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https://www.readbyqxmd.com/read/30304047/unilateral-electrical-stimulation-of-the-heart-7-acupuncture-point-to-prevent-emergence-agitation-in-children-a-prospective-double-blinded-randomized-clinical-trial
#1
Nobuhito Nakamura, Takahiro Mihara, Toshiyuki Hijikata, Takahisa Goto, Koui Ka
BACKGROUND: Emergence agitation (EA) is a frequent phenomenon in children recovering from general anaesthesia and increases the risk of self-injury. Previously, our group reported that stimulating the heart 7 (HT7) acupuncture point bilaterally using two neuromuscular transmission monitoring devices (NTMs) decreased the incidence of EA. However, bilateral stimulation is a barrier to clinical use because two NTMs are needed for one patient. OBJECTIVE: The objective of this study was to examine the efficacy of unilateral electrical stimulation of HT7 using an NTM to prevent EA in children...
2018: PloS One
https://www.readbyqxmd.com/read/30093367/the-use-of-aspirin-to-reduce-the-risk-of-thrombotic-events-in-patients-with-end-stage-renal-disease-protocol-for-a-randomized-controlled-trial
#2
Tiago Lemos Cerqueira, Armando Fartolino Guerrero, Clara Krystal Pérez Fermin, Ricardo Wang, Evelin Elfriede Balbino, Janis L Breeze, Paola Gonzalez Mego, Daniele Argentina Silva, Walid Ezzeldin Omer, Nathalie Monique Vandevelde
BACKGROUND: End-stage renal disease (ESRD) is the last stage of chronic kidney disease, mainly caused by type 2 diabetes mellitus and characterized by an increased mortality risk related to cardiovascular disease. Low-dose aspirin (acetylsalicylic acid or ASA) seems to effectively prevent cardiovascular events in patients with ESRD. However, the number of interventional studies in this population remains limited and the mechanisms of aspirin-related bleeding remain poorly understood. Aspirin's efficacy and safety may be modified by the presence of type 2 diabetes mellitus or platelet hyperreactivity...
August 9, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30086742/effects-of-medication-reviews-on-use-of-potentially-inappropriate-medications-in-elderly-patients-a-cross-sectional-study-in-swedish-primary-care
#3
Cecilia Lenander, Åsa Bondesson, Nina Viberg, Anders Beckman, Patrik Midlöv
BACKGROUND: Drug use among the elderly population is generally extensive and the use of potentially inappropriate medications (PIMs) is common, which increases the risk for drug-related problems (DRP). Medication reviews are one method to improve drug therapy by identifying, preventing and solving DRPs. The aim of this study was to evaluate the effect of medication reviews on total drug use and potentially inappropriate drug use in elderly patients, as well as describe the occurrence and types of drug-related problems...
August 7, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/30004572/antiplatelet-and-anticoagulant-agents-for-primary-prevention-of-thrombosis-in-individuals-with-antiphospholipid-antibodies
#4
REVIEW
Malgorzata M Bala, Elżbieta Paszek, Wiktoria Lesniak, Dorota Wloch-Kopec, Katarzyna Jasinska, Anetta Undas
BACKGROUND: Antiphospholipid syndrome (APS) is an autoimmune disease characterised by the presence of antiphospholipid (aPL) antibodies that have prothrombotic activity. Antiphospholipid antibodies are associated with an increased risk of pregnancy complications (recurrent miscarriage, premature birth, intrauterine growth retardation) and thrombotic events (both arterial and venous). The most common thrombotic events include brain ischaemia (stroke or transient ischaemic attack) and deep vein thrombosis...
July 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30002694/standardised-tomato-extract-as-an-alternative-to-acetylsalicylic-acid-in-patients-with-primary-hypertension-and-high-cardiovascular-risk-a-randomised-controlled-trial
#5
Beata Krasinska, Angelika Osińska, Maciej Osinski, Aleksandra Krasinska, Piotr Rzymski, Andrzej Tykarski, Zbigniew Krasiński
Introduction: Cardiovascular (CV) diseases remain a leading global cause of death. It has been proven that the use of acetylsalicylic acid (ASA) in secondary prevention reduces the CV risk, while the benefits of ASA in primary prevention have recently been debated. The aim of the study was to compare the antiplatelet effect of standardised tomato extract (STE) and ASA in hypertensive patients with high CV risk. Material and methods: The study involved high-risk patients with arterial hypertension (AH) randomly assigned to one of two groups: group 1 included 33 patients receiving ASA and group 2 included 32 patients receiving STE...
June 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29984591/does-continuation-of-low-dose-aspirin-during-robot-assisted-radical-prostatectomy-compromise-surgical-outcomes
#6
Ashwin Sunil Tamhankar, Saurabh Ramesh Patil, Puneet Ahluwalia, Gagan Gautam
OBJECTIVE: To evaluate the perioperative outcomes and 90-day complication rates of continuation of low-dose aspirin through surgery in patients undergoing robot-assisted radical prostatectomy (RARP). A significant proportion of patients undergoing RARP are on antiplatelet medications for primary or secondary prevention of cardiovascular events. However, there is still a relative lack of data with regard to the advantages and complications of continuing these medications through surgery...
September 12, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29890982/effectiveness-of-a-package-of-postpartum-family-planning-interventions-on-the-uptake-of-contraceptive-methods-until-twelve-months-postpartum-in-burkina-faso-and-the-democratic-republic-of-congo-the-yam-daabo-study-protocol
#7
Nguyen Toan Tran, Mary Eluned Gaffield, Armando Seuc, Sihem Landoulsi, Wambi Maurice E Yamaego, Asa Cuzin-Kihl, Seni Kouanda, Blandine Thieba, Désiré Mashinda, Rachel Yodi, James Kiarie, Suzanne Reier
BACKGROUND: Postpartum family planning (PPFP) information and services can prevent maternal and child morbidity and mortality in low-resource countries, where high unmet need for PPFP remains despite opportunities offered by routine postnatal care visits. This study aims to identify a package of PPFP interventions and determine its effectiveness on the uptake of contraceptive methods during the first year postpartum. We hypothesize that implementing a PPFP intervention package that is designed to strengthen existing antenatal and postnatal care services will result in an increase in contraceptive use...
June 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29804325/patent-foramen-ovale-closure-for-patients-with-cryptogenic-stroke-a-systematic-review-and-comprehensive-meta-analysis-of-5-randomized-controlled-trials-and-14-observational-studies
#8
Xi Chen, Shi-Dong Chen, Yi Dong, Qiang Dong
BACKGROUND: Previous review from randomized controlled trials (RCT) showed that patients with cryptogenic stroke may benefit from patent foramen ovale (PFO) closure. However, the findings from the systematic review were not clear when observational studies were also included. METHODS: We searched MEDLINE, Embase, and Cochrane databases. The primary endpoints were recurrent stroke or transient ischemic attack (TIA). The secondary outcomes were all-cause death, atrial fibrillation (AF), and hemorrhagic events...
October 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29775142/aspirin-for-primary-prevention-of-stroke-in-traumatic-cerebrovascular-injury-association-with-increased-risk-of-transfusion
#9
Russell L Griffin, Stephanie R Falatko, Stella Aslibekyan, Virginia Strickland, Mark R Harrigan
OBJECTIVE Blunt traumatic extracranial carotid or vertebral artery injury (i.e., traumatic cerebrovascular injury [TCVI]) occurs in 1%-2% of all blunt trauma admissions, carries a 10% risk of thromboembolic ischemic stroke, and accounts for up to 9600 strokes annually in the US. Screening CT angiograms (CTAs) of patients with trauma has become ubiquitous in recent years, and patients with initially asymptomatic TCVI are commonly treated with antiplatelet agents to prevent stroke. Prophylaxis with antiplatelets is thought to be safer than anticoagulation, which carries a significant risk of hemorrhage in patients with trauma...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29771804/preemptive-analgesia-decreases-pain-following-anorectal-surgery-a-prospective-randomized-double-blinded-placebo-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Justin T Van Backer, Matthew R Jordan, Danielle T Leahy, Jesse S Moore, Peter Callas, Timothy Dominick, Peter A Cataldo
BACKGROUND: Postoperative pain is a frequent cause for delayed discharge following outpatient procedures, including anorectal surgery. Both central and peripheral pain receptor sensitization are thought to contribute to postoperative pain. Blocking these receptors and preempting sensitization prevents hyperalgesia leading to lower pain medication requirements. Studies in the orthopedic, urologic, and gynecologic literature support this practice, but the use of preemptive analgesia in anorectal surgery is understudied...
July 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29757761/aspirin-resistance-cardiovascular-risk-game-changer
#11
Ahmed S Yassin, Hossam Abubakar, Tushar Mishra, Ahmed Subahi, Melanie Hartman, Abdelrahman Ahmed, Walid Ibrahim, Manmohan Singh, Mohit Pahuja
BACKGROUND: Aspirin (ASA) is the most used medication on the globe. ASA is a primary pillar of the secondary prevention of cardiovascular atherothromboembolic events. However, a fraction of the population does not respond to ASA as expected in a unique phenomenon called ASA resistance. Multiple mechanisms were described and studied in the literature to explain this phenomenon. AREA OF UNCERTAINTY: ASA resistance is an interesting phenomenon that is worth studying and reviewing...
May 3, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29682714/-factors-associated-with-anastomotic-leakage-after-anterior-resection-in-rectal-cancer
#12
Kai Deng, Jianli Zhang, Xiuli Jiang, Shuai Feng
OBJECTIVE: To investigate the factors associated with the anastomotic leakage after anterior resection in rectal cancer. METHODS: From January 2014 to January 2017 471 patients underwent Dixon procedure for rectal cancer in The Affiliated Hospital of Qingdao University. The data of those patients was collected and reviewed retrospectively. Inclusion criteria included: 1) rectal cancer confirmed by preoperative electron colonoscopy; 2) the standard of total mesorectal excision followed by the surgeon during the surgery; and 3) elective surgery...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29625599/a-healthy-school-start-plus-for-prevention-of-childhood-overweight-and-obesity-in-disadvantaged-areas-through-parental-support-in-the-school-setting-study-protocol-for-a-parallel-group-cluster-randomised-trial
#13
Liselotte Schäfer Elinder, Emma Patterson, Gisela Nyberg, Åsa Norman
BACKGROUND: Systematic reviews conclude that interventions to prevent overweight and obesity in children obtain stronger effects when parents are involved. Parenting practices and parent-child interactions shape children's health-related behaviours. The Healthy School Start Plus intervention aims to promote healthy dietary habits and physical activity and prevent obesity in children through parental support in disadvantaged areas with increased health needs, delivered by teachers and school nurses...
April 6, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29570108/intra-operative-lidocaine-in-the-prevention-of-vomiting-after-elective-tonsillectomy-in-children-a-randomised-controlled-trial
#14
Ghislaine C Echevarría, Fernando R Altermatt, Sebastian Paredes, Valentina Puga, Hernán Auad, Ana M Veloso, María F Elgueta
BACKGROUND: Postoperative vomiting (POV) is a frequent complication of tonsillectomy in children. In adult patients undergoing abdominal surgeries, the use of intravenous lidocaine infusion can prevent POV. OBJECTIVE: To evaluate the anti-emetic effect of an intravenous lidocaine infusion used as an adjuvant to general anaesthesia, in children undergoing elective ear, nose and throat surgery. DESIGN: Double-blind, randomised, controlled study...
May 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29553001/risk-of-surgical-site-infection-ssi-following-colorectal-resection-is-higher-in-patients-with-disseminated-cancer-an-nccn-member-cohort-study
#15
Mini Kamboj, Teresa Childers, Jessica Sugalski, Donna Antonelli, Juliane Bingener-Casey, Jamie Cannon, Karie Cluff, Kimberly A Davis, E Patchen Dellinger, Sean C Dowdy, Kim Duncan, Julie Fedderson, Robert Glasgow, Bruce Hall, Marilyn Hirsch, Matthew Hutter, Lisa Kimbro, Boris Kuvshinoff, Martin Makary, Melanie Morris, Sharon Nehring, Sonia Ramamoorthy, Rebekah Scott, Mindy Sovel, Vivian Strong, Ashley Webster, Elizabeth Wick, Julio Garcia Aguilar, Robert Carlson, Kent Sepkowitz
BACKGROUNDSurgical site infections (SSIs) following colorectal surgery (CRS) are among the most common healthcare-associated infections (HAIs). Reduction in colorectal SSI rates is an important goal for surgical quality improvement.OBJECTIVETo examine rates of SSI in patients with and without cancer and to identify potential predictors of SSI risk following CRSDESIGNAmerican College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data files for 2011-2013 from a sample of 12 National Comprehensive Cancer Network (NCCN) member institutions were combined...
May 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29529673/mobile-compression-reduces-bleeding-related-readmissions-and-wound-complications-after-tha-and-tka
#16
Diren Arsoy, Nicholas J Giori, Steven T Woolson
BACKGROUND: The use of chemoprophylaxis to prevent thromboembolic disease after primary THA and TKA can be associated with postoperative bleeding complications. Mechanical prophylaxis has been studied as an alternative to chemoprophylaxis with greater safety in patients undergoing THA, but no data have been published comparing the safety of chemoprophylaxis versus mechanical methods for patients undergoing TKA. The risk of readmission resulting from bleeding and venous thromboembolism (VTE) has also not been determined for patients undergoing THA or TKA when treated with low-molecular-weight heparin (LMWH) alone compared with mechanical prophylaxis plus aspirin (ASA)...
February 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29525076/characterization-of-patients-with-embolic-strokes-of-undetermined-source-in-the-navigate-esus-randomized-trial
#17
RANDOMIZED CONTROLLED TRIAL
Scott E Kasner, Pablo Lavados, Mukul Sharma, Yongjun Wang, Yilong Wang, Antoni Dávalos, Nikolay Shamalov, Luis Cunha, Arne Lindgren, Robert Mikulik, Antonio Arauz, Wilfried Lang, Anna Czlonkowska, Jens Eckstein, Rubens Gagliardi, Pierre Amarenco, Sebastián F Ameriso, Turgut Tatlisumak, Roland Veltkamp, Graeme J Hankey, Danilo S Toni, Daniel Bereczki, Shinichiro Uchiyama, George Ntaios, Byung-Woo Yoon, Raf Brouns, M M DeVries Basson, Matthias Endres, Keith Muir, Natan Bornstein, Serefnur Ozturk, Martin O'Donnell, Hardi Mundl, Calin Pater, Jeffrey Weitz, W Frank Peacock, Balakumar Swaminathan, Bodo Kirsch, Scott D Berkowitz, Gary Peters, Guillaume Pare, Ellison Themeles, Ashkan Shoamanesh, Stuart J Connolly, Robert G Hart
BACKGROUND: The New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial vs. ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial is a randomized phase-III trial comparing rivaroxaban versus aspirin in patients with recent ESUS. AIMS: We aimed to describe the baseline characteristics of this large ESUS cohort to explore relationships among key subgroups. METHODS: We enrolled 7213 patients at 459 sites in 31 countries...
June 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29501711/clinical-evaluation-of-a-safety-device-to-prevent-urinary-catheter-inflation-related-injuries
#18
Niall F Davis, Eoghan M Cunnane, Rory O'C Mooney, James C Forde, Michael T Walsh
OBJECTIVE: To evaluate the feasibility of a novel "safety-valve" device for preventing catheter related urethral trauma during urethral catheterization (UC). To assess the opinions of clinicians on the performance of the safety-valve device. MATERIALS AND METHODS: A validated prototype "safety-valve" device for preventing catheter balloon inflation related urethral injuries was prospectively piloted in male patients requiring UC in a tertiary referral teaching hospital (n = 100)...
May 2018: Urology
https://www.readbyqxmd.com/read/29376199/prophylactic-negative-pressure-wound-therapy-after-lower-extremity-fracture-surgery-a-pilot-study
#19
Siem A Dingemans, Merel F N Birnie, Manouk Backes, Vincent M de Jong, Jan S Luitse, J Carel Goslings, Tim Schepers
PURPOSE: Infectious complications following lower extremity fracture surgery are a major concern and account for a substantial socio-economic burden to society. The aim of this pilot study was to investigate the feasibility of a new portable single-use negative pressure wound therapy device in patients undergoing major foot ankle surgery. METHODS: Patients undergoing major foot ankle fracture surgery at a single level 1 trauma centre were eligible for this prospective case series...
April 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29358428/time-trends-in-peripheral-artery-disease-incidence-prevalence-and-secondary-preventive-therapy-a-cohort-study-in-the-health-improvement-network-in-the-uk
#20
Lucía Cea-Soriano, F Gerry R Fowkes, Saga Johansson, Alaster M Allum, Luis Alberto García Rodriguez
OBJECTIVES: To assess time trends in symptomatic peripheral artery disease (PAD) incidence and prevalence, and secondary preventive therapy. DESIGN: Cohort study using The Health Improvement Network. SETTING: UK primary care. PARTICIPANTS: Individuals aged 50-89 years identified annually between 2000 and 2014. Participants with symptomatic PAD were identified using Read codes. OUTCOME MEASURES: Incidence and prevalence of symptomatic PAD from 2000 to 2014, overall and by sex and age...
January 21, 2018: BMJ Open
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