Read by QxMD icon Read

inflammation Parkinson

Paula Perez-Pardo, Hemraj B Dodiya, Phillip A Engen, Christopher B Forsyth, Andrea M Huschens, Maliha Shaikh, Robin M Voigt, Ankur Naqib, Stefan J Green, Jeffrey H Kordower, Kathleen M Shannon, Johan Garssen, Aletta D Kraneveld, Ali Keshavarzian
OBJECTIVE: Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we propose that toll-like receptor 4 (TLR4)-mediated intestinal dysfunction could contribute to intestinal and central inflammation in PD-related neurodegeneration. DESIGN: To test this hypothesis we performed studies in both human tissue and a murine model of PD...
December 15, 2018: Gut
Omid Reza Tamtaji, Mohsen Taghizadeh, Esmat Aghadavod, Alireza Mafi, Ehsan Dadgostar, Reza Daneshvar Kakhaki, Javad Abolhassani, Zatollah Asemi
OBJECTIVE: This study was conducted to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in subjects with Parkinson's disease (PD). PATIENTS AND METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed in 40 subjects with PD. Participants were randomly allocated into two groups to take either 1000 mg/day of omega-3 fatty acids from flaxseed oil plus 400 IU/day of vitamin E supplements or placebo (n = 20 each group) for 12 weeks...
December 8, 2018: Clinical Neurology and Neurosurgery
Yuqing Yan, Jiezhong Yu, Ye Gao, Gajendra Kumar, Minfang Guo, Yijin Zhao, Qingli Fang, Huiyu Zhang, Jingwen Yu, Yuqiang Jiang, Han-Ting Zhang, Cun-Gen Ma
Multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and other neurodegenerative diseases of central nervous system (CNS) disorders are serious human health problems. Rho-kinase (ROCK) is emerging as a potentially important therapeutic target relevant to inflammatory neurodegeneration diseases. This is supported by studies showing the beneficial effects of fasudil, a ROCK inhibitor, in inflammatory neurodegeneration diseases. MS is an autoimmune disease resulting from inflammation and demyelination in the white matter of the CNS...
December 14, 2018: Metabolic Brain Disease
Feng Zhou, Jing Ju, Yongjun Fang, Xiaoxuan Fan, Shuguang Yan, Qiang Wang, Pengfang Wei, Fuliang Duan, Feng Miao, Zhenyuan Hu, Maode Wang
The present study aimed to investigate the protective effects of salidroside (SAL) on 1-methyl-4-phenylpyridinium (MPP+ )-induced PC12 cell model for Parkinson's disease. PC12 cells were pretreated with SAL in different concentration and then exposed to MPP+ . To evaluate the effects of SAL on cytotoxicity, the survival rate was tested by MTT asssay and the apoptosis was tested via flow cytometry and western blot. ROS, GSH and MDA were detected to analysis the effects of SAL on oxidative stress. The mRNA and protein levels of inflammatory factors TNF-α and IL-1β were also determined by RT-qPCR and western blot...
December 13, 2018: Biotechnology and Applied Biochemistry
Tracy L Habermehl, Kate C Parkinson, Gene B Hubbard, Yuji Ikeno, Jennifer I Engelmeyer, Björn Schumacher, Jeffrey B Mason
Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span...
December 13, 2018: GeroScience
Yanwei Cheng, Tony N Marion, Xue Cao, Wanting Wang, Yu Cao
Sepsis remains a serious and life-threatening condition with high morbidity and mortality due to uncontrolled inflammation together with immunosuppression with few therapeutic options. Macrophages are recognized to play essential roles throughout all phases of sepsis and affect both immune homeostasis and inflammatory processes, and macrophage dysfunction is considered to be one of the major causes for sepsis-induced immunosuppression. Currently, Parkinson disease protein 7 (Park 7) is known to play an important role in regulating the production of reactive oxygen species (ROS) through interaction with p47phox , a subunit of NADPH oxidase...
2018: Frontiers in Immunology
Lap Ho, Danyue Zhao, Kenjiro Ono, Kai Ruan, Ilaria Mogno, Mayumi Tsuji, Eileen Carry, Justin Brathwaite, Steven Sims, Tal Frolinger, Susan Westfall, Paolo Mazzola, Qingli Wu, Ke Hao, Thomas E Lloyd, James E Simon, Jeremiah Faith, Giulio M Pasinetti
The intestinal microbiota actively converts dietary flavanols into phenolic acids, some of which are bioavailable in vivo and may promote resilience to select neurological disorders by interfering with key pathologic mechanisms. Since every person harbors a unique set of gut bacteria, we investigated the influence of the gut microbiota's interpersonal heterogeneity on the production and bioavailability of flavonoid metabolites that may interfere with the misfolding of alpha (α)-synuclein, a process that plays a central role in Parkinson's disease and other α-synucleinopathies...
November 14, 2018: Journal of Nutritional Biochemistry
Yena Lee, Mehala Subramaniapillai, Elisa Brietzke, Rodrigo B Mansur, Roger C Ho, Samantha J Yim, Roger S McIntyre
The etiology of mood disorders is mechanistically heterogeneous, underscoring the need for a dimensional approach to identify and develop targeted treatments in psychiatry. Accumulating evidence implicates inflammation as an important contributor to the pathophysiology of depression and presents the immune system as a viable therapeutic target that may be more proximate to the pathogenic nexus of brain-based disorders in specific subpopulations. Anhedonia is a transdiagnostic (e.g. Parkinson's disease, diabetes mellitus, rheumatic diseases), yet specific, and clinically relevant symptom dimension subserved by well-characterized neurobiological and neurophysiological substrates of the positive valence systems (PVS)...
December 2018: Therapeutic Advances in Psychopharmacology
Meng-Meng Jin, Fen Wang, Di Qi, Wen-Wen Liu, Chao Gu, Cheng-Jie Mao, Ya-Ping Yang, Zhong Zhao, Li-Fang Hu, Chun-Feng Liu
Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in microglia polarization and neuroinflammation is poorly understood. TNF-α, which is highly toxic to dopaminergic neurons, is implicated as a major mediator of neuroinflammation in PD. In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker (iNOS/NO, IL-1β, and IL-6) expression and reduction of M2 marker (Arginase1, Ym1/2, and IL-10) were observed in TNF-α challenged microglia...
2018: Frontiers in Aging Neuroscience
Stephana Carelli, Toniella Giallongo, Zuzana Gombalova, Federica Rey, Maria Carlotta F Gorio, Massimiliano Mazza, Anna Maria Di Giulio
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease, presenting with midbrain dopaminergic neurons degeneration. A number of studies suggest that microglial activation may have a role in PD. It has emerged that inflammation-derived oxidative stress and cytokine-dependent toxicity may contribute to nigrostriatal pathway degeneration and exacerbate the progression of the disease in patients with idiopathic PD. Cell therapies have long been considered a feasible regenerative approach to compensate for the loss of specific cell populations such as the one that occurs in PD...
November 30, 2018: Journal of Neuroinflammation
Laiana A Quagliato, Antonio E Nardi
Increases in the activated state of microglia, the main neuroimmune cells, are widely reported in the brains of patients with neurological and psychiatric disorders. Microglia transform from the resting to the activated state by sensing their environment, aided by a variety of ion channels. To examine the effect of ion channels on microglial phenotypes, we conducted a systematic review of immunohistochemical analyses of these neuroimmune cells in animal models following administration of ion channel antagonists, compared to control conditions...
November 29, 2018: Translational Psychiatry
Qing Yuan, Yawen Yao, Xiangchun Zhang, Jinling Yuan, Baoyun Sun, Xueyun Gao
Neurodegenerative diseases have become a huge challenge to public health, such as Alzheimer's and Parkinson's diseases. Microglia driving inflammation in the central nervous system (CNS) has been involved in the pathological process of these disorders and could be novel therapy target. However, traditional anti-inflammatory drugs are not effective in alleviating neuroinflammation. In this study, a potential neuroprotective effect of a peptide-templated gold nanocluster (Au25 Sv9 ) was investigated. Firstly, effect of the nanocluster on cytotoxins' secretion of activated BV-2 microglia cells was assessed...
April 1, 2019: Journal of Nanoscience and Nanotechnology
Xuetao Lu, Xianlong Qi, Xiuli Yi, Zhe Jian, Tianwen Gao
BACKGROUND: Propionibacterium acnes (P. acnes) is an anaerobe commonly stay in the body as part of the commensal microbiota, and a dominant bacterium of the human skin and hair follicles. It has been found that this bacterium could participate in brain inflammation that causes Alzheimer's disease (AD) and Parkinson's disease (PD). But how P. acnes invade the brain remains elusive. METHODS: We established the in vitro blood-brain barrier (BBB) model by culturing the HBMEC/D3 cell line on collagen-coated PFTE membrane...
November 28, 2018: Journal of Cellular Biochemistry
Ping Gan, Qiaofang Xia, Guihua Hang, Yincai Zhou, Xiaojuan Qian, Xiaomei Wang, Lidong Ding
Parkinson's disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Cathepsin D (CathD), a soluble aspartic protease, has been reported to play an important role in neurodegenerative diseases such as PD. This research focused on the role of CathD and the molecular mechanisms involved in the process of neuroinflammation and neurotoxicity...
November 28, 2018: Clinical and Experimental Pharmacology & Physiology
Miora Rakotoarisoa, Angelina Angelova
Neurodegenerative diseases have become a major challenge for public health because of their incurable status. Soft nanotechnology provides potential for slowing down the progression of neurodegenerative disorders by using innovative formulations of neuroprotective antioxidants like curcumin, resveratrol, vitamin E, rosmarinic acid, 7,8-dihydroxyflavone, coenzyme Q10, and fish oil. Curcumin is a natural, liposoluble compound, which is of considerable interest for nanomedicine development in combination therapies...
November 23, 2018: Medicines (Basel, Switzerland)
Hua-Ying Cai, Ke-Wei Tian, Yuan-Yuan Zhang, Hong Jiang, Shu Han
Amyotrophic lateral sclerosis (ALS) is an adult disorder of neurodegeneration that manifests as the destruction of upper and lower motor neurons. Beta-N-methylamino-L-alanine (L-BMAA), an amino acid not present in proteins, was found to cause intraneuronal protein misfolding and to induce ALS/Parkinsonism dementia complex (PDC), which presents symptoms analogous to those of Alzheimer's-like dementia and Parkinsonism. L-serine suppresses the erroneous incorporation of L-BMAA into proteins in the human nervous system...
November 25, 2018: Aging
Unbin Chae, Han Seop Kim, Hyun-Shik Lee, Sang-Rae Lee, Dong-Seok Lee
Microglial activation is known to be an important event during innate immunity, but microglial inflammation is also thought to play a role in the etiology of neurodegenerative diseases. Recently, it was reported that autophagy could influence inflammation and activation of microglia. However, little is known about the regulation of autophagy during microglial activation. In this study, we demonstrated that mitochondrial fission-induced ROS can promote autophagy in microglia. Following LPS-induced autophagy, GFP-LC3 puncta were increased, and this was suppressed by inhibiting mitochondrial fission and mitochondrial ROS...
November 26, 2018: Bioscience, Biotechnology, and Biochemistry
Jianying He, Wenwen Zhong, Ming Zhang, Rongping Zhang, Weiyan Hu
Parkinson's disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson's disease are not fully understood, considerable evidence suggests that neuro-inflammation, oxidative stress, mitochondrial dysfunction, cell proliferation, differentiation and apoptosis are involved in the disease. p38MAPK, an important member of the mitogen-activated protein family, controls several important functions in the cell, suggesting a potential pathogenic role in PD...
2018: Translational Neuroscience
Nancy H Mejias, Camila C Martinez, Marisa E Stephens, Juan Pablo de Rivero Vaccari
Background: Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer's disease and Parkinson's disease. The inflammasome is a multi-protein complex of the innate immune response involved in the activation of caspase-1 and the processing of the inflammatory cytokines interleukin (IL)-1β and IL-18. We have previously shown that the inflammasome plays a role in the aging process in the brain...
2018: Journal of Inflammation
Emily G Severance, Robert H Yolken
The body's microbiome represents an actively regulated network of novel mechanisms that potentially underlie the etiology and pathophysiology of a wide range of diseases. For complex brain disorders such as schizophrenia, understanding the cellular and molecular pathways that intersect the bidirectional gut-brain axis is anticipated to lead to new methods of treatment. The means by which the microbiome might differ across neuropsychiatric and neurological disorders are not known. Brain disorders as diverse as schizophrenia, major depression, Parkinson's disease and multiple sclerosis appear to share a common pathology of an imbalanced community of commensal microbiota, often measured in terms of a leaky gut phenotype accompanied by low level systemic inflammation...
November 21, 2018: Neurobiology of Disease
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"