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Liver And Surgery

Kuei-Yen Tsai, Hsin-An Chen, Wan-Yu Wang, Ming-Te Huang
BACKGROUND: Pulmonary complications remain relatively high in morbidities that arise after liver surgery and are associated with increased length of hospital stay and higher cost. Identification of possible risk factors in this retrospective analysis may help reduce operative morbidity and achieve better outcomes. METHODS: In all, 363 consecutive patients underwent elective hepatectomies between July 2008 and November 2013 and these were identified and analyzed retrospectively...
December 5, 2018: Digestive Surgery
Frederico Ribeiro Deliberador, Aline Monise Sebastiani, Jennifer Gerber, Luana Bonetto, Gabriela Tórtora, Allan Fernando Giovanini, Tatiana Miranda Deliberador, Joao César Zielak, Rafaela Scariot
This study aimed to evaluate the effect of two methods of local application of alendronate and parathyroid hormone (PTH) on bone repair and the systemic implications. A critically sized defect (5 mm) was created in the cranial region of twenty-five male Wistar rats, and the bone removed was particulated, and grafted back to the defect with different treatments. The animals were randomly divided into five groups: A1- bone graft immersion in alendronate solution (3 mg/kg) for 5 minutes; P1- bone graft immersion in PTH solution (20 µg); A2- weekly local applications of alendronate 1 mg/kg; P2- weekly local applications of PTH (20 µg); C- no drugs were used...
September 2018: Brazilian Dental Journal
Maria Angélica Baron Magalhães, Andy Petroianu, Alfredo José Afonso Barbosa, Juliano Alves Figueiredo, Luiz Ronaldo Alberti, Jurandir Marcondes Ribas Filho
PURPOSE: To evaluate the hepatic changes associated with gastric ischemia. METHODS: Thirty male rabbits were studied, distributed in 3 groups (n=10). Group 1: ligature and section of the gastric vasculature and removal of the liver after three hours; Group 2: ligature and section of the gastric vasculature and removal of the liver after 6 hours; Group 3: ligature and section of the gastric vasculature and removal of the liver after 12 hours. Blood samples were collected immediately before surgery and after the determined time of ischemia in each group to evaluate the hepatic function...
November 2018: Acta Cirúrgica Brasileira
Zong Jie Koh, Hrishikesh Pandurang Salgaonkar, Wei Jie Jonathan Lee, Guo Wei Kim, Chun Hai Tan, Anton Cheng, Davide Lomanto, Jimmy Bok Yan So, Yock Young Dan, Asim Shabbir
PURPOSE: Incidence of non-alcoholic fatty liver disease (NAFLD) is on the rise and is one of the most common causes of chronic liver disease worldwide. Obesity and metabolic syndrome are considered the most significant risk factors. Bariatric surgery is the only treatment modality in morbid obesity which allows long-term weight loss with improvement in associated co-morbid conditions. However, the effects of bariatric surgery on NAFLD are not well established. NAFLD fibrosis score (NFS) is a validated non-invasive scoring system used to assess advanced fibrosis...
December 4, 2018: Obesity Surgery
Heng Zhou, Guomin Xie, Yudi Mao, Ke Zhou, Ruixue Ren, Qihong Zhao, Hua Wang, Shi Yin
Liver ischemia-reperfusion injury (IRI) and regeneration deficiency are two major challenges for surgery patients with chronic liver disease. As a survival factor for hepatocytes, interleukin 22 (IL-22) plays an important role in hepatoprotection and the promotion of regeneration after hepatectomy. In this study, we aim to investigate the roles of an interleukin 22 fusion protein (IL-22-FP) in mice with a predamaged liver after a two-third partial hepatectomy (PHx). Predamaged livers in mice were induced by concanavalin A (ConA)/carbon tetrachloride (CCl4) following PHx with or without IL-22-FP treatment...
2018: Journal of Immunology Research
Mohammad Golriz, Omid Ghamarnejad, Elias Khajeh, Mohammadsadegh Sabagh, Markus Mieth, Katrin Hoffmann, Alexis Ulrich, Thilo Hackert, Karl Heinz Weiss, Peter Schirmacher, Markus W Büchler, Arianeb Mehrabi
Background: It is a novel idea that platelet counts may be associated with postoperative outcome following liver surgery. This may help in planning an extended hepatectomy (EH), which is a surgical procedure with high morbidity and mortality. Aim: The aim of this study was to evaluate the predictive potential of platelet counts on the outcome of EH in patients without portal hypertension, splenomegaly, or cirrhosis. Methods: A series of 213 consecutive patients underwent EH (resection of ≥ five liver segments) between 2001 and 2016...
2018: Canadian Journal of Gastroenterology & Hepatology
Laith Mukdad, William Toppen, Son Nguyen, Kwang Kim, Abie H Mendelsohn, Ali Zarrinpar, Peyman Benharash
INTRODUCTION: Postoperative dysphagia leads to aspiration pneumonia, prolonged hospital stay, and is associated with increased mortality. We have demonstrated the validity of a bedside targeted swallow evaluation following cardiac surgery. Since dysphagia following liver transplantation is not well examined, we evaluated the efficacy of this swallow screen method in postoperative liver transplant patients. METHODS: This was a prospective trial involving adult patients who underwent liver transplant surgery at our institution over a 5-month period...
December 4, 2018: Progress in Transplantation
Yi Liang, Edward Lo-Cao, Gratian Punch, Vincent Lam, Arthur Richardson
BACKGROUND: There is growing interest in publishing trends given the increasing amount of research publication across various specialities. Studies relating to hepato-pancreato-biliary (HPB) surgery show an oncological focus compared to benign, emergency and trauma. METHODS: Analysis of ISI JCR impact factors in the Web of Knowledge and the Scimago Journal Rank through Scopus was performed to select four readily available, relevant and frequently read journals from the surgery category...
December 4, 2018: ANZ Journal of Surgery
Grace Gold, Su Kah Goh, Christopher Christophi, Vijayaragavan Muralidharan
INTRODUCTION: Serum carbohydrate antigen 19-9 (CA19-9) is routinely used in the management of pancreatic cancer for diagnosis, prognostication and surveillance purposes despite its low specificity. CASE PRESENTATION: This case report demonstrates the challenges of interpreting elevated serum CA19.9 levels in a patient with pancreatic cancer. We performed a Whipple's procedure in an otherwise fit 78-year-old man for pancreatic adenocarcinoma. One year after surgery, he presented with a non-malignant anastomotic stricture that was associated with an elevated serum CA19-9...
November 20, 2018: International Journal of Surgery Case Reports
(no author information available yet)
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period...
December 2018: BJS open
John Griniatsos, Dimitris Trafalis
The Dutch D1D2 Trial revealed a noncompliance rate of 51% in gastric cancer patients who should have undergone a D2 dissection, while it disclosed that the D2 lymph node dissection group of patients exhibited a higher 15-year overall survival (OS) rate, lower rates of local and regional recurrence, lower rates of liver metastases and lower cancer-related death rates compared to the D1 group, implying that the surgical technique per se may influence outcomes. On the other hand, the predominant up-regulation of invasive and metastatic genes in the Western tumor libraries, the differences in the criteria used for gastric cancer diagnosis in the East and the steady fnding that the Asian ethnicity is a favorable prognostic factor for patients with gastric cancer treated in the US, have been proposed as possible explanations for the differences observed in the gastric cancer outcome between the East and the West...
September 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Athina Chasapi, Kostas Balampanis, Eleni Kourea, Fotios Kalfarentzos, Vaia Lambadiari, George I Lambrou, Maria Melachrinou, Georgia Sotiropoulou-Bonikou
OBJECTIVES: Obesity is characterized by a chronic, low grade, systemic inflammation. However, little is known about the role of skeletal muscle, which represents an active metabolic organ whose activities need to be determined. The purpose of our study was to detect relationships between skeletal muscle and adipose tissue inflammation with nonalcoholic fatty liver disease (NAFLD) and diabetes, as well as to explore associations with clinicopathological parameters. METHODS: Our study population consisted of 50 morbidly obese patients undergoing planned bariatric surgery...
December 1, 2018: Journal of Musculoskeletal & Neuronal Interactions
Guido Torzilli, Luca Viganò
No abstract text is available yet for this article.
December 3, 2018: Annals of Surgical Oncology
Feng Xu, Bin Tang, Tian-Qiang Jin, Chao-Liu Dai
Liver metastasis (LM) is one of the major causes of death in patients with colorectal cancer (CRC). Approximately 60% of CRC patients develop LM during the course of their illness. About 85% of these patients have unresectable disease at the time of presentation. Surgical resection is currently the only curative treatment for patients with colorectal LM (CRLM). In recent years, with the help of modern multimodality therapy including systemic chemotherapy, radiation therapy, and surgery, the outcomes of CRLM treatment have significantly improved...
November 26, 2018: World Journal of Clinical Cases
Weiwei Zhang, Mujian Teng, Baochi Liu, Qiling Liu, Xin Liu, Yanhui Si, Lei Li
Objective: This study is aimed at examining the impact of repeated intraportal autologous bone marrow transfusion (ABMT) in patients with decompensated liver cirrhosis after splenectomy. Methods: A total of 25 patients with decompensated liver cirrhosis undergoing splenectomy were divided into ABMT and control groups. The portal vein was cannulated intraoperatively using Celsite Implantofix through the right gastroomental vein. Both groups were given a routine medical treatment...
2018: Gastroenterology Research and Practice
Sina Bagheri, Shahrbanoo Shahbazi, Masih Shafa, Afshin Borhani-Haghighi, Mahsa Kiani, Mohammad Mahdi Sagheb
Background: Remote ischemic preconditioning (RIPC) protects other organs from subsequent lethal ischemic injury, but uncertainty remains. We investigated if RIPC could prevent acute kidney injury (AKI) in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: This parallel-group, double-blind, randomized, controlled trial was done on adults undergoing elective or urgent on-pump CABG surgery from 2013 to 2017 in Shiraz, Iran. Patients were allocated to RIPC or control groups through permuted blocking...
November 2018: Iranian Journal of Medical Sciences
Muhammad Nadeem Cheema, Anam Nazir, Bin Sheng, Ping Li, Jing Qin, Jinman Kim, Dagan Feng
During hepatic minimal invasive surgery (MIS), 3D reconstruction of a liver surface by interpreting the geometry of its soft-tissues is achieving attractions. One of the major issues to be addressed in MIS is liver deformation. Moreover, it severely inhibits free sight and dexterity of tissue manipulation which causes its intra-operative morphology and soft tissue motion altered as compared to its pre-operative shape. While many applications focus on 3D reconstruction of rigid or semi-rigid scenes, the techniques applied in hepatic MIS must be able to cope with a dynamic and deformable environment...
November 30, 2018: IEEE Transactions on Bio-medical Engineering
Vanessa P Ho, Nicholas K Schiltz, Andrew P Reimer, Elizabeth A Madigan, Siran M Koroukian
BACKGROUND/OBJECTIVES: Over a million older patients in the United States are admitted yearly for emergency general surgery (EGS) conditions. Seven procedure types dominate: colon, small bowel, gallbladder, ulcer disease, adhesiolysis, appendix, and laparotomy operations. A higher comorbidity burden is known to increase mortality in this population, but the impact of specific comorbidity combinations is unknown. Our objectives were to (1) characterize the distribution of procedures, comorbidities, and outcomes for older patients undergoing EGS; and (2) apply a data-driven approach (association rule mining) to identify comorbidity combinations associated with disproportionately high mortality...
December 2, 2018: Journal of the American Geriatrics Society
Xionghu Shen, Xian Cui, Hai Cui, Yongmin Jin, Wenbiao Jin, Honghua Sun
OBJECTIVES: Hepatocarcinoma is one of the most lethal cancers, leading to a 5-year survival rate as low as 30% due to recurrence and metastasis. The treatment of liver cancer includes surgery and medication, of which, the former is more effective. However, surgical resection is applicable in less than 40% of patients. Therefore, it is imperative to find effective medication options for liver cancer therapy. METHODS: In this study, we found that two natural products, geraniol and lupeol, had antiproliferative and proapoptotic effects on the hepatocarcinoma cell lines SMMC7721 and HepG2...
December 2, 2018: Journal of Cellular Biochemistry
Lingquan Wang, Wei Xu, Xuexin Yao, Chao Yan, Chen Li, Zhenggang Zhu, Wentao Liu, Min Yan
OBJECTIVE: To investigate the clinical characteristics and prognostic factors of reoperation patients with postoperative recurrence or metastasis of gastrointestinal stromal tumor (GIST). METHODS: A retrospective case-control study was performed on the clinical data of 31 patients with GIST who had recurrence or metastasis after the first surgery and underwent one or more operations again from February 2003 to January 2016 at Ruijin Hospital, Shanghai Jiaotong University School of Medicine...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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