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https://www.readbyqxmd.com/read/27890958/nonhealing-genital-ulcer-in-aids-a-diagnostic-dilemma
#1
Yogesh S Marfatia, Devi Sathianadha Menon, Sheethal Jose, Brijesh Kumar Patel
HIV/AIDS-related immune alteration poses many diagnostic and therapeutic challenges. HIV-positive 44-year-old male, on second-line antiretroviral therapy (ART) presented with asymptomatic non healing, well-defined, erythematous ulcer over penis since 8 months with serosanguinous discharge. Inguinal lymph nodes were not palpable. Tzanck smear was negative. Biopsy was not done as the patient was not willing for the same. Acyclovir was given considering herpes infection to which there was no response, and hence azithromycin and metronidazole were given, without improvement...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27869384/-atypical-mucocutaneous-manifestations-in-neonates-and-infants-with-chikungunya-fever-in-the-municipalities-of-c%C3%A3%C2%BAcuta-los-patios-and-villa-del-rosario-norte-de-santander-colombia-2014
#2
Claudia Marcela Muñoz, José Orlando Castillo, Daniela Salas, Milena Alexandra Valderrama, Claudia Teresa Rangel, Heiddy Patricia Vargas, Diana Carolina Silva
INTRODUCTION: Atypical clinical manifestations have been observed in newborns and infants suffering from fever caused by the chikungunya virus. Objective: To describe the cases of fever caused by the chikungunya virus in newborns and infants with atypical mucocutaneous lesions. Materials and methods: We reviewed the clinical records, as well as lab tests and histopathological results, of newborns and infants diagnosed with Chikungunya virus and atypical mucocutaneous lesions in three regional hospitals...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27868164/efficient-production-of-recombinant-glycoprotein-d-of-herpes-simplex-virus-type-2-in-pichia-pastoris-and-its-protective-efficacy-against-viral-challenge-in-mice
#3
Man Wang, Shuai Jiang, Li Zhou, Chaoqun Wang, Ruifeng Mao, Murugavel Ponnusamy
Herpes simplex virus type 2 (HSV-2) infection is the leading cause of genital ulcer disease and a significant public health concern. However, there are no approved vaccines available to prevent HSV-2 infection. The glycoprotein D (gD) of HSV-2 is the most important candidate antigen for vaccine development. In this study, a truncated form of gD (codons 1-340, gD1-340) was produced as a secretory protein in the methylotrophic yeast Pichia pastoris. The recombinant gD1-340 with a His6 tag was purified to homogeneity by one-step affinity chromatography...
November 21, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27854250/association-of-urogenital-symptoms-with-history-of-water-contact-in-young-women-in-areas-endemic-for-s-haematobium-a-cross-sectional-study-in-rural-south-africa
#4
Hashini Nilushika Galappaththi-Arachchige, Ingrid Elise Amlie Hegertun, Sigve Holmen, Erik Qvigstad, Elisabeth Kleppa, Motshedisi Sebitloane, Patricia Doris Ndhlovu, Birgitte Jyding Vennervald, Svein Gunnar Gundersen, Myra Taylor, Eyrun Floerecke Kjetland
Female genital schistosomiasis is a neglected tropical disease caused by Schistosoma haematobium. Infected females may suffer from symptoms mimicking sexually transmitted infections. We explored if self-reported history of unsafe water contact could be used as a simple predictor of genital schistosomiasis. In a cross-sectional study in rural South Africa, 883 sexually active women aged 16-22 years were included. Questions were asked about urogenital symptoms and water contact history. Urine samples were tested for S...
November 14, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27852659/case-of-steven-johnson-syndrome-in-a-male-with-breast-cancer-secondary-to-docetaxel-cyclophosphamide-therapy
#5
Benjamin Jarrett, Sehem Ghazala, Joseph Chao, Sachin Chaudhary
The mortality rate for Stevens-Johnson syndrome (SJS) is estimated to be ∼12% and for toxic epidermal necrolysis (TEN) it is around 30%. It continues to be a severe life-threatening drug reaction. We present a 60-year-old Caucasian man with a medical history significant for breast cancer status post mastectomy and chemotherapy with docetaxel and cyclophosphamide who presented with severe mucositis and a progressing skin rash consistent with SJS. He was started on high-dose corticosteroids and IVIG but continued to have worsening mucosal ulcerations and severe bleeding from the oral, conjunctival and genital mucosa...
November 15, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27847659/interferon-induced-focal-segmental-glomerulosclerosis
#6
Yusuf Kayar, Nuket Bayram Kayar, Nadir Alpay, Jamshid Hamdard, Iskender Ekinci, Sebnem Emegil, Rabia Bag Soydas, Birol Baysal
Behçet's disease is an inflammatory disease of unknown etiology which involves recurring oral and genital aphthous ulcers and ocular lesions as well as articular, vascular, and nervous system involvement. Focal segmental glomerulosclerosis (FSGS) is usually seen in viral infections, immune deficiency syndrome, sickle cell anemia, and hyperfiltration and secondary to interferon therapy. Here, we present a case of FSGS identified with kidney biopsy in a patient who had been diagnosed with Behçet's disease and received interferon-alpha treatment for uveitis and presented with acute renal failure and nephrotic syndrome associated with interferon...
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27843865/a-rare-case-of-isolated-testicular-tuberculosis-and-review-of-literature
#7
Anirban Das, Saikat Batabyal, Soumya Bhattacharjee, Amitabha Sengupta
Testicular tuberculosis (TB) is a rare form of genitourinary TB. It is usually presented as painful or painless testicular swelling with or without scrotal ulceration or discharging sinus. Infertility may occur. Epididymal involvement is usually seen in testicular TB. In most cases, genital TB is associated with TB involvement of kidneys or lower urinary tract. Ultrasound (USG) and USG-guided fine needle aspiration cytology of testicular swelling confirm the diagnosis. Anti-TB chemotherapy is the mainstay of treatment to ensure the complete resolution of the lesion...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27830291/-cutaneous-involvement-in-chronic-inflammatory-bowel-disease-crohn-s-disease-and-ulcerative-colitis
#8
REVIEW
L Richter, K Rappersberger
BACKGROUND: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity. OBJECTIVES: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC). MATERIALS AND METHODS: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27793121/seroprevalence-and-correlates-of-herpes-simplex-virus-type-2-infection-among-young-adults-in-arkhangelsk-northwest-russia-a-population-based-cross-sectional-study
#9
Tatiana Balaeva, Andrej M Grjibovski, Oleg Sidorenkov, Olga Samodova, Natalia Firsova, Anatoly Sannikov, Elise Klouman
BACKGROUND: Herpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcer disease (GUD) worldwide. Mother to child transmission causes high morbidity and mortality among infants. Russia is on the brink of a generalized HIV-epidemic, but Arkhangelsk is still a low-prevalence area. HSV-2 infection is associated with a three-fold increased risk of HIV-infection. The evidence on the seroprevalence of HSV-2 in Russia is limited. The aim of this study was to assess HSV-2 seroprevalence and correlates among young adults in the city of Arkhangelsk...
October 28, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27791954/ocular-beh%C3%A3-et-s-disease-is-less-complicated-with-allergic-disorders-a-nationwide-survey-in-japan
#10
Yukihiro Horie, Nobuyoshi Kitaichi, Kuniaki Hijioka, Koh-Hei Sonoda, Yoshitsugu Saishin, Takeshi Kezuka, Hiroshi Goto, Masaru Takeuchi, Satoshi Nakamura, Takashi Kimoto, Machiko Shimakawa, Mihori Kita, Sunao Sugita, Manabu Mochizuki, Junko Hori, Mitsuhiro Iwata, Jun Shoji, Masahide Fukuda, Toshikatsu Kaburaki, Jiro Numaga, Hidetoshi Kawashima, Astuki Fukushima, Takeshi Joko, Nanae Takai, Yoko Ozawa, Akira Meguro, Nobuhisa Mizuki, Kenichi Namba, Susumu Ishida, Shigeaki Ohno
OBJECTIVES: Behçet's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. METHODS: The study involved a large-scale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27776949/beh%C3%A3-et-s-disease%C3%A2-and-fmf-two-sides-of-the-same-coin-or-just-an-association-a-cross-sectional-study%C3%A2
#11
Abdulla Watad, Shmuel Tiosano, Dana Yahav, Doron Comaneshter, Yehuda Shoenfeld, Arnon D Cohen, Howard Amital
BACKGROUND: Familial Mediterranean fever (FMF) is a genetic disease, characterized by attacks of fever, arthritis, serositis and pain. Behçet's disease (BD) is an inflammatory disorder with a genetic basis, characterized by oral and genital ulcers, uveitis, pustular erythematous cutaneous lesions, arthritis, central nervous system involvement and possible vascular manifestations such as venous thrombosis, arteritis and aneurysms. OBJECTIVES: To investigate the association and actual differentiation between these two entities in a large-scale population-based study...
October 21, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27776814/-genital-ulcers
#12
C Derancourt, M Janier, N Dupin, C Vernay-Vaïsse, B Milpied, A L Pinault
No abstract text is available yet for this article.
October 21, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27761567/an-extraordinary-case-of-syphilis-presenting-with-a-labial-ulcer
#13
Filiz T Demir, Kenyul Salaeva, Ilknur K Altunay, Ozben Yalcın
In the differential diagnosis of patients with ulcers on the lips characteristics like the duration of the ulcer, number, size, depth, shape, base, margins, and distribution are considered. Such ulcers arise from many diseases particularly, viral and bacterial infections, malignancies can also be responsible. Classic syphilitic chancres are painless erosions settled on hard papule; these are evident in the genital area in more than 90% of patients. This study describes a case of a 38-year-old female patient presenting with a painful ulcer covering 3 quarters of the upper lip showing settlement on erythematous, edematous, and indurated plaque covered with hemorrhagic crusts...
November 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27752180/-panuveitis-with-oral-and-genital-ulcer-misdiagnosed-as-behcet-s-disease-two-cases-report-and-literature-review
#14
Y Wang, L Yang, Z L Zhang
Here we reported two patients who presented with panuveitis and were transferred from ophthalmologists to rheumatologists, for both the patients had oral and genital ulcers. They were misdiagnosed with Behcet's disease at first glance. Two young males presented with acute uveitis with history of recurrent oral and genital ulcers. They initially presented with symptoms and signs resembling Behcet's disease and were treated with systemic steroids with suboptimal responses. Routine laboratory test revealed syphilis and human immunodeficiency virus (HIV) infection...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27750273/a-case-report-of-severe-neuro-behcet-s-disease-treated-with-a-combination-of-immunosuppressives-and-a-tnf-inhibitor-a-difficult-therapeutic-choice
#15
Fatma Nur Korkmaz, Gulsen Ozen, Ali Uğur Ünal, Pınar Kahraman Koytak, Nese Tuncer, Haner Direskeneli
Abstract/ Resumo Behcet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers, skin lesions and uveitis. The nervous system involvement of BD, neuro-Behcet's disease (NBD), is one of the important causes of mortality of the disease. Herein, we present a 29-year-old male with parenchymal NBD who has progressed rapidly and was managed with an uncommon aggressive immunosuppresive combination therapy. The patient first presented six years ago with vertigo and difficulty in talking and walking...
September 28, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27744360/chronic-signs-of-memory-b-cell-activation-in-patients-with-beh%C3%A3-et-s-disease-are-partially-restored-by-anti-tumour-necrosis-factor-treatment
#16
Tim B van der Houwen, P Martin van Hagen, Wilhemina M C Timmermans, Sophinus J W Bartol, King H Lam, Jasper H Kappen, Menno C van Zelm, Jan A M van Laar
OBJECTIVES: Behçet's disease (BD), an auto-inflammatory vasculitis with oro-genital ulcerations, skin lesions and uveitis, is regarded as T cell mediated. A successful trial with rituximab suggests an additive role for B cells in the pathogenesis. Therefore, we studied B cell abnormalities in BD patients and the effect of TNF-blocking therapy. METHODS: B cells in blood (n = 36) and tissue (n = 6) of BD patients were analysed with flow cytometry and/or immunohistochemistry and compared with healthy controls (n = 22)...
October 15, 2016: Rheumatology
https://www.readbyqxmd.com/read/27716399/continuous-evolution-of-clinical-phenotype-in-578-japanese-patients-with-beh%C3%A3-et-s-disease-a-retrospective-observational-study
#17
Yohei Kirino, Haruko Ideguchi, Mitsuhiro Takeno, Akiko Suda, Kana Higashitani, Yosuke Kunishita, Kaoru Takase-Minegishi, Maasa Tamura, Toshiyuki Watanabe, Yukiko Asami, Takeaki Uehara, Ryusuke Yoshimi, Tetsu Yamazaki, Akiko Sekiguchi, Atsushi Ihata, Shigeru Ohno, Atsuhisa Ueda, Toshihisa Igarashi, Shohei Nagaoka, Yoshiaki Ishigatsubo, Hideaki Nakajima
BACKGROUND: It has been suggested that the phenotypes of Behçet's disease (BD) in Japan are changing. To ask whether the evolution of BD holds true in recent-onset cases in Japan, we performed a retrospective study. METHODS: We reviewed the records of 578 patients with BD who met the 1987 revised diagnostic criteria of the Behçet's disease research committee of Japan. The patients were divided into three groups based on the date of disease onset. We compared the demography, clinical features, and treatments among them with or without adjustment for the observation period...
October 3, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27703597/a-study-on-usefulness-of-a-set-of-known-risk-factors-in-predicting-maternal-syphilis-infections-in-three-districts-of-western-province-zambia
#18
Jacob Sakala, Nellisiwe Chizuni, Selestine Nzala
INTRODUCTION: Despite roll-out of cost-effective point-of-care tests, less than half antenatal attendees in rural western Zambia are screened for syphilis. This study formulated a clinical, risk-based assessment criteria and evaluated its usefulness as a non-biomedical alternative for identifying high-risk prenatal cases. METHODS: We conducted a cross-sectional survey of antenatal clinic attendees in Kaoma, Luampa and Nkeyema districts to collect data on exposure to nine pre-selected syphilis risk factors...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27683204/genital-hsv-shedding-among-kenyan-women-initiating-antiretroviral-therapy
#19
Griffins O Manguro, Linnet N Masese, Ruth W Deya, Amalia Magaret, Anna Wald, R Scott McClelland, Susan M Graham
OBJECTIVES: Genital ulcer disease (GUD) prevalence increases in the first month of antiretroviral treatment (ART), followed by a return to baseline prevalence by month 3. Since most GUD is caused by herpes simplex virus type 2 (HSV-2), we hypothesized that genital HSV detection would follow a similar pattern after treatment initiation. METHODS: We conducted a prospective cohort study of 122 HSV-2 and HIV-1 co-infected women with advanced HIV disease who initiated ART and were followed closely with collection of genital swab specimens for the first three months of treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27668294/intimate-partner-violence-is-associated-with-increased-cd4-t-cell-activation-among-hiv-negative-high-risk-women
#20
Ameeta S Kalokhe, Chris C Ibegbu, Surinder P Kaur, Rama R Amara, Mary E Kelley, Carlos Del Rio, Rob Stephenson
BACKGROUND: Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV was associated with immune profiles linked to HIV susceptibility: CD4 activation and diminished regulatory T-cell (Treg) frequency. METHODS: Seventy-five HIV-negative high-risk women were surveyed regarding their IPV experience...
2016: Pathogens & Immunity
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