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Sex differences AND pain

Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, Patricia Palomo-López, David Rodríguez-Sanz, Juan Manuel Brandariz-Pereira, César Calvo-Lobo
OBJECTIVE: Foot problems (FP) may be considered to be a prevalent conditions in people but there is limited evidence of their effect on the quality of life (QoL) related to foot health in men and women. The aim of this study was to assess the impact of FPs on both overall foot health and QoL, stratified by gender. DESIGN: A cross sectional study. SETTING: Clinic of Podiatric Medicine and Surgery at University of A Coruña in the city of Ferrol (Spain)...
October 18, 2018: BMJ Open
Vinicius M Gadotti, Gerald W Zamponi
Cav3.2 T-type calcium channels are important for the signaling of nociceptive information in the primary afferent pain pathway. During neuropathy and peripheral inflammation, Cav3.2 channels are upregulated due to an increased association with the deubiquitinase USP5. Disrupting these interactions in male mice by the use of cell permeant peptides reverses mechanical and thermal hypersensitivity. Here we explore the effects of interfering with USP5 binding to the channel in female mice with synchronized estrous cycle...
October 19, 2018: Molecular Brain
Sarah F Rosen, Boram Ham, Michael Haichin, Ilana C Walters, Sarasa Tohyama, Susana G Sotocinal, Jeffrey S Mogil
The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T cell populations, very little attention has been given to the converse: how T cells may affect opioid regulation. We find here that in addition to displaying significantly increased baseline pain sensitivity across various pain modalities, T cell deficient mice (CD-1 nude, Rag1 null mutant and Cd4 null mutant) exhibit pronounced deficiencies in morphine inhibition of thermal or inflammatory pain...
October 16, 2018: Pain
Bertram Baenziger, Najia Nadi, Ramon Doerig, Peter Proemmel, Brigitta Gahl, Daniel Hodel, Oliver N Hausmann
BACKGROUND: There are only a few prospective clinical trials investigating the effects of different anesthetic techniques on clinical outcomes after lumbar spine surgery. The purpose of this study was to evaluate clinical outcomes in patients receiving general (GA) and regional anesthesia (RA) for lumbar spine surgery. METHODS: This was a single-center, 2-arm, trial in which 100 patients undergoing lumbar spine surgery were randomized to receive either RA or GA (50 per group)...
October 16, 2018: Journal of Neurosurgical Anesthesiology
Kristine Risum, Bjørge Herman Hansen, Anne Marit Selvaag, Øyvind Molberg, Hanne Dagfinrud, Helga Sanner
BACKGROUND: Knowledge about objectively measured levels of physical activity (PA) and PA participation (included facilitators and barriers for PA) in patients with juvenile idiopathic arthritis (JIA) diagnosed in the era of biologics is limited. We aimed to compare objectively measured PA in patients with oligo- and polyarticular JIA diagnosed in the biologic era with controls and to examine associations between PA and disease variables; furthermore, to explore participation in PA, physical education (PE) and facilitators and barriers for PA participation in patients and controls...
October 17, 2018: Pediatric Rheumatology Online Journal
Rui-Jian Peng, Yong-Hong Zhang, Xiao-Hui Li, Hua-Nan Shi, Yan-Jun Lu, Qi Yang
OBJECTIVE: To discuss clinical outcomes of accordion operation for the Ilizarov technique in treating tibial bone defects. METHODS: From January 2014 to June 2016, 22 patients with tibial bone defects were treated by Ilizarov bone-transport technique, including 19 males and 3 females with an average age of 44.04 years old ranging from 23 to 60 years old;the length of the bone defects before the bone transport was 5 to 11 cm with an average 7.68 cm; Cause of injury invlved traffic accidents in 14 cases, fall injury in 3, smashing injury in 4, high drop injury in 1; 6 cases were on the left and 16 cases were on the right...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Alaaddin Yorulmaz, Hikmet Akbulut, Suna Adeviye Taş, Merve Tıraş, İbaa Yahya, Harun Peru
In this study, we aimed to investigate whether neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) might be helpful in the diagnosis of subclinical inflammation of familial Mediterranean fever (FMF). Clinical, laboratory, and genetic results of the patients who were followed up with the diagnosis of FMF were obtained retrospectively from the hospital files and recorded to standardized form. Age- and sex-matched healthy subjects were included as the control group...
October 16, 2018: Clinical Rheumatology
Thula U Koops, Peer Briken
INTRODUCTION: Sexual difficulties, and sexual pain in particular, represent a global health issue for women, and their prevalence has been shown to differ across countries. AIM: To review the existing literature on the prevalence of female sexual difficulties and sexual pain worldwide measured by the Female Sexual Function Index (FSFI). METHODS: We conducted a systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
October 13, 2018: Journal of Sexual Medicine
Benjamin J Levy, Brandon M Tauberg, Ari J Holtzman, Konrad I Gruson
INTRODUCTION: To report on the effectiveness of a standardized patient positioning and padding protocol in reducing lateral femoral cutaneous nerve (LFCN) palsy in obese patients who have undergone shoulder surgery in the beach chair position. METHODS: We retrospectively reviewed the medical records of 400 consecutive patients with a body mass index (BMI) of ≥30 kg/m who underwent either open or arthroscopic shoulder surgery in the beach chair position by a single surgeon...
October 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
Kharma C Foucher, Samuel J Chmell, Carol A Courtney
Impaired descending pain inhibition has been linked to chronic pain and poorer patient outcomes. Vibration perception threshold (VPT) has also been observed and linked to radiographic stage of OA. However, it is not known how duration of symptoms may influence these neurophysiological measures. Our purpose was to evaluate the relationship between duration of symptoms and conditioned pain modulation (CPM), a measure of descending pain inhibition, and VPT, and to determine whether these relationships differed in men and women seeking orthopedic care...
October 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Garrett D Locketz, Jason D Brant, Nithin D Adappa, James N Palmer, Andrew N Goldberg, Patricia A Loftus, Rakesh K Chandra, Benjamin S Bleier, Sarina K Mueller, Richard R Orlandi, Madeleine Becker, Cindy A Dorminy, Sophia D Becker, Mariel Blasetti, Daniel G Becker
Objective To survey patients following sinonasal surgery regarding postoperative pain and opioid use. Study Design Patients were surveyed for 4 days following sinus and/or nasal surgery regarding their pain level and use of prescribed opioids. Setting Four academic medical centers and 1 private practice institution. Subjects Consecutive adult patients undergoing sinonasal surgery. Results A total of 219 subjects met criteria and were included for analysis; 134 patients (61%) took 5 or fewer combination oxycodone (5-mg) and acetaminophen (325-mg) tablets in the first 3 postoperative days, and 196 patients (89...
October 16, 2018: Otolaryngology—Head and Neck Surgery
Aklilu Abrham Roba, Tamirat Tesfaye Dasa, Fitsum Weldegebreal, Abyot Asfaw, Habtamu Mitiku, Zelalem Teklemariam, Mahantash Naganuri, Bahubali Jinnappa Geddugol, Frehiwot Mesfin, Hilina Befikadu, Eden Tesfaye
INTRODUCTION: Pulmonary tuberculosis (TB) impairs respiratory physiology and functional ability, resulting in economic and social dependence upon others. Patients with tuberculosis especially multi drug resistant (MDR-TB) suffer from social isolation, stigma, lack of support and economic constraints. In Ethiopia, the trend of MDR TB is increasing and becoming a serious public health problem. However, little is known about patients except treatment outcomes, financial burden and psychological distress with serious deficiency of data on Health Related Quality of Life (HRQOL)...
2018: PloS One
Iris Palma Lopes, Victor Barbosa Ribeiro, Rosana Maria Reis, Rafael Costa Silva, Hugo Celso Dutra de Souza, Gislaine Satyko Kogure, Rui Alberto Ferriani, Lúcia Alves da Silva Lara
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common condition characterized by hyperandrogenism, anthropometric changes (increased weight and waist-to-hip ratio [WHR]), behavioral changes (sexual dysfunction, anxiety, and depression), and reduced quality of life. Physical exercise may reduce many of the adverse effects of PCOS. However, no studies have yet evaluated the effects of aerobic exercise on the sexual function of women with PCOS. AIM: To compare the effects of continuous and intermittent aerobic physical training on the sexual function and mood of women with PCOS...
October 10, 2018: Journal of Sexual Medicine
Eitaro Ito, Akihiro Takai, Yoshinori Imai, Hiromi Otani, Yoshihiro Onishi, Yosuke Yamamoto, Kohei Ogawa, Taiji Tohyama, Shunichi Fukuhara, Yasutsugu Takada
BACKGROUND: Controversy continues as to whether single-incision laparoscopic cholecystectomy, with the somewhat larger incision at the umbilicus, may lead to a worse postoperative quality of life and more pain compared with the more classic 4-port laparoscopic cholecystectomy. The aim of this study was to compare single-incision and 4-port laparoscopic cholecystectomy from the perspective of quality of life. METHODS: This study was a multicenter, parallel-group, open-label, randomized clinical trial...
October 9, 2018: Surgery
Juneyoung L Yi, Christina A Porucznik, Lisa H Gren, Jian Guan, Evan Joyce, Darrel S Brodke, Andrew T Dailey, Mark A Mahan, Robert S Hood, Brandon D Lawrence, William R Spiker, Nicholas T Spina, Erica F Bisson
BACKGROUND: Prescription opioid medications negatively affect postoperative outcomes after lumbar spine surgery. Furthermore, opioid-related overdose death rates in the U.S. increased by 200% between 2000 and 2014. Thus, alternatives are imperative. Mindfulness-based stress reduction (MBSR), a mind-body therapy, has been associated with improved activity and mood in opioid-using chronic pain patients. This study assessed whether preoperative MBSR is an effective adjunct to standard postoperative care in adult patients undergoing lumbar spine surgery for degenerative disease...
October 9, 2018: World Neurosurgery
Vega Jovani, Mar Blasco-Blasco, Eliseo Pascual, M Teresa Ruiz-Cantero
BACKGROUND: Diagnostic delay is well-known in spondyloarthritis and studies have demonstrated a longer deferral in women. The aim of this study was to explore whether diagnostic delay of spondyloarthritis depends on clinical manifestations expressed by patients according to sex or whether it is related to a doctor's misdiagnosis bias. METHODS: A cross-sectional study of 96 men and 54 women with spondyloarthritis was performed at Alicante University General Hospital in Spain using a semistructured interview and clinical records...
2018: PloS One
Carolina Rodrigues Mendonça, Matias Noll, Erika Aparecida Silveira
Background: Although a variety of instruments implement body maps for the precise identification of pain symptoms, no instrument has been validated for use in people with obesity. This study reports the adaptation and validation of body maps for musculoskeletal pain location in people with obesity. Methods: Nine key anatomical regions were highlighted based on the original images of the Nordic Musculoskeletal Questionnaire body maps. Adult silhouettes were generated from photographs of men and women with obesity...
October 2018: Korean Journal of Pain
A Sundén, K Lidengren, E M Roos, L S Lohmander, E Ekvall Hansson
BACKGROUND: The Hip disability and Osteoarthritis Outcome Score (HOOS) is a self-administered hip-specific questionnaire intended to evaluate symptoms and functional limitations, and it is commonly used to evaluate interventions in individuals with hip dysfunction or hip osteoarthritis. The HOOS consists of 43 questions in five subscales: Pain, Symptoms, Function in daily living, Function in sport and recreation and Hip-Related Quality of Life. This study aimed to establish population-based reference values for the HOOS and to describe the variation of hip-related symptoms in an adult population...
October 11, 2018: Health and Quality of Life Outcomes
Marco Brayda-Bruno, Domenico Albano, Guglielmo Cannella, Fabio Galbusera, Alberto Zerbi
PURPOSE: The aims of the study were to introduce a classification scheme for endplate lesions based on T2-weighted magnetic resonance imaging and to detect possible associations between endplate lesions and other variables such as age, sex, disc degeneration and Modic changes in a large population. METHODS: MRI images of 996 low back pain patients were collected. All intervertebral spaces were classified as "normal", "wavy/irregular", "notched", "Schmorl's node" and "fracture"...
October 10, 2018: European Spine Journal
Samuel Maxwell, Nicholas Pergaminelis, Jesse Renouf, Oren Tirosh, Phong Tran
PURPOSE: To determine a Patient Acceptable Symptomatic State (PASS) score for the 33-item International Hip Outcome Tool (iHOT-33) in people undergoing hip arthroscopy for primary diagnoses of femoroacetabular impingement syndrome, acetabular labral tears, and/or ligamentum teres pathology. METHODS: Consecutive participants underwent hip arthroscopy by a single surgeon between August 2011 and May 2016. Participants were included if they were between ages 18 and 60 years and underwent hip arthroscopy for femoroacetabular impingement syndrome, acetabular labral tears, or ligamentum teres pathology...
October 6, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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