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Mahmoud I Traina, Daniel R Sanchez, Salvador Hernandez, Jason S Bradfield, Mohamed R Labedi, Tarik A Ngab, Frank Steurer, Susan P Montgomery, Sheba K Meymandi
BACKGROUND: Chagas disease is a well-known cause of cardiomyopathy in Latin America; however, 300 000 individuals are estimated to have Chagas disease in the United States. This study examined the prevalence and impact of Chagas cardiomyopathy (CCM) in a US population. We hypothesized that patients with CCM would have increased morbidity and mortality when compared with patients with non-CCM. METHODS AND RESULTS: This is a single-center, prospective cohort study...
September 2015: Circulation. Heart Failure
Patricia Maria Sens, Clemente Isnard Ribeiro de Almeida, Marisa Mara Neves de Souza, Josyane Borges A Gonçalves, Luiz Claudio do Carmo
UNLABELLED: The Synthetic Sentence Identification (SSI) test assesses central auditory pathways by measuring auditory and visual sensitivity and testing selective attention. Cerebellum activation in auditory attention and sensorial activity modulation have already been described. Assessing patients with cerebellar lesions alone using the SSI test can confirm the role of the cerebellum in auditory processing. AIM: To evaluate the role of the cerebellum in auditory processing in individuals with normal hearing and in those with chronic cerebellum lesions, using the SSI test...
September 2011: Brazilian Journal of Otorhinolaryngology
Adriana Ribeiro Tavares Anastasio, Teresa Maria Momensohn-Santos
BACKGROUND: The study of the relationship of the contralateral acoustic reflex with the auditory skill of closure. AIM: To analyze the identification of a speech signal in the presence of competitive sounds in subjects with absence of contralateral acoustic reflex. METHOD: Application of the synthetic sentence identification (SSI) test under the conditions of competitive contralateral message (SSI-CCM), with the signal-to-noise ratio of 0 and -40dB, and ipsilateral competitive message (SSI-ICM), with the signal-to-noise ratio of 0, -10, -15 and -20dB, in 43 young adults (group A = 21 subjects with contralateral acoustic reflex present in all of the investigated frequencies, and group B = 22 subjects with contralateral reflex absent at the frequency of 500Hz, or in all of the investigated frequencies, or still in some of the investigated frequencies necessarily including 500Hz), of both gender, with no hearing, otologic or learning disabilities...
April 2005: Pró-fono: Revista de Atualização Científica
Mathias H Wilhelmi, Rainer G Leyh, Michaela Wilhelmi, Axel Haverich
OBJECTIVE: In recent years many data emphasized, that inflammatory reactions seem to be involved in the pathogenesis of ischemic (ICM) and congestive (CCM) heart disease. Since, it is well known that endothelial adhesion molecules play a pivotal role in the initiation and maintenance of inflammatory reactions we therefore, evaluated the endothelial expression of a wide variety of different adhesion molecules in hearts suffering from ICM and CCM. METHODS: Tissue samples from coronary arteries, and left and right ventricle myocardium originating form heart with ICM and CCM were evaluated...
January 2005: European Journal of Cardio-thoracic Surgery
Stefan Gattenlöhner, Christiane Waller, Georg Ertl, Burkhard-Dieter Bültmann, Hans-Konrad Müller-Hermelink, Alexander Marx
Chronic myocardial ischemia is the leading cause of impaired myocardial contractility and heart failure. To identify differentially expressed genes in human ischemic cardiomyopathy (ICM), we constructed a subtracted cDNA library using specimens of ICM compared to normal human heart. Among 100 randomly sequenced clones, seven sequences represented recently identified candidate genes for differential expression in cardiac hypertrophy. A further clone without a known hypertrophy-association coded for the adhesion molecule NCAM(CD56)...
September 2003: American Journal of Pathology
R L Allen, J L Cranford, N Pay
A young adult subject with congenital absence of the left temporal lobe received extensive behavioral and electrophysiologic tests to identify deficits in central auditory processing. Tests included the dichotic digits, staggered spondaic words (SSW), synthetic sentence identification with ipsilateral (SSI-ICM) and contralateral (SSI-CCM) competing messages, pitch pattern, and duration pattern measures. Additional special tests included the precedence effect in sound localization, measurement of frequency difference limens for short (5 msec) and long (200 msec) duration tones, and the P300 event-related potential...
August 1996: Journal of the American Academy of Audiology
A D Kligerman, R E Chapin, G L Erexson, D R Germolec, P Kwanyuen, R S Yang
Male Fischer 344 rats and female B6C3F1 mice were each exposed through their drinking water to a mixture of pesticides and ammonium nitrate that simulated contaminated groundwater in California (California Chemical Mixture [CCM]). Exposures were for 71 or 91 days, respectively. In addition, B6C3F1 female mice were exposed for 91 days to another pesticide and ammonium nitrate mixture (Iowa Chemical Mixture [ICM]) through their drinking water. The spleens were removed from the animals, and the splenocytes were cultured for analyses of sister-chromatid exchange (SCE), chromosome aberrations (CA), and micronuclei (MN) in cytochalasin B-induced binucleate cells...
July 1993: Mutation Research
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