Maja Skov Kragsnaes, Jennifer Rugaard Bregndahl Jensen, Anna Christine Nilsson, Muhammad Irfan Malik, Heidi Lausten Munk, Jens Kristian Pedersen, Hans Christian Horn, Mogens Kruhøffer, Karsten Kristiansen, Benjamin H Mullish, Julian R Marchesi, Jens Kjeldsen, Richard Röttger, Torkell Ellingsen
OBJECTIVES: The gut microbiota can mediate both pro and anti-inflammatory responses. In patients with psoriatic arthritis (PsA), we investigated the impact of faecal microbiota transplantation (FMT), relative to sham transplantation, on 92 inflammation-associated plasma proteins. METHODS: This study relates to the FLORA trial cohort, where 31 patients with moderate-to-high peripheral PsA disease activity, despite at least 3 months of methotrexate treatment, were included in a 26-week, double-blind, randomised, sham-controlled trial...
January 30, 2024: RMD Open