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Sex differences AND pain

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https://www.readbyqxmd.com/read/30115262/conditioned-pain-modulation-identifies-altered-sensitivity-in-extremely-preterm-young-adult-males-and-females
#1
S M Walker, H O'Reilly, J Beckmann, N Marlow
BACKGROUND: Conditioned pain modulation is a potential biomarker for risk of persistent pain. As early-life experience can alter subsequent somatosensory processing and pain response, we evaluated conditioned pain modulation after extremely preterm birth. METHODS: This observational study recruited extremely preterm (<26 weeks gestation; n=98) and term-born control (n=48) young adults (19-20 yr) from the longitudinal EPICure cohort. Pressure pain threshold (PPT; variable test stimulus lower leg) was measured before, during, and after a conditioning stimulus (contralateral hand immersion; 5°C water; 30 s)...
September 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30115261/somatosensory-function-and-pain-in-extremely-preterm-young-adults-from-the-uk-epicure-cohort-sex-dependent-differences-and-impact-of-neonatal-surgery
#2
S M Walker, A Melbourne, H O'Reilly, J Beckmann, Z Eaton-Rosen, S Ourselin, N Marlow
BACKGROUND: Surgery or multiple procedural interventions in extremely preterm neonates influence neurodevelopmental outcome and may be associated with long-term changes in somatosensory function or pain response. METHODS: This observational study recruited extremely preterm (EP, <26 weeks' gestation; n=102, 60% female) and term-born controls (TC; n=48) aged 18-20 yr from the UK EPICure cohort. Thirty EP but no TC participants had neonatal surgery. Evaluation included: quantitative sensory testing (thenar eminence, chest wall); clinical pain history; questionnaires (intelligence quotient; pain catastrophising; anxiety); and structural brain imaging...
September 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30114476/up-regulation-of-asic3-expression-by-%C3%AE-estradiol
#3
Ping Ren, Wen-Bin Wang, Hai-Hua Pan, Chun-Yu Qiu, Wang-Ping Hu
Sex differences occur in nociceptive pain, and estrogens are involved in the sex differences. Our previous study shows sex differences exist in acidosis-induced nociception in rats, with females being more sensitive than males to acetic acid. However, the mechanisms underlying the sex differences remain unclear. We report here17β-estradiol (E2) up-regulates expression of acid-sensing ion channel 3 (ASIC3), which can mediate the acidosis-induced events. The recombinant plasmid of pCDNA3.1-ASIC3-GFP and pCDNA3...
August 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30113664/postoperative-rigid-cervical-collar-leads-to-less-axial-neck-pain-in-the-early-stage-after-open-door-laminoplasty-a-single-blinded-randomized-controlled-trial
#4
Jason Pui Yin Cheung, Prudence Wing Hang Cheung, Karlen Law, Vishal Borse, Yuk Ming Lau, Ling Fung Mak, Aldous Cheng, Dino Samartzis, Kenneth Man Chee Cheung
BACKGROUND: Cervical collars are used after laminoplasty to protect the hinge opening, reduce risks of hinge fractures, and avoid spring-back phenomena. However, their use may lead to reduced range of motion and worse neck pain. OBJECTIVE: To investigate the clinical, radiological, and functional outcomes of patients undergoing single-door laminoplasty with or without collar immobilization. METHODS: This was a prospective, parallel, single-blinded randomized controlled trial...
August 3, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30112716/comparing-endoscopic-and-open-decompression-of-the-ulnar-nerve-in-cubital-tunnel-syndrome-a-prospective-randomized-study
#5
T Krejčí, Z Večeřa, O Krejčí, D Šalounová, M Houdek, Radim Lipina
BACKGROUND: Prospective randomized data is currently lacking which compares endoscopically assisted surgery with open surgical techniques in the treatment of cubital tunnel syndrome (CUTS). The aim of this study is to compare patient outcome in both techniques. METHOD: This prospective study comprised of 45 patients who, between October 2014 and February 2017, were randomly assigned to undergo either endoscopic or open surgery (22 and 23 patients respectively) for decompression of the ulnar nerve...
August 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/30112628/are-clinical-outcomes-affected-by-type-of-plate-used-for-management-of-mid-shaft-clavicle-fractures
#6
Mohammad M Alzahrani, Adam Cota, Khalid Alkhelaifi, Aljarrah Aleidan, Gregory Berry, Rudy Reindl, Edward Harvey
BACKGROUND: Open reduction and internal fixation (ORIF) using plate osteosynthesis for midshaft clavicle fractures is often complicated by the prominence of the implant due to the subcutaneous position of the clavicle. Reoperation rates for symptomatic clavicle plate removal have been reported to be as high as 53%. We sought to determine to which degree do clinical outcomes (all cause reoperation rate and rate of fracture union) differ between types of clavicle plates. MATERIALS AND METHODS: A retrospective chart review was performed using our hospital database for patients treated with ORIF for mid-shaft clavicle fractures (OTA/AO type 15-B)...
August 15, 2018: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/30108277/nanohydroxyapatite-polyamide-66-strut-subsidence-after-one-level-corpectomy-underlying-mechanism-and-effect-on-cervical-neurological-function
#7
Weiyang Zhong, Xinjie Liang, Ke Tang, Xiaoji Luo, Zhengxue Quan, Dianming Jiang
The aim of this study was to investigate n-HA/PA66 strut subsidence after one-level in Anterior cervical corpectomy decompression and fusion (ACCF) and its effect on treatment outcomes to better understand the underlying mechanism and related risk factors. In total, 56 patients undergoing ACCF using n-HA/PA66 struts were analysed retrospectively. After a 12-month follow-up, the height of the fused segments and fused intervertebral heights were measured, the neurological findings were evaluated using the Japanese Orthopedic Association (JOA) and axial pain was assessed using a Visual Analogue Scale(VAS)...
August 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30107891/sex-differences-in-symptoms-experienced-knowledge-about-symptoms-symptom-attribution-and-perceived-urgency-for-treatment-seeking-among-acute-coronary-syndrome-patients-in-karachi-pakistan
#8
Saleema Allana, Dr Debra K Moser, Dr Tazeen Saeed Ali, Dr Aamir Hameed Khan
BACKGROUND: Patients' experience of acute coronary syndrome (ACS) symptoms is important in determining their prehospital delay. OBJECTIVE: To explore gender differences in acute symptoms of ACS, knowledge about the symptoms, their attribution, and perception of urgency, among Pakistani ACS patients. METHODS: Comparative, cross-sectional study design with 249 ACS patients. RESULTS: The most commonly reported symptoms were ghabrahat (fidgetiness), chest pain, and chest heaviness...
August 11, 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/30104988/failure-to-find-a-conditioned-placebo-analgesic-response
#9
Magne A Flaten, Espen Bjørkedal, Peter S Lyby, Yngve Figenschau, Per M Aslaksen
Background: Associative learning has, in several studies, been modulated by the sex of the participant. Consistent with this, a recent review found that conditioned nocebo effects are stronger in females than in males. Purpose: It has been suggested that conditioned placebo responses are stronger in females, and this hypothesis was investigated in the present study. Cortisol and measures of negative emotions were taken to investigate if these processes could mediate any conditioned placebo effects. Methods: Cold pain was applied to the volar forearm...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30098106/prevalence-of-self-reported-chronic-pain-among-adolescents-evidence-from-42-countries-and-regions
#10
Inese Gobina, Jari Villberg, Raili Välimaa, Jorma Tynjälä, Ross Whitehead, Alina Cosma, Fiona Brooks, Franco Cavallo, Kwok Ng, Margarida Gaspar de Matos, Anita Villerusa
BACKGROUND: Reports of the overall chronic pain prevalence and its associated demographic characteristics among adolescents vary greatly across existing studies. Using internationally comparable data, the present study investigates age, sex and country-level effects in the prevalence of chronic single-site and multi-site pain among adolescents during the last six months preceding the survey. METHODS: Data (n = 214,283) from the 2013/2014 Health Behaviour in School-aged Children (HBSC) study were used including nationally representative samples of 11-, 13- and 15-year-olds from general schools in 42 participating countries...
August 11, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/30096584/sex-specific-walking-kinematics-and-kinetics-in-individuals-with-unilateral-symptomatic-hip-osteoarthritis-a-cross-sectional-study
#11
Kim Allison, Michelle Hall, Tim V Wrigley, Yong-Hao Pua, Ben Metcalf, Kim L Bennell
BACKGROUND: Hip osteoarthritis (OA) is a significant cause of disability, with hip pain and reduced external hip moments during walking being key features of the condition. The external hip adduction moment is greater in healthy women than men, however these between-sex differences are not evident in those with end-stage hip OA. Whether sex-specific hip kinetics are associated with early-midstage hip OA has not been investigated and may be a potential target for directed treatment. METHODS: Thirty-eight women and twenty-eight men with a diagnosis of symptomatic, unilateral, mild-to-moderate hip OA (Kellegren-Lawrence Grade 2 or 3) underwent three-dimensional gait analysis of normal walking gait using Vicon motion capture...
July 31, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30094517/intracortical-facilitation-within-the-migraine-motor-cortex-depends-on-the-stimulation-intensity-a-paired-pulse-tms-study
#12
Giuseppe Cosentino, Salvatore Di Marco, Salvatore Ferlisi, Francesca Valentino, Walter M Capitano, Brigida Fierro, Filippo Brighina
INTRODUCTION: Connectivity within the primary motor cortex can be measured using the paired-pulse transcranial magnetic stimulation (TMS) paradigm. This evaluates the effect of a first conditioning stimulus on the motor evoked potential (MEP) elicited by a second test stimulus when different interstimulus intervals are used. Aim of the present study was to provide, in patients suffering from migraine without aura (MwoA), additional information on intracortical facilitation (ICF), short intracortical inhibition (SICI), and long intracortical inhibition (LICI), using different intensities of the test stimulus (TS)...
August 9, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/30092111/the-use-of-triphasic-bone-graft-for-the-treatment-of-pediatric-bone-cysts-experience-at-2-institutions
#13
Ting Zhang, Charles T Price, James J McCarthy, Jie Nguyen, Kenneth J Noonan
Unicameral/aneurysmal bone cysts can lead to pain, fracture, and limb deformity. In this study, the authors evaluated the outcome of triphasic bone graft to treat unicameral/aneurysmal bone cysts. They retrospectively evaluated 41 immature patients from a prospectively enrolled cohort from 2 institutions treated from May 9, 2007, to November 1, 2014. Medical record review and evaluation of radiographs and computed tomography scans were performed. The authors characterized replacement of the material by normal bone or recurrent cyst at final follow-up...
August 9, 2018: Orthopedics
https://www.readbyqxmd.com/read/30087405/course-and-characteristics-of-work-disability-3-years-before-and-after-lumbar-spine-decompression-surgery-a-national-population-based-study
#14
Thomas E Dorner, Magnus Helgesson, Kerstin Nilsson, Konstantinos A Pazarlis, Annina Ropponen, Pia Svedberg, Ellenor Mittendorfer-Rutz
Despite decompression surgery being a widespread intervention for patients with dorsopathies (i.e. back pain) affecting the lumbar spine, the scientific knowledge on patterns and characteristics of work disability before and after the surgery is limited. Sickness absence (SA) and disability pension (DP) were examined three years before and after surgery in 8558 patients aged 25-60 years who underwent lumbar spine decompression surgery in Sweden. They were compared to individuals with diagnosed dorsopathies but no surgery and individuals from the general population as matched comparison groups...
August 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30076211/estrogen-regulation-of-grk2-inactivates-kappa-opioid-receptor-signaling-mediating-analgesia-but-not-aversion
#15
Antony D Abraham, Selena S Schattauer, Kathryn L Reichard, Joshua H Cohen, Harrison M Fontaine, Allisa J Song, Salina D Johnson, Benjamin B Land, Charles Chavkin
Activation of kappa opioid receptors (KOR) produces analgesia and aversion via distinct intracellular signaling pathways, but whether G protein-biased KOR agonists can be designed to have clinical utility will depend on a better understanding of the signaling mechanisms involved. We found that KOR activation produced conditioned place aversion and potentiated conditioned place preference for cocaine in male and female C57BL/6N mice. Consistent with this, males and females both showed arrestin-mediated increases in phospho-p38 MAPK following KOR activation...
August 3, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/30074844/patient-reported-outcomes-within-the-first-year-after-hip-arthroscopy-and-rehabilitation-for-femoroacetabular-impingement-and-or-labral-injury-the-difference-between-getting-better-and-getting-back-to-normal
#16
Kristian Thorborg, Otto Kraemer, Anne-Dorthe Madsen, Per Hölmich
BACKGROUND: The Copenhagen Hip and Groin Outcome Score (HAGOS) was recently found valid, reliable, and responsive for patients undergoing hip arthroscopy. However, it is currently unknown to what degree patients undergoing hip arthroscopy improve and/or normalize their HAGOS result within the first year after surgery. PURPOSE: First, to use HAGOS to evaluate clinical outcomes at 3, 6, and 12 months after hip arthroscopy for femoroacetabular impingement (FAI) and/or labral injury and compare the HAGOS results with the modified Harris Hip Score (mHHS)...
August 3, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/30073771/comparison-of-outpatient-reimbursement-for-interstitial-cystitis-bladder-pain-syndrome-and-rheumatoid-arthritis-treatment-in-taiwan-a-nationwide-population-based-study
#17
Hsiu-Ying Lin, Ming-Huei Lee, Kun-Min Chang, Huei-Ching Wu
OBJECTIVE: This study compared Taiwanese public health insurance outpatient reimbursements for interstitial cystitis (IC)/bladder pain syndrome (BPS) and rheumatoid arthritis (RA) treatment. METHODS: This observational study used data from the Taiwan Longitudinal Health Insurance Database between 2002 and 2013. Patients with International Classification of Diseases, Ninth Revision, Clinical Modification codes for IC/BPS and RA were selected and matched in a ratio of 1 : 5 based on index year...
August 2, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/30073295/association-of-marijuana-use-with-psychosocial-and-quality-of-life-outcomes-among-patients-with-head-and-neck-cancer
#18
Han Zhang, Michael Xie, Stuart D Archibald, B Stanley Jackson, Michael K Gupta
Importance: Cannabis sativa, the most widely used illicit substance in Canada, has a unique ability to facilitate relaxation and relieve anxiety while reducing pain. However, no study to date has examined quality of life (QOL) and psychosocial issues in relation to the use of this drug among patients with newly diagnosed head and neck cancer (HNC). Objective: To examine the differences in QOL and psychosocial outcomes between marijuana users and nonusers with newly diagnosed HNC...
August 2, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/30065787/incorrectly-fitted-footwear-foot-pain-and-foot-disorders-a-systematic-search-and-narrative-review-of-the-literature
#19
REVIEW
Andrew K Buldt, Hylton B Menz
Background: Correct footwear fitting is acknowledged as being vitally important, as incorrectly fitted footwear has been linked to foot pathology. The aim of this narrative review was to determine the prevalence of incorrectly fitted footwear and to examine the association between incorrectly fitted footwear, foot pain and foot disorders. Methods: A database search of Ovid MEDLINE and CINAHL yielded 1,681 citations for title and abstract review. Eighteen articles were included...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/30064441/early-and-late-fixation-of-ulnar-styloid-base-fractures-yields-different-outcomes
#20
Alvin Chao-Yu Chen, Chih-Hao Chiu, Chun-Jui Weng, Shih-Sheng Chang, Chun-Ying Cheng
BACKGROUND: The role of surgical fixation of ulnar styloid fractures remains a subject of debate. The purpose of this study was to compare the surgical outcomes following early and late intervention. METHODS: We retrospectively reviewed 28 patients who underwent surgical repair for unilateral ulnar styloid fractures with distal radioulnar instability between 2004 and 2014. Surgical fixation was performed within 3 months of injury in 13 patients (group A) and beyond 3 months in 15 patients (group B)...
July 31, 2018: Journal of Orthopaedic Surgery and Research
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