keyword
https://read.qxmd.com/read/37176566/the-comparison-between-the-composition-of-100-autologous-serum-and-100-platelet-rich-plasma-eye-drops-and-their-impact-on-the-treatment-effectiveness-of-dry-eye-disease-in-primary-sjogren-syndrome
#21
JOURNAL ARTICLE
Dominika Wróbel-Dudzińska, Agata Przekora, Paulina Kazimierczak, Agnieszka Ćwiklińska-Haszcz, Ewa Kosior-Jarecka, Tomasz Żarnowski
PURPOSE: The aim of the study was to compare the difference in composition between 100% autologous serum (AS) and 100% platelet-rich plasma (PRP) eye drops and assess their impact on the clinical outcomes after the treatment of severe dry eye (DE) in primary Sjogren Syndrome patients (pSS). MATERIALS AND METHODS: This is an interventional, non-randomized, comparative, three-month study. 22 patients with severe DE in pSS were treated with 100% AS (22 eyes) and 100% PRP (22 eyes) eye drops 5 times per day in monotherapy mode...
April 25, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37160658/devo-aging-intersections-between-development-and-aging
#22
JOURNAL ARTICLE
Carlos Giovanni Silva-García
There are two fundamental questions in developmental biology. How does a single fertilized cell give rise to a whole body? and how does this body later produce progeny? Synchronization of these embryonic and postembryonic developments ensures continuity of life from one generation to the next. An enormous amount of work has been done to unravel the molecular mechanisms behind these processes, but more recently, modern developmental biology has been expanded to study development in wider contexts, including regeneration, environment, disease, and even aging...
May 9, 2023: GeroScience
https://read.qxmd.com/read/37143267/phytochemicals-as-substances-that-affect-astrogliosis-and-their-implications-for-the-management-of-neurodegenerative-diseases
#23
JOURNAL ARTICLE
Fatemeh Forouzanfar, Ali Mohammad Pourbagher-Shahri, Farzaneh Vafaee, Thozhukat Sathyapalan, Amirhossein Sahebkar
Astrocytes are a multifunctional subset of glial cells that are important in maintaining the health and function of the central nervous system (CNS). Reactive astrocytes may release inflammatory mediators, chemokines, and cytokines, as well as neurotrophic factors. There may be neuroprotective (e.g., cytokines, like IL-6 and TGF-b) and neurotoxic effects (e.g., IL-1β and TNF-a) associated with these molecules. In response to CNS pathologies, astrocytes go to a state called astrogliosis which produces diverse and heterogenic functions specific to the pathology...
May 4, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37097749/impaired-angiogenesis-in-diabetic-critical-limb-ischemia-is-mediated-by-a-mir-130b-inhba-signaling-axis
#24
JOURNAL ARTICLE
Henry S Cheng, Daniel Pérez-Cremades, Rulin Zhuang, Anurag Jamaiyar, Winona W Wu, Jingshu Chen, Aspasia Tzani, Lauren Stone, Jorge Plutzky, Terence E Ryan, Philip P Goodney, Mark A Creager, Marc S Sabatine, Marc P Bonaca, Mark W Feinberg
Patients with peripheral artery disease (PAD) and diabetes constitute a high risk population for development of critical limb ischemia (CLI) and amputation, although the underlying mechanisms remain poorly understood. Comparison of dysregulated microRNAs from diabetic human subjects with PAD and diabetic mice with limb ischemia revealed the conserved microRNA, miR-130b-3p. In vitro angiogenic assays demonstrated miR-130b rapidly promoted proliferation, migration, and sprouting in endothelial cells (ECs), whereas miR-130b inhibition exerted anti-angiogenic effects...
April 25, 2023: JCI Insight
https://read.qxmd.com/read/37085817/analogies-between-the-periphery-of-cancer-and-the-leading-edge-of-pulmonary-fibrosis
#25
EDITORIAL
Monica Pernia Marin, Mary Salvatore
The periphery of malignant tumors and the leading edge of fibrotic tissue have analogous metabolic pathways. Both use glycolysis as the primary source of energy to produce biomass with consequential acidification of the microenvironment. A low PH has been shown to increase the ability of cancer cells to invade the surrounding tissue in both in vitro and in vivo studies. The pH-dependent activation of TGF-B leading to myofibroblast activation is an important step in the initiation and progression of fibrosis...
April 21, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/36999032/breast-milk-micrornas-potential-players-in-oral-tolerance-development
#26
REVIEW
Emelie Ahlberg, Ahmed Al-Kaabawi, Rebecka Thune, Melanie Rae Simpson, Sindre Andre Pedersen, Erika Cione, Maria Christina Jenmalm, Lina Tingö
Breast milk is an essential source of nutrition and hydration for the infant. In addition, this highly complex biological fluid contains numerous immunologically active factors such as microorganisms, immunoglobulins, cytokines and microRNAs (miRNAs). Here, we set out to predict the function of the top 10 expressed miRNAs in human breast milk, focusing on their relevance in oral tolerance development and allergy prevention in the infant. The top expressed miRNAs in human breast milk were identified on basis of previous peer-reviewed studies gathered from a recent systematic review and an updated literature search...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36987413/mirna-200b-level-in-peripheral-blood-predicts-renal-interstitial-injury-in-patients-with-diabetic-nephropathy
#27
JOURNAL ARTICLE
Tingfang Chen, Zhenzhen Jiang, Haiying Zhang, Ruifeng Yang, Yan Wu, Yongping Guo
BACKGROUND: To uncover the diagnostic potential of peripheral blood microRNA-200b (miRNA-200b) in renal interstitial injury in diabetic nephropathy (DN) patients. METHODS: A total of 50 diabetes subjects, 50 mild DN subjects, 50 moderate-severe DN subjects and 50 healthy subjects were included. Peripheral blood level of miRNA-200b in every subject was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Serum levels of renal function indicators were determined by enzyme-linked immunosorbent assay (ELISA)...
March 15, 2023: Journal of Medical Biochemistry
https://read.qxmd.com/read/36930654/endothelial-derived-extracellular-vesicles-from-obese-hypertensive-adults-increase-factors-associated-with-hypertrophy-and-fibrosis-in-cardiomyocytes
#28
JOURNAL ARTICLE
Hannah K Fandl, Vinicius P Garcia, John W Treuth, Lillian M Brewster, Jared J Greiner, Kevin P Davy, Brian L Stauffer, Christopher A DeSouza
Obesity and hypertension, independently and combined, are associated with increased risk of heart failure and heart failure-related morbidity and mortality. Interest in circulating endothelial cell-derived microvesicles (EMVs) has intensified due to their involvement in the development and progression of endothelial dysfunction, atherosclerosis, and cardiomyopathy. The experimental aim of this study was to determine, in vitro, the effects of EMVs isolated from obese/hypertensive adults on key proteins regulating cardiomyocyte hypertrophy (cardiac troponin T [cTnT], a-actinin, nuclear factor-kB [NF-kB]) and fibrosis (transforming growth factor [TGF]-b, collagen1-a1) as well as endothelial nitric oxide synthase (eNOS) expression and NO production...
March 17, 2023: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/36836180/a-systematic-pan-cancer-analysis-of-meis1-in-human-tumors-as-prognostic-biomarker-and-immunotherapy-target
#29
JOURNAL ARTICLE
Han Li, Ying Tang, Lichun Hua, Zemin Wang, Guoping Du, Shuai Wang, Shifeng Lu, Wei Li
BACKGROUND: We intended to explore the potential immunological functions and prognostic value of Myeloid Ecotropic Viral Integration Site 1 (MEIS1) across 33 cancer types. METHODS: The data were acquired from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) and Gene expression omnibus (GEO) datasets. Bioinformatics was used to excavate the potential mechanisms of MEIS1 across different cancers. RESULTS: MEIS1 was downregulated in most tumors, and it was linked to the immune infiltration level of cancer patients...
February 18, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36749873/addition-of-losartan-to-folfirinox-and-chemoradiation-reduces-immunosuppression-associated-genes-tregs-and-foxp3-cancer-cells-in-locally-advanced-pancreatic-cancer
#30
JOURNAL ARTICLE
Yves Boucher, Jessica M Posada, Sonu Subudhi, Ashwin S Kumar, Spencer R Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P Talele, Dan G Duda, Dai Fukumura, Jennifer Y Wo, Jeffrey W Clark, David P Ryan, Carlos Fernandez-Del Castillo, Theodore S Hong, Mikael J Pittet, Rakesh K Jain
PURPOSE: Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechanisms of benefit by assessing the effects of neoadjuvant LOS on the tumor microenvironment. EXPERIMENTAL DESIGN: We performed a gene expression and immunofluorescence (IF) analysis using archived surgical samples from patients treated with LOS+FFX+CRT (NCT01821729), FFX+CRT (NCT01591733), or surgery upfront, without any neoadjuvant therapy...
April 14, 2023: Clinical Cancer Research
https://read.qxmd.com/read/36660892/evaluation-of-associations-of-growth-differentiation-factor-11-growth-differentiation-factor-8-and-their-binding-proteins-follistatin-and-follistatin-like-protein-3-with-dementia-and-cognition
#31
JOURNAL ARTICLE
Anne B Newman, Sheena Patel, Jorge Kizer, Se-Jin Lee, Shalinder Bhasin, Peggy Cawthon, Nathan LeBrasseur, Russel P Tracy, Peter Ganz, Steve Cummings
BACKGROUND: Studies using heterochronic parabiosis discovered that circulating factors mediate brain aging in animal models. METHODS: We assessed Growth Differentiation Factor (GDF)-11 and GDF-8 using mass spectrometry and inhibitors follistatin and follistatin-like protein-3 (FSTL-3) with ELISA in in the Cardiovascular Health Study (N=1506) and the Health ABC study (N=1237). CLL-11 and Beta 2 microglobulin (B2M) were measured with ELISA in a subset of 400 individuals in Health ABC...
January 20, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/36637640/pi3k-pathway-alterations-in-peritoneal-metastases-are-associated-with-earlier-recurrence-in-patients-with-colorectal-cancer-undergoing-optimal-cytoreductive-surgery
#32
JOURNAL ARTICLE
Rayne Peerenboom, Ankit Dhiman, Hunter D D Witmer, Liam F Spurr, Blase Polite, Oliver S Eng, Ardaman Shergill, Kiran K Turaga
BACKGROUND: Colorectal cancer with peritoneal metastasis (CRC-PM) represents a biologically heterogeneous disease; yet little is known regarding the impact of tumor biology on survival outcomes following optimal cytoreductive surgery (CRS). We analyzed the frequency of alterations in cancer signaling pathways in patients with CRC-PM and their impact on recurrence-free survival (RFS) following optimal CRS. METHODS: Thirty-five consecutive CRC-PM patients who underwent optimal CRS/HIPEC and next generation sequencing of peritoneal metastases were included in the study...
January 13, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36625900/complex-roles-of-tgf-beta-signaling-pathways-in-lung-development-and-bronchopulmonary-dysplasia
#33
REVIEW
Rebecca J Calthorpe, Caroline Poulter, Alan R Smyth, Don Sharkey, Jayesh Bhatt, Gisli Jenkins, Amanda L Tatler
As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular and neurological morbidity. Transforming growth factor beta (TGF-b) is an important signaling pathway in lung development, organ injury and fibrosis and is implicated in the development of BPD...
January 10, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/36613761/the-role-of-local-inflammation-and-hypoxia-in-the-formation-of-hypertrophic-scars-a-new-model-in-the-duroc-pig
#34
JOURNAL ARTICLE
Sebastian P Nischwitz, Julia Fink, Marlies Schellnegger, Hanna Luze, Vladimir Bubalo, Carolin Tetyczka, Eva Roblegg, Christian Holecek, Martin Zacharias, Lars-Peter Kamolz, Petra Kotzbeck
Hypertrophic scars continue to be a major burden, especially after burns. Persistent inflammation during wound healing appears to be the precipitating aspect in pathologic scarring. The lack of a standardized model hinders research from fully elucidating pathophysiology and therapy, as most therapeutic approaches have sparse evidence. The goal of this project was to investigate the mechanisms of scar formation after prolonged wound inflammation and to introduce a method for generating standardized hypertrophic scars by inducing prolonged inflammation...
December 24, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36552048/what-are-the-roles-of-proprotein-convertases-in-the-immune-escape-of-tumors
#35
REVIEW
Elham Mehranzadeh, Olatz Crende, Iker Badiola, Patricia Garcia-Gallastegi
Protein convertases (PCs) play a significant role in post-translational procedures by transforming inactive precursor proteins into their active forms. The role of PCs is crucial for cellular homeostasis because they are involved in cell signaling. They have also been described in many diseases such as Alzheimer's and cancer. Cancer cells are secretory cells that send signals to the tumor microenvironment (TME), remodeling the surrounding space for their own benefits. One of the most important components of the TME is the immune system of the tumor...
December 19, 2022: Biomedicines
https://read.qxmd.com/read/36469714/-morphogenetic-and-pathogenetic-features-of-hypertrophic-and-keloid-scars-of-the-head-and-neck
#36
JOURNAL ARTICLE
E A Kogan, V V Andreeva, I V Reshetov, T A Demura, N V Zharkov
OBJECTIVE: Evaluate the morphogenetic and pathogenetic features of hypertrophic and keloid scars of the head and neck. MATERIAL AND METHODS: The study included 286 patients, among them 176 (61.5%) patients with hypertrophic and 110 (38.5%) with keloid scars aged 18 to 65 years with a disease duration from 1 month to 2 years. Material for histological and immunohistochemical (IHC) studies of scar tissue was fixed in 10% buffered formalin. Serial paraffin sections were stained with H&E, according to Van Gieson and Weigert...
2022: Arkhiv Patologii
https://read.qxmd.com/read/36410882/orthobiologic-interventions-for-muscle-injuries
#37
REVIEW
Philip M Stephens, Ryan P Nussbaum, Kentaro Onishi
Muscle injuries represent a common problem in active populations. Orthobiologics continue to be studied for their ability to improve muscle healing. To date, the basic science research for treating muscle injuries with platelet-rich plasma or stem cell remains novel. Furthermore, there are even fewer clinical studies on these topics, and their findings are inconclusive. Reviewing the literature, muscle injuries treated with ultrasound-guided leukocyte-rich PRP injections appear to have the strongest evidence...
February 2023: Physical Medicine and Rehabilitation Clinics of North America
https://read.qxmd.com/read/36283106/il-13-il-4-signaling-contributes-to-fibrotic-progression-of-the-myeloproliferative-neoplasms
#38
JOURNAL ARTICLE
Johanna Melo-Cardenas, Lavanya Bezavada, Jeremy Chase Crawford, Sandeep Gurbuxani, Anitria Cotton, Guolian Kang, Jeffrey Gossett, Christian Marinaccio, Rona Weinberg, Ronald Hoffman, Anna Rita Migliaccio, Yan Zheng, Marta Derecka, Ciro R Rinaldi, John D Crispino
Myelofibrosis (MF) is a disease associated with high unmet medical needs because allogeneic stem cell transplantation is not an option for most patients, and JAK inhibitors are generally effective for only 2 to 3 years and do not delay disease progression. MF is characterized by dysplastic megakaryocytic hyperplasia and progression to fulminant disease, which is associated with progressively increasing marrow fibrosis. Despite evidence that the inflammatory milieu in MF contributes to disease progression, the specific factors that promote megakaryocyte growth are poorly understood...
December 29, 2022: Blood
https://read.qxmd.com/read/36272241/unraveling-the-peripheral-and-local-role-of-inflammatory-cytokines-in-glioblastoma-survival
#39
JOURNAL ARTICLE
Vitor J Cavalheiro, Ana Carolina P Campos, Luiz G C A Lima, Cairo Thomé Roça, Marcos Fernando L Docema, Carmen Lucia P Lancellotti, Raquel C R Martinez, Rosana L Pagano, Roger Chammas, Manoel J Teixeira, Marcos V C Maldaun, Iuri S Neville
Glioblastoma (GBM) is a life-threatening disease that presents high morbidity and mortality. The standardized treatment protocol results in a global survival of less than three years in the majority of cases. Immunotherapies have gained wide recognition in cancer treatment; however, GBM has an immunosuppressive microenvironment diminishing the possible effectiveness of this therapy. In this sense, investigating the inflammatory settings and the tumoral nature of GBM patients are an important goal to create an individual plan of treatment to improve overall survival rate and quality of life of these patients...
October 19, 2022: Cytokine
https://read.qxmd.com/read/36269647/smad3-promotes-adverse-cardiovascular-remodeling-and-dysfunction-in-doxorubicin-treated-hearts
#40
JOURNAL ARTICLE
Melissa S Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P Heruth, Ralph V Shohet, Buddhadeb Dawn, Eugene A Konorev
Many anticancer therapies cause serious cardiovascular complications that degrade quality of life and cause early mortality in treated patients. Specifically, doxorubicin is known as an effective anticancer agent that causes cardiomyopathy in treated patients. There has been growing interest in defining the role of endothelial cells in cardiac damage by doxorubicin. We have shown in the present study that endothelial nuclei accumulate more intravenously administered doxorubicin than other cardiac cell types...
October 21, 2022: American Journal of Physiology. Heart and Circulatory Physiology
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