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Ayumi Matsumoto, Isao Matsui, Takayasu Mori, Yusuke Sakaguchi, Masayuki Mizui, Yoshiyasu Ueda, Atsushi Takahashi, Yohei Doi, Karin Shimada, Satoshi Yamaguchi, Keiichi Kubota, Nobuhiro Hashimoto, Tatsufumi Oka, Yoshitsugu Takabatake, Eisei Sohara, Takayuki Hamano, Shinichi Uchida, Yoshitaka Isaka
We present a case of Dent disease caused by a novel intronic mutation, 1348-1G>A, of the chloride voltage-gated channel 5 (CLCN5) gene. Cultured proximal tubule cells obtained from the patient showed impaired acidification of the endosome and/or lysosome, indicating that the 1348-1G>A mutation was indeed the cause of Dent disease. Although the prevalence of osteomalacia in Dent disease is low in Japan, several factors-including poor medication adherence-caused severe osteomalacia in the current case. Oral supplementation with calcium and native/active vitamin D therapy, with careful attention to medication adherence, led to the improvement of the patient's bone status...
August 10, 2018: Internal Medicine
J Dollard, G Harvey, E Dent, L Trotta, N Williams, J Beilby, E Hoon, A Kitson, C Seiboth, J Karnon
Older frequent users of acute care can experience fragmented care. There is a need to understand the issues in a local context before attempting to address fragmented care. 0.5% (n=61) of the population in a defined local government area were identified as having ≥4 unplanned emergency department (ED) presentations/ admissions to an acute-care hospital over 13 months. A retrospective case-series study was conducted to examine detailed pathways of care for 17 patients within the identified population. The two dominant presentation reasons were clinical symptoms associated with a declining/significant loss of capacity in fundamental self-care activities and chronic cardiac/respiratory conditions...
2018: Journal of Frailty & Aging
Anne Sophie Fischer, Niels Marcussen, Maria Rasmussen, Else Randers
Dent's disease is characterized by manifestations of proximal tubule dysfunction including hypercalciuria, kidney stones, proteinuria, rickets and progressively declining kidney function. The diagnosis is based on the presence of low-molecular-weight proteinuria, hypercalciuria and at least one of the following: nephrocalcinosis, kidney stones, haematuria, hypophosphataemia or renal insufficiency. Dent's disease is a hereditary condition that is caused by variants in the CLCN5 gene or the OCRL1 gene and affects only males...
August 2018: Clinical Kidney Journal
Chau T Dang, Anne Blaes, Filipa Lynce, Sandra M Swain, Susan Dent
No abstract text is available yet for this article.
August 2018: JACC. Cardiovascular Imaging
Vivian Mendes, Gustavo Oliveira Dos Santos, Vittorio Moraschini
No abstract text is available yet for this article.
August 4, 2018: Journal of Dentistry
Caitlin A Fitzgerald, Dipan C Patel, Christopher J Dente, Anuradha Subramanian
No abstract text is available yet for this article.
July 1, 2018: American Surgeon
Ricardo Luiz de Barreto Aranha, Mauro Henrique Nogueira Guimarães De Abreu, Júnia Maria Serra-Negra, Renata Castro Martins
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Prosthodontic planning in patients with temporomandibular disorders and/or bruxism: A systematic review. Manfredini D, Poggio CE. J Prosthet Dent. 2017;117(5):606-13. SOURCE OF FUNDING: Information not available. TYPE OF STUDY/DESIGN: Review.
September 2018: Journal of Evidence-based Dental Practice
Reann Cornell, Jae Hyun Park
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Influence of orthodontic premolar extraction therapy on the eruption of the third molars: A systematic review of the literature. Brezulier D, Fau V, Sorel O. J Am Dent Assoc 2017;148(12):903-12. SOURCE OF FUNDING: Information not available.
September 2018: Journal of Evidence-based Dental Practice
Sonja H M Derman
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Intrapocket topical anesthetic versus injected anesthetic for pain control during scaling and root planing in adult patients: systematic review and meta-analysis. Wambier LM, de Geus JL, Boing TF, Chibinski ACR, Wambier DS, Rego RO, Loguercio AD, Reis A. J Am Dent Assoc 2017;148(11):814-24.e812. SOURCE OF FUNDING: Institutional, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data...
September 2018: Journal of Evidence-based Dental Practice
Leslie Cho, Ricardo Dent, Erik S G Stroes, Evan A Stein, David Sullivan, Andrea Ruzza, Andrea Flower, Ransi Somaratne, Robert S Rosenson
PURPOSE: Evolocumab reduced low-density lipoprotein cholesterol (LDL-C) in 12-week trials in statin-intolerant patients (GAUSS-1 and GAUSS-2); however, the persistence of efficacy during longer-term treatment is unknown. This subset analysis of the open-label extension studies (OSLER-1 and OSLER-2) aimed to evaluate the safety and efficacy of evolocumab up to 2 years in statin-intolerant patients. METHODS: Patients who completed GAUSS-1 and GAUSS-2 were enrolled in the OSLER studies and rerandomized 2:1 to evolocumab (140 mg biweekly or 420 mg monthly) plus standard of care (SOC) or SOC during year 1, and thereafter, evolocumab plus SOC...
August 2, 2018: Cardiovascular Drugs and Therapy
Kevin Thomas, Callum George Brownstein, Jack Dent, Paul Parker, Stuart Goodall, Glyn Howatson
PURPOSE: Training methods that require maximal intensity efforts against light- and heavy-resistance are commonly used for athletic development. Typically these sessions are separated by at least 48 hours recovery on the assumption that such efforts elicit marked fatigue of the central nervous system (CNS), but this posit has not been well-studied. The aim of the study was to assess the aetiology and recovery of fatigue after heavy-resistance (strength), jump, and sprint training methods...
July 31, 2018: Medicine and Science in Sports and Exercise
Kh Sarabandi, S H Peighambardoust, A R Sadeghi Mahoonak, S P Samaei
Adhesion is the most important factor in product loss in the spray drying of syrups and juices. The main solution to reduce adhesion is using drying aids. The aim of this study was to evaluate effect of maltodextrin (MD) and gum Arabic as drying aids, and pectin and whey protein concentrate (WPC) as complementary drying aid on the powder yield, physical, functional and microstructural properties of spray dried apple juice concentrate. The studied variables and composition of the carriers were used. The inlet air temperature, atomizer rotational speed, feed flow rate, feed temperature and atomizer pressure were kept constant at 160 °C, 18,000 rpm, 15 ml/min, 25 ± 1 °C and 4...
August 2018: Journal of Food Science and Technology
Nicky Phillips
No abstract text is available yet for this article.
August 2018: Nature
Laura S Johnson, Mitchell Chaar, Chad G Ball, Sebastian Perez, Jeffrey M Nicholas, Amy D Wyrzykowski, Grace S Rozycki, David V Feliciano, Christopher J Dente
INTRODUCTION: Morbidity from the treatment of extremity compartment syndrome is underappreciated. Closure technique effectiveness has yet to be definitively established. METHODS: A randomized non-blinded prospective study was performed involving patients who underwent an extremity fasciotomy following trauma. Shoelace wounds were strapped with vessel loops under tension and VAC wounds were treated with a standard KCI VAC dressing. After randomization, patients returned to the OR every 96 h until primarily closed or skin grafted...
July 26, 2018: American Journal of Surgery
Caitlin A Fitzgerald, Dipan C Patel, Christopher J Dente, Anuradha Subramanian
No abstract text is available yet for this article.
July 1, 2018: American Surgeon
Yoon-Sim Yap, Angad P Singh, John H C Lim, Jin-Hee Ahn, Kyung-Hae Jung, Jeongeun Kim, Rebecca A Dent, Raymond C H Ng, Sung-Bae Kim, Derek Y Chiang
Breast cancer is an increasing problem in Asia, with a higher proportion of premenopausal patients who are at higher risk of recurrence. Targeted sequencing was performed on DNA extracted from primary tumor specimens of 63 premenopausal Asian patients who relapsed after initial diagnosis of non-metastatic breast cancer. The most prevalent alterations included: TP53 (65%); PIK3CA (32%); GATA3 (29%); ERBB2 (27%); MYC (25%); KMT2C (21%); MCL1 (17%); PRKDC, TPR, BRIP1 (14%); MDM4, PCDH15, PRKAR1A, CDKN1B (13%); CCND1, KMT2D, STK11 , and MLH1 (11%)...
2018: NPJ Breast Cancer
Matthew T Mefford, Gabriel S Tajeu, Rikki M Tanner, Lisandro D Colantonio, Keri L Monda, Ricardo Dent, Michael E Farkouh, Robert S Rosenson, Monika M Safford, Paul Muntner
Guidelines recommend attempting to reinitiate statins in patients who discontinue treatment. Previous experiences while taking a statin, including side effects, may reduce a patient's willingness to reinitiate treatment. We determined the percentage of adults who are willing to reinitiate statin therapy after treatment discontinuation. Factors associated with willingness to reinitiate a statin were also examined. A statin questionnaire was administered and study examination conducted in black and white US adults enrolled in the nationwide REasons for Geographic And Racial Differences in Stroke study from 2013 to 2017...
June 2, 2018: American Journal of Cardiology
Jacob Kamdem, Dennis Palmer, Charles Barrier, Richard Bardin, James Allen Brown, Mark Topazian
Introduction: Gastrointestinal endoscopy is an important modality for diagnosis and treatment of gastrointestinal disease, but there are limited data regarding the diagnostic yield of endoscopy in Cameroon and changes in the prevalence of endoscopic findings over time. Our aims were to describe the diagnostic utility of esophagogastroduodenoscopy (EGD) and colonoscopy, the impact of periodic on-site mentorship on cecal intubation rate and changes in the prevalence of common upper gastrointestinal findings when compared to a similar report from our region published in 1990...
2018: Pan African Medical Journal
Emiel O Hoogendijk, Judith J M Rijnhart, Paul Kowal, Mario U Pérez-Zepeda, Matteo Cesari, Pedro Abizanda, Teresa Flores Ruano, Astrid Schop-Etman, Martijn Huisman, Elsa Dent
OBJECTIVES: The aim of this study was to investigate socioeconomic inequalities in frailty among older adults in six low- and middle-income countries (LMICs), and to examine to what extent chronic diseases account for these inequalities. STUDY DESIGN: Data were used from the Study on global AGEing and adult health (SAGE) wave 1 (2007-2010). Nationally representative samples of adults aged 50+ years from China, Ghana, India, Mexico, the Russian Federation and South Africa were analyzed (n = 31,174)...
September 2018: Maturitas
Maegan Capitano, Liang Zhao, Scott Cooper, Chelsea Thorsheim, Aae Suzuki, Xinxin Huang, Alexander L Dent, Michael S Marks, Charles S Abrams, Hal E Broxmeyer
We hypothesized that megakaryocyte (MK) phosphoinositide signaling mediated by phosphatidylinositol transfer protein(s) (Pitp) contributes to hematopoietic stem (HSC) and progenitor (HPC) cell regulation. Conditional knockout mice lacking Pitps specifically in MKs and platelets (pitpα-/- and pitpα-/- /β-/- ) bone marrow (BM) manifested decreased numbers of HSC, megakaryocyte-erythrocyte progenitors, and cycling HPC. Further, pitpα-/- /β-/- BM had significantly reduced engrafting capability in competitive transplantation and limiting dilution analysis...
July 24, 2018: Blood
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