Fayez Kheir, Juan Pablo Uribe Becerra, Brittany Bissell, Marya Ghazipura, Derrick Herman, Stephanie M Hon, Tanzib Hossain, Yet H Khor, Shandra L Knight, Michael Kreuter, Madalina Macrea, Manoj J Mammen, Fernando J Martinez, Venerino Poletti, Lauren Troy, Ganesh Raghu, Kevin C Wilson
Background: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis (IPF), the prototypical interstitial lung disease (ILD). Diagnosis of IPF requires that a typical UIP pattern be identified by using high-resolution chest computed tomography or lung sampling. A genomic classifier for UIP has been developed to predict histopathologic UIP by using lung samples obtained through bronchoscopy. Objective: To perform a systematic review to evaluate genomic classifier testing in the detection of histopathologic UIP to inform new American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax guidelines...
May 2022: Annals of the American Thoracic Society