Jian-Shiun Chiou, Ying-Ju Lin, Cherry Yin-Yi Chang, Wen-Miin Liang, Ting-Yuan Liu, Jai-Sing Yang, Chen-Hsing Chou, Hsing-Fang Lu, Mu-Lin Chiu, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, I-Ching Chou, Te-Mao Li, Peng-Yan Huang, Tzu-Shun Chien, Hou-Ren Chen, Fuu-Jen Tsai
STUDY QUESTION: Are there associations of age at menarche (AAM) with health-related outcomes in East Asians? SUMMARY ANSWER: AAM is associated with osteoporosis, Type 2 diabetes (T2D), glaucoma, and uterine fibroids, as demonstrated through observational studies, polygenic risk scores, genetic correlations, and Mendelian randomization (MR), with additional findings indicating a causal effect of BMI and T2D on earlier AAM. WHAT IS KNOWN ALREADY: Puberty timing is linked to adult disease risk, but research predominantly focuses on European populations, with limited studies in other groups...
March 25, 2024: Human Reproduction