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JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#2
JOURNAL ARTICLE
A-Reum Kim, Surjyasish Mitra, Sudip Shyam, Boxin Zhao, Sushanta K Mitra
Raindrops falling on window-panes spread upon contact, whereas hail can cause dents or scratches on the same glass window upon contact. While the former phenomenon resembles classical wetting, the latter is dictated by contact and adhesion theories. The classical Young-Dupre law applies to the wetting of pure liquids on rigid solids, whereas conventional contact mechanics theories account for rigid-on-soft or soft-on-rigid contacts with small deformations in the elastic limit. However, the crossover between adhesion and wetting is yet to be fully resolved...
April 23, 2024: Soft Matter
#3
Emily R Hannon, Carmen J Marsit, Arlene E Dent, Paula Embury, Sidney Ogolla, David Midem, Scott M Williams, James W Kazura
Background Changing cell-type proportions can confound studies of differential gene expression or DNA methylation (DNAm) from peripheral blood mononuclear cells (PBMCs). We examined how cell-type proportions derived from the transcriptome versus the methylome (DNAm) influence estimates of differentially expressed genes (DEGs) and differentially methylated positions (DMPs). Methods Transcriptome and DNAm data were obtained from PBMC RNA and DNA of Kenyan children (n = 8) before, during, and 6 weeks following uncomplicated malaria...
April 3, 2024: Research Square
#4
RANDOMIZED CONTROLLED TRIAL
David E Teytelbaum, Neil S Kumar, Craig S Dent, Spencer Neaville, Deborah H Warren, Peter Simon, Christopher E Baker
BACKGROUND: Historically, in-person physical therapy serves as a foundational component of nonoperative treatment of adhesive capsulitis (AC). This study compares the effectiveness of an at-home high-intensity stretch (HIS) device to traditional physical therapy (PT) and to PT in combination with the HIS device. We hypothesize that the HIS device will be as effective as PT alone or as combination therapy in the first-line treatment of AC and use of the HIS device will exhibit improvement at higher rate...
April 20, 2024: BMC Musculoskeletal Disorders
#5
JOURNAL ARTICLE
Sridevi Sureshkumar, Champa Bandaranayake, Junqing Lv, Craig I Dent, Prakash Kumar Bhagat, Sourav Mukherjee, Rucha Sarwade, Chhaya Atri, Harrison M York, Prashanth Tamizhselvan, Nawar Shamaya, Giulia Folini, Benjamin G Bergey, Avilash Singh Yadav, Subhasree Kumar, Oliver S Grummisch, Prince Saini, Ram K Yadav, Senthil Arumugam, Emanuel Rosonina, Ari Sadanandom, Hongtao Liu, Sureshkumar Balasubramanian
Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich's ataxia in humans. The molecular mechanisms underlying repeat expansion-induced epigenetic silencing remain largely unknown. Using a plant model with a temperature-sensitive phenotype, we have previously shown that expanded repeats can induce small RNAs, which in turn can lead to epigenetic silencing through the RNA-dependent DNA methylation pathway...
April 19, 2024: Nature Plants
#6
JOURNAL ARTICLE
Lucas G Dent, Nathan Curry, Hugh Sparks, Vicky Bousgouni, Vincent Maioli, Sunil Kumar, Ian Munro, Francesca Butera, Ian Jones, Mar Arias-Garcia, Leo Rowe-Brown, Chris Dunsby, Chris Bakal
How cancer cells determine their shape in response to three-dimensional (3D) geometric and mechanical cues is unclear. We develop an approach to quantify the 3D cell shape of over 60,000 melanoma cells in collagen hydrogels using high-throughput stage-scanning oblique plane microscopy (ssOPM). We identify stereotypic and environmentally dependent changes in shape and protrusivity depending on whether a cell is proximal to a flat and rigid surface or is embedded in a soft environment. Environmental sensitivity metrics calculated for small molecules and gene knockdowns identify interactions between the environment and cellular factors that are important for morphogenesis...
April 16, 2024: Cell Reports
#7
JOURNAL ARTICLE
Elizabeth D Holland, Hannah L Miller, Matthew M Millette, Russell J Taylor, Gabrielle L Drucker, Erik W Dent
Dendritic spines, the mushroom-shaped extensions along dendritic shafts of excitatory neurons, are critical for synaptic function and are one of the first neuronal structures disrupted in neurodevelopmental and neurodegenerative diseases. Microtubule (MT) polymerization into dendritic spines is an activity-dependent process capable of affecting spine shape and function. Studies have shown that MT polymerization into spines occurs specifically in spines undergoing plastic changes. However, discerning the function of MT invasion of dendritic spines requires the specific inhibition of MT polymerization into spines, while leaving MT dynamics in the dendritic shaft, synaptically connected axons and associated glial cells intact...
April 17, 2024: Molecular Biology of the Cell
#8
JOURNAL ARTICLE
Jorge A Tricio, Catalina Braithwaite, Constanza M Herrera, Daniela P Vicuña, Franco R Cacciuttolo, Gilbert A Jorquera, Mario F Gutiérrez, Christian G Córdova, Pablo A Villalón, Gustavo A Moncada, Renzo A Casanova, María I González, Macarena A Ilić Dent Stud, César A Orsini
INTRODUCTION: Three-dimensional (3D)-printing technology can provide customizable simulations, but its effects on patient care quality have not been well studied. This study aimed to assess the impact of practicing with patient-specific 3D-printed teeth models on the quality of patients' dental preparations performed by students transitioning to clinical training. Accordingly, the quality of posterior crown preparations was evaluated by objectively analyzing digital scans and grades in two groups: the study group, which practiced beforehand with patient-specific 3D-printed teeth models, and the control group, which did not practice with these models...
April 16, 2024: Journal of Dental Education
#9
JOURNAL ARTICLE
Kallisse R Dent, Grace M Brennan, Lara Khalifeh, Leah S Richmond-Rakerd
BACKGROUND: Rising midlife mortality in the United States is largely attributable to 'deaths of despair' (deaths from suicide, drug poisonings, and alcohol-related diseases) and deaths from cardiometabolic conditions. Although despair- and cardiometabolic-related mortality are increasing concurrently, it is unclear whether they share common developmental origins. We tested adolescent psychopathology as a potential common origin of midlife diseases of despair and cardiometabolic risk. METHODS: Participants ( N = 4578) were from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative cohort followed from adolescence to early midlife...
April 15, 2024: Psychological Medicine
#10
REVIEW
G Curigliano, R Dent, H Earle, S Modi, P Tarantino, G Viale, S M Tolaney
Approximately 60% of traditionally defined human epidermal growth factor receptor 2 (HER2)-negative breast cancers express low levels of HER2 [HER2-low; defined as immunohistochemistry (IHC) 1+ or IHC 2+/in situ hybridization (ISH)-]. HER2-low breast cancers encompass a large percentage of both hormone receptor-positive (up to 85%) and triple-negative (up to 63%) breast cancers. The DESTINY-Breast04 trial established that HER2-low tumors are targetable, leading to the approval of trastuzumab deruxtecan (T-DXd) as the first HER2-directed therapy for the treatment of HER2-low breast cancer in the United States and Europe...
April 12, 2024: ESMO Open
#11
JOURNAL ARTICLE
Ninad V Mhatre, Satish Kumar
Droplets on inclined substrates can depin and slide freely above a critical substrate inclination angle. Pinning can be caused by topographical defects on the substrate, and understanding the influence of defect geometry on the pinning-depinning transition is important for diverse applications such as fog harvesting, droplet-based microfluidic devices, self-cleaning surfaces, and inkjet printing. Here, we develop a lubrication-theory-based model to investigate the motion of droplets on inclined substrates with a single three-dimensional Gaussian-shaped defect that can be in the form of a bump or a dent...
April 11, 2024: Soft Matter
#12
JOURNAL ARTICLE
Asmaa A Elbanna, Radwa I El-Toukhy, Mohamed Abbas, Nadia M Zaghloul
BACKGROUND: To evaluate the effect of dimethyl sulfoxide (DMSO) primer on microtensile bond strength (μTBS) and the micromorphological pattern of a hydroxyethyl methacrylate (HEMA)-free universal adhesive (UA) applied on wet/dry dentin in etch and rinse (E&R) mode before/after thermomechanical aging. MATERIAL AND METHODS: For the μTBS test, the mid-coronal dentin of 80 human mandibular first molars was exposed and etched with 35% phosphoric acid...
March 2024: Journal of Clinical and Experimental Dentistry
#13
JOURNAL ARTICLE
Dhouha Dallali, Jawhar Fakhfakh, Cédric Paris, Nissaf Aoiadni, Stéphanie Philippot, Arnaud Risler, Mihayl Varbanov, Noureddine Allouche
The current study aimed to investigate the chemical composition, antioxidant, antibacterial, and cytotoxic properties of three extracts (hexane, dichloromethane, and methanol) from Cynoglossum tubiflorus. The composition of the methanolic extract was elucidated using HPLC-HESI-MS/MS analysis. The antioxidant effect was examined using NO, DPPH, FRAP, and TAC assays. Antimicrobial activity was evaluated by broth microdilution using various bacterial strains such as S. aureus , S. epidermidis , P. aeruginosa , E...
March 21, 2024: Plants (Basel, Switzerland)
#14
JOURNAL ARTICLE
Iacopo Fabiani, Michela Chianca, Alberto Aimo, Michele Emdin, Susan Dent, Antonella Fedele, Carlo Maria Cipolla, Daniela Maria Cardinale
The last decade has witnessed a paradigm shift in cancer therapy, from non-specific cytotoxic chemotherapies to agents targeting specific molecular mechanisms. Nonetheless, cardiovascular toxicity of cancer therapies remains an important concern. This is particularly relevant given the significant improvement in survival of solid and haematological cancers achieved in the last decades. Cardio-oncology is a subspecialty of medicine focusing on the identification and prevention of cancer therapy-related cardiovascular toxicity (CTR-CVT)...
April 9, 2024: European Heart Journal
#15
JOURNAL ARTICLE
Juanjuan Shi, Yanwen Guo, Xiaomei Huang, Hongxia Chen, Haijian Cao
In this study, five three-dimensional angle-interlock fabrics with different warp and weft densities were fabricated using 1000D Kevlar filaments. The Kevlar/EP composites were prepared by vacuum-assisted molding techniques. The low-velocity impact property of the composite was tested, focusing on the effects of the warp and weft densities, impact energy, impactor shape, and impactor diameter. The damage area, dent depth, and crack lengths in the warp and weft direction were used to evaluate the impact performance, and the specimens were compared with plain-weave composites with similar areal densities...
January 31, 2024: Materials
#16
Ying-Jiun C Chen, Govinal Badiger Bhaskara, Yue Lu, Kevin Lin, Sharon Y R Dent
Despite recent advances in therapeutic treatments, multiple myeloma (MM) remains an incurable malignancy. Epigenetic factors contribute to the initiation, progression, relapse, and clonal heterogeneity in MM, but our knowledge on epigenetic mechanisms underlying MM development is far from complete. The SAGA complex serves as a coactivator in transcription and catalyzes acetylation and deubiquitylation. Analyses of datasets in the Cancer Dependency Map Project revealed many SAGA components are selective dependencies in MM...
March 28, 2024: bioRxiv
#17
Sara Rossi, Federica Volpi, Roberto Castellana, Roberta Pancani, Federico Dente, Roberta Gaeta, Laura Carrozzi, Emanuele Neri, Chiara Romei
Mounier-Kuhn syndrome is a rare airway disease characterized by tracheal and bronchial dilatation, primarily affecting middle-aged men. We present a case of Mounier-Kuhn syndrome in a 40-year-old man with a history of recurrent respiratory infections since adolescence. The diagnostic journey involved a multidisciplinary approach incorporating clinical evaluation, radiological imaging, and bronchoscopy. Computed tomography findings, including maximum intensity projection reconstructions and 3D rendering, facilitated the diagnosis by revealing significant airway dilation and associated abnormalities...
June 2024: Radiology Case Reports
#18
JOURNAL ARTICLE
Philippe Tresson, Maria Tawdi, Emeraude Rivoire, Antoine Million, Guillaume Passot, Olivier Rouvière, Anne Long
OBJECTIVE: The purpose of this study was to assess whether the presence of an aneurysmal or dissecting arterial disease was a risk factor of poor prognosis in patients presenting a dissection of the celiac trunk (CT). METHODS: All patients presenting a CT dissection between January 1, 2014 and June 30, 2022 were included. Patients with a CT dissection due to the extension of an aortic dissection were excluded. Les antécédents familiaux de dissection, de maladie anévrysmale, de maladie athéromateuse ou du tissu conjonctif, la pratique d'une activité physique ou sportive, un effort inhabituel les jours précédant la dissection ainsi qu'un traumatisme étaient recherchés...
April 5, 2024: Annals of Vascular Surgery
#19
Maryam Amiri, Arezoo Mirzaie
Endodontic treatment in dens invaginatus anomaly is associated with challenges in all stages. This case report outlines the therapy provided for tooth #10 with occasional pain. In examinations, tenderness to percussion and touch and non-response to sensibility tests were observed, and pulp necrosis and symptomatic periapical periodontitis were diagnosed. Radiographic evaluation showed a structural anomaly related to the dens invaginatus and the associated periapical lesion. Cone-beam computed tomography confirmed the presence of DI type II...
2024: Iranian Endodontic Journal
#20
JOURNAL ARTICLE
Ashwath S Nayak, Kiran Kumar H C
OBJECTIVES: Thermoplastic polymers show alteration in their mechanical properties after thermoforming on a dental model. The purpose of this in-vitro study was to evaluate the tensile strength of different thermoplastic polymer sheets thermoformed on a pre-treatment (moderate crowding) and post-treatment (well-aligned) maxillary model of a patient. MATERIALS AND METHODS: Forty maxillary models (Twenty Pre-treatment & twenty Post-treatment of uniform dimension) were made by duplicating them using alginate Hydrogum 5 (Zhermack)...
April 3, 2024: Clinical Oral Investigations
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