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Fujita Haruka, Otomaru Takafumi, Takahashi Hidekazu, Iwasaki Naohiko, Sumita Yuka
No abstract text is available yet for this article.
October 2018: Journal of Indian Prosthodontic Society
Kate L Thomson, Elizabeth Ormondroyd, Andrew R Harper, Tim Dent, Karen McGuire, John Baksi, Edward Blair, Paul Brennan, Rachel Buchan, Teofila Bueser, Carolyn Campbell, Gerald Carr-White, Stuart Cook, Matthew Daniels, Sri V V Deevi, Judith Goodship, Jesse B G Hayesmoore, Alex Henderson, Teresa Lamb, Sanjay Prasad, Paula Rayner-Matthews, Leema Robert, Linda Sneddon, Hannah Stark, Roddy Walsh, James S Ware, Martin Farrall, Hugh C Watkins
PURPOSE: Increasing numbers of genes are being implicated in Mendelian disorders and incorporated into clinical test panels. However, lack of evidence supporting the gene-disease relationship can hinder interpretation. We explored the utility of testing 51 additional genes for hypertrophic cardiomyopathy (HCM), one of the most commonly tested Mendelian disorders. METHODS: Using genome sequencing data from 240 sarcomere gene negative HCM cases and 6229 controls, we undertook case-control and individual variant analyses to assess 51 genes that have been proposed for HCM testing...
December 11, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Antonella Calzone, Alessandra Podda, Giacomo Lorenzini, Bianca Elena Maserti, Elisa Carrari, Elena Deleanu, Yasutomo Hoshika, Matthew Haworth, Cristina Nali, Ovidiu Badea, Elisa Pellegrini, Silvano Fares, Elena Paoletti
Plants are exposed to a broad range of environmental stresses, such as salinity and ozone (O3 ), and survive due to their ability to adjust their metabolism. The aim of this study was to evaluate the physiological and biochemical adjustments adopted by pomegranate (Punica granatum L. cv. Dente di cavallo) under realistic field conditions. One-year-old saplings were exposed to O3 [two levels denoted as ambient (AO) and elevated (EO) O3 concentrations] and salinity [S (salt, 50 mM NaCl)] for three consecutive months...
November 28, 2018: Science of the Total Environment
Federica Novelli, Elena Bacci, Manuela Latorre, Veronica Seccia, Maria Laura Bartoli, Silvana Cianchetti, Federico Lorenzo Dente, Antonella Di Franco, Alessandro Celi, Pierluigi Paggiaro
Background: According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma. Methods: The aim of this study was to assess the independent effect of different comorbidities on clinical, functional and biologic features of SA. Seventy-two patients with SA according to GINA guidelines were examined. We collected demographic data, smoking habit, asthma history, and assessment of comorbidities...
2018: Clinical and Molecular Allergy: CMA
Indu Bharti, Sukhcharn Singh, D C Saxena
Present investigation was aimed to characterize the influence of alkali treatment on physicochemical, pasting, morphological and structural properties of mango kernel starches from three cultivars viz. Safeda, Chausa, Dussheri when treated with 0.1, 0.25 and 0.5% NaOH for 0, 5 and 10 days at 25 °C. Alkali treated starches have shown significant reduction (p < 0.05) in water binding capacity and amylose content whereas significant increase was observed in solubility and swelling power when compared with their native counterparts...
December 3, 2018: International Journal of Biological Macromolecules
Marina Rechden Lobato Palmeiro, Mariana Bauer Bronstrup, Justin Durham, Angus Walls, Rosemary Sadami Arai Shinkai
The impact of oral rehabilitation on masticatory function and oral health-related quality of life (OHRQoL) may vary with the experience of the individual with tissue loss. Our hypothesis is that patient-centered outcomes vary among adults who have experienced large defects in the maxilla due to congenital or acquired conditions even after oral rehabilitation to restore aesthetics and function. This study compared OHRQoL, perceived masticatory ability, maximum bite force (MBF), and symptoms of pain and depression among subjects with acquired (edentulous maxilla) and congenital (cleft lip and palate) loss of oral tissues in the maxilla after dental treatment...
November 29, 2018: Brazilian Oral Research
Shivani Butala, Leena Palomo
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Bone density and clinical periodontal attachment in postmenopausal women. Penoni DC, Fidalgo TKS, Torres SR, Varela VM, Masterson D, Leão ATT, Maia LC. J Dent Res 2017; 96(3):261-9.s SOURCE OF FUNDING: Information not available. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.
December 2018: Journal of Evidence-based Dental Practice
Fang Hua, Hongye Yang, Hong He
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Enamel remineralization therapies for treating postorthodontic white spot lesions: a systematic review. Fernández-Ferrer L, Vicente-Ruíz M, García-Sanz V, Montiel-Company JM, Paredes-Gallardo V, Almerich-Silla JM, Bellot-Arcís C. J Am Dent Assoc 2018; 149(9):778-86.e2. SOURCE OF FUNDING: No financial support was reported. TYPE OF STUDY/DESIGN: Systematic review.
December 2018: Journal of Evidence-based Dental Practice
Paul S Farsai
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Do HEMA-free adhesive systems have better clinical performance than HEMA-containing systems in noncarious cervical lesions? A systematic review and meta-analysis. da Silva TSP, de Castro RF, Magno MB, Maia LC, da Silva 3 Souza Júnior. J Dent 2018; 74: 1-14. SOURCE OF FUNDING: Information not available. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.
December 2018: Journal of Evidence-based Dental Practice
Ben Stocks, Jessica R Dent, Henry B Ogden, Martina Zemp, Andrew Philp
Exercise performed in the fasted state acutely increases fatty acid availability and utilization. Furthermore, activation of energy-sensing pathways and fatty acid metabolic genes can be augmented by fasting and fasted exercise. However, whether a similar effect occurs at higher exercise intensities remains poorly understood. This study aimed to assess the effect of fed and fasted exercise upon post-exercise signaling and mRNA responses during moderate- to high-intensity steady-state exercise. Eight male participants (age: 25 ± 2 y, O2peak : 47...
December 4, 2018: American Journal of Physiology. Endocrinology and Metabolism
Flávia Casale Abe, Cristiane de Cássia Bergamaschi, Mabel Fernandes Figueiró, Luciane Cruz Lopes
BACKGROUND: Antimicrobial resistance is currently considered the main risk to global health. A variety of microbial species have been isolated from endodontic and periodontal infections. However, clinical endodontic and periodontics bacterial isolates have not been sufficiently characterized with regard to their capacity for antibiotic resistance. We aim to assess the existing evidence to estimate the prevalence of the main antimicrobial resistance and multidrug resistant organisms in endodontics and periodontics and to describe their geographic distribution in Latin America...
November 2018: Medicine (Baltimore)
Tobias A Schrag, Wolfgang Schipprack, Albrecht E Melchinger
Inclusion of historical training data improved the genomics-based prediction of performance of maize hybrids, the extent depending on the phenotypic trait and genotype-by-year interaction. Prediction of hybrid performance using existing phenotypic data on previous hybrids combined with molecular data collected on the parent lines allows to identify the most promising candidates from a huge number of possible hybrids at an early stage. Phenotypic data on yield and dry matter of 1970 grain maize hybrids from 19 years of a public breeding program were aggregated considering the underlying structure of factorial sets of hybrids...
November 29, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
E Dent, J E Morley, A J Cruz-Jentoft, H Arai, S B Kritchevsky, J Guralnik, J M Bauer, M Pahor, B C Clark, M Cesari, J Ruiz, C C Sieber, M Aubertin-Leheudre, D L Waters, R Visvanathan, F Landi, D T Villareal, R Fielding, C W Won, O Theou, F C Martin, B Dong, J Woo, L Flicker, L Ferrucci, R A Merchant, L Cao, T Cederholm, S M L Ribeiro, L Rodríguez-Mañas, S D Anker, J Lundy, L M Gutiérrez Robledo, I Bautmans, I Aprahamian, J M G A Schols, M Izquierdo, B Vellas
OBJECTIVES: Sarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR). METHODS: To develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia...
2018: Journal of Nutrition, Health & Aging
Melissa D Olfert, Amanda Dent, Rachel A Wattick
Metabolic Syndrome (MetS) contributes to the development of cardiovascular disease (CVD) and type II diabetes mellitus (T2DM). Few studies have investigated the MetS risk of young adults (18⁻24 years old). This study aims to determine the prevalence of MetS in Appalachian and non-Appalachian students attending West Virginia University. The prevalence of MetS in this population was 15%. There was no difference in MetS prevalence between male students and female students (18.8% males and 11.1% females, p -value = 0...
November 27, 2018: Journal of Clinical Medicine
Barry M O'Callaghan, Jules C Hancox, Alan G Stuart, Catherine Armstrong, Maggie M Williams, Alison Hills, Hazel Pearce, Carolyn L Dent, Mary Gable, Mark A Walsh
No abstract text is available yet for this article.
November 2018: HeartRhythm Case Reports
Xuan Li, Abraham P Lee
Single-cell analysis is of critical importance in revealing population heterogeneity, identifying minority sub-populations of interest, as well as discovering unique characteristics of individual cells. Microfluidic platforms work at the scale comparable to cell diameter and is suitable for single-cell manipulation. Here we present a microfluidic trapping array which is able to rapidly and deterministically trap single-cells in highly-packed microwells. This chapter first describes the design and fabrication protocols of the trapping array, and then presents its two representative applications: single-cell mRNA probing when integrated with a dielectrophoretic nanotweezer (DENT), and live-cell real-time imaging when combined with fluorescence lifetime imaging microscopy (FLIM)...
2018: Methods in Cell Biology
Giovanni Gambaro, G Zaza, F Citterio, A Naticchia, P M Ferraro
Deciding whether to accept a donor with nephrolithiasis is a multifaceted task because of the challenge of finding enough suitable donors while at the same time ensuring the safety of both donors and recipients. Until not long ago, donors with a history of renal stones or with stones emerging during screening on imaging were not considered ideal, but recent guidelines have adopted less stringent criteria for potential donors at risk of stones. This review goes through the problems that need to be approached to arrive at a wise clinical decision, balancing the safety of donors and recipients with the need to expand the organ pool...
November 23, 2018: Urolithiasis
Punita Kumari, Jihui Wang, Saahil Khan
The effect of multiple/repeated impacts on a repaired composite was investigated using a low-velocity impact test. The composite samples were fabricated through a vacuum resin infusion method (VARI) and repaired by a scarf repair technique. Later, a repeated low-velocity impact test was performed on the original and repaired composites samples. Performance of the multi-impacted repaired and original samples was evaluated and compared by measuring maximum contact force, maximum displacement, maximum time duration, absorbed energy and damage area...
November 22, 2018: Materials
Abdulla M Ehlayel, Lawrence Copelovitch
Dent disease is an X-linked form of chronic kidney disease characterized by hypercalciuria, low molecular weight proteinuria, nephrocalcinosis, and proximal tubular dysfunction. Clinical presentation is highly variable. Male patients may present with early-onset rickets, recurrent nephrolithiasis, or insidiously with asymptomatic proteinuria or chronic kidney disease. Mutations in both the CLCN5 and OCRL1 genes have been associated with the Dent phenotype and are now classified as Dent-1 and Dent-2, respectively...
February 2019: Pediatric Clinics of North America
Caitlin A Fitzgerald, Dipan C Patel, Christopher J Dente, Anuradha Subramanian
No abstract text is available yet for this article.
July 1, 2018: American Surgeon
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