Henry S Cheng, Daniel Pérez-Cremades, Rulin Zhuang, Anurag Jamaiyar, Winona W Wu, Jingshu Chen, Aspasia Tzani, Lauren Stone, Jorge Plutzky, Terence E Ryan, Philip P Goodney, Mark A Creager, Marc S Sabatine, Marc P Bonaca, Mark W Feinberg
Patients with peripheral artery disease (PAD) and diabetes constitute a high risk population for development of critical limb ischemia (CLI) and amputation, although the underlying mechanisms remain poorly understood. Comparison of dysregulated microRNAs from diabetic human subjects with PAD and diabetic mice with limb ischemia revealed the conserved microRNA, miR-130b-3p. In vitro angiogenic assays demonstrated miR-130b rapidly promoted proliferation, migration, and sprouting in endothelial cells (ECs), whereas miR-130b inhibition exerted anti-angiogenic effects...
April 25, 2023: JCI Insight