keyword
https://read.qxmd.com/read/38493181/corneal-confocal-microscopy-may-help-to-distinguish-multiple-system-atrophy-from-parkinson-s-disease
#21
JOURNAL ARTICLE
Xuebin Niu, Peixiao Yin, Chenyang Guan, Qiuyue Shao, Guiyun Cui, Kun Zan, Chuanying Xu
Multiple system atrophy (MSA) and Parkinson's disease (PD) have clinical overlapping symptoms, which makes differential diagnosis difficult. Our research aimed to distinguish MSA from PD using corneal confocal microscopy (CCM), a noninvasive and objective test. The study included 63 PD patients, 30 MSA patients, and 31 healthy controls (HC). When recruiting PD and MSA, questionnaires were conducted on motor and non-motor functions, such as autonomic and cognitive functions. Participants underwent CCM to quantify the corneal nerve fibers...
March 16, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38493058/neuroprotective-effects-of-niclosamide-on-disease-progression-via-inflammatory-pathways-modulation-in-sod1-g93a-and-fus-associated-amyotrophic-lateral-sclerosis-models
#22
JOURNAL ARTICLE
Martina Milani, Ilaria Della Valle, Simona Rossi, Paola Fabbrizio, Cassandra Margotta, Giovanni Nardo, Mauro Cozzolino, Nadia D'Ambrosi, Savina Apolloni
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease influenced by genetic, epigenetic, and environmental factors, resulting in dysfunction in cellular and molecular pathways. The limited efficacy of current treatments highlights the need for combination therapies targeting multiple aspects of the disease. Niclosamide, an anthelminthic drug listed as an essential medicine, has been repurposed in clinical trials for different diseases due to its anti-inflammatory and anti-fibrotic properties...
March 15, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38487400/preclinical-models-of-orthopaedic-trauma-orthopaedic-research-society-ors-and-orthopaedic-trauma-association-ota-symposium-2022
#23
JOURNAL ARTICLE
Patrick M Wise, Augustine M Saiz, Justin Haller, Joseph C Wenke, Thomas Schaer, Prism Schneider, Saam Morshed, Chelsea S Bahney
Orthopaedic trauma remains a leading cause of patient morbidity, mortality, and global health care burden. Although significant advances have been made in the diagnosis, treatment, and rehabilitation of these injuries, complications such as malunion, nonunion, infection, disuse muscle atrophy and osteopenia, and incomplete return to baseline function still occur. The significant inherent clinical variability in fracture care such as differing patient demographics, injury patterns, and treatment protocols make standardized and replicable study, especially of cellular and molecular based mechanisms, nearly impossible...
March 2024: OTA international: the open access journal of orthopaedic trauma
https://read.qxmd.com/read/38486967/3d-cam-a-novel-context-aware-feature-extraction-framework-for-neurological-disease-classification
#24
JOURNAL ARTICLE
Yuhan Ying, Xin Huang, Guoli Song, Yiwen Zhao, XinGang Zhao, Lin Shi, Ziqi Gao, Andi Li, Tian Gao, Hua Lu, Guoguang Fan
In clinical practice and research, the classification and diagnosis of neurological diseases such as Parkinson's Disease (PD) and Multiple System Atrophy (MSA) have long posed a significant challenge. Currently, deep learning, as a cutting-edge technology, has demonstrated immense potential in computer-aided diagnosis of PD and MSA. However, existing methods rely heavily on manually selecting key feature slices and segmenting regions of interest. This not only increases subjectivity and complexity in the classification process but also limits the model's comprehensive analysis of global data features...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38483626/multiple-system-atrophy-an-update-and-emerging-directions-of-biomarkers-and-clinical-trials
#25
REVIEW
Min Liu, Zhiyao Wang, Huifang Shang
Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple system atrophy, the diagnosis of clinically established multiple system atrophy requires the manifestation of autonomic dysfunction in combination with poorly levo-dopa responsive parkinsonism and/or cerebellar syndrome...
March 14, 2024: Journal of Neurology
https://read.qxmd.com/read/38482486/cancer-triggered-systemic-disease-and-therapeutic-targets
#26
JOURNAL ARTICLE
Yihai Cao
Cancer provokes systemic diseases through three possible mechanisms: 1) Distal metastasis in multiple tissues and organs, which directly causes functional damage and impairment of involved organs; 2) Paraneoplastic syndrome (PNS) that affects multiple organ systems, including the endocrine, gastrointestinal, hematologic, neurologic, dermatologic, and ophthalmologic systems; and 3) Cancer cachexia (CCA) or self-wasting syndrome characterized by anorexia, progressive bodyweight loss, adipose atrophy, and muscle atrophy...
2024: Holist Integr Oncol
https://read.qxmd.com/read/38480080/post-covid-parkinsonism-a-scoping-review
#27
REVIEW
Paola Polverino, Antoniangela Cocco, Alberto Albanese
BACKGROUND: The clinical features and outcomes of post-COVID parkinsonism have not been organized systematically, and the possible correlations between COVID-19 and parkinsonism have not been elucidated. This scoping review addresses these two unmet needs. METHODS: We searched two databases (Pubmed, Embase) for all published cases of post-COVID parkinsonism. Data were extracted from eligible studies using standardized forms and predefined inclusion and exclusion criteria...
February 28, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38476865/focused-ultrasound-thalamotomy-for-tremor-relief-in-atypical-parkisnsonism
#28
JOURNAL ARTICLE
Alon Sinai, Maria Nassar, Lev Shornikov, Marius Constantinescu, Menashe Zaaroor, Ilana Schlesinger
BACKGROUND: Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson's disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. OBJECTIVE: To report on the efficacy and safety of FUS VIM-thalamotomy in 8 patients with parkinsonism, multiple system atrophy-Parkinsonian type (MSA-P) ( n  = 5), and dementia with Lewy bodies (DLB) ( n  = 3)...
2024: Parkinson's Disease
https://read.qxmd.com/read/38471435/longitudinal-prognosis-of-parkinson-s-outcomes-using-causal-connectivity
#29
JOURNAL ARTICLE
Cooper J Mellema, Kevin P Nguyen, Alex Treacher, Aixa X Andrade, Nader Pouratian, Vibhash D Sharma, Padraig O'Suileabhain, Albert A Montillo
Despite the prevalence of Parkinson's disease (PD), there are no clinically-accepted neuroimaging biomarkers to predict the trajectory of motor or cognitive decline or differentiate Parkinson's disease from atypical progressive parkinsonian diseases. Since abnormal connectivity in the motor circuit and basal ganglia have been previously shown as early markers of neurodegeneration, we hypothesize that patterns of interregional connectivity could be useful to form patient-specific predictive models of disease state and of PD progression...
February 6, 2024: NeuroImage: Clinical
https://read.qxmd.com/read/38469809/natalizumab-reduces-loss-of-gray-matter-and-thalamic-volume-in-patients-with-relapsing-remitting-multiple-sclerosis-a-post-hoc-analysis-from-the-randomized-placebo-controlled-affirm-trial
#30
JOURNAL ARTICLE
Kunio Nakamura, Zhaonan Sun, Claire Hara-Cleaver, Karthik Bodhinathan, Robin L Avila
BACKGROUND: Loss of brain gray matter fractional volume predicts multiple sclerosis (MS) progression and is associated with worsening physical and cognitive symptoms. Within deep gray matter, thalamic damage is evident in early stages of MS and correlates with physical and cognitive impairment. Natalizumab is a highly effective treatment that reduces disease progression and the number of inflammatory lesions in patients with relapsing-remitting MS (RRMS). OBJECTIVE: To evaluate the effect of natalizumab on gray matter and thalamic atrophy...
March 12, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38468536/clinical-characteristics-and-outcomes-in-young-onset-multiple-system-atrophy
#31
JOURNAL ARTICLE
Negin Badihian, Rodolfo Savica, Charles H Adler, Zbigniew K Wszolek, Lauren M Jackson, Eduardo E Benarroch, Paola Sandroni, Phillip A Low, Wolfgang Singer, Elizabeth A Coon
BACKGROUND: Young-onset multiple system atrophy (YOMSA) is defined as the onset of multiple system atrophy (MSA) before the age of 40 years old. YOMSA is rare and there is much uncertainty of the phenotype and natural history in patients with YOMSA. OBJECTIVE: The objective is to evaluate the characteristics and disease course of patients with YOMSA. METHODS: We retrospectively reviewed medical records of patients with MSA who were evaluated at all Mayo Clinic sites from 1998 to 2021...
March 2024: Movement Disorders Clinical Practice
https://read.qxmd.com/read/38468041/fractal-dimension-studies-of-the-brain-shape-in-aging-and-neurodegenerative-diseases
#32
JOURNAL ARTICLE
Jennilee M Davidson, Luduan Zhang, Guang H Yue, Antonio Di Ieva
The fractal dimension is a morphometric measure that has been used to investigate the changes of brain shape complexity in aging and neurodegenerative diseases. This chapter reviews fractal dimension studies in aging and neurodegenerative disorders in the literature. Research has shown that the fractal dimension of the left cerebral hemisphere increases until adolescence and then decreases with aging, while the fractal dimension of the right hemisphere continues to increase until adulthood. Studies in neurodegenerative diseases demonstrated a decline in the fractal dimension of the gray matter and white matter in Alzheimer's disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38461739/erratum-to-the-characteristic-of-nonmotor-symptoms-with-different-phenotypes-and-onsets-in-multiple-system-atrophy-patients-j-clin-neurosci-109c-2023-10258
#33
Jinhong Zhang, Jiuyan Han, Zhihong Shi, Jiewen Zhang, Zhi Zhou, Junyan Liu, Gaiqing Yang, Yongan Sun, Ping Gu, Ping Zhao, Lili Ma, Zhongying Gong, Jingxia Zhao, Shuai Liu, Chunyan Liu, Xiaoyan Zhai, Wanyu Shang, Zhichao Chen, Jinghuan Gan, Lingyun Ma, Wenzheng Hu, Hongcan Zhu, Yong Ji
No abstract text is available yet for this article.
March 9, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38461037/loss-of-monomeric-alpha-synuclein-synucleinopenia-and-the-origin-of-parkinson-s-disease
#34
REVIEW
Alberto J Espay, Andrew J Lees
These facts argue against the gain-of-function synucleinopathy hypothesis, which proposes that Lewy pathology causes Parkinson's disease: (1) most brains from people without neurological symptoms have multiple pathologies; (2) neither pathology type nor distribution correlate with disease severity or progression in Parkinson's disease; (3) aggregated α-synuclein in the form of Lewy bodies is not a space-occupying lesion but the insoluble fraction of its precursor, soluble monomeric α-synuclein; (4) pathology spread is passive, occurring by irreversible nucleation, not active replication; and (5) low cerebrospinal fluid α-synuclein levels predict brain atrophy and clinical disease progression...
March 3, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38453600/prevalence-of-multiple-system-atrophy-a-literature-review
#35
JOURNAL ARTICLE
S Kaplan
INTRODUCTION: This paper aims to provide a literature overview on multiple system atrophy (MSA) prevalence in European and other pan-European populations. METHODS: A literature search (PubMed, EMBASE) was performed through 2022 to identify published studies on MSA prevalence in European countries. Of these search results, titles and abstracts were screened for relevance. A standardized assessment tool was used for systematically data extraction and comparison. For studies where only the incidence rate was reported, MSA prevalence was derived based on the incidence and duration of disease...
March 6, 2024: Revue Neurologique
https://read.qxmd.com/read/38453477/patient-perceived-progression-in-multiple-system-atrophy-natural-history-of-quality-of-life
#36
JOURNAL ARTICLE
Tiphaine Saulnier, Margherita Fabbri, Mélanie Le Goff, Catherine Helmer, Anne Pavy-Le Traon, Wassilios G Meissner, Olivier Rascol, Cecile Proust-Lima, Alexandra Foubert-Samier
BACKGROUND: Health-related quality of life (Hr-QoL) scales provide crucial information on neurodegenerative disease progression, help improve patient care and constitute a meaningful endpoint for therapeutic research. However, Hr-QoL progression is usually poorly documented, as for multiple system atrophy (MSA), a rare and rapidly progressing alpha-synucleinopathy. This work aimed to describe Hr-QoL progression during the natural course of MSA, explore disparities between patients and identify informative items using a four-step statistical strategy...
March 7, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38452646/disparities-in-dmt-treatment-demographic-and-neurocognitive-differences-between-ms-patients-currently-treated-versus-not-treated-with-disease-modifying-therapies
#37
JOURNAL ARTICLE
Victoria M Leavitt, Jordan D Dworkin, Rachel Galioto, Alexander S Ratzan
BACKGROUND: Current treatment guidelines recommend consideration of disease-modifying therapy (DMT) for all multiple sclerosis (MS) patients, but barriers to access have begun to be identified. In particular, prior studies have found that people with higher education have better access to DMTs, perhaps explained by the association of higher education with higher income. And while the majority of people with MS are women, being male is also associated with higher income. These factors argue for the need to better understand whether there are differences in DMT uptake based on sex and education...
February 22, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38449950/role-of-diffusion-tensor-imaging-in-early-diagnosis-and-characterization-of-movement-disorders
#38
JOURNAL ARTICLE
M Meyyappan, Biji Babu, M Anitha, Gopinath Ganesan, Anita S, Paarthipan Natarajan
BACKGROUND: Symptoms of movement disorders in early stages are similar, which makes definite diagnosis difficult. Hence this study was conducted to explore the role of diffusion tensor imaging (DTI) in enhancing the early diagnosis and characterization of movement disorders. METHODOLOGY: A cross-sectional study was conducted including 60 subjects. All of them were reviewed using conventional magnetic resonance imaging (MRI) and movement disorder DTI protocol. Commercially available software was used to produce fractional anisotropy (FA) maps...
February 2024: Curēus
https://read.qxmd.com/read/38448050/retraction-very-late-onset-friedreich-s-ataxia-with-rapid-course-mimicking-as-possible-multiple-system-atrophy-cerebellar-type
#39
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 6, 2024: BMJ Case Reports
https://read.qxmd.com/read/38446362/tilt-evoked-breathing-driven-blood-pressure-oscillations-independence-from-baroreflex-sympathoneural-function
#40
JOURNAL ARTICLE
Edward Grabov, Patti Sullivan, Siqi Wang, David S Goldstein
PURPOSE: Orthostasis increases the variability of continuously recorded blood pressure (BP). Low-frequency (LF) BP oscillations (Mayer waves) in this setting are related to the vascular-sympathetic baroreflex. Mechanisms of increased high-frequency (HF) BP oscillations at the periodicity of respiration during orthostasis have received less research attention. A previously reported patient with post-neurosurgical orthostatic hypotension (OH) and vascular-sympathetic baroreflex failure had large tilt-evoked, breathing-driven BP oscillations, suggesting that such oscillations can occur independently of vascular-sympathetic baroreflex modulation...
March 6, 2024: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
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