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Judith Heinzler, Janina Brucker, Thomas Bruckner, Christine Dinkic, Janine Hoffmann, Nadja Dornhöfer, Stephan Seitz, Christof Sohn, Joachim Rom, Timm C Schott, Sarah Schott
PURPOSE: In this case-control study, the impact on quality of life and sexual function in women with cervical dysplasia and conization will be evaluated, in order to address coping with such a premalignant lesion and to improve strategies for salutogenesis. METHODS: This multicenter case-control study evaluates women at special dysplasia outpatient clinic (T1) as well as 3 (T2) and 6 (T3) months after the diagnosis of a dysplasia. The women were subgrouped upon dysplasia only (S2) or dysplasia with conization (S1)...
August 3, 2018: Archives of Gynecology and Obstetrics
Jill H Tseng, Alessia Aloisi, Yukio Sonoda, Ginger J Gardner, Oliver Zivanovic, Nadeem R Abu-Rustum, Mario M Leitao
OBJECTIVE: This study aimed to evaluate oncologic outcomes of women with stage IB1 cervical cancer treated with uterine-preserving surgery (UPS) (defined as conization or trachelectomy) versus non-UPS (defined as hysterectomy of any type). METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify women younger than 45 years diagnosed with stage IB1 cervical cancer from 1998 to 2012. Only those who underwent lymph node (LN) assessment were included...
July 20, 2018: International Journal of Gynecological Cancer
Joël Fokom Domgue, Kathleen M Schmeler
Recent advances in screening and early diagnosis have decreased cervical cancer incidence and mortality rates in high-resource settings. The postponement of childbearing, combined with an increased number of cervical cancer survivors, has yielded new paradigms in patient care. In recent years, radical surgery has been challenged as the standard of care for early-stage cervical cancer owing to its significant morbidity and fertility impairment. Attention has been directed to assessing more conservative procedures that can reduce treatment-induced morbidity without compromising oncologic safety and reproductive potential of patients with early-stage disease...
June 28, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Yuyeon Jung, Ah Ra Lee, Sung-Jong Lee, Yong Seok Lee, Dong Choon Park, Eun Kyung Park
Objective: This study aimed to determine the factors affecting pathologic discrepancy and final diagnosis between colposcopic biopsy and pathology by loop electrosurgical excision procedure (LEEP). Methods: Between 2004 and 2016, 1,200 patients who underwent LEEP were enrolled for this study. 667 underwent cervical cytology, human papillomavirus (HPV) test, colposcopic biopsy, and LEEP. We analyzed patient's age, menopausal status, number of delivery, abortion times, cervical cytology, number of punch biopsies, HPV type, LEEP, and interval between colposcopic biopsy and LEEP...
July 2018: Obstetrics & Gynecology Science
Geum Joon Cho, Yung-Taek Ouh, Log Young Kim, Tae-Seon Lee, Geun U Park, Ki Hoon Ahn, Soon-Cheol Hong, Min-Jeong Oh, Hai-Joong Kim
BACKGROUND: The aim of this study was to determine the effect of cerclage in women who underwent cervical conization. METHODS: Study data were collected from the Korea National Health Insurance Claims Database of the Health Insurance Review and Assessment Service for 2009-2013. Women who had a conization in 2009 and a subsequent first delivery between 2009 and 2013 in Korea were enrolled. RESULTS: Among the women who had conization in 2009, 1075 women had their first delivery between 2009 and 2013...
July 3, 2018: BMC Pregnancy and Childbirth
Lukas Dostalek, Elisabeth Åvall-Lundqvist, Carien L Creutzberg, Dina Kurdiani, Jordi Ponce, Iva Dostalkova, David Cibula
OBJECTIVE: The aim of this survey was to acquire an overview of the current management of cervical cancer with an emphasis on the early disease stages. MATERIALS AND METHODS: A hyperlink to the survey was sent to the European Society of Gynaecological Oncology Office database. The survey contained 6 groups of questions regarding the characteristics of respondents, pretreatment workup, management of the early stages of cervical cancer, adjuvant treatment, fertility-sparing treatment, and surveillance...
July 2018: International Journal of Gynecological Cancer
Jill H Tseng, Alessia Aloisi, Yukio Sonoda, Ginger J Gardner, Oliver Zivanovic, Nadeem R Abu-Rustum, Mario M Leitao
BACKGROUND: Standard surgical treatment for women with stage IB1 cervical cancer consists of radical hysterectomy. This study assesses survival outcomes of those treated with less radical surgery (LRS; conization, trachelectomy, simple hysterectomy) compared to more radical surgery (MRS; modified radical, radical hysterectomy). METHODS: Using the Surveillance, Epidemiology and End Results database, we identified women <45 years with FIGO stage IB1 cervical cancer diagnosed from 1/1998 to 12/2012...
July 2018: Gynecologic Oncology
Chalaithorn Nantasupha, Kittipat Charoenkwan
OBJECTIVE: To determine factors affecting voiding recovery on the day of Foley catheter removal (postoperative day 7, POD7) after nerve-sparing radical hysterectomy (NSRH) for early-stage cervical cancer. METHODS: Early-stage cervical cancer patients, who underwent type C1 radical hysterectomy between January 2006 and June 2016 were included. Clinical and pathological data were reviewed. Association between inability to attain adequate voiding function on POD7 and potential predicting factors were evaluated in univariate and multivariate analysis...
July 2018: Journal of Gynecologic Oncology
Yi Jou Tai, Yun Yuan Chen, Huang Cheng Hsu, Chun Ju Chiang, San Lin You, Chi An Chen, Wen Fang Cheng
OBJECTIVE: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements. METHODS: Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model...
July 2018: Journal of Gynecologic Oncology
U Chul Ju, Woo Dae Kang, Seok Mo Kim
OBJECTIVE: Because villoglandular adenocarcinoma (VGA) of the uterine cervix has favorable features and outcomes, patients receive less radical surgery and young women preserve their ovaries. We aimed to evaluate the clinicopathological features and outcomes of VGA and to see if the ovarian preservation is safe in young women with VGA. METHODS: We retrospectively reviewed medical records and identified patients with VGA, who had been treated and followed from January 2004 to December 2015...
July 2018: Journal of Gynecologic Oncology
Mikio Mikami, Masae Ikeda, Hidetaka Sato, Haruko Iwase, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi
OBJECTIVE: To evaluate the clinical efficiency of identifying patients with suspicious severe lesions by conization among prediagnosed cervical intraepithelial neoplasia (CIN) 1 and 2 patients in Japan. METHODS: The data in a Japanese nation-wide registry for cervical cancer (2009 and 2011) was collected to analyze the clinical efficacy of pre- and postdiagnosis for 13,215 Japanese women who underwent treatment by conization. Their preoperative and postoperative histologic findings and clinical outcomes were evaluated using standard statistical procedures including clinical and demographic characteristics...
July 2018: Journal of Gynecologic Oncology
Aiping Fan, Chen Wang, Cha Han, Yingmei Wang, Fengxia Xue, Liqin Zhang
To identify factors for predicting residual or recurrent cervical intraepithelial neoplasia (CIN) after cervical conization with negative margins. A total of 172 patients with histologically verified high-grade squamous intraepithelial lesions who underwent conization with negative margins were recruited at the General Hospital of Tianjin Medical University from December 2006 to January 2016. Follow-up comprised clinical examination, a liquid-based cytology test, a human papillomavirus (HPV) DNA genotyping test, colposcopy assessment, and if indicated, colposcopy-directed punch biopsy...
September 2018: Journal of Medical Virology
D Schmidt
Of the numerous aspects involved in the diagnosis, treatment, and follow-up of cervical uterine precursor lesions, epidemiology, virology, cytology, human papillomavirus (HPV) testing, and diagnostic algorithms for equivocal and HPV-positive findings are important for pathologists. Cytology will continue to be used as a preventive medical check-up in young women, while HPV-based screening is suggested for older women. HPV screening has yielded a significant reduction in cancer precursors and invasive cervical carcinoma in numerous studies...
May 2018: Der Pathologe
Igor Aluloski, Mile Tanturovski, Gordana Petrusevska, Rubens Jovanovic, Slavica Kostadinova-Kunovska
AIM: To evaluate the factors that influence the surgical margin state in patients undergoing cold knife conization at the University Clinic of Gynecology and Obstetrics in Skopje, Republic of Macedonia Materials and methods: We have retrospectively analyzed the medical records of all patients that underwent a cold knife conization at our Clinic in 2015. We cross-referenced the surgical margin state with the histopathological diagnosis (LSIL, HSIL or micro-invasive/invasive cancer), menopausal status of the patients, number of pregnancies, surgeon experience, operating time and cone depth...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Katrin Ochs, Gesine Meili, Joachim Diebold, Volker Arndt, Andreas Günthert
Objective: Cervical cancer (CC) screening by Pap smears has led to a decrease in the incidence of CC worldwide. Indeed, the incidence of CC in Switzerland is very low; however, there is a lack of data to evaluate the efficiency of the Pap smear as a screening tool. Until now, only Pap smears have been used and other methods such as the presence of an infection with HPV have not been integrated into the routine screening. The aim of this study is to evaluate trends in the incidence of CC and its precancerous lesions in Central Switzerland, which represents a rural region, with those in urban regions and the entire country of Switzerland...
2018: Frontiers in Medicine
Y Song, Q Wang, L Sui, S J Gao
Objective: To evaluate the accuracy of colposcopic biopsy on diagnosis of cervical adenocarcinoma in situ (AIS) and the clinical significance of loop electrosurgical excisional procedure (LEEP) on diagnosis and treatment of AIS and invasive adenocarcinoma. Methods: All medical records of 193 patients diagnosed as AIS by colposcopic biopsy and (or) AIS or invasive adenocarcinoma diagnosed by LEEP conization from Jan. 2015 to Dec. 2016 in Obstetrics and Gynecology Hospital of Fudan University were retrospectively reviewed...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
Eliana Montanari, Christoph Grimm, Richard Schwameis, Lorenz Kuessel, Stephan Polterauer, Chiara Paternostro, Heinrich Husslein
OBJECTIVE: To explore whether a surgeon's training level influences the rate of incomplete resections or the amount of resected cervical tissue in women treated with large loop excision of the transformation zone (LLETZ). METHODS: The present study is a retrospective analysis of the data of women who had undergone LLETZ for cervical intraepithelial neoplasia (CIN) within the years 2004-2008 at the Medical University of Vienna. Women were grouped according to the level of training of the operating surgeon (i...
June 2018: Archives of Gynecology and Obstetrics
K Ulrich Petry, Pekka J Nieminen, Simon C Leeson, Christine O M A Bergeron, Charles W E Redman
A refinement of quality indicators (QIs) is described whereby the quality of care can be measured across colposcopy services in different countries and healthcare settings. A five-round Delphi process was conducted at successive satellite meetings from 2011 to 2015 of leading European colposcopists to refine the most high-scoring QIs relevant to colposcopic practice. A review and refinement of the wording of the standards and their criteria was undertaken by national society representatives. Six quality indicators were identified and refined...
May 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
K Ichizuka, K Seo, S Dohi, T Ishikawa, A Sekizawa, M Nagatsuka
No abstract text is available yet for this article.
May 2018: Ultrasound in Obstetrics & Gynecology
Lucas Minig, Anna Fagotti, Giovanni Scambia, Gloria Salvo, María Guadalupe Patrono, Dimitrios Haidopoulos, Ignacio Zapardiel, Santiago Domingo, Maria Sotiropoulou, Gary Chisholm, Pedro T Ramirez
OBJECTIVE: To determine the incidence of lymph node metastasis in women with low-risk cervical cancer stage IA2 or IB1 (<2 cm) without lymph-vascular space invasion. METHODS: A multicenter retrospective study was performed in patients who underwent radical or simple hysterectomy, conization, or trachelectomy plus pelvic lymphadenectomy for cervical cancer between January 2000 and June 2016. RESULTS: A total of 271 patients were included in the study...
May 2018: International Journal of Gynecological Cancer
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