Danna L Arellano, Patricia Juárez, Andrea Verdugo-Meza, Paloma S Almeida-Luna, Juan A Corral-Avila, Florian Drescher, Felipe Olvera, Samanta Jiménez, Bennett D Elzey, Theresa A Guise, Pierrick G J Fournier
Immunotherapies use components of the immune system, such as T cells, to fight cancer cells, and are changing cancer treatment, causing durable responses in some patients. Bone metastases are a debilitating complication in advanced breast and prostate cancer patients. Approved treatments fail to cure bone metastases or increase patient survival and it remains unclear whether immunotherapy could benefit patients. The bone microenvironment combines various immunosuppressive factors, and combined with T cell products could increase bone resorption fueling the vicious cycle of bone metastases...
August 2022: Journal of Bone and Mineral Research