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Philippe F D Bowles, Satish Agrawal, Mahmoud A Salam
BACKGROUND: Prospective study investigating the incidence of concurrent Eustachian Tube dysfunction (ETD) in patients with CRS refractory to medical therapy, and the effect of Endoscopic Sinus Surgery (ESS) on ETD in this patient group. METHODS: Prospective study of 57 CRS patients. Outcome measures were SNOT-22 and ETDQ-7 questionnaires, tympanometry and Valsalva manoeuvre recorded pre-operatively and at 3 and 9 months post ESS. RESULTS: There was a moderate positive correlation between pre-operative ETDQ-7 and SNOT 22 scores (r equals 0...
December 11, 2018: Rhinology
Joseph F Konopka, Yuo-Yu Lee, Edwin P Su, Alexander S McLawhorn
Background: The quality-adjusted life year (QALY) is the preferred outcome measurement for cost-effectiveness analysis in health care. QALYs measure patient health-related quality of life with use of a value between 0 and 1. Few studies have provided original data delineating QALYs after hip and knee arthroplasty. In the present study, we evaluated patient utility preoperatively and 2 years after total hip arthroplasty, hip resurfacing, revision hip arthroplasty, total knee arthroplasty, unicompartmental knee arthroplasty, and revision knee arthroplasty...
September 25, 2018: JB & JS open access
Maurits C F J de Rotte, Saskia M F Pluijm, Pascal H P de Jong, Maja Bulatović Ćalasan, Nico M Wulffraat, Angelique E A M Weel, Jan Lindemans, J M W Hazes, Robert de Jonge
OBJECTIVE: The objective was to predict insufficient response to 3 months methotrexate (MTX) in DMARD naïve rheumatoid arthritis patients. METHODS: A Multivariable logistic regression model of rheumatoid arthritis patients starting MTX was developed in a derivation cohort with 285 patients starting MTX in a clinical multicentre, stratified single-blinded trial, performed in seven secondary care clinics and a tertiary care clinic. The model was validated in a validation cohort with 102 patients starting MTX at a tertiary care clinic...
2018: PloS One
Dana DeMaster, Johanna Bick, Ursula Johnson, Janelle J Montroy, Susan Landry, Andrea F Duncan
An intrinsic feature of the developing brain is high susceptibility to environmental influence-known as plasticity. Research indicates cascading disruption to neurological development following preterm (PT) birth; yet, the interactive effects of PT birth and plasticity remain unclear. It is possible that, with regard to neuropsychological outcomes in the PT population, plasticity is a double-edged sword. On one side, high plasticity of rapidly developing neural tissue makes the PT brain more vulnerable to injury resulting from events, including inflammation, hypoxia, and ischemia...
October 16, 2018: Pediatric Research
Kemble K Wang, Tom F Novacheck, Adam Rozumalski, Andrew G Georgiadis
BACKGROUND: Fixed knee flexion deformity is common in children with neuromuscular disorders. Anterior guided growth (AGG) of the distal femur can achieve gradual correction in patients who are skeletally immature. Little outcome data are available on this procedure. METHODS: This is a retrospective matched cohort study. Forty-two knees (26 patients) underwent AGG surgery at our institution between 2007 and 2017. All patients underwent instrumented 3-dimensional gait analysis (3DGA)...
December 8, 2018: Journal of Pediatric Orthopedics
Jessica J Lin, Ginger Y Jiang, Nencyben Joshipura, Jennifer Ackil, Subba R Digumarthy, Sandra P Rincon, Beow Y Yeap, Justin F Gainor, Alice T Shaw
BACKGROUND: Central nervous system (CNS) metastases represent a significant source of morbidity and mortality for patients with ALK-positive non-small cell lung cancer (NSCLC). Alectinib has demonstrated robust CNS activity in both crizotinib-naïve and crizotinib-resistant settings. However, the CNS efficacy of alectinib has not been established in patients with untreated symptomatic, large CNS metastases. METHODS: In this retrospective study, patients were eligible if they had advanced ALK-positive NSCLC with large (defined as ≥1 cm) or symptomatic CNS metastases and received alectinib...
December 7, 2018: Journal of Thoracic Oncology
François Faitot, Pietro F Addeo, Camille Besch, Michard Baptiste, Constantin Oncioiu, Bernard Ellero, Marie-Lorraine Woehl-Jaeglé, Philippe Bachellier
BACKGROUND: Temporary portocaval shunt has a positive impact on short-term outcomes after liver transplantation. An alternative to temporary portocaval shunt is a distal passive decompression through mesenterico-saphenous shunt. The purpose of this study was to compare outcomes of these two types of surgical portosystemic shunt and discuss their respective place during the anhepatic phase. METHODS: Patients transplanted with portal decompression during a 4-year period were included...
December 7, 2018: Surgery
Steven D Criss, Davis T Weaver, Deirdre F Sheehan, Richard J Lee, Pari V Pandharipande, Chung Yin Kong
PURPOSE: Our purpose was to evaluate the effect of PD-L1 testing on the cost-effectiveness of pembrolizumab for second-line treatment of advanced urothelial carcinoma in the bladder from the U.S. societal perspective. MATERIALS AND METHODS: We developed a microsimulation model to compare 3 treatment strategies: (1) treat all patients with standard-of-care chemotherapy, (2) treat all patients with pembrolizumab, and (3) treat patients with PD-L1-positive tumors at a ≥1% expression threshold with pembrolizumab, and all others with standard-of-care chemotherapy...
December 6, 2018: Urologic Oncology
S Iodice, M Hoxha, L Ferrari, I F Carbone, C Anceschi, M Miragoli, A C Pesatori, N Persico, V Bollati
Growing evidences have shown that particulate matter (PM) exposures during pregnancy are associated with impaired fetal development and adverse birth outcomes, possibly as a result of an exaggerated systemic oxidative stress and inflammation. Telomere length (TL) is strongly linked to biological age and is impacted by oxidative stress. We hypothesized that PM exposure during different time windows in the first trimester of pregnancy influences both mitochondrial DNA copy number (mtDNAcn), an established biomarker for oxidative stress, and TL...
2018: Oxidative Medicine and Cellular Longevity
Graham F Moore, Rebecca Cox, Rhiannon E Evans, Britt Hallingberg, Jemma Hawkins, Hannah J Littlecott, Sara J Long, Simon Murphy
Positive relationships with family, friends and school staff are consistently linked with health and wellbeing during adolescence, though fewer studies explore how these micro-systems interact to influence adolescent health. This study tests the independent and interacting roles of family, peer and school relationships in predicting substance use, subjective wellbeing and mental health symptoms among 11-16 year olds in Wales. It presents cross-sectional analyses of the 2013 Health Behaviour in School-aged Children survey, completed by 9055 young people aged 11-16 years...
2018: Child Indicators Research
Rosanne B van Dijsseldonk, Lysanne A F de Jong, Brenda E Groen, Marije Vos-van der Hulst, Alexander C H Geurts, Noel L W Keijsers
Many patients with incomplete spinal cord injury (iSCI) have impaired gait and balance capacity, which may impact daily functioning. Reduced walking speed and impaired gait stability are considered important underlying factors for reduced daily functioning. With conventional therapy, patients are limited in training gait stability, but this can be trained on a treadmill in a virtual environment, such as with the Gait Real-time Analysis Interactive Lab (GRAIL). Our objective was to evaluate the effect of 6-weeks GRAIL-training on gait and dynamic balance in ambulatory iSCI patients...
2018: Frontiers in Neurology
Wenbin Xiao, Aaron D Goldberg, Christopher Famulare, Sean Devlin, Nghia Nguyen, Sinnifer Sim, Charlene C Kabel, Mina A Patel, Erin McGovern, Akshar Patel, Jessica Schulman, Andrew Dunbar, Zachary D Epstein-Peterson, Kamal Menghrajani, Bartlomiej M Getta, Sheng F Cai, Mark B Geyer, Jacob Glass, Justin Taylor, Aaron D Viny, Ross L Levine, Yanming Zhang, Sergio Giralt, Virginia Klimek, Martin S Tallman, Mikhail Roshal
Measurable residual disease is associated with inferior outcomes in patients with acute myeloid leukemia. Measurable residual disease monitoring enhances risk stratification and may guide therapeutic intervention. European LeukemiaNet working party recently came to a consensus recommendation incorporating leukemia associated immunophenotype-based different from normal approach by multi-color flow cytometry for measurable residual disease evaluation. However, the analytical approach is highly expertise-dependent and difficult to standardize...
December 6, 2018: Haematologica
An-Sofie Schelpe, Elien Roose, Bérangère S Joly, Inge Pareyn, Ilaria Mancini, Marina Biganzoli, Hans Deckmyn, Jan Voorberg, Rob Fijnheer, Flora Peyvandi, Simon F De Meyer, Paul Coppo, Agnes Veyradier, Karen Vanhoorelbeke
In autoantibody-mediated autoimmune diseases, autoantibody profiling allows to stratify patients and link autoantibodies with disease severity and outcome. However, in immune-mediated thrombotic thrombocytopenic purpura patients, stratification according to antibody profiles and their clinical relevance has not been fully explored. We aimed at developing a new type of autoantibody profiling assay for immune-mediated thrombotic thrombocytopenic purpura based on the use of anti-idiotypic antibodies. Anti-idiotypic antibodies against 3 anti-spacer autoantibodies were generated in mice and were used to capture the respective anti-spacer idiotopes from 151 acute immune-mediated thrombotic thrombocytopenic purpura plasma samples...
December 6, 2018: Haematologica
Ellen T M Laan, Jan M Prins, Rik H W van Lunsen, Pythia T Nieuwkerk, Marian A F Nievaard-Boon
INTRODUCTION: Now that HIV infection has become a chronic disease, optimizing health status is an important goal of care for HIV-infected patients. Testosterone insufficiency (TI) can compromise health status, but little is known about the prevalence of TI and possible related factors in HIV-infected women. AIM: To investigate the prevalence of TI among HIV-infected women attending our HIV outpatient clinic, and to study the relationship between TI and sexual function, fatigue, health status, and depression...
December 3, 2018: Sexual Medicine
Gerald F Fletcher, Carolyn Landolfo, Josef Niebauer, Cemal Ozemek, Ross Arena, Carl J Lavie
Physical inactivity is one of the leading modifiable risk factors for global mortality, with an estimated 20% to 30% increased risk of death compared with those who are physically active. The "behavior" of physical activity (PA) is multifactorial, including social, environmental, psychological, and genetic factors. Abundant scientific evidence has demonstrated that physically active people of all age groups and ethnicities have higher levels of cardiorespiratory fitness, health, and wellness, and a lower risk for developing several chronic medical illnesses, including cardiovascular disease, compared with those who are physically inactive...
December 11, 2018: Journal of the American College of Cardiology
Melissa A Elafros, Brent A Johnson, Omar K Siddiqi, Jason F Okulicz, Izukanji Sikazwe, Christopher M Bositis, Michael J Potchen, Igor J Koralnik, William H Theodore, Lisa Kalungwana, Gretchen L Birbeck
BACKGROUND: Recurrent seizure risks in HIV-positive people with new-onset seizure are largely unknown, making it challenging to offer optimal recommendations regarding antiepileptic drug (AED) initiation. Existing outcomes data is limited, and risk factor identification requires a diagnostic assessment, which is often unavailable in regions heavily effected by HIV, like sub-Saharan Africa. METHODS: HIV-positive Zambian adults with new-onset seizure were enrolled in a prospective cohort study to determine seizure recurrence and risk factors for recurrence...
December 7, 2018: BMC Neurology
F Han, H Q Liu, S Y Wang
Objective: To investigate the correlation between the expression of CD117, MITF, NAT10 and clinical parameters in sinonasal mucosal melanoma (SNMM). Methods: Formalin-fixed paraffin-embedded tumor specimens of 80 cases of SNMM at the Eye, Ear, Nose and Throat Hospital, Fudan University, from December 1999 to November 2013 were analyzed for CD117, MITF and NAT10 expression by immunohistochemistry. Results: There were 40 men and 40 women. The median age was 61 years, age 26 to 85 years. There was no correlation of the expression of CD117, MITF and NAT10 with the patients' age, gender, tumor site, stage, therapy method and brain metastases ( P >0...
December 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
O Servitje, F Climent, L Colomo, N Ruiz, A García-Herrera, F Gallardo, S Mercadal, H Pomares, C Muniesa, C Martin-Callizo, J Marcoval, R Rovira, T Estrach, R M Pujol
BACKGROUND: Primary cutaneous follicular center-cell lymphoma (PCFCL) is one of the most common types of cutaneous B-cell lymphoma. Differences in immunohistochemical expression of BCL2 and CD10 antigens along with the presence of t(14:18) translocation in neoplastic cells have been postulated as relevant clues in differentiating PCFCL from cutaneous lesions secondary to a systemic follicular lymphoma (SCFL). The aim of this study is to evaluate the significance and usefulness of these parameters in a large series of patients...
December 4, 2018: Journal of Cutaneous Pathology
F Yuan, W Wang, J Xu
The novel colorectal neoplasia differentially expressed lncRNA (CRNDE) has been discovered in many solid tumors. We conducted this systematic review and meta-analysis to illuminate the function of CRNDE in cancer. Published articles were identified by electronic search of PubMed, EMBASE, and MEDLINE using the keywords "cancer or carcinoma or neoplasm or tumor" and "long noncoding RNA CRNDE or noncoding RNA CRNED or CRNDE". Hazard ratios (HRs), standard errors (SEs) and their corresponding 95% confidence intervals (CIs) were estimated from study survival curves...
August 9, 2018: Neoplasma
Norbert Brüggemann, Aloysius Domingo, Dirk Rasche, Christian K E Moll, Raymond L Rosales, Roland Dominic G Jamora, Henrike Hanssen, Alexander Münchau, Julia Graf, Anne Weissbach, Vera Tadic, Cid C Diesta, Jens Volkmann, Andrea Kühn, Thomas F Münte, Volker Tronnier, Christine Klein
Importance: Anecdotal evidence suggests that deep brain stimulation (DBS) of the internal globus pallidus (GPi) is effective in ameliorating dystonia in X-linked dystonia parkinsonism (XDP), a disease that is usually refractive to medical therapy. Objective: To determine the efficacy of GPi-DBS in a cohort of patients with XDP in a prospective study and identify predictors of postoperative outcomes. Design, Setting, and Participants: This observational prospective cohort study enrolled patients in February 2013 and was completed in December 2014...
December 3, 2018: JAMA Neurology
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