Nicola Gambacorta, Valeria Gasperi, Tatiana Guzzo, Francesco Saverio Di Leva, Fulvio Ciriaco, Cristina Sánchez, Valentina Tullio, Diego Rozzi, Luciana Marinelli, Alessandra Topai, Orazio Nicolotti, Mauro Maccarrone
The discovery of selective agonists of cannabinoid receptor 2 (CB2 ) is strongly pursued to successfully tuning endocannabinoid signaling for therapeutic purposes. However, the design of selective CB2 agonists is still challenging because of the high homology with the cannabinoid receptor 1 (CB1 ) and for the yet unclear molecular basis of the agonist/antagonist switch. Here, the 1,3-benzoxazine scaffold is presented as a versatile chemotype for the design of CB2 agonists from which 25 derivatives were synthesized...
July 14, 2023: European Journal of Medicinal Chemistry