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leptomeningeal metastasis

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https://www.readbyqxmd.com/read/30072392/intracranial-response-to-anti-programmed-death-1-therapy-in-a-patient-with-metastatic-non-small-cell-lung-cancer-with-leptomeningeal-carcinomatosis
#1
Suneel D Kamath, Priya U Kumthekar, Tim J Kruser, Nisha A Mohindra
Central nervous system metastasis in non-small cell lung cancer remains a therapeutic challenge and confers a poor prognosis. Here we describe a patient with lung adenocarcinoma, parenchymal brain metastases, and leptomeningeal carcinomatosis who demonstrated a sustained response to programmed death 1 inhibition combined with stereotactic radiosurgery.
August 2, 2018: Oncologist
https://www.readbyqxmd.com/read/30058049/neurosurgical-management-of-patients-with-brain-metastasis
#2
REVIEW
Mustafa Aziz Hatiboglu, Kerime Akdur, Raymond Sawaya
Brain metastasis is a serious complication in patients with systemic cancer. The main goal of the treatment in patients with brain metastasis is to control the disease in the brain, to prevent death from neurological disease and provide a satisfactory quality of life. Management of a patient with brain metastasis is important and sometimes demanding, and several factors such as tumor histology, status of primary disease, number of brain lesions, size of lesions, and performance status may influence the decision making process...
July 29, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/30039345/efficacy-of-osimertinib-in-egfr-mutated-non-small-cell-lung-cancer-with-leptomeningeal-metastases-pretreated-with-egfr-tyrosine-kinase-inhibitors
#3
Karima Saboundji, Jean-Bernard Auliac, Maurice Pérol, Géraldine François, Henri Janicot, Marie Marcq, Catherine Dubos-Arvis, Aldo Renault, Florian Guisier, Luc Odier, Radj Gervais, Christos Chouaïd
BACKGROUND: The prognosis of patients with non-small cell lung cancer (NSCLC) who develop leptomeningeal metastasis (LM) is poor. OBJECTIVE: To assess the clinical efficacy of osimertinib, a third-generation tyrosine-kinase inhibitor (TKI), in patients with epidermal growth-factor receptor (EGFR)-mutated NSCLCs and LM. PATIENTS AND METHODS: Retrospective study of NSCLC patients with osimertinib-treated EGFR-mutated NSCLC and LM. RESULTS: Twenty patients (mean age, 61...
July 23, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30022166/leukaemia-hijacks-a-neural-mechanism-to-invade-the-central-nervous-system
#4
Hisayuki Yao, Trevor T Price, Gaia Cantelli, Brandon Ngo, Matthew J Warner, Lindsey Olivere, Sarah M Ridge, Elizabeth M Jablonski, Joseph Therrien, Stacey Tannheimer, Chad M McCall, Anjen Chenn, Dorothy A Sipkins
Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours, metastases of ALL seldom involve the parenchyma but are isolated to the leptomeninges, which is an infrequent site for carcinomatous invasion. Although metastasis to the CNS occurs across all subtypes of ALL, a unifying mechanism for invasion has not yet been determined. Here we show that ALL cells in the circulation are unable to breach the blood-brain barrier in mice; instead, they migrate into the CNS along vessels that pass directly between vertebral or calvarial bone marrow and the subarachnoid space...
August 2018: Nature
https://www.readbyqxmd.com/read/30015053/management-of-leptomeningeal-metastasis-in-breast-cancer
#5
REVIEW
Hazem I Assi, Tala Mahmoud, Fadi S Saadeh, Haidar El Darsa
Leptomeningeal metastasis (LM), which occurs when malignant cells spread to the central nervous system, is becoming an increasingly common complication in patients with breast cancer. Diagnosis and treatment of LM is challenging. Moreover, prognosis of patients with LM is poor, with a median survival of 6 months after diagnosis. This review highlights the strengths and limitations of currently available diagnostic tools and therapies for LM. The current treatments for LM, including radiotherapy, systemic therapy, and intrathecal treatment, aim to maintain the quality of life of patients by correcting neurological deficits and arresting neurological degeneration...
July 7, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30012875/seminoma-with-neoplastic-meningitis-treated-with-craniospinal-irradiation
#6
Kaylyn D Sinicrope, Alexander B Kaplan, Priscilla K Brastianos
Pure seminoma is a histological subtype of testicular cancer that accounts for 50% of testicular germ cell tumors. It has a very low rate of metastasis to the central nervous system, with only one previously reported case of neoplastic meningitis (cancer that has spread to the cerebrospinal fluid). Traditionally, neoplastic meningitis has an ominous prognosis when associated with primary tumors that commonly spread to the leptomeninges, like breast and lung. This article highlights a unique case of pure seminoma with neoplastic meningitis and illustrates the effectiveness of craniospinal irradiation as a treatment modality...
July 16, 2018: Oncologist
https://www.readbyqxmd.com/read/30002052/application-of-3d-fast-spin-echo-t1-black-blood-imaging-in-the-diagnosis-and-prognostic-prediction-of-patients-with-leptomeningeal-carcinomatosis
#7
J Oh, S H Choi, E Lee, D J Shin, S W Jo, R-E Yoo, K M Kang, T J Yun, J-H Kim, C-H Sohn
BACKGROUND AND PURPOSE: Contrast-enhanced 3D fast spin-echo T1 black-blood imaging selectively suppresses the signal of blood flow and could provide a higher contrast-to-noise ratio compared with contrast-enhanced 3D ultrafast gradient recalled echo (contrast-enhanced gradient recalled echo) and 2D spin-echo T1WI (contrast-enhanced spin-echo). The purpose of our study was to evaluate whether black-blood imaging can improve the diagnostic accuracy for leptomeningeal carcinomatosis compared with contrast-enhanced gradient recalled-echo and contrast-enhanced spin-echo and, furthermore, to determine whether the grade of leptomeningeal carcinomatosis evaluated on black-blood imaging is a significant predictor of progression-free survival...
July 12, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29992998/leptomeningeal-metastasis-from-solid-tumors-clinical-features-and-its-diagnostic-implication
#8
Zhenyu Pan, Guozi Yang, Hua He, Tingting Yuan, Yongxiang Wang, Yu Li, Weiyan Shi, Pengxiang Gao, Lihua Dong, Gang Zhao
In this study, we examined the characteristics and aimed to increase the knowledge of clinical features of leptomeningeal metastasis (LM). The clinical data, including initial diagnosis and treatment of primary tumor, clinical manifestations, neuroimaging findings, cerebrospinal fluid (CSF) examination, were analyzed. For the patients with adenocarcinoma/breast cancer, the incidence of cranial lesions and cranial nerve paralysis was obviously higher than patients with small cell lung cancer. Whereas, the incidence of involvement of intravertebral canal was obviously lower than that of small cell lung cancer...
July 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29990605/surgical-treatment-of-intramedullary-spinal-metastasis-in-medulloblastoma-case-report-and-review-of-literature
#9
Anshit Goyal, Iahn Cajigas, George M Ibrahim, Carole D Brathwaite, Ziad Khatib, Toba Niazi, Sanjiv Bhatia, John Ragheb
BACKGROUND: Medulloblastomas are common childhood CNS tumors that are prone to leptomeningeal spread. Intramedullary dissemination is rare with very few case reports existing in the available literature. CASE DESCRIPTION: The authors here present a case of a 14-year-old boy with Li-Fraumeni syndrome and medulloblastoma who underwent surgical resection of spinal intramedullary spread. Histopathology revealed the tumor to be anaplastic medulloblastoma, same as the intracranial lesions...
July 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29971546/leptomeningeal-recurrence-after-long-term-alectinib-therapy-for-non-small-cell-lung-cancer-harboring-an-eml4-alk-fusion-protein
#10
Takahisa Kawamura, Haruyasu Murakami, Haruki Kobayashi, Kazuhisa Nakashima, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Tateaki Naito, Masahiro Endo, Toshiaki Takahashi
The recent approval of anaplastic lymphoma kinase (ALK) inhibitors for the treatment of ALK-rearranged non-small cell lung cancer (NSCLC) has dramatically transformed cancer therapy. However, leptomeningeal metastases (LM) are frequent and often devastating complications of ALK-rearranged NSCLC, and treatment against LM remains challenging. Herein we report a case of a 19-year-old male diagnosed with ALK-rearranged NSCLC with LM. He experienced heavy treatment before introduction of alectinib therapy, which continued for approximately 5...
July 3, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29935321/posterior-fossa-metastasis-associated-obstructive-hydrocephalus-in-adult-patients-literature-review-and-practical-considerations-from-the-neuro-oncology-club-of-the-french-society-of-neurosurgery
#11
REVIEW
Alexandre Roux, Céline Botella, Megan Still, Marc Zanello, Frédéric Dhermain, Philippe Metellus, Johan Pallud
BACKGROUND: There is no consensus concerning the management of adult posterior fossa metastasis-associated obstructive hydrocephalus patients, especially regarding surgical procedures. OBJECTIVES: Literature review to assess the surgical strategy in the management of metastatic brain tumor patients. DATA SOURCES: Literature search conducted on PubMed in November 2017 to identify all studies concerning brain metastases and obstructive hydrocephalus in the English language...
June 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29930180/an-unusual-case-of-leptomeningeal-carcinomatosis-in-a-patient-with-primary-adenocarcinoma-of-the-lung
#12
Nadina Tinsley, Nikitha Yemula, Satheesh Ramalingam, Shyam Madathil
A 72-year-old man was brought to the emergency department with acute onset confusion and haemoptysis. Chest X-ray showed a possible lung mass, while CT head showed a fluid-filled, space-occupying lesion (SOL) in the right frontal lobe of the brain. MRI head indicated that this SOL had spilt its contents into the subarachnoid and intraventricular spaces. Due to a fluctuating Glasgow Coma Scale (GCS), the patient underwent emergency debulking. Macroscopically, a frail-walled cystic tumour filled with straw-coloured fluid was noted; histology confirmed metastasis from a primary lung adenocarcinoma...
June 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29906422/comparing-the-performance-of-ca-15-3-csf-to-cytology-in-a-cohort-of-patients-with-breast-cancer-leptomeningeal-metastasis
#13
Stacy M Kenyon, Tifani L Flieth, Alicia Algeciras-Schimnich
BACKGROUND AND OBJECTIVE: Leptomeningeal metastasis (LM) can occur as a late manifestation of breast cancer and has traditionally been diagnosed by CSF cytology; however, cytology suffers from low sensitivity and it is believed that many cases of LM go undiagnosed. Some studies have suggested the use of CA 15-3 in CSF (CA 15-3 CSF) to aid in the detection of LM. The purpose of this study was to compare the performance of CA 15-3 CSF to cytology for the detection and treatment monitoring of breast cancer LM...
August 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29902914/cytologic-diagnosis-of-metastatic-alveolar-rhabdomyosarcoma-in-cerebrospinal-fluid-a-case-report
#14
Bobae Shim, Jiwon Koh, Ji Hye Moon, In Ae Park, Han Suk Ryu
Rhabdomyosarcoma is a malignant soft tissue tumor which shows skeletal muscle differentiation. Leptomeningeal metastasis can occur as a late complication, but currently there are no reports that have documented the cytologic features in cerebrospinal fluid (CSF). We report a case of metastatic alveolar rhabdomyosarcoma diagnosed in the CSF of a 28-year-old male who was originally diagnosed with rhabdomyosarcoma on the neck, and that went through systemic therapy. The tumor was positive for anaplastic lymphoma kinase, but progressed despite additional therapy with crizotinib...
July 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29891723/integrated-genomic-classification-of-melanocytic-tumors-of-the-central-nervous-system-using-mutation-analysis-copy-number-alterations-and-dna-methylation-profiling
#15
Klaus Griewank, Christian Koelsche, Johannes A P van de Nes, Daniel Schrimpf, Marco Gessi, Inga Möller, Antje Sucker, Richard A Scolyer, Michael E Buckland, Rajmohan Murali, Torsten Pietsch, Andreas von Deimling, Dirk Schadendorf
PURPOSE: In the central nervous system, distinguishing primary leptomeningeal melanocytic tumors from melanoma metastases and predicting their biological behavior solely using histopathologic criteria can be challenging. We aimed to assess the diagnostic and prognostic value of integrated molecular analysis. EXPERIMENTAL DESIGN: Targeted next-generation-sequencing, array-based genome-wide methylation analysis and BAP1 immunohistochemistry was performed on the largest cohort of central nervous system melanocytic tumors analyzed to date, incl...
June 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29881714/mechanisms-and-therapy-for-cancer-metastasis-to-the-brain
#16
REVIEW
Federica Franchino, Roberta Rudà, Riccardo Soffietti
Advances in chemotherapy and targeted therapies have improved survival in cancer patients with an increase of the incidence of newly diagnosed brain metastases (BMs). Intracranial metastases are symptomatic in 60-70% of patients. Magnetic resonance imaging (MRI) with gadolinium is more sensitive than computed tomography and advanced neuroimaging techniques have been increasingly used in the detection, treatment planning, and follow-up of BM. Apart from the morphological analysis, the most effective tool for characterizing BM is immunohistochemistry...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29772358/tumor-to-lesion-metastasis-case-report-of-carcinoma-metastasis-to-multiple-sclerosis-lesion
#17
Jian-Qiang Lu, Suresh Menon, Crystal Fong, Boleslaw Lach, Christopher Power
BACKGROUND: The term "tumor-to-lesion metastasis" is an extension of "tumor-to-tumor metastasis," which is a rare but well-documented phenomenon. Tumor metastasis to the meninges and/or central nervous system (CNS) is rare in patents with multiple sclerosis (MS), although MS lesions bear many similarities to the primary tumor microenvironment and metastatic niche. We present the first case of malignant tumor metastasis to MS lesions with immunophenotyping of inflammatory cells in the metastatic foci...
August 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29749569/postoperative-hypofractionated-stereotactic-brain-radiation-hsrt-for-resected-brain-metastases-improved-local-control-with-higher-bed-10
#18
Aryavarta M S Kumar, Jonathan Miller, Seth A Hoffer, David B Mansur, Michael Coffey, Simon S Lo, Andrew E Sloan, Mitchell Machtay
INTRODUCTION: HSRT directed to large surgical beds in patients with resected brain metastases improves local control while sparing patients the toxicity associated with whole brain radiation. We review our institutional series to determine factors predictive of local failure. METHODS: In a total of 39 consecutive patients with brain metastases treated from August 2011 to August 2016, 43 surgical beds were treated with HSRT in three or five fractions. All treatments were completed on a robotic radiosurgery platform using the 6D Skull tracking system...
May 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29725432/a-nomogram-for-predicting-survival-in-patients-with-breast-cancer-brain-metastasis
#19
Zhou Huang, Bing Sun, Shikai Wu, Xiangying Meng, Yang Cong, Ge Shen, Santai Song
Brain metastasis (BM) is common in patients with breast cancer. Predicting patient survival is critical for the clinical management of breast cancer brain metastasis (BCBM). The present study was designed to develop and evaluate a prognostic model for patients with newly diagnosed BCBM. Based on the clinical data of patients with BCBM treated in the Affiliated Hospital of Academy of Military Medical Sciences (Beijing, China) between 2002 and 2014, a nomogram was developed to predict survival using proportional hazards regression analysis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29721166/isolated-metastasis-of-an-egfr-l858r-mutated-nsclc-of-the-meninges-the-potential-impact-of-cxcl12-cxcr4-axis-in-egfr-mut-nsclc-in-diagnosis-follow-up-and-treatment
#20
Florian Lüke, Raquel Blazquez, Rezan Fahrioglu Yamaci, Xin Lu, Benedikt Pregler, Stefan Hannus, Karin Menhart, Dirk Hellwig, Hans-Jürgen Wester, Saskia Kropf, Daniel Heudobler, Jirka Grosse, Jutta Moosbauer, Markus Hutterer, Peter Hau, Markus J Riemenschneider, Michaela Bayerlová, Annalen Bleckmann, Bernhard Polzer, Tim Beißbarth, Christoph A Klein, Tobias Pukrop
Brain and leptomeningeal metastasis (LMM) of non-small cell lung cancer is still associated with poor prognosis. Moreover, the current diagnostic standard for LMM often yields false negative results and the scientific progress in this field is still unsatisfying. We present a case of a 71-year old patient with an isolated LMM. While standard diagnostics could only diagnose a cancer of unknown primary, the use of [68 Ga]-Pentixafor-PET/CT (CXCR4-PET/CT, a radiotracer targeting CXCR4) and a liquid biopsy of the cerebrospinal fluid revealed the primary NSCLC...
April 10, 2018: Oncotarget
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