keyword
MENU ▼
Read by QxMD icon Read
search

Snake

keyword
https://www.readbyqxmd.com/read/28427959/beneficial-effects-of-heparin-and-l-arginine-on-dermonecrosis-effect-induced-by-vipera-lebetina-venom-involvement-of-no-in-skin-regeneration
#1
Nouara Bennacef-Heffar, Fatima Laraba-Djebari
It is well known that snake venoms such as Viperidae caused severe local effects such as hemorrhage, myonecrosis and dermonecrosis which can lead to permanent tissue loss or the disability. The aim of this study is to evaluate the skin regeneration using heparin and L-arginine as well as the dermonecrotic effects induced by Vipera lebetina venom (VLV). To better understand the toxic effects induced by VLV and to prevent or treat these effects, we evaluate the local effects and the skin regeneration with or without drugs...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28425932/validation-of-a-novel-technique-and-evaluation-of-the-surface-free-energy-of-food
#2
Tugce Senturk Parreidt, Markus Schmid, Carolin Hauser
Characterizing the physical properties of a surface is largely dependent on determining the contact angle exhibited by a liquid. Contact angles on the surfaces of rough and irregularly-shaped food samples are difficult to measure using a contact angle meter (goniometer). As a consequence, values for the surface energy and its components can be mismeasured. The aim of this work was to use a novel contact angle measurement method, namely the snake-based ImageJ program, to accurately measure the contact angles of rough and irregular shapes, such as food samples, and so enable more accurate calculation of the surface energy of food materials...
April 20, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28425175/haemorrhagic-snake-venom-metalloproteases-and-human-adams-cleave-lrp5-6-which-disrupts-cell-cell-adhesions-in-vitro-and-induces-haemorrhage-in-vivo
#3
Tadahiko Seo, Taketo Sakon, Shiori Nakazawa, Asuka Nishioka, Kohei Watanabe, Kaori Matsumoto, Mari Akasaka, Narumi Shioi, Hitoshi Sawada, Satohiko Araki
Snake venom metalloproteases (SVMPs) are members of the a disintegrin and metalloprotease (ADAM) family of proteins, as they possess similar domains. SVMPs are known to elicit snake venom-induced haemorrhage; however, the target proteins and cleavage sites are not known. In this work, we identified a target protein of vascular apoptosis-inducing protein 1 (VAP1), an SVMP, relevant to its ability to induce haemorrhage. VAP1 disrupted cell-cell adhesions by relocating VE-cadherin and γ-catenin from the cell-cell junction to the cytosol, without inducing proteolysis of VE-cadherin...
April 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28425157/geographic-variation-in-mimetic-precision-among-different-species-of-coral-snake-mimics
#4
Christopher K Akcali, David W Pfennig
Batesian mimicry is widespread, but whether and why different species of mimics vary geographically in resemblance to their model is unclear. We characterized geographic variation in mimetic precision among four Batesian mimics of coral snakes. Each mimic occurs where its model is abundant (i.e., in "deep sympatry"), rare (i.e., at the sympatry/allopatry boundary or "edge sympatry"), and absent (i.e., in allopatry). Geographic variation in mimetic precision was qualitatively different among these mimics. In one mimic, the most precise individuals occurred in edge sympatry; in another, they occurred in deep sympatry; in the third, they occurred in allopatry; and in the fourth, precise mimics were not concentrated anywhere throughout their range...
April 20, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28425037/a-new-species-of-caryospora-l%C3%A3-ger-1904-apicomplexa-eimeriidae-from-the-guanabara-spotted-night-snake-siphlophis-pulcher-raddi-reptilia-dipsadidae-in-the-atlantic-forest-brazil
#5
Marcos Tobias de Santana Miglionico, Lúcio André Viana
A new coccidian species of the genus Caryospora Léger, 1904 (Apicomplexa, Eimeriidae) is described based on material from the Guanabara spotted night snake Siphlophis pulcher (Raddi) (Reptilia: Dipsadidae) in a coastal area of the Atlantic Forest in Ilha Grande Island, state of Rio de Janeiro, southeastern Brazil. Caryospora ceadsensis n. sp. possesses spheroidal to slightly subspheroidal oöcysts measuring 17-24 × 17-24 (22.1 × 22.0) µm, with a c.1.3 µm thick bi-layered wall (inner layer smooth, outer layer slightly striated), length/width (L/W) ratio of 1...
April 19, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28424837/arsenic-cadmium-chromium-lead-mercury-and-selenium-concentrations-in-pine-snakes-pituophis-melanoleucus-from-the-new-jersey-pine-barrens
#6
Joanna Burger, Michael Gochfeld, Christian Jeitner, Robert Zappalorti, Taryn Pittfield, Emile DeVito
Top trophic level predators are at risk from bioaccumulation of heavy metals from their prey. Using nondestructively collected tissues as a method of assessing metal concentrations in snakes is useful for populations that are threatened or declining. This paper reports concentrations of arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), and selenium (Se) in tissues of Northern pine snakes (Pituophis melanoleucus) from the New Jersey Pine Barrens, a relatively pristine, undisturbed habitat. We also determined if skin is an appropriate indicator of internal concentrations and identified the factors (tissue, year of collection, length, sex) that might explain variations in metal concentrations...
April 19, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28424783/peptide-fraction-poh2-exerts-antiadipogenic-activity-through-inhibition-of-c-ebp-%C3%AE-and-ppar-%C3%AE-expression-in-3t3-l1-adipocytes
#7
Thi Tuyet Nhung Nguyen, Thi Thu Ha, Thi Hoa Nguyen, Thi Hien Vu, Nam Hai Truong, Hoang Ha Chu, Dong Van Quyen
Many studies have comprehensively examined the venom of Ophiophagus hannah snake. Its venom comprises different compounds exhibiting a wide range of pharmacological activities. In this investigation, four peptide fractions (PFs), ranging from 3 kDa to 10 kDa, isolated from the Vietnamese snake venom of O. hannah were separated by HPLC and investigated for their inhibitory activity on adipogenesis in 3T3-L1 adipocytes. The most effective PF was then further purified, generating two peptides, pOh1 and pOh2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28422078/antivenom-for-neuromuscular-paralysis-resulting-from-snake-envenoming
#8
REVIEW
Anjana Silva, Wayne C Hodgson, Geoffrey K Isbister
Antivenom therapy is currently the standard practice for treating neuromuscular dysfunction in snake envenoming. We reviewed the clinical and experimental evidence-base for the efficacy and effectiveness of antivenom in snakebite neurotoxicity. The main site of snake neurotoxins is the neuromuscular junction, and the majority are either: (1) pre-synaptic neurotoxins irreversibly damaging the presynaptic terminal; or (2) post-synaptic neurotoxins that bind to the nicotinic acetylcholine receptor. Pre-clinical tests of antivenom efficacy for neurotoxicity include rodent lethality tests, which are problematic, and in vitro pharmacological tests such as nerve-muscle preparation studies, that appear to provide more clinically meaningful information...
April 19, 2017: Toxins
https://www.readbyqxmd.com/read/28421973/-bitten-by-an-exotic-venomous-snake
#9
M A Dijkman, I de Vries, M van Dam, D W de Lange
BACKGROUND: Patients who have been bitten by an exotic venomous snake are at risk of severe morbidity and a fatal outcome following an incorrect risk-assessment. Treatment with an antivenom can be necessary and can turn out to be lifesaving. In the Netherlands there are only a few cases of bites from exotic venomous snakes each year. CASE DESCRIPTION: A 28-year-old man presented at the emergency department (ED) after having been bitten by a monocled cobra (Naja kaouthia)...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28419970/effect-of-premedication-with-subcutaneous-adrenaline-on-the-pharmacokinetics-and-immunogenicity-of-equine-whole-igg-antivenom-in-a-rabbit-model
#10
María Herrera, Melvin Sánchez, Anderson Machado, Nils Ramírez, Mariángela Vargas, Mauren Villalta, Andrés Sánchez, Álvaro Segura, Aarón Gómez, Gabriela Solano, José María Gutiérrez, Guillermo León
Subcutaneous administration of a low dose of adrenaline is used to prevent the early adverse reactions (EARs) induced by snake antivenoms. We used a rabbit model to study the effect of premedication with adrenaline on the potential of antivenoms to exert therapeutic effects and to induce late adverse reactions. We found that premedication with adrenaline did not change the heart rate or blood pressure of normal rabbits, but reduced the rise in temperature in rabbits previously sensitized with antivenom. Pharmacokinetic studies suggest that premedication with adrenaline does not affect the ability of the antivenom to exert the initial control of envenomation nor the susceptibility of rabbits to develop recurrence of antigenemia and envenomation...
April 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28416444/the-pharmacology-of-voltage-gated-sodium-channel-activators
#11
REVIEW
Jennifer R Deuis, Alexander Mueller, Mathilde R Israel, Irina Vetter
Toxins and venom components that target voltage-gated sodium (NaV) channels have evolved numerous times due to the importance of this class of ion channels in the normal physiological function of peripheral and central neurons as well as cardiac and skeletal muscle. NaV channel activators in particular have been isolated from the venom of spiders, wasps, snakes, scorpions, cone snails and sea anemone and are also produced by plants, bacteria and algae. These compounds have provided key insight into the molecular structure, function and pathophysiological roles of NaV channels and are important tools due to their at times exquisite subtype-selectivity...
April 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28415211/dynamics-of-vortex-antivortex-pairs-and-rarefaction-pulses-in-liquid-light
#12
David Feijoo, Angel Paredes, Humberto Michinel
We present a numerical study of the cubic-quintic nonlinear Schrödinger equation in two transverse dimensions, relevant for the propagation of light in certain exotic media. A well-known feature of the model is the existence of flat-top bright solitons of fixed intensity, whose dynamics resembles the physics of a liquid. They support traveling wave solutions, consisting of rarefaction pulses and vortex-antivortex pairs. In this work, we demonstrate how the vortex-antivortex pairs can be generated in bright soliton collisions displaying destructive interference followed by a snake instability...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28414083/functional-characterization-of-neotropical-snakes-peripheral-blood-leukocytes-subsets-linking-flow-cytometry-cell-features-microscopy-images-and-serum-corticosterone-levels
#13
Marcelo Pires Nogueira de Carvalho, Nicolle Gilda Teixeira Queiroz-Hazarbassanov, Cristina de Oliveira Massoco, Sávio Stefanini Sant'Anna, Mariana Mathias Lourenço, Gabriel Levin, Mari Cleide Sogayar, Kathleen Fernandes Grego, José Luiz Catão-Dias
Reptiles are the unique ectothermic amniotes, providing the key link between ectothermic anamniotes fish and amphibians, and endothermic birds and mammals; becoming an important group to study with the aim of providing significant knowledge into the evolutionary history of vertebrate immunity. Classification systems for reptiles' leukocytes have been described by their appearance rather than function, being still inconsistent. With the advent of modern techniques and the establishment of analytical protocols for snakes' blood by flow cytometry, we bring a qualitative and quantitative assessment of innate activities presented by snakes' peripheral blood leukocytes, thereby linking flow cytometric features with fluorescent and light microscopy images...
April 13, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28414035/bothrops-jararaca-venom-gland-secretory-cells-in-culture-effects-of-noradrenaline-on-toxin-production-and-secretion
#14
Luciana Godoy Viana, Richard Hemmi Valente, Cíntia Scucuglia Heluany, Andreia Souza-Imberg, Milene Schmidt Luna, Jonas Perales, Norma Yamanouye
Primary culture of snake venom gland secretory cells could be a good model to study the mechanism(s) of toxin(s) production. These cells can produce and secrete venom to the medium with a hemorrhagic activity comparable to that induced by venom collected from snakes. Production of new venom is triggered by the sympathetic outflow, through the release of noradrenaline, but the importance of this neurotransmitter on toxin synthesis has not been addressed. This work led to the identification and comparison of the toxin panel produced by cultured secretory cells, during a 12-day time-course analysis, as well as to the effects of noradrenaline on the process...
April 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28411932/arthropod-envenomation-in-north-america
#15
REVIEW
Timothy B Erickson, Navneet Cheema
Arthropods (phylum Arthopoda) account for a higher percentage of morbidity and mortality to humans than do mammalian bites, snake bites, or marine envenomation. They are ubiquitous in domestic dwellings, caves, and campsites and in wilderness settings such as deserts, forests, and lakes. Although arthropods are most intrusive during warmer months, many are active throughout the winter, particularly indoors. Arthropods are also nocturnal and often bite unsuspecting victims while they are sleeping. Encounters with humans are generally defensive, accidental, or reactive...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28411931/north-american-snake-envenomation
#16
REVIEW
Bryan Corbett, Richard F Clark
Native US snakes that produce clinically significant envenomation can be divided into 2 groups, crotalids and elapids. The crotalids include rattlesnakes, cottonmouths, and copperheads. Crotalid envenomation can result in significant local tissue damage as well as thrombocytopenia and coagulopathy. Rarely are bites fatal. Native US elapids are all coral snakes that possess neurotoxic venom that can cause weakness, respiratory paralysis, and rarely death. Treatment of both types of envenomation revolves around general supportive care and antivenom administration when indicated...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28411930/marine-envenomation
#17
REVIEW
Kirsten B Hornbeak, Paul S Auerbach
Venomous aquatic animals are hazardous to swimmers, surfers, divers, and fishermen. Exposures include mild stings, bites, abrasions, and lacerations. Severe envenomations can be life threatening. This article reviews common marine envenomations, exploring causative species, clinical presentation, and current treatment recommendations. Recommendations are included for cnidaria, sponges, bristle worms, crown-of-thorns starfish, sea urchins, venomous fish, stingrays, cone snails, stonefish, blue-ringed octopus, and sea snakes...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28409495/antiplatelet-and-anti-proliferative-action-of-disintegrin-from-echis-multisquamatis-snake-venom
#18
Volodymyr Chernyshenko, Natalia Petruk, Darya Korolova, Ludmila Kasatkina, Olha Gornytska, Tetyana Platonova, Tamara Chernyshenko, Andriy Rebriev, Olena Dzhus, Liudmyla Garmanchuk, Eduard Lugovskoy
AIM: To purify the platelet aggregation inhibitor from Echis multisquamatis snake venom (PAIEM) and characterize its effect on platelet aggregation and HeLa cell proliferation. METHODS: Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) were used for PAIEM identification. Platelet aggregation in the presence of PAIEM was studied on aggregometer Solar-AP2110. The changes of shape and granularity of platelets in the presence of PAIEM were studied on flow cytometer COULTER EPICS XL, and degranulation of platelets was estimated using spectrofluorimetry...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28404727/when-less-means-more-dehydration-improves-innate-immunity-in-rattlesnakes
#19
George A Brusch, Dale F DeNardo
Immune function can vary based on availability of resources, and most studies of such influences have focused on the co-investment of energy into immune and other physiological functions. When energy resources are limited, trade-offs exist, which can compromise immunity for other functions. As with energy, water limitation can also alter various physiological processes, yet water has received little consideration for its role in possibly modulating immune functions. We examined the relationship between immunocompetence and hydration state using the western diamond-backed rattlesnake (Crotalus atrox)...
April 12, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28400263/peptidomimetic-hydroxamate-metalloproteinase-inhibitors-abrogate-local-and-systemic-toxicity-induced-by-echis-ocellatus-saw-scaled-snake-venom
#20
Ana Silvia Arias, Alexandra Rucavado, José María Gutiérrez
The ability of two peptidomimetic hydroxamate metalloproteinase inhibitors, Batimastat and Marimastat, to abrogate toxic and proteinase activities of the venom of Echis ocellatus from Cameroon and Ghana was assessed. Since this venom largely relies for its toxicity on the action of zinc-dependent metalloproteinases (SVMPs), the hypothesis was raised that toxicity could be largely eliminated by using SVMP inhibitors. Both hydroxamate molecules inhibited local and pulmonary hemorrhagic, in vitro coagulant, defibrinogenating, and proteinase activities of the venoms in conditions in which venom and inhibitors were incubated prior to the test...
April 8, 2017: Toxicon: Official Journal of the International Society on Toxinology
keyword
keyword
16522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"