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Andrew Buskard, Brian Zalma, Nicholes Cherup, Catherine Armitage, Craig Dent, Joseph F Signorile
BACKGROUND: Periodization is a systematic training calendar designed to provide variations in performance targeting, while maximizing results and reducing the potential for overtraining. When provided across multiple weeks, termed a mesocycle, it may also incorporate active recovery periods using specified drills designed to translate neuromuscular gains into targeted functional abilities. There are a number of models that can be used when applying periodization to resistance training (RT)...
October 11, 2018: Experimental Gerontology
Leopoldo Staiano, Maria Antonietta De Matteis
Phosphoinositides (PIs) play pivotal roles in the regulation of many biological processes. The quality and quantity of PIs is regulated in time and space by the activity of PI-kinases and PI-phosphatases. The number of PI metabolizing enzymes exceeds the number of PIs with, in many cases, more than one enzyme controlling the same biochemical step. This would suggest that the PI system has an intrinsic ability to buffer and compensate for the absence of a specific enzymatic activity. However, there are several examples of severe inherited human diseases caused by mutations in one of the PI-enzymes, although other enzymes with the same activity are fully functional...
October 12, 2018: Journal of Lipid Research
Nikolas Gioia Cipola, Javier Arbea, Enrique Baquero, Rafael Jordana, JosÉ Wellington de Morais, Bruno Cavalcante Bellini
Here we present a survey of Seira fauna from Iberian Peninsula and Canary Islands, including the description of three new species from Spain: Seira barrai sp. nov., Seira betica sp. nov. and Seira burgersi sp. nov., the latter with unprece-dented antennal morphology for Seira. Five species from Western Europe are redescribed and their dorsal detailed chaetotaxy is revealed for the first time: S. domestica (Nicolet), S. dinizi Gama, S. ferrarii Parona, S. mantis Zeppelini Bellini and S. pini Jordana Arbea, the first two from type locality, and the latter two based on analysis of the type material...
August 13, 2018: Zootaxa
Rebecca E W Kaplan, Amy K Webster, Rojin Chitrakar, Joseph A Dent, L Ryan Baugh
BACKGROUND: Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. In addition, larvae arrested in the dauer diapause, a non-feeding state of developmental arrest that occurs during the L3 stage, initiate recovery when exposed to food. Despite the essential role of food in C. elegans development, the contribution of food perception versus ingestion on physiology has not been delineated...
October 8, 2018: BMC Biology
Simon Rio, Tristan Mary-Huard, Laurence Moreau, Alain Charcosset
Population structure affects genomic selection efficiency as well as the ability to forecast accuracy using standard GBLUP. Genomic prediction models usually assume that the individuals used for calibration belong to the same population as those to be predicted. Most of the a priori indicators of precision, such as the coefficient of determination (CD), were derived from those same models. But genetic structure is a common feature in plant species, and it may impact genomic selection efficiency and the ability to forecast prediction accuracy...
October 4, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Jingtao Lilue, Anthony G Doran, Ian T Fiddes, Monica Abrudan, Joel Armstrong, Ruth Bennett, William Chow, Joanna Collins, Stephan Collins, Anne Czechanski, Petr Danecek, Mark Diekhans, Dirk-Dominik Dolle, Matt Dunn, Richard Durbin, Dent Earl, Anne Ferguson-Smith, Paul Flicek, Jonathan Flint, Adam Frankish, Beiyuan Fu, Mark Gerstein, James Gilbert, Leo Goodstadt, Jennifer Harrow, Kerstin Howe, Ximena Ibarra-Soria, Mikhail Kolmogorov, Chris J Lelliott, Darren W Logan, Jane Loveland, Clayton E Mathews, Richard Mott, Paul Muir, Stefanie Nachtweide, Fabio C P Navarro, Duncan T Odom, Naomi Park, Sarah Pelan, Son K Pham, Mike Quail, Laura Reinholdt, Lars Romoth, Lesley Shirley, Cristina Sisu, Marcela Sjoberg-Herrera, Mario Stanke, Charles Steward, Mark Thomas, Glen Threadgold, David Thybert, James Torrance, Kim Wong, Jonathan Wood, Binnaz Yalcin, Fengtang Yang, David J Adams, Benedict Paten, Thomas M Keane
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains and find extensive strain-specific haplotype variation. We identify and characterize 2,567 regions on the current mouse reference genome exhibiting the greatest sequence diversity. These regions are enriched for genes involved in pathogen defence and immunity and exhibit enrichment of transposable elements and signatures of recent retrotransposition events. Combinations of alleles and genes unique to an individual strain are commonly observed at these loci, reflecting distinct strain phenotypes...
October 1, 2018: Nature Genetics
Nele Kettler, Nicolas Frenzel Baudisch, David Klingenberger, Rainer Andreas Jordan
STUDY AIM: In the context of a shortfall in medical care, the question arises whether a similar trend in dental care may be anticipated. This study analyses preferred working regions and future town-country distribution of young dentists in Germany. METHODS: This online-survey was conducted in spring 2017. It is the second wave of the longitudinal nationwide study "Y-dent: Professional identity of future and young dentists". Study end points were (1) favoured permanent working region of young dentists, (2) favoured future working city size, and (3) correlation between the region of origin and the favoured working region...
October 1, 2018: Das Gesundheitswesen
Laurel A Screven, Micheal L Dent
Mice must perceive and interpret the signals they are presented with to evaluate potential mates, and should show a preference for high quality conspecifics. The present experiment was designed to investigate preference for acoustic, olfactory, and acoustic + olfactory signals in laboratory mice. Eighteen female CBA/CaJ mice, socially housed or isolated, were tested to evaluate preference for signals produced by males. Social experience influenced female preference for male USV playback and soiled bedding...
September 28, 2018: Behavioural Processes
Jason S Radowsky, Romon Neely, Jonathan A Forsberg, Felipe A Lisboa, Christopher J Dente, Eric A Elster, Nicole J Crane
BACKGROUND: The complexity and severity of traumatic wounds in military and civilian trauma demands improved wound assessment, before, during, and after treatment. Here, we explore the potential of 3 charge-coupled device (3CCD) imaging values to distinguish between traumatic wounds that heal following closure and those that fail. Previous studies demonstrate that normalized 3CCD imaging values exhibit a high correlation with oxygen saturation and allow for comparison of values between diverse clinical settings, including utilizing different equipment and lighting...
2018: PloS One
Rongrong Wu, Xinwen Ou, Ranran Tian, Jie Zhang, Hangshuai Jin, Mingdong Dong, Jingyuan Li, Lei Liu
The interaction of two-dimensional (2D) nanomaterials and bacterial membranes has attracted tremendous attention in antibacterial applications. Various peculiarities of 2D nanomaterials may lead to multiple mechanisms of their interactions with membranes. Here, we investigated the interaction between molybdenum disulfide (MoS2) nanosheets and the bacterial membrane by using both theoretical and experimental approaches. Molecular dynamics simulation presented that MoS2 nanosheets can disrupt the structure of the lipid membrane by making dents on its surface and extracting phospholipid molecules to reduce the integrity of the membrane...
September 27, 2018: Nanoscale
P H Chapuis, E Bokey, C Chan, A Keshava, M J F X Rickard, P Stewart, C J Young, O F Dent
AIM: The recommended standard of care for patients after resection of stage III colon cancer is adjuvant 5FU-based chemotherapy - FOLFOX (fluorouracil, leucovorin with oxaliplatin) - or CAPOX (capecitabine, oxaliplatin). This may be modified in older patients or depending on comorbidity. This has been challenged recently, as the apparent benefit of adjuvant chemotherapy may arise from improvements in surgery or preoperative imaging or pathology staging. This study compares recurrence and colon cancer-specific death between patients who received postoperative adjuvant chemotherapy and those who did not...
September 25, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Marjan Abbasi, Darryl Rolfson, Amandeep S Khera, Julia Dabravolskaj, Elsa Dent, Linda Xia
No abstract text is available yet for this article.
September 24, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Matthew P Dent, Hequn Li, Paul L Carmichael, Francis L Martin
This study investigated the use of androgen receptor (AR) reporter gene assay data in a non-animal exposure-led risk assessment in which in vitro anti-androgenic activity and exposure data were put into context using a naturally occurring comparator substance with a history of dietary consumption. First, several dietary components were screened to identify which selectively interfered with AR signaling in vitro, using the AR CALUX® test. The IC50 values from these dose-response data together with measured or predicted human exposure levels were used to calculate exposure:activity ratios (EARs) for the dietary components and a number of other well-known anti-androgenic substances...
September 22, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Caitlin A Fitzgerald, Dipan C Patel, Christopher J Dente, Anuradha Subramanian
No abstract text is available yet for this article.
July 1, 2018: American Surgeon
Roselle De Guzman, Monica Malik, Gilberto de Lima Lopes, Rebecca Alexandra Dent, Shaheenah Dawood
No abstract text is available yet for this article.
September 2018: Journal of Global Oncology
Laurie M Bianchi, Katherine M Phillips, Ryan C McGinty, Jaspreet K Ahuja, Pamela R Pehrsson
The quantitative effect of different preparation variables on the sodium content of cooked dry pasta was evaluated. Semolina spaghetti (<5 mg sodium/100 g) was cooked by a typical method (454 g, 5.68 L water, 36 g salt, al dente, no rinsing) and after systematic variation of amount of salt, water:pasta ratio, cooking volume and time, rinsing, pasta shape, whole grain. Sodium was assayed by ICP-MS, including rigorous quality control. Pasta cooked without salt had <5 mg sodium/140 g serving, and 247-490 mg/serving when cooked in salted water by the different variations...
January 15, 2019: Food Chemistry
Satish Kumar, Sanjiv Kumar, Basab Gupta
Urban population in our country has increased at an annual rate of 2.7% during the last decade and it is estimated that by 2031, there would be about 600 million people living in urban India. The fast pace of urbanization has come to stay with increasing proportion of urban poor and vulnerable with health indicators much worse than their rural counterparts. The need to provide health care to urban poor has been emphasized in the past in various health committees' reports and National 5-year Development Plans, but no significant dent was made to improve the urban health scenario of the country...
July 2018: Indian Journal of Public Health
Caomhán Stewart, Emma K Gibson, Kevin Morgan, Giannantonio Cibin, Andrew J Dent, Christopher Hardacre, Evgenii V Kondratenko, Vita A Kondratenko, Colin McManus, Scott Rogers, Cristina E Stere, Sarayute Chansai, Yi-Chi Wang, Sarah J Haigh, Peter P Wells, Alexandre Goguet
The promotional effect of H2 on the oxidation of CO is of topical interest, and there is debate over whether this promotion is due to either thermal or chemical effects. As yet there is no definitive consensus in the literature. Combining spatially resolved mass spectrometry and X-ray absorption spectroscopy (XAS), we observe a specific environment of the active catalyst during CO oxidation, having the same specific local coordination of the Pd in both the absence and presence of H2 . In combination with Temporal Analysis of Products (TAP), performed under isothermal conditions, a mechanistic insight into the promotional effect of H2 was found, providing clear evidence of nonthermal effects in the hydrogen-promoted oxidation of carbon monoxide...
September 7, 2018: ACS Catalysis
Kristin Hollister, Praveen Kusumanchi, Ruth Ann Ross, Kristina Chandler, AdePeju Oshodi, Laura Heathers, Sean Teagarden, Li Wang, Alexander L Dent, Suthat Liangpunsakul
Background: Excessive drinkers (ED) and patients with alcoholic liver disease (ALD) are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations. Follicular helper T (TFH) cells are essential to select B cells in the germinal center and to produce antibodies. TFH cells express both a membrane-associated and a soluble form of CD40 ligand (sCD40L); in which the latter form is released to circulation upon T cell activation...
March 2018: Liver research
Mario Diplomatico, Pierluigi Marzuillo, Daniela Capalbo, Michela Stanco, Rosaria Marotta, Stefano Guarino
: A 12-year-old boy, with intermittent abdominal pain from 3 years of age, presented with increased frequency of right lower quadrant pain (at least three episodes per week over the past six months) and pain during micturition affecting school attendance. His family history included referred urolithiasis. An abdominal ultrasound performed 1 year before our visit showed a small stone of 4 mm in the right renal pelvis for which he did not receive any therapy. The patient brought 25 hard stones with irregular outline, 2-8 mm in diameter, of deep brown/grey colour that he claimed to have found in his underwear (figure 1)...
September 15, 2018: Archives of Disease in Childhood. Education and Practice Edition
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