Emmeline Marchal-Duval, Méline Homps-Legrand, Antoine Froidure, Madeleine Jaillet, Mada Ghanem, Deneuville Lou, Aurélien Justet, Arnaud Maurac, Aurelie Vadel, Emilie Fortas, Aurelie Cazes, Audrey Joannes, Laura Giersh, Herve Mal, Pierre Mordant, Tristan Piolot, Marin Truchin, Carine M Mounier, Ksenija Schirduan, Martina Korfei, Andreas Gunther, Bernard Mari, Frank Jaschinski, Bruno Crestani, Arnaud A Mailleux
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of transcriptomic database identified the mesenchymal transcription factor PRRX1 as upregulated in IPF. PRRX1, strongly expressed by lung fibroblasts, was regulated by a TGF-b/PGE2 balance in vitro in control and IPF human lung fibroblasts, while IPF fibroblast-derived matrix increased PRRX1 expression in a PDGFR dependent manner in control ones...
June 1, 2023: ELife