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https://www.readbyqxmd.com/read/29150918/central-role-of-transforming-ggrowth-factor-type-beta-1-in-skeletal-muscle-dysfunctions-an-update-on-therapeutic-strategies
#1
Johanna Abrigo, Felipe Simon, Daniel Cabrera, Gonzalo Cordova, Capucine Trollet, Claudio Cabello Verrugio
Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-b1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-b has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-b1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy...
November 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29131834/plasma-microrna-profiling-exploring-better-biomarkers-for-lymphoma-surveillance
#2
Drirh Khare, Neta Goldschmidt, Aya Bardugo, Devorah Gur-Wahnon, Iddo Z Ben-Dov, Batia Avni
Early detection of relapsed lymphoma improves response and survival. Current tools lack power for detection of early relapse, while being cumbersome and expensive. We searched for sensitive biomarkers that precede clinical relapse, and serve for further studies on therapy response and relapse. We recruited 20 healthy adults, 14 diffuse large B-cell lymphoma (DLBCL) patients and 11 Hodgkin lymphoma (HL) patients at diagnosis. Using small-RNA sequencing we identified in DLBCL patients increased plasma levels of miR-124 and miR-532-5p, and decreased levels of miR-425, miR-141, miR-145, miR-197, miR-345, miR-424, miR-128 and miR-122...
2017: PloS One
https://www.readbyqxmd.com/read/29089473/transforming-growth-factor-b-signaling-in-systemic-sclerosis
#3
Nolan B Ayers, Chenming Sun, Shi-You Chen
Systemic sclerosis (SSc) is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the antigen-specific immune system and the non-specific immune system, resulting in autoantibody production; vascular endothelial activation of small blood vessels; and tissue fibrosis as a result of fibroblast dysfunction. Given the heterogeneity of clinical presentation of the disease, a lack of universal models has impeded adequate testing of potential therapies for SSc...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29069829/the-mir-486-5p-plays-a-causative-role-in-prostate-cancer-through-negative-regulation-of-multiple-tumor-suppressor-pathways
#4
Yang Yang, Changwei Ji, Suhan Guo, Xin Su, Xiaozhi Zhao, Shiwei Zhang, Guangxiang Liu, Xuefeng Qiu, Qing Zhang, Hongqian Guo, Huimei Chen
MicroRNAs have been broadly implicated in cancer, but their exact function and mechanism in carcinogenesis remain poorly understood. Aberrant miR-486-5p expression is frequently found in human cancers. Here we showed a significant overexpression of miR-486-5p in prostate cancer compared with that in normal tissue and cells, and we proposed that altered expression of miR-486-5p in the prostate contributed to prostate cancer. Firstly, miR-486-5p inhibition expression reduced prostate cancercell proliferation, migration, and colonization in vitro and prostate tumor development in vivo...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026214/treatment-with-the-tgf-b-superfamily-cytokine-mic-1-gdf15-reduces-the-adiposity-and-corrects-the-metabolic-dysfunction-of-mice-with-diet-induced-obesity
#5
Vw-W Tsai, H P Zhang, R Manandhar, K K M Lee-Ng, H Lebhar, C P Marquis, Y Husaini, A Sainsbury, D A Brown, S N Breit
OBJECTIVES: To test the potential efficacy of recombinant macrophage inhibitory cytokine-1 (MIC-1/GDF15) as an obesity therapeutic. METHODS: Male C57BL/6J mice, either fed on normal-chow or high-fat-diet for 16 weeks in order to induce diet-induced obesity, were infused with either recombinant MIC-1/GDF15 or vehicle for 34 days by osmotic-mini-pump. During the experimental period metabolic parameters were measured. Blood and tissue were collected for analysis of inflammatory markers...
October 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29018490/the-promotion-of-nephropathy-by-porphyromonas-gingivalis-lipopolysaccharide-via-toll-like-receptors
#6
Koichiro Kajiwara, Shunsuke Takata, Thao T To, Kenyo Takara, Yuji Hatakeyama, Sachio Tamaoki, Richard Peters Darveau, Hiroyuki Ishikawa, Yoshihiko Sawa
BACKGROUND: Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration lowered the survival rate of diabetic mice. The present study aims to examine the effect of TLR4 blocking on the suppression of Pg-LPS-induced diabetic nephropathy. METHODS: The survival rate and morphological/biochemical features for streptozotocin-induced diabetic mice with Pg-LPS and TLR4 blocker eritoran administration were investigated by reporter gene assay, urine and blood analysis, immunohistochemistry, and real time-PCR...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28965860/hepatic-stellate-cell-targeted-imatinib-nanomedicine-versus-conventional-imatinib-a-novel-strategy-with-potent-efficacy-in-experimental-liver-fibrosis
#7
Nesrine S El-Mezayen, Wessam F El-Hadidy, Wessam M El-Refaie, Th I Shalaby, Mahmoud M Khattab, Aiman S El-Khatib
Liver fibrosis is a global health problem without approved treatment. Imatinib inhibits two key profibrotic pathways; platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) and thus can be used to treat liver fibrosis. However, conventional imatinib therapy is hampered by low concentration at target tissue and increased toxicity to other tissues especially heart, lung and liver. Since hepatic stellate cells (HSCs) are the main contributors to liver fibrosis pathogenesis and sole hepatic vitamin A (VA) storage cells, they can be actively targeted by coupling liposomes to VA...
September 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28929009/meta-analysis-of-biomarkers-for-severe-dengue-infections
#8
Kuan-Meng Soo, Bahariah Khalid, Siew-Mooi Ching, Chau Ling Tham, Rusliza Basir, Hui-Yee Chee
BACKGROUND: Dengue viral infection is an acute infection that has the potential to have severe complications as its major sequela. Currently, there is no routine laboratory biomarker with which to predict the severity of dengue infection or monitor the effectiveness of standard management. Hence, this meta-analysis compared biomarker levels between dengue fever (DF) and severe dengue infections (SDI) to identify potential biomarkers for SDI. METHODS: Data concerning levels of cytokines, chemokines, and other potential biomarkers of DF, dengue hemorrhagic fever, dengue shock syndrome, and severe dengue were obtained for patients of all ages and populations using the Scopus, PubMed, and Ovid search engines...
2017: PeerJ
https://www.readbyqxmd.com/read/28912302/prevention-of-renal-apob-retention-is-protective-against-diabetic-nephropathy-role-of-tgf-%C3%AE-inhibition
#9
Patricia G Wilson, Joel C Thompson, Meghan H Yoder, Richard Charnigo, Lisa R Tannock
Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy. We previously demonstrated that renal lipoproteins co-localize with biglycan, a renal proteoglycan. The purpose of this study was to determine if prevention of renal lipid (apoB) accumulation attenuates diabetic nephropathy. Biglycan deficient and biglycan wildtype Ldlr-/- mice were made diabetic via streptozotocin and fed a high cholesterol diet. As biglycan deficiency is associated with elevated TGF-b, in some experiments mice were injected with either the TGF-b neutralizing antibody 1D11 or with 13C4, an irrelevant control antibody...
September 14, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28706151/osteoblast-oriented-differentiation-of-bmscs-by-co-culturing-with-composite-scaffolds-constructed-using-silicon-substituted-calcium-phosphate-autogenous-fine-particulate-bone-powder-and-alginate-in-vitro
#10
Ye Tian, Li-Huang Cui, Shou-Yang Xiang, Wen-Xiao Xu, De-Chun Chen, Rui Fu, Chang-Long Zhou, Xiao-Qi Liu, Yu-Fu Wang, Xin-Tao Wang
Autogenous bone graft is the best for spinal fusion in clinics, however, lacking sources, bleeding and infection are limited its practice. Seeking alternative materials are urgent for orthopaedic surgeon. Here, we evaluated osteoblast-oriented differentiation of rabbit BMSCs by co-culturing with composite scaffolds constructed using silicon-substituted-CaP-fine particulate bone powder-alginate. Using CCk8-kit, biocompatibility was evaluated by testing BMSCs proliferation; morphology and survival of osteoblasts within scaffolds were observed using EM and HE staining; growth factors and related genes were detected using RT-PCR...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28681467/proliferation-of-endogenous-regulatory-t-cells-improve-the-pathophysiology-associated-with-placental-ischaemia-of-pregnancy
#11
Tarek Ibrahim, Lukasz Przybyl, Ashlyn C Harmon, Lorena M Amaral, Jessica L Faulkner, Denise C Cornelius, Mark W Cunningham, Thomas Hünig, Florian Herse, Gerd Wallukat, Ralf Dechend, Babbette LaMarca
PROBLEM: Preeclampsia (PE) is associated with inflammation and decreased Treg cells and IL-10. The reduced uterine perfusion pressure (RUPP) rat model of PE exhibits these characteristics, and we hypothesized that induction of endogenous Tregs by a specific stimulus (CD28 superagonistic monoclonal antibody) would reduce inflammation, vasoactive factors, and hypertension in RUPP rats. METHOD OF STUDY: RUPP was performed at gestation day (GD) 14; CD28 superagonist was administered intraperitoneally GD15; GD18 carotid catheters were inserted, and GD19 MAP and pup weight, blood, and tissues were collected...
July 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28578597/optimization-of-methods-for-articular-cartilage-surface-tissue-engineering-cell-density-and-transforming-growth-factor-beta-are-critical-for-self-assembly-and-lubricin-secretion
#12
Kenjiro Iwasa, A Hari Reddi
OBJECTIVE: Lubricin/superficial zone protein (SZP)/proteoglycan4 (PRG4) plays an important role in boundary lubrication in articular cartilage. Lubricin is secreted by superficial zone chondrocytes and synoviocytes of the synovium. The specific objective of this investigation is to optimize the methods for tissue engineering of articular cartilage surface. The aim of this study is to investigate the effect of cell density on the self-assembly of superficial zone chondrocytes and lubricin secretion as a functional assessment...
July 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28440536/selected-bone-morphogenetic-proteins-the-possibility-of-their-use-in-the-diagnostics-and-therapy-of-severe-asthma
#13
Marcelina Koćwin, Mateusz Jonakowski, Marcelina Przemęcka, Michał Panek, Piotr Kuna
Asthma is a chronic heterogeneous illness of the lower airway with an inflammatory basis, developing from hyperresponsiveness and bronchial obstruction. One of the more unfavourable processes occurring in the airway are the long-term changes of the respiratory tract known as remodelling, resulting in complete irreversible obstruction. Bone morphogenetic protein (BMP) is a member of the Transforming Growth Factor beta (TGF-b) superfamily, which regulates processes in embryonic and post-embryonic development...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28427435/prohibitin-targeting-peptide-coupled-to-ovarian-cancer-luteinization-and-tgf-%C3%AE-pathways
#14
Nour M El-Etreby, Amany A Ghazy, Radwaa Rashad
BACKGROUND: Ovarian epithelial tumor (OET) is a silent disease of late diagnosis and poor prognosis. Currently treatment options are limited and patient response to treatment is difficult to predict so there is a serious need to delineate the real pathogenesis to predict tumour prognosis. Prohibitin (PHB) is an evolutionarily protein that regulates the cell cycle. TGF-β has been shown to be a positive and negative regulator of cellular proliferation and differentiation. The present study provides an overview on the role played by PHB1, TGF-β and LH in ovarian cancer...
April 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28420724/a-zebrafish-model-discovers-a-novel-mechanism-of-stromal-fibroblast-mediated-cancer-metastasis
#15
Caifeng Liu, Yunjian Zhang, Sharon Lim, Kayoko Hosaka, Yunlong Yang, Tatiana Pavlova, Twana Alkasalias, Johan Hartman, Lasse Jensen, Xiaoming Xing, Xinsheng Wang, Yongtian Lu, Guohui Nie, Yihai Cao
Purpose: Cancer metastasis can occur at the early stage of tumor development when a primary tumor is at the microscopic size. In particular, the interaction of malignant cells with other cell types including cancer-associated fibroblasts (CAF) in promoting metastasis at the early stage of tumor development remains largely unknown. Here, we investigated the role of CAFs in facilitating the initial events of cancer metastasis when primary tumors were at microscopic sizes.Experimental Design: Multicolor-coded cancer cells and CAFs were coimplanted into the transparent zebrafish body and metastasis at a single-cell level was monitored in living animals...
August 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28379592/severe-hepatocytotoxicity-linked-to-denosumab
#16
S Malnick, Y Maor, E Melzer, N N Ziv-Sokolowskaia, M G Neuman
OBJECTIVE: Denosumab (Prolia, Amgen, Thousand Oaks, CA, USA) is a fully human antibody to the receptor activator of nuclear factor-KB ligand (RANKL). We present a case of submassive hepatic necrosis with evidence implicating cytokine induction resulting from an immune reaction to denosumab. CASE REPORT: A 72-year-old lady presented with elevated liver enzymes. One month previously, she received a s/c administration of 60 mg of denosumab. Viral hepatitis A, B and C and human herpes viruses 6-7 were negative as were routine autoimmune serology...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28364361/a-novel-method-to-generate-single-cell-derived-cancer-associated-fibroblast-clones
#17
Hiroko Hashimoto, Yoshitaka Suda, Tomoyuki Miyashita, Atsushi Ochiai, Masahiro Tsuboi, Kenkichi Masutomi, Tohru Kiyono, Genichiro Ishii
BACKGROUND: Cancer-associated fibroblasts (CAFs) communicate with cancer cells to play important roles in tumor progression. However, CAFs have heterogeneous phenotypes and functions. To understand how much of this heterogeneity relates to different biological responses, a more efficient method of generating single-cell-derived CAF clones is required. METHOD: We transduced two primary CAF cultures (CAFs-608 and CAFs-621) from lung adenocarcinoma with human telomerase reverse transcriptase (hTERT), mutant forms of cyclin dependent kinase 4 (CDK4R24C) independently and in combination (hTERT/CDK4R24C)...
August 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28298474/tumor-protein-d52-expression-is-post-transcriptionally-regulated-by-t-cell-intercellular-antigen-tia-1-and-tia-related-protein-via-mrna-stability
#18
COMPARATIVE STUDY
Hiromi Motohashi, Yoshiki Mukudai, Chihiro Ito, Kosuke Kato, Toshikazu Shimane, Seiji Kondo, Tatsuo Shirota
Although tumor protein D52 (TPD52) family proteins were first identified nearly 20 years ago, their molecular regulatory mechanisms remain unclear. Therefore, we investigated the post-transcriptional regulation of TPD52 family genes. An RNA immunoprecipitation (RIP) assay showed the potential binding ability of TPD52 family mRNAs to several RNA-binding proteins, and an RNA degradation assay revealed that TPD52 is subject to more prominent post-transcriptional regulation than are TPD53 and TPD54. We subsequently focused on the 3'-untranslated region (3'-UTR) of TPD52 as a cis-acting element in post-transcriptional gene regulation...
May 4, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28298070/pulmonary-injury-associated-with-radiation-therapy-assessment-complications-and-therapeutic-targets
#19
REVIEW
Rasmi Rajan Radha, Guruvayoorappan Chandrasekharan
Pulmonary injury is more common in patients undergoing radiation therapy for lungs and other thoracic malignancies. Recently with the use of most-advanced technologies powerful doses of radiation can be delivered directly to tumor site with exquisite precision. The awareness of technical and clinical parameters that influence the chance of radiation induced lung injury is important to guide patient selection and toxicity minimization strategies. At the cellular level, radiation activates free radical production, leading to DNA damage, apoptosis, cell cycle changes, and reduced cell survival...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28192881/stem-cell-biomaterials-and-growth-factors-therapy-for-hepatocellular-carcinoma
#20
REVIEW
Soleiman Jaferian, Maryam Soleymaninejad, Babak Negahdari, Ali Eatemadi
Hepatocellular carcinoma is an antecedent of liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. Transforming growth factor-Beta (TGF-b) plays an important role in creating a favorable microenvironment for tumor cell growth via two major mechanisms: an intrinsic activity as an autocrine growth factor and an extrinsic activity by inducing microenvironment changes. Recently stem cell therapy as also been a promising and potential treatment for liver cancer and in addition signaling pathways like GF/GFR systems, SDF-1α/CXC4 ligand receptor interaction and PI3K/Akt signaling, and cytokines has been identified to regulate cell fate decisions, and can be utilized to positively influence cell therapy outcomes...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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