keyword
MENU ▼
Read by QxMD icon Read
search

Snake

keyword
https://www.readbyqxmd.com/read/28528176/production-and-preclinical-assessment-of-camelid-immunoglobulins-against-echis-sochureki-venom-from-desert-of-rajasthan-india
#1
P D Tanwar, S K Ghorui, S K Kochar, Raghvendar Singh, N V Patil
Snakebite is a significant cause of death and disability in subsistent farming populations of rural India. Antivenom is the most effective treatment of envenoming and is manufactured from IgG of venom-immunised horses. Because of complex fiscal reasons, the production, testing and delivery of antivenoms designed to treat envenoming by the most medically-important snakes in the region has been questioned time to time. In this study, we report successful immunisation of dromedaries (Camelus dromedarius) against the venom of Indian saw-scaled Viper- Echis carinatus sochureki...
May 17, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28527998/molecular-cloning-and-structural-modelling-of-gamma-phospholipase-a2-inhibitors-from-bothrops-atrox-and-micrurus-lemniscatus-snakes
#2
Carina G Picelli, Rafael J Borges, Carlos A H Fernandes, Fabio M Matioli, Carla F C Fernandes, Juliana C Sobrinho, Rudson J Holanda, Luiz S Ozaki, Anderson M Kayano, Leonardo A Calderon, Marcos R M Fontes, Rodrigo G Stábeli, Andreimar M Soares
Phospholipases A2 inhibitors (PLIs) produced by venomous and non-venomous snakes play essential role in this resistance. These endogenous inhibitors may be classified by their fold in PLIα, PLIβ and PLIγ. Phospholipases A2 (PLA2s) develop myonecrosis in snake envenomation, a consequence that is not efficiently neutralized by antivenom treatment. This work aimed to identify and characterize two PLIs from Amazonian snake species, Bothrops atrox and Micrurus lemniscatus. Liver tissues RNA of specimens from each species were isolated and amplified by RT-PCR using PCR primers based on known PLIγ gene sequences, followed by cloning and sequencing of amplified fragments...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28526989/first-molecular-detection-and-characterization-of-hepatozoon-and-sarcocystis-spp-in-field-mice-and-voles-from-japan
#3
Mohamed Abdallah Mohamed Moustafa, Michito Shimozuru, Wessam Mohamed, Kyle Rueben Taylor, Ryo Nakao, Mariko Sashika, Toshio Tsubota
Sarcocystis and Hepatozoon species are protozoan parasites that are frequently detected in domestic and wild animals. Rodents are considered common intermediate and paratenic hosts for several Sarcocystis and Hepatozoon species. Here, blood DNA samples from a total of six rodents, including one Myodes rutilus, one Myodes rufocanus, and four Apodemus speciosus, collected from Hokkaido, Japan, were shown by conventional PCR of the 18S ribosomal RNA (rRNA) gene to contain Sarcocystis and Hepatozoon DNA. Sequencing of the DNA detected one Sarcocystis sp...
May 19, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28521280/stimulus-fear-relevance-and-the-speed-magnitude-and-robustness-of-vicariously-learned-fear
#4
Güler Dunne, Gemma Reynolds, Chris Askew
Superior learning for fear-relevant stimuli is typically indicated in the laboratory by faster acquisition of fear responses, greater learned fear, and enhanced resistance to extinction. Three experiments investigated the speed, magnitude, and robustness of UK children's (6-10 years; N = 290; 122 boys, 168 girls) vicariously learned fear responses for three types of stimuli. In two experiments, children were presented with pictures of novel animals (Australian marsupials) and flowers (fear-irrelevant stimuli) alone (control) or together with faces expressing fear or happiness...
May 6, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28516321/evaluating-local-adaptation-of-a-complex-phenotype-reciprocal-tests-of-pigmy-rattlesnake-venoms-on-treefrog-prey
#5
Sarah A Smiley-Walters, Terence M Farrell, H Lisle Gibbs
Theory predicts that predator-prey interactions can generate reciprocal selection pressures on species pairs, which can result in local adaptation, yet the presence and pattern of local adaptation is poorly studied in vertebrate predator-prey systems. Here, we used a reciprocal common garden (laboratory) experimental design involving comparisons between local and foreign populations to determine if local adaptation was present between a generalist predator-the pigmy rattlesnake (Sistrurus miliarius)-and a co-occurring prey-the squirrel treefrog (Hyla squirella)...
May 17, 2017: Oecologia
https://www.readbyqxmd.com/read/28515291/differential-disease-susceptibility-in-experimentally-reptarenavirus-infected-boa-constrictors-and-ball-pythons
#6
Mark D Stenglein, David Sanchez-Migallon Guzman, Valentina E Garcia, Marylee L Layton, Laura L Hoon-Hanks, Scott M Boback, M Kevin Keel, Tracy Drazenovich, Michelle G Hawkins, Joseph L DeRisi
Inclusion body disease (IBD) is an infectious disease originally described in captive snakes. It has traditionally been diagnosed by the presence of large eosinophilic cytoplasmic inclusions, and is associated with neurological, gastrointestinal and lymphoproliferative disorders. Previously, we identified and established a culture system for a novel lineage of arenaviruses isolated from boa constrictors diagnosed with IBD. Although ample circumstantial evidence suggested that these viruses, now known as reptarenaviruses, cause IBD, there has been no formal demonstration of disease causality since their discovery...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28513267/self-use-of-snake-venom-the-other-side-of-the-coin
#7
Subramanian Senthilkumaran, Nanjundan Karthikeyan, Narendra Nath Jena, Ponniah Thirumalaikolundusubramanian
No abstract text is available yet for this article.
January 1, 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28507562/antivenomics-as-a-tool-to-improve-the-neutralizing-capacity-of-the-crotalic-antivenom-a-study-with-crotamine
#8
Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali, Carlos Correa-Netto
BACKGROUND: Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrificus) bites is produced by public institutions based on the guidelines defined by the regulatory agency of the Brazilian Ministry of Health, ANVISA...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28505387/interspecific-combat-observed-among-viperid-snakes
#9
David A Steen, Dawn Kelly
No abstract text is available yet for this article.
May 15, 2017: Ecology
https://www.readbyqxmd.com/read/28505100/preclinical-evaluation-of-the-efficacy-of-antivenoms-for-snakebite-envenoming-state-of-the-art-and-challenges-ahead
#10
REVIEW
José María Gutiérrez, Gabriela Solano, Davinia Pla, María Herrera, Álvaro Segura, Mariángela Vargas, Mauren Villalta, Andrés Sánchez, Libia Sanz, Bruno Lomonte, Guillermo León, Juan J Calvete
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous preclinical testing before their introduction into the clinical setting. The gold standard in the preclinical assessment and quality control of antivenoms is the neutralization of venom-induced lethality. In addition, depending on the pathophysiological profile of snake venoms, the neutralization of other toxic activities has to be evaluated, such as hemorrhagic, myotoxic, edema-forming, dermonecrotic, in vitro coagulant, and defibrinogenating effects...
May 13, 2017: Toxins
https://www.readbyqxmd.com/read/28504478/reduced-egg-shell-permeability-affects-embryonic-development-and-hatchling-traits-in-dinodon-rufozonatum-and-pelodiscus-sinensis
#11
Wen-Qi Tang, Bo Zhao, Ye Chen, Wei-Guo Du
The response of embryos to unpredictable hypoxia is critical for successful embryonic development, yet there remain significant gaps in our understanding of such responses in reptiles with different types of eggshell. We experimentally generated external regional hypoxia by sealing either the upper- or bottom-half of the surface area of eggs in two species of reptiles [snake (Dinodon rufozonatum) with parchment eggshell and Chinese soft-shelled turtle (Pelodiscus sinensis) with rigid eggshell], then monitored growth pattern of the opaque white patch in turtle eggs, embryonic heart rate, developmental rate, and hatchling traits in turtle and snake eggs in response to external regional hypoxia...
May 15, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/28503857/recent-developments-in-structural-studies-on-acetylcholinesterase
#12
REVIEW
Israel Silman, Joel L Sussman
This review focuses on several recent developments concerning structure-function relationships in vertebrate acetylcholinesterase. These include studies on high-resolution structures of human acetylcholinesterase and its complexes; the first crystal structure of a snake venom acetylcholinesterase, in which open and closed states of the 'back door' are visualized; a powerful algorithm for redesigning proteins for enhanced expression in prokaryotic systems, as applied to human acetylcholinesterase, which has hitherto been an intractable target; in situ implementation of 'click chemistry' in crystalline acetylcholinesterase, which yields novel insights into the steric and dynamic changes involved in the reaction within the active-site gorge; and a study that demonstrates the effect of crystallization conditions on ligand alignment within a protein complex, in this case the methylene blue-Torpedo californica acetylcholinesterase complex, which highlights the relevance of the precipitant employed to structure-based drug design...
May 15, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28502905/inhibition-of-proinflammatory-mediators-by-coumaroyl-lupendioic-acid-a-new-lupane-type-triterpene-from-careya-arborea-on-inflammation-induced-animal-model
#13
Rayhana Begum, Manjur Ali Sheliya, Showkat R Mir, Ekta Singh, Manju Sharma
ETHNOPHARMACOLOGICAL RELEVANCE: Careya arborea Roxb. (Lecythidaceae) is a large tree found throughout India in deciduous forests and grasslands. C. arborea is traditionally used in tumors, inflammation, anthelmintic, bronchitis, epileptic fits, astringents, antidote to snake-venom, skin disease, diarrhea, dysentery with bloody stools, dyspepsia, ulcer, tooth ache, and ear pain. AIM OF THE STUDY: In our previous work, the methanolic extract of Careya arborea stem bark showed significant anti-inflammatory activity...
May 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28498964/superior-neuronal-detection-of-snakes-and-conspecific-faces-in-the-macaque-medial-prefrontal-cortex
#14
Ha Trong Dinh, Hiroshi Nishimaru, Jumpei Matsumoto, Yusaku Takamura, Quan Van Le, Etsuro Hori, Rafael S Maior, Carlos Tomaz, Anh Hai Tran, Taketoshi Ono, Hisao Nishijo
Snakes and conspecific faces are quickly and efficiently detected in primates. Because the medial prefrontal cortex (mPFC) has been implicated in attentional allocation to biologically relevant stimuli, we hypothesized that it might also be highly responsive to snakes and conspecific faces. In this study, neuronal responses in the monkey mPFC were recorded, while monkeys discriminated 8 categories of visual stimuli. Here, we show that the monkey mPFC neuronal responses to snakes and conspecific faces were unique...
May 11, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28496483/antibacterial-activity-of-isolated-immunodominant-proteins-of-naja-naja-oxiana-venom
#15
Mahboobeh Talebi Mehrdar, Rasool Madani, Reza Hajihosseini, Soheila Moradi Bidhendi
The aim of this study is to investigate antibacterial effects of immunodominant proteins isolated from the venom of Naja Naja Oxiana snake against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa. The innate immune system is an important line of defense against bacterial diseases. Antibacterial peptides and proteins produced by snake venoms have recently attracted significant attention due to their relevance to bacterial diseases and the potential of being converted into new therapeutic agents...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28496322/photoresponsive-nanocapsulation-of-cobra-neurotoxin-and-enhancement-of-its-central-analgesic-effects-under-red-light
#16
Qian Yang, Chuang Zhao, Jun Zhao, Yong Ye
Cobra neurotoxin (CNT), a peptide isolated from snake venom of Naja naja atra, shows central analgesic effects in our previous research. In order to help CNT pass through blood-brain barrier (BBB) and improve its central analgesic effects, a new kind of CNT nanocapsules were prepared by double emulsification with soybean lecithin and cholesterol as the shell, and pheophorbide as the photosensitizer added to make it photoresponsive. The analgesic effects were evaluated by hot plate test and acetic acid-induced writhing in mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28495622/a-new-l-amino-acid-oxidase-from-bothrops-jararacussu-snake-venom-isolation-partial-characterization-and-assessment-of-pro-apoptotic-and-antiprotozoal-activities
#17
Sante E I Carone, Tássia R Costa, Sandra M Burin, Adélia C O Cintra, Karina F Zoccal, Francine J Bianchini, Luiz F F Tucci, João J Franco, Maria R Torqueti, Lúcia H Faccioli, Sérgio de Albuquerque, Fabíola A de Castro, Suely V Sampaio
A new l-amino acid oxidase (LAAO) from Bothrops jararacussu venom (BjussuLAAO-II) was isolated by using a three-step chromatographic procedure based on molecular exclusion, hydrophobicity, and affinity. BjussuLAAO-II is an acidic enzyme with pI=3.9 and molecular mass=60.36kDa that represents 0.3% of the venom proteins and exhibits high enzymatic activity (4884.53U/mg/mim). We determined part of the primary sequence of BjussuLAAO-II by identifying 96 amino acids, from which 34 compose the N-terminal of the enzyme (ADDRNPLEECFRETDYEEFLEIARNGLSDTDNPK)...
May 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28490966/survey-of-the-reptilian-fauna-of-the-kingdom-of-saudi-arabia-vi-the-snake-fauna-of-turaif-region
#18
Mohammed K Al-Sadoon, Bilal Ahmad Paray, Hamad Al-Otaibi
A collection of snakes in Turaif region, Kingdom of Saudi Arabia, an area that has been poorly documented for reptiles, consists of 28 specimens representing 11 species belonging to 4 families (Colubridae, Elapidae, Viperidae and Atractaspididae). This study presents the first comprehensive inventory of the herpetofauna of the Turaif province of Saudi Arabia. Co-ordinates: Latitude, longitude and altitude, of the collected specimens were mapped using GPS. Three of the snake species Lytorhynchus diadema, Pseudocerastes fieldi and Walterinnesia morgani reported by the authors in the present survey proved to be new records for Turaif region of Saudi Arabia...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28488239/automatic-classification-of-lung-nodules-on-mdct-images-with-the-temporal-subtraction-technique
#19
Yuriko Yoshino, Takahiro Miyajima, Huimin Lu, Jookooi Tan, Hyoungseop Kim, Seiichi Murakami, Takatoshi Aoki, Rie Tachibana, Yasushi Hirano, Shoji Kido
PURPOSE: A temporal subtraction (TS) image is obtained by subtracting a previous image, which is warped to match the structures of the previous image and the related current image. The TS technique removes normal structures and enhances interval changes such as new lesions and substitutes in existing abnormalities from a medical image. However, many artifacts remaining on the TS image can be detected as false positives. METHOD: This paper presents a novel automatic segmentation of lung nodules using the Watershed method, multiscale gradient vector flow snakes and a detection method using the extracted features and classifiers for small lung nodules (20 mm or less)...
May 9, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28487791/a-horned-viper-bite-victim-with-pres
#20
Ahmed Mustafa Ibrahim, Tarek Talaat ElSefi, Maha Ghanem, Akram Muhammad Fayed, Nesreen Adel Shaban
Neurological complications of snake bites have been well documented in the literature as neuromuscular paralysis and cerebrovascular complications; posterior reversible encephalopathy syndrome was rarely described. A 23-year-old lady presented near full term of her pregnancy with a horned snake Cerastes cerastes bite; after successful delivery she started complaining of altered mental status and visual disturbance with ulceration over the site of the snake bite. On admission, the patient had Glasgow Coma Score of 12, blood pressure 130/80 mmHg, temperature 38°C, sinus tachycardia at 120 beats per minute, severe dehydration, and reduction in visual acuity to "hand motion" in both eyes with poor light projection and sluggish pupillary reactions...
2017: Case Reports in Neurological Medicine
keyword
keyword
16522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"