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Lymphoblastic leukaemia

Areesha Alam, Archana Kumar
BACKGROUND: Treatment refusal or abandonment are among the major causes of the survival gap between developed and developing countries. METHODS: This retrospective observational study analyzed records of children aged <18 years with acute lymphoblastic leukemia (ALL) registered for treatment at a tertiary-care teaching hospital, North India, between 1995 and 2012. Children who refused or abandoned therapy were tracked, and reasons for refusal/abandonment were recorded by telephone interviews or by surface mail...
October 10, 2018: Cancer Epidemiology
Mengting Liu, Wenjuan Ma, Qianshun Li, Dan Zhao, Xiaoru Shao, Qian Huang, Liying Hao, Yunfeng Lin
OBJECTIVES: Aptamer sgc8c is a short DNA sequence that can target protein tyrosine kinase 7 (PTK7), which was overexpressed on many tumour cells. This study aimed to fabricate a novelty DNA nanostructure drug delivery system target on PTK7-positive cells-CCRF-CEM (human T-cell ALL). METHODS: Aptamer-modified tetrahedron DNA was synthesized through one-step thermal annealing process. The sgc8c-TDNs (s-TDNs) loading DOX complexes were applied to investigate the effect to PTK7-negative and -positive cells...
October 12, 2018: Cell Proliferation
Ayesha Khalid, Amna Jabbar Siddiqui, Jian-Hua Huang, Tahir Shamsi, Syed Ghulam Musharraf
Acute Leukaemia (AL) is a neoplasm of WBCs (white blood cells). Being an important class of metabolites, alteration in free fatty acids (FFAs) levels play a key role in cancer development and progression. As they involve in cell signaling, maintain membrane integrity, regulate homeostasis and effect cell and tissue functions. Considering this fact, a comprehensive analysis of FFAs was conducted to monitor their alteration in AL, pre-leukaemic diseases and healthy control. Fifteen FFAs were analyzed in 179 serum samples of myelodysplastic syndrome (MDS), aplastic anemia (APA), acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML) and healthy control using gas chromatography-multiple reaction monitoring-mass spectrometry (GC-MRM-MS)...
October 5, 2018: Scientific Reports
Y-N Sun, Y-X Hu, L Gao, P-F Xiao, J Lu, S-Y Wu, M Wang, X-J Shao, C-Y Zhou, J Ling, J-Q Li, J Pan, J Gao, S-Y Hu
OBJECTIVE: In this study, we retrospectively evaluated the therapeutic efficacy of China Children Leukemia Group-ALL2008 (CCLG-ALL 2008) protocol in pediatric patients with mixed-lineage leukaemia (MLL) gene rearrangement of acute lymphoblastic leukemia (ALL) to identify the prognostic factors. PATIENTS AND METHODS: Six hundred and thirty-four patients with ALL were enrolled in this study between June 2008 and Dec 2014. High-risk group (HR) consisted of 217 cases, of which 28 cases were MLL related positive (first group), 22 cases were BCR/ABL positive (second group), and 167 cases were negative with MLL related or BCR/ABL (third group)...
September 2018: European Review for Medical and Pharmacological Sciences
Charlotte Graham, Agnieszka Jozwik, Andrea Pepper, Reuben Benjamin
Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably B-acute lymphoblastic leukaemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL). However, there are limitations, including inability to manufacture CAR-T cells from the patient's own T cells, disease progression and death prior to return of engineered cells. T cell dysfunction is known to occur in cancer patients, and several groups have recently described differences in CAR-T cells generated from chronic lymphocytic leukaemia (CLL) patients compared with those from a healthy donor...
October 1, 2018: Cells
Pan Zhao, Jingcao Huang, Dan Zhang, Danfeng Zhang, Fangfang Wang, Ying Qu, Tingting Guo, Yu Qin, Jin Wei, Ting Niu, Yuhuan Zheng
To study glycolysis/glycogenesis-related genes expression in childhood B-cell acute lymphoblastic leukaemia (B-ALL), we performed a microarray-based analysis using published gene expression profiles. We found that SLC2A5, which encodes solute carrier family 2 member 5 (SLC2A5, previously termed GLUT5) that facilitates cell fructose uptake, was up-regulated in Philadelphia chromosome-positive ALL (Ph+ALL). Microarray-based analyses also suggested that SLC2A5 expression was significantly down-regulated in childhood B-ALL with t(1;19) or 11q23 mutation...
September 11, 2018: British Journal of Haematology
Shahrzad Bakhtiar, Emilia Salzmann-Manrique, Martin Hutter, Thomas Krenn, Matthias Duerken, Joerg Faber, Harald Reinhard, Hermann Kreyenberg, Sabine Huenecke, Claudia Cappel, Melanie Bremm, Verena Pfirrmann, Michael Merker, Anke Barnbrock, Stefan Schöning, Andre Manfred Willasch, Eva Rettinger, Jan Soerensen, Thomas Erich Klingebiel, Andrea Jarisch, Peter Bader
Allogeneic hematopoietic stem cell transplantation (alloHSCT) has become a well-established treatment option for many patients suffering from malignant and non-malignant diseases. In the past decade, high-resolution HLA-typing, remission surveillance, pre-emptive immune intervention, and standardisation in supportive care measures have substantially improved transplant outcomes. This retrospective study evaluated transplant procedures in 162 paediatric patients with acute lymphoblastic leukaemia (n = 124) or acute myeloid leukaemia (n = 38) who received their first alloHSCT in our institution over an 11-year period...
September 26, 2018: Bone Marrow Transplantation
Roba M Talaat, Medhat Y K El-Kelliny, Basima A El-Akhras, Rania M Bakry, Khaled F Riad, Adel A Guirgis
Background: P-glycoprotein (P-gp), a membrane transporter encoded by the multidrug resistance-1 (MDR1) gene, influences pharmacokinetics and metabolism of anticancer drugs and contributes to multidrug resistance phenotype in acute lymphoblastic leukemia (ALL). Genetic variation ofMDR1 in ALL patients is increasingly recognized as a factor influencing response to treatment. Aim: To investigate the possible role of MDR-1 gene polymorphisms (C3435T, C1236T and C4125A) as risk factors for the development and clinical outcome of ALL in Egyptian children...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Farhat Butt, Martin McKibbin
BACKGROUND: Bone marrow transplantation retinopathy is a rare condition affecting the posterior pole. The purpose of this case report is to highlight the possible risk factors and clinical features. CASE PRESENTATION: A 19y old male with relapsed and refractory acute lymphoblastic leukaemia was admitted under haematology with pyrexia of unknown origin. At the time of his admission, he reported bilateral and sequential visual impairment for 2 days. On examination, there was bilateral profound retinopathy across the posterior poles...
September 14, 2018: BMC Ophthalmology
Thomas B Alexander, Zhaohui Gu, Ilaria Iacobucci, Kirsten Dickerson, John K Choi, Beisi Xu, Debbie Payne-Turner, Hiroki Yoshihara, Mignon L Loh, John Horan, Barbara Buldini, Giuseppe Basso, Sarah Elitzur, Valerie de Haas, C Michel Zwaan, Allen Yeoh, Dirk Reinhardt, Daisuke Tomizawa, Nobutaka Kiyokawa, Tim Lammens, Barbara De Moerloose, Daniel Catchpoole, Hiroki Hori, Anthony Moorman, Andrew S Moore, Ondrej Hrusak, Soheil Meshinchi, Etan Orgel, Meenakshi Devidas, Michael Borowitz, Brent Wood, Nyla A Heerema, Andrew Carrol, Yung-Li Yang, Malcolm A Smith, Tanja M Davidsen, Leandro C Hermida, Patee Gesuwan, Marco A Marra, Yussanne Ma, Andrew J Mungall, Richard A Moore, Steven J M Jones, Marcus Valentine, Laura J Janke, Jeffrey E Rubnitz, Ching-Hon Pui, Liang Ding, Yu Liu, Jinghui Zhang, Kim E Nichols, James R Downing, Xueyuan Cao, Lei Shi, Stanley Pounds, Scott Newman, Deqing Pei, Jaime M Guidry Auvil, Daniela S Gerhard, Stephen P Hunger, Hiroto Inaba, Charles G Mullighan
Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid and lymphoid features, limited genetic characterization, and a lack of consensus regarding appropriate therapy. Here we show that the two principal subtypes of MPAL, T/myeloid (T/M) and B/myeloid (B/M), are genetically distinct. Rearrangement of ZNF384 is common in B/M MPAL, and biallelic WT1 alterations are common in T/M MPAL, which shares genomic features with early T-cell precursor acute lymphoblastic leukaemia. We show that the intratumoral immunophenotypic heterogeneity characteristic of MPAL is independent of somatic genetic variation, that founding lesions arise in primitive haematopoietic progenitors, and that individual phenotypic subpopulations can reconstitute the immunophenotypic diversity in vivo...
September 12, 2018: Nature
Catherine Potter, Anthony Vincent Moorman, Caroline Laura Relton, Dianne Ford, John Cummings Mathers, Gordon Strathdee, Jill Ann McKay
Scope; Inadequate maternal folate intake is associated with increased childhood acute lymphoblastic leukaemia (ALL) risk. Folate provides methyl groups for DNA methylation, which is dramatically disrupted in ALL. We investigated if maternal folate (and related B-vitamin) intake during pregnancy may affect ALL risk via influencing DNA methylation. Methods and Results; We identified genes in which methylation changes were reported both in response to folate status and in ALL. Folate-responsive genes (n = 526) were identified from mouse models of maternal folate depletion during pregnancy...
September 7, 2018: Molecular Nutrition & Food Research
Ching-Hon Pui, Jun J Yang, Nickhill Bhakta, Carlos Rodriguez-Galindo
Improvements in risk-directed treatment and supportive care, together with increased reliance on both national and international collaborative studies, have made childhood acute lymphoblastic leukaemia (ALL) one of the most curable human cancers. Next-generation sequencing studies of leukaemia cells and the host germline provide new opportunities for precision medicine and thus potential improvements in the cure rate and quality of life of patients. Efforts are underway to assess the global impact of childhood ALL and develop initiatives that can meet the long-term challenge of providing quality care to children with this disease worldwide and improving cure rates globally...
June 2018: Lancet Child & Adolescent Health
Joanne F Aitken, Danny R Youlden, Andrew S Moore, Peter D Baade, Leisa J Ward, Vicky J Thursfield, Patricia C Valery, Adèle C Green, Sumit Gupta, A Lindsay Frazier
BACKGROUND: Cancer stage at diagnosis is crucial for assessing global efforts to increase awareness of childhood cancer and improve outcomes. However, consistent information on childhood cancer stage is absent from population cancer registries worldwide. The Toronto Childhood Cancer Stage Guidelines, compiled through an international consensus process, were designed to provide a standard framework for collection of information on stage at diagnosis of childhood cancers. We aimed to assess the feasibility of implementing the Toronto Guidelines within a national population cancer registry...
March 2018: The lancet child & adolescent health
H Tomiyasu, A Doi, J K Chambers, Y Goto-Koshino, A Ohmi, K Ohno, H Tsujimoto
OBJECTIVES: To investigate the clinical characteristics of feline acute lymphoblastic leukaemia patients diagnosed according to the recent diagnostic criteria for the equivalent canine condition. MATERIALS AND METHODS: The medical records of six cats diagnosed with acute lymphoblastic leukaemia were retrospectively reviewed to extract data on clinicopathological characteristics and outcomes. The lymphoid origin of the tumour cells was confirmed by polymerase chain reaction for antigen receptor gene rearrangement, flow cytometry or immunohistochemistry...
August 31, 2018: Journal of Small Animal Practice
Mayur Parihar, Manish K Singh, Rubina Islam, Debparna Saha, Deepak Kumar Mishra, Vaskar Saha, Shekhar Krishnan
Karyotyping along with a 3-probe fluorescence in situ hybridization (FISH) strategy was used to risk stratify therapy in 303 children with B-cell precursor acute lymphoblastic leukaemia. Of the 166 patients risk stratified, karyotype identified 91 (55%). FISH identified all karyotypes accurately, with the exception of hypodiploidy, and risk stratified an additional 75 patients. The frequency of ETV6-RUNX1 is lower and high hyperdiploidy, higher than reported in the west. An adapted 3-probe FISH strategy identified two patients with ETV6-ABL1 fusion who received imatinib...
August 31, 2018: Pediatric Blood & Cancer
Panos Kefalas, Omar Ali, Jesper Jørgensen, Nick Merryfield, Tim Richardson, Adam Meads, Laura Mungapen, Matthew Durdy
Background : Market access stakeholders consider the adoption of Managed Entry Agreements (MEAs), however a clearly described methodology to quantify their implementation burden is not available in the public domain. Objective : To quantify the cost of implementing a performance-based MEA at the hospital level. Methods : The analysis involved a hypothetical one-off therapy targeting Acute Lymphoblastic Leukaemia. Data collection from five NHS Hospital Trusts in England captured costs by task, job band, personnel time and capital investment...
2018: Journal of Market Access & Health Policy
Preeti Prerna M Vaswani, Teresita E Dumagay
Trisomy 5 as the sole cytogenetic aberration in acute lymphoblastic leukaemia (ALL) is exceedingly rare. As such, its prognostic and therapeutic relevance remains unknown. We report a case of an 18-year-old young man who was diagnosed with B cell ALL with trisomy 5 as the sole chromosomal abnormality. He was treated with chemotherapy and went into complete remission. On the 14th month of treatment, he relapsed with central nervous system involvement characterised by leukaemic infiltration of the optic nerve and facial palsy...
August 20, 2018: BMJ Case Reports
Natthapon Angsubhakorn, Attaya Suvannasankha
A previously healthy 37-year-old man presented with a 10-month history of intractable back pain. On examination, there was tenderness to palpation along lower thoracic and lumbar spine. Complete blood count showed mild anaemia but was otherwise unremarkable. Imaging studies revealed compression deformities with multiple osteolytic lesions involving multiple levels of the thoracic and lumbar spine. Bone marrow aspiration and biopsy were performed and demonstrated blast cells involving 80% of the bone marrow cellularity...
August 11, 2018: BMJ Case Reports
Narges Kalantari, Javad Rezanejad, Ahmad Tamadoni, Salman Ghaffari, Jaber Alipour, Masomeh Bayani
The possible association between Toxoplasma gondii infection and paediatric haematological malignancies in a group of patients and control subjects was evaluated in the present study. We performed an age-, gender- and residence frequency-matched case-control study of 101 blood cancer patients under 18 years of age, all of which were treated in Amirkola Pediatric Hospital. One hundred and thirty-eight control samples were gathered from the outpatient clinic in the hospital. All cases and controls were tested for the presence of anti-Toxoplasma IgG antibodies and then IgG-positive subjects were evaluated for IgM antibodies by enzyme-linked immunoassays...
August 10, 2018: Epidemiology and Infection
Zaina T Al-Salama
The intravenous CD22-directed antibody drug conjugate inotuzumab ozogamicin (Besponsa® ) is approved in several countries including in the USA, EU and Japan, as monotherapy for the treatment of adults with relapsed/refractory B-cell acute lymphoblastic leukaemia (ALL). In adults with relapsed/refractory B-cell ALL who had received one or two prior treatment regimens, inotuzumab ozogamicin was associated with significantly higher rates of complete remission (including complete remission with incomplete haematological recovery) [CR/CRi] than standard therapy in the pivotal INO-VATE ALL trial...
August 2018: Targeted Oncology
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