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Fast And Insulin And Analogue

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https://www.readbyqxmd.com/read/30114258/in-vitro-assessment-of-the-influence-of-intravenous-extension-set-materials-on-insulin-aspart-drug-delivery
#1
Morgane Masse, Mickael Maton, Stéphanie Genay, Nicolas Blanchemain, Christine Barthélémy, Bertrand Décaudin, Pascal Odou
Insulin is a frequently prescribed drug in hospitals and is usually administered by syringe pumps with an extension line which can be made of various materials. Two insulin solutions were studied: an insulin analogue, Novorapid® which contains insulin aspart and two phenolic preservatives (e.g. phenol and metacresol) and Umuline rapide® with human insulin and metacresol as preservative. Some studies have indicated interactions between insulin, polyvinyl chloride (PVC) and polyethylene (PE). The aim of this work was to study such interactions between Novorapid® or Umuline rapide® and infusion extension line materials (PVC, PE and coextruded (PE/PVC))...
2018: PloS One
https://www.readbyqxmd.com/read/30112792/efficacy-and-safety-of-myl-1501d-versus-insulin-glargine-in-patients-with-type-2-diabetes-after-24-weeks-results-of-the-phase-3-instride-2-study
#2
Thomas C Blevins, Abhijit Barve, Bin Sun, Yaron Raiter, Patrick Aubonnet, Rafael Muniz, Sandeep Athalye, Michael Ankersen
AIMS: Insulin glargine is a long-acting human insulin analogue that can be administered once daily in patients with type 2 diabetes mellitus (T2DM). MYL-1501D is a proposed biosimilar or follow-on biologic to marketed insulin glargine. This study assessed noninferiority of MYL-1501D to reference insulin glargine (Lantus®; Sanofi-Aventis US LLC, Bridgewater, NJ) based on change in glycosylated hemoglobin (HbA1c ). MATERIALS AND METHODS: INSTRIDE 2 was a multicenter, open-label, randomized, parallel-group, phase 3 noninferiority study comparing efficacy and safety of MYL-1501D with those of reference insulin glargine in insulin-naive and insulin-non-naive patients with T2DM receiving oral antidiabetic drugs (OADs)...
August 15, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30073766/liraglutide-treatment-improves-postprandial-lipid-metabolism-and-cardiometabolic-risk-factors-in-humans-with-adequately-controlled-type-2-diabetes-a-single-centre-randomised-controlled-study
#3
Niina Matikainen, Sanni Söderlund, Elias Björnson, Kirsi Pietiläinen, Antti Hakkarainen, Nina Lundbom, Marja-Riitta Taskinen, Jan Borén
AIMS/HYPOTHESIS: Subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) exhibit considerable residual risk for cardiovascular disease (CVD). There is therefore increasing interest in targeting postprandial lipid metabolism and remnant cholesterol. Treatment with the glucagon-like peptide 1 (GLP-1) analogue liraglutide reduces CVD risk by partly unexplained mechanisms. Here we investigated the effects of liraglutide intervention on ectopic fat depots, hepatic lipogenesis and fat oxidation, postprandial lipid metabolism and glycaemia in humans with type 2 diabetes...
August 2, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30008232/-improvement-in-the-glycaemic-control-of-patients-after-switching-from-human-insulin-to-insulin-glargine-based-basal-bolus-regimen
#4
Erzsébet Nagy, Gábor Kovács
INTRODUCTION: The effectiveness of human and analogue insulins is similar but the latter have more advantageous pharmacokinetic features, leading to an improvement in hypoglycaemia and come closer to achieving the physiologic insulin profile. AIM: To demonstrate that switching from a human basal-bolus insulin treatment to an insulin glargine-based basal-bolus regimen can achieve a better glycaemic control. METHOD: This 3-month prospective, non-interventional study, including a 12-month retrospective data collection phase, enrolled patients who were switched to the insulin glargine- - 100 U/mL - based basal-bolus treatment at the time of enrolment if they were inadequately controlled and had at least one additional HbA1c result in the 12 months before the switch...
July 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29989928/modeling-subcutaneous-absorption-of-fast-acting-insulin-in-type-1-diabetes
#5
Michele Schiavon, Chiara Dalla Man, Claudio Cobelli
OBJECTIVE: Subcutaneous (sc) administration of fast-acting insulin analogues is key in conventional therapy of type 1 diabetes (T1D). A model of sc insulin absorption would be helpful for optimizing insulin therapy and test new open- and closed-loop treatment strategies in in silico platforms. Some models have been published in literature, but none was assessed on a frequently-sampled large dataset of T1D subjects. The aim here is to propose a model of sc absorption of fast-acting insulin able to describe the data and precisely estimate model parameters with a clear physiological interpretation...
December 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29977497/the-value-of-fast-acting-insulin-aspart-compared-with-insulin-aspart-for-patients-with-diabetes-mellitus-treated-with-bolus-insulin-from-a-uk-health-care-system-perspective
#6
Lalantha Leelarathna, Donna Ashley, Carrie Fidler, Witesh Parekh
Background: Fast-acting insulin aspart is a new formulation of the rapid-acting insulin analogue insulin aspart and represents an advancement over current rapid-acting insulin analogues in terms of onset of action and postprandial glucose control. The objective of the current analysis was to demonstrate the cost impact of prescribing fast-acting insulin aspart instead of insulin aspart, to highlight the value of fast-acting insulin aspart for the treatment of people with diabetes requiring mealtime insulin...
July 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29958403/influence-of-diet-and-gender-on-plasma-dpp4-activity-and-glp-1-in-patients-with-metabolic-syndrome-an-experimental-pilot-study
#7
Francisco Tomás Pérez-Durillo, Ana Belén Segarra, Ana Belén Villarejo, Manuel Ramírez-Sánchez, Isabel Prieto
Glucagon-Like Peptide-1 (GLP-1) is hydrolyzed by Dipeptidyl-Peptidase 4 (DPP4), and several studies suggest that both GLP-1 and DPP4 inhibitors have potentially beneficial effects on cardiovascular risks. The objective of this study was to analyze the differences between plasma GLP-1 and DPP4 activity in male and female patients with metabolic syndrome, and its relationship with physiological and metabolic parameters. The study included 25 apparently healthy Controls (C) and 21 Metabolic Syndrome patients (MS)...
June 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29951978/contribution-of-bhg-and-pphg-to-overall-hyperglycemia-in-t2dm-patients-treated-with-lm25-and-lm50-post-hoc-analysis-of-a-randomized-crossover-trial
#8
Wei Li, Fan Ping, Lingling Xu, Huabing Zhang, Yaxiu Dong, Hongmei Li, Qi Sun, Yuxiu Li
INTRODUCTION: To investigate the relative contribution rates of basal hyperglycemia (BHG) and postprandial hyperglycemia (PPHG) to overall hyperglycemia in patients with type 2 diabetes mellitus (T2DM) treated with insulin lispro mix 25 and 50 (LM25 and LM50) as evaluated by continuous glucose monitoring (CGM). METHODS: Eighty-one T2DM patients treated with premixed human insulin 70/30 (PHI70/30) were randomly divided into two groups and received a crossover protocol...
August 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29949429/comparison-of-cabergoline-versus-raloxifene-add-on-therapy-to-long-acting-somatostatin-analogue-in-patients-with-inadequately-controlled-acromegaly-a-randomized-open-label-clinical-trial
#9
Mehrnaz Imani, Mohammad Ebrahim Khamseh, Poopak Asadi, Mohammad Ghorbani, Hamideh Akbari, Fariba Alaei-Shahmiri, Maryam Honardoost, Mahmoud Reza Kaynama, Mojtaba Malek
OBJECTIVE: The present study aimed to evaluate the efficacy of add-on therapy of cabergoline versus raloxifene to long-acting somatostatin analogues (SAs) in patients with inadequately controlled acromegaly. METHODS: This was a prospective, randomized open label clinical trial. Forty-four patients (22 per group) completed the study; where participants received either cabergoline (3 mg/week) or raloxifene (60 mg twice daily) add-on therapy for 12 weeks in a parallel manner...
June 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29928940/physico-chemical-properties-of-co-formulated-fast-acting-insulin-with-pramlintide
#10
Dayana Cabral da Silva, Luís Maurício T R Lima
Since the discovery of amylin its use has been discouraged by the inadequacy of the protocol involving multiple injections in addition to insulin. We aimed here to develop a combined fixed-dose formulation of pramlintide with fast-acting insulin. We have investigated the compatibility of regular and fast-acting insulin analogues (Aspart, AspB28 , and LisPro, LysB28 ProB29 ) with the amylin analogue pramlintide by using electrospray ionization - ion mobility spectrometry-mass spectrometry (ESI-IMS-MS), kinetic aggregation assays monitored by thioflavin T, and transmission electron microscopy (TEM) in the evaluation of the aggregation product...
August 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29921786/the-effect-of-exercise-intensity-on-gastric-emptying-rate-appetite-and-gut-derived-hormone-responses-after-consuming-a-standardised-semi-solid-meal-in-healthy-males
#11
Lewis R Mattin, Adora M W Yau, Victoria McIver, Lewis J James, Gethin H Evans
This study investigated the acute circulating gut hormone, appetite and gastric emptying rate responses to a semi-solid meal following exercise at different intensities. Twelve men completed three trials in a randomised-crossover design, consisting of continuous cycling at 70% V˙O2Peak (HIGH), 40% V˙O2Peak (LOW) or rest (CONTROL). Baseline samples were collected after an overnight fast before undertaking the 60 min exercise or rest period, followed by 30 min rest before consumption of a standardised semi-solid meal (~242 kcal)...
June 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29899115/probing-the-correlation-between-insulin-activity-and-structural-stability-through-introduction-of-the-rigid-a6-a11-bond
#12
Shee Chee Ong, Alessia Belgi, Bianca van Lierop, Carlie Delaine, Sofianos Andrikopoulos, Christopher A MacRaild, Raymond S Norton, Naomi L Haworth, Andrea J Robinson, Briony E Forbes
The development of fast-acting and highly stable insulin analogues is challenging. Insulin undergoes structural transitions essential for binding and activation of the insulin receptor (IR), but these conformational changes can also affect insulin stability. Previously, we substituted the insulin A6-A11 cystine with a rigid, non-reducible C=C linkage ("dicarba" linkage). A cis -alkene permitted the conformational flexibility of the A-chain N-terminal helix necessary for high-affinity IR binding, resulting in surprisingly rapid activity in vivo Here, we show that, unlike the rapidly acting LysB28 ProB29 insulin analogue (KP insulin), cis -dicarba insulin is not inherently monomeric...
July 27, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29780415/comparison-of-efficacy-and-safety-of-lispro-and-aspart-evaluated-by-continuous-glucose-monitoring-system-in-patients-with-newly-diagnosed-type-2-diabetes
#13
Bing-Li Liu, Guo-Ping Yin, Feng-Fei Li, Yun Hu, Jin-Dan Wu, Mao-Yuan Chen, Lei Ye, Xiao-Fei Su, Jian-Hua Ma
Objective: To compare the effect of the rapid-acting insulin analogues (RAIAs) aspart (NovoRapid) and lispro (Prandilin) on glycemic variations by continuous glucose monitoring system (CGMS) in patients within newly diagnosed type 2 diabetes mellitus (T2DM) receiving continuous subcutaneous insulin infusion (CSII) and metformin intensive therapy. Methods: This is a single-blind randomized controlled trial. A total of 110 patients with newly diagnosed T2DM and with hemoglobin A1c (HbA1c%) above 9% was hospitalized and randomly divided into two groups: group Asp (NovoRapid group) and group Lis (Prandilin group)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29686412/short-term-effects-of-six-greek-honey-varieties-on-glycemic-response-a-randomized-clinical-trial-in-healthy-subjects
#14
Theodora Gourdomichali, Emilia Papakonstantinou
BACKGROUND/OBJECTIVES: This randomized, double blind, cross-over study investigated the glycemic response to six Greek honey grades differing in floral source and carbohydrate composition. SUBJECTS/METHODS: Eleven clinically and metabolically healthy, fasting individuals (27 ± 7 years; nine women; BMI 24 ± 4 kg/m2 ) received isoglucidic test meals (50 g available carbohydrate) and 50 g glucose reference, in random order. GI was calculated using the FAO/WHO method...
April 24, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29656504/efficacy-and-safety-of-myl-1501d-vs-insulin-glargine-in-patients-with-type-1-diabetes-after-52-weeks-results-of-the-instride-1-phase-iii-study
#15
Thomas C Blevins, Abhijit Barve, Bin Sun, Michael Ankersen
AIM: To test the safety and efficacy of MYL-1501D, a proposed insulin glargine biosimilar, in patients with type 1 diabetes mellitus (T1DM). METHODS: The safety and efficacy of MYL-1501D and reference insulin glargine were evaluated in INSTRIDE 1, a 52-week, open-label, randomized, phase III study in patients with T1DM. The primary objective was to determine whether once-daily MYL-1501D was non-inferior to once-daily insulin glargine when administered in combination with mealtime insulin lispro based on change in glycated haemoglobin (HbA1c) from baseline to week 24...
August 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29596514/characterisation-of-insulin-analogues-therapeutically-available-to-patients
#16
Gary G Adams, Andrew Meal, Paul S Morgan, Qushmua E Alzahrani, Hanne Zobel, Ryan Lithgo, M Samil Kok, David T M Besong, Shahwar I Jiwani, Simon Ballance, Stephen E Harding, Naomi Chayen, Richard B Gillis
The structure and function of clinical dosage insulin and its analogues were assessed. This included 'native insulins' (human recombinant, bovine, porcine), 'fast-acting analogues' (aspart, glulisine, lispro) and 'slow-acting analogues' (glargine, detemir, degludec). Analytical ultracentrifugation, both sedimentation velocity and equilibrium experiments, were employed to yield distributions of both molar mass and sedimentation coefficient of all nine insulins. Size exclusion chromatography, coupled to multi-angle light scattering, was also used to explore the function of these analogues...
2018: PloS One
https://www.readbyqxmd.com/read/29559408/perioperative-management-of-adult-diabetic-patients-review-of-hyperglycaemia-definitions-and-pathophysiology
#17
Gaëlle Cheisson, Sophie Jacqueminet, Emmanuel Cosson, Carole Ichai, Anne-Marie Leguerrier, Bogdan Nicolescu-Catargi, Alexandre Ouattara, Igor Tauveron, Paul Valensi, Dan Benhamou
Diabetes mellitus is defined by chronic elevation of blood glucose linked to insulin resistance and/or insulinopaenia. Its diagnosis is based on a fasting blood-glucose level of ≥1.26g/L or, in some countries, a blood glycated haemoglobin (HbA1c) level of >6.5%. Of the several forms of diabetes, type-2 diabetes (T2D) is the most common and is found in patients with other risk factors. In contrast, type-1 diabetes (T1D) is linked to the autoimmune destruction of β-pancreatic cells, leading to insulinopaenia...
June 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29524296/liraglutide-a-human-glucagon-like-peptide-1-analogue-stimulates-akt-dependent-survival-signalling-and-inhibits-pancreatic-%C3%AE-cell-apoptosis
#18
Katerina Kapodistria, Effie-Photini Tsilibary, Eleni Kotsopoulou, Petros Moustardas, Paraskevi Kitsiou
Liraglutide, a human long-lasting GLP-1 analogue, is currently regarded as a powerful treatment option for type 2 diabetes. Apart from glucoregulatory and insulinotropic actions, liraglutide increases β-cell mass through stimulation of β-cell proliferation and islet neogenesis, as well as inhibition of β-cell apoptosis. However, the underline molecular mechanisms have not been fully characterized. In this study, we investigated the mechanism by which liraglutide preserves islet β-cells in an animal model of overt diabetes, the obese db/db mice, and protects a mouse pancreatic β-cell line (βTC-6 cells) against apoptosis...
June 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29508275/eadsg-guidelines-insulin-therapy-in-diabetes
#19
Bahendeka Silver, Kaushik Ramaiya, Swai Babu Andrew, Otieno Fredrick, Sarita Bajaj, Sanjay Kalra, Bavuma M Charlotte, Karigire Claudine, Anthony Makhoba
A diagnosis of diabetes or hyperglycemia should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) (A). Typically, patients with T1DM will require initiation with multiple daily injections at the time of diagnosis. This is usually short-acting insulin or rapid-acting insulin analogue given 0 to 15 min before meals together with one or more daily separate injections of intermediate or long-acting insulin...
April 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29475006/glutamine-up-regulates-pancreatic-sodium-dependent-neutral-aminoacid-transporter-2-and-mitigates-islets-apoptosis-in-diabetic-rats
#20
Zekrayat J H Medras, Norhan M El-Sayed, Sawsan A Zaitone, Eman A Toraih, Manal M Sami, Yasser M Moustafa
BACKGROUND: Glutamine aminoacid regulates insulin exocytosis from pancreatic β-cells. Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue that has fascinated function in inhibiting β-cell apoptosis and preserving pancreatic β-cell mass. The present study investigated the benefit of adding glutamine to a regimen of liraglutide in diabetic rats focusing on their role in increasing insulin production and upregulation of the expression of sodium-dependent neutral aminoacid transporter-2 (SNAT2)...
April 2018: Pharmacological Reports: PR
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