization of U(VI) by Bacillus cereus 12-2 was investigated in this work. The maximum biosorption capability of intact cells was 448.68 mg U/g biomass (dry weight) at pH 5, while a decrease over 60% was induced when phosphate, amino, and especially carboxyl groups were shielded...
September 2018: Chemosphere
Mounesha N Garaga, Vassilios Dracopoulos, Ulrike Werner-Zwanziger, Josef W Zwanziger, Manuel Maréchal, Michael Persson, Lars Nordstierna, Anna Martinelli
We report enhanced protonic and ionic dynamics in an imidazole/protic ionic liquid mixture confined within the nanopores of silica particles. The ionic liquid is 1-octylimidazolium bis(trifluoromethanesulfonyl)imide ([HC8Im][TFSI]), while the silica particles are microsized and characterized by internal well connected nanopores. We demonstrate that the addition of imidazole is crucial to promote a proton motion decoupled from molecular diffusion, which occurs due to the establishment of new N-HN hydrogen bonds and fast proton exchange events in the ionic domains, as evidenced by both infrared and 1H NMR spectroscopy...
July 9, 2018: Nanoscale
Wen Yang, Vyacheslav R Misko, Fabio Marchesoni, Franco Nori
We investigate the dynamics of a binary mixture consisting of active and passive colloidal particles diffusing in a 2D array of truncated harmonic wells, or traps. We explore the possibility of using a small fraction of active particles to manipulate a much larger fraction of passive particles, for instance, to confine them in or extract them from the traps. The results of our study have potential application in biology and medical sciences, for example, to remove dead cells or undesired contaminants from biological systems by means of self-propelled nano-robots...
July 4, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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