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microRNA17

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https://www.readbyqxmd.com/read/26948077/diminution-of-signal-transducer-and-activator-of-transcription-3-signaling-inhibits-vascular-permeability-and-anaphylaxis
#1
Valerie Hox, Michael P O'Connell, Jonathan J Lyons, Paul Sackstein, Thomas Dimaggio, Nina Jones, Celeste Nelson, Manfred Boehm, Steven M Holland, Alexandra F Freeman, David J Tweardy, Ana Olivera, Dean D Metcalfe, Joshua D Milner
BACKGROUND: During IgE-mediated immediate hypersensitivity reactions, vascular endothelial cells permeabilize in response to mast cell mediators. We have demonstrated previously that patients and mice with signal transducer and activator of transcription 3 (STAT3) mutations (autosomal dominant hyper-IgE syndrome [AD-HIES]) are partially protected from anaphylaxis. OBJECTIVES: We sought to study the mechanism by which STAT3 contributes to anaphylaxis and determine whether small-molecule inhibition of STAT3 can prevent anaphylaxis...
July 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26131291/expression-of-micrornas-differed-in-the-omental-adipose-tissue-of-obese-rats
#2
Cuiju Zhi, Ying Huang, Weigang Qi, Jiajia Shen, Jinghua Tan, Haiyan Hu, Daifu Zhang
OBJECTIVE: To establish obese rat models by high-fat diet, screen microRNAs by microarray in the omental adipose tissue, and find out differential expression of microRNAs in obese rats, for further understanding the role of microRNAs as regulating molecules in obesity-induced lipid metabolism disorders. METHODS: 40 male SD rats were randomly divided into normal diet group and high-fat diet group, respectively. After fed for 8 weeks, rats were weighted, measured length and other characteristics were observed...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/20406904/microrna-17-20-inhibits-cellular-invasion-and-tumor-metastasis-in-breast-cancer-by-heterotypic-signaling
#3
Zuoren Yu, Nicole E Willmarth, Jie Zhou, Sanjay Katiyar, Min Wang, Yang Liu, Peter A McCue, Andrew A Quong, Michael P Lisanti, Richard G Pestell
microRNAs are thought to regulate tumor progression and invasion via direct interaction with target genes within cells. Here the microRNA17/20 cluster is shown to govern cellular migration and invasion of nearby cells via heterotypic secreted signals. microRNA17/20 abundance is reduced in highly invasive breast cancer cell lines and node-positive breast cancer specimens. Cell-conditioned medium from microRNA17/20-overexpressing noninvasive breast cancer cell MCF7 was sufficient to inhibit MDA-MB-231 cell migration and invasion through inhibiting secretion of a subset of cytokines, and suppressing plasminogen activation via inhibition of the secreted plasminogen activators (cytokeratin 8 and alpha-enolase)...
May 4, 2010: Proceedings of the National Academy of Sciences of the United States of America
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