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Sirt aging

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https://www.readbyqxmd.com/read/30104552/effects-of-rhizome-extract-of-dioscorea-batatas-and-its-active-compound-allantoin-on-the-regulation-of-myoblast-differentiation-and-mitochondrial-biogenesis-in-c2c12-myotubes
#1
Junnan Ma, Seok Yong Kang, Xianglong Meng, An Na Kang, Jong Hun Park, Yong-Ki Park, Hyo Won Jung
With the aging process, a loss of skeletal muscle mass and dysfunction related to metabolic syndrome is observed in older people. Yams are commonly use in functional foods and medications with various effects. The present study was conducted to investigate the effects of rhizome extract of Dioscorea batatas (Dioscoreae Rhizoma, Chinese yam) and its bioactive compound, allantoin, on myoblast differentiation and mitochondrial biogenesis in skeletal muscle cells. Yams were extracted in water and allantoin was analyzed by high performance liquid chromatography (HPLC)...
August 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30082184/clinical-utility-of-one-month-imaging-following-selective-internal-radiation-therapy
#2
S Young, A Taylor, J Golzarian, S Flanagan, D D'Souza, T Sanghvi
PURPOSE: The goal of this retrospective review was to determine the clinical relevance of one-month post-treatment imaging in the selective internal radiation therapy (SIRT) patient population by reporting the incidence of change in clinical management. MATERIALS AND METHODS: Between January 2012 and January 2016, 85 patients underwent 109 SIRT treatments for either primary or secondary hepatic malignancies. There were 59 men and 26 women with a mean age of 62.4 years (range: 39-89 years)...
August 3, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29971668/exercise-training-protects-against-aging-induced-cognitive-dysfunction-via-activation-of-the-hippocampal-pgc-1%C3%AE-fndc5-bdnf-pathway
#3
Muaz Belviranlı, Nilsel Okudan
This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats (P < 0...
July 3, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29937556/the-role-of-forkhead-box-class-o3a-and-sirt1-gene-variants-in-early-onset-psoriasis
#4
Suzan Demir Pektas, Gursoy Dogan, Tuba Gokdogan Edgunlu, Sevim Karakas-Celik, Esra Ermis, Nilgun Solak Tekin
Background: Psoriasis is a chronic inflammatory skin disorder, which is characterized by a heightened immunological response. Although the immunogenetics of this chronic inflammatory disorder is poorly understood, its expression is known to be dependent on proinflammatory cytokines. It is known that two distinct subtypes of chronic plaque psoriasis: Early-onset psoriasis (EOP) before the age of 40 years and late-onset psoriasis after the age of 40 years. Forkhead box class O3A (FOXO3A) is a transcription factor, which plays an important role in cell-cycle regulation, apoptosis, oxidative stress, and DNA repair...
May 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29849892/short-duration-swimming-exercise-after-myocardial-infarction-attenuates-cardiac-dysfunction-and-regulates-mitochondrial-quality-control-in-aged-mice
#5
Dajun Zhao, Yang Sun, Yanzhen Tan, Zhengbin Zhang, Zuoxu Hou, Chao Gao, Pan Feng, Xing Zhang, Wei Yi, Feng Gao
Background: Exercise benefits to cardiac rehabilitation (CR) following stable myocardial infarction (MI). The suitable exercise duration for aged patients with coronary heart disease (CHD) remains controversial, and the underlying molecular mechanism is still unclear. Methods and Results: 18-Month-old mice after stable MI were randomly submitted to different durations of exercise, including 15 and 60 min swimming training (ST) once per day, five times a week for 8 weeks...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29802939/depressed-mitochondrial-function-and-electron-transport-complex-ii-mediated-h-2-o-2-production-in-the-cortex-of-type-1-diabetic-rodents
#6
Subir Roy Chowdhury, Jelena Djordjevic, Ella Thomson, Darrell R Smith, Benedict C Albensi, Paul Fernyhough
AIMS: Abnormalities in mitochondrial function under diabetic conditions can lead to deficits in function of cortical neurons and their support cells exhibiting a pivotal role in the pathogenesis of several neurodegenerative disorders, including Alzheimer's disease. We aimed to assess mitochondrial respiration rates and membrane potential or H2 O2 generation simultaneously and expression of proteins involved in mitochondrial dynamics, ROS scavenging and AMPK/SIRT/PGC-1α pathway activity in cortex under diabetic conditions...
May 23, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29745797/reversing-age-associated-arterial-dysfunction-insight-from-preclinical-models
#7
Venkateswara Reddy Gogulamudi, Jinjin Cai, Lisa A Lesniewski
Cardiovascular diseases (CVDs) remain the leading causes of death in the US, and advancing age is a primary risk factor. Impaired endothelium dependent dilation and increased stiffening of the arteries with aging are independent predictors of CVD. Increased tissue and systemic oxidative stress and inflammation underlie this age-associated arterial dysfunction. Calorie restriction (CR) is the most powerful intervention known to increase lifespan and improve age-related phenotypes, including arterial dysfunction...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29693113/role-of-sirtuin-1-in-the-pathogenesis-of-ocular-disease-review
#8
Mengwen Zhou, Jing Luo, Huiming Zhang
Sirtuin (SIRT)1, a member of the SIRT family, is a highly conserved NAD+‑dependent histone deacetylase, which has a regulatory role in numerous physiological and pathological processes by removing acetyl groups from various proteins. SIRT1 controls the activity of numerous transcription factors and cofactors, which impacts the downstream gene expression, and eventually alleviates oxidative stress and associated damage. Numerous studies have revealed that dysfunction of SIRT1 is linked with ocular diseases, including cataract, age‑associated macular degeneration, diabetic retinopathy and glaucoma, while ectopic upregulation of SIRT1 protects against various ocular diseases...
July 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29686722/energy-restriction-exercise-and-atorvastatin-treatment-improve-endothelial-dysfunction-and-inhibit-mirna-155-in-the-erectile-tissue-of-the-aged-rat
#9
B Rocha, A R Rodrigues, I Tomada, M J Martins, J T Guimarães, A M Gouveia, H Almeida, D Neves
Background: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet pattern, exercise and atorvastatin modulate the expression of eNOS, inducible NOS (iNOS), endothelin-1, sirtuins (SIRT) and microRNA-155 in the erectile tissue of high-fat fed aged rats...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29659739/physical-exercise-improves-aging-related-changes-in-angiotensin-igf-1-sirt-1-sirt3-and-vegf-in-the-substantia-nigra
#10
Ana Muñoz, Clynton L Corrêa, Andrea Lopez-Lopez, Maria A Costa-Besada, Carmen Diaz-Ruiz, Jose L Labandeira-Garcia
Dysregulation of tissue renin-angiotensin system (RAS) is involved in oxidative and inflammatory processes observed in major aging-related diseases, including neurodegenerative diseases such as Parkinson´s disease (PD). Physical exercise has beneficial effects against aging-related changes, dopaminergic neuron vulnerability and PD progression. The present study indicates that sedentary aged rats have an increase in activity of the nigral angiotensin (Ang) II/Ang type 1 receptor (AT1) axis (i.e. the pro-oxidative pro-inflammatory arm), and a decrease in the activity of the RAS protective arm (i...
April 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29657112/high-expression-of-cpt1b-in-skeletal-muscle-in-metabolically-healthy-older-subjects
#11
C Bétry, E Meugnier, M Pflieger, G Grenet, S Hercberg, P Galan, E Kesse-Guyot, H Vidal, M Laville
AIM: Ageing is often associated with metabolic abnormalities such as insulin resistance, although some people remain metabolically healthy throughout their lives. The aim of this study was to gain more insight into metabolic health with increasing age. METHODS: Two groups of robust and of frail subjects, respectively, were identified based on a composite ageing indicator and recruited from the French SU.VI.MAX 2 cohort of older disease-free subjects. In all, 14 men and 12 women, aged 67±4 years, with similar anthropometric and metabolic characteristics at baseline (BMI: 24...
February 12, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29579543/igfbp-3-plays-an-important-role-in-senescence-as-an-aging-marker
#12
Sugyeong Hong, Moon-Moo Kim
Aging study requires aging markers to measure the degree of aging process. The aging markers such as senescence associated-β-galactosidase (SA-β-gal), lipofuscin, telomere, p53 and p16 have been known in aging study until now. Therefore, we investigated the role of genes and proteins related to aging in young, senescent and H2 O2 -induced old cells to develop a novel aging marker involved in aging mechanism. After cellular aging was compared in young, senescent and H2 O2 -induced old cells using SA-β-galactosidase staining assay, the expression level of genes and proteins in senescent and H2 O2 -induced old cells were compared and analyzed with those of young cells using RT-PCR, western blot and immunofluorescence staining...
April 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29570854/daily-melatonin-protects-the-endothelial-lineage-and-functional-integrity-against-the-aging-process-oxidative-stress-and-toxic-environment-and-restores-blood-flow-in-critical-limb-ischemia-area-in-mice
#13
Fan-Yen Lee, Cheuk-Kwan Sun, Pei-Hsun Sung, Kuan-Hung Chen, Sarah Chua, Jiunn-Jye Sheu, Sheng-Ying Chung, Han-Tan Chai, Yi-Ling Chen, Tien-Hung Huang, Chi-Ruei Huang, Yi-Chen Li, Chi-Wen Luo, Hon-Kan Yip
We tested the hypothesis that daily melatonin treatment protects endothelial lineage and functional integrity against the aging process, oxidative stress/endothelial denudation (ED), and toxic environment and restored blood flow in murine critical limb ischemia (CLI). In vitro study using HUVECs, in vivo models (ie, CLI through left femoral artery ligation and ED through carotid artery wire injury), and model of lipopolysaccharide-induced aortic injury in young (3 months old) and aged (8 months old) mice were used to elucidate effects of melatonin treatment on vascular endothelial integrity...
March 23, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29550994/sirtuins-and-accelerated-aging-in-scleroderma
#14
REVIEW
Anne E Wyman, Sergei P Atamas
PURPOSE OF REVIEW: Premature activation of aging-associated molecular mechanisms is emerging as an important contributor to many diseases, including scleroderma. Among central regulators of the aging process are a group of histone deacetylases called sirtuins (SIRTs). Recent findings implicate these molecules as pathophysiological players in scleroderma skin and lung fibrosis. The goal of this article is to review recent studies on the involvement of SIRTs in scleroderma from the perspective of aging-related molecular mechanisms...
March 17, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29532856/sirt3-deficiency-exacerbates-p53-parkin%C3%A2-mediated-mitophagy-inhibition-and-promotes-mitochondrial-dysfunction-implication-for-aged-hearts
#15
Yan Li, Ying Ma, Liqiang Song, Lu Yu, Le Zhang, Yingmei Zhang, Yuan Xing, Yue Yin, Heng Ma
Mitochondrial dynamics have critical roles in aging, and their impairment represents a prominent risk factor for myocardial dysfunction. Mitochondrial deacetylase sirtuin (SIRT)3 contributes greatly to the prevention of redox stress and cell aging. The present study explored the role of SIRT3 on myocardium aging. Western blot analysis demonstrated that SIRT3 expression levels were significantly lower in the myocardia of aged mice compared with young mice. Immunoprecipitation and western blot assays indicated that the activity of mitochondrial manganese superoxide dismutase (MnSOD) and peroxisome proliferator‑activated receptor γ coactivator (PGC)‑1α was reduced in the aged heart...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29523614/selective-internal-radiation-therapy-sirt-with-yttrium-90-microspheres-for-unresectable-intrahepatic-cholangiocarcinoma
#16
Vindya Abeysinghe, Siva Sundararajan, Luc Delriviere, Jonathan Tibballs
Unresectableintrahepaticcholangiocarcinoma has a very poor prognosis despite various treatment options. The case presented describes the diagnostic challenges of a young pregnant woman with unresectable cholangiocarcinoma. The current treatment options for cholangiocarcinoma have limited evidence and high recurrence rate. Given the young age of this patient, selective internal radiotherapy was trialled with traditional chemotherapy with a clinically significant result. This case highlights the delays when diagnosing cholangiocarcinoma in younger patients and the possibility of selective internal radiation therapy in combination with chemotherapy as a potential first-line treatment for a complete response in unresectable disease...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29383678/hepatic-intra-arterial-therapies-in-metastatic-neuroendocrine-tumors-lessons-from-clinical-practice
#17
S Grozinsky-Glasberg, G Kaltsas, M Kaltsatou, N Lev-Cohain, A Klimov, V Vergadis, I Uri, A I Bloom, D J Gross
BACKGROUND: Liver metastases are common in patients with neuroendocrine tumors (NETs), having a negative impact on disease prognosis. The options for selective therapy in patients with unresectable multiple liver metastases are limited to TACE (transarterial chemoembolization), TAE (transarterial embolization), or SIRT (selective internal radiation therapy). AIM: To explore the clinical outcome, survival and safety of these therapies in NETs patients. METHODS: Retrospective case series of consecutive patients (mean age 56...
June 2018: Endocrine
https://www.readbyqxmd.com/read/29374686/inhibition-of-sirtuin-6-induces-neuroblastoma-differentiation
#18
Ha Yong Song, Eric J Rellinger, Seong-Hoon Park, Pritha Paul, Jingbo Qiao, Athanasios Vasilopoulos, Ozkan Ozden, David Gius, Dai H Chung
BACKGROUND/AIM: Sirtuins (SIRTs) play crucial roles in various signaling pathways that modulate differentiation and proliferation. We sought to elucidate the role of SIRTs in differentiation and proliferation of human neuroblastoma (NB). MATERIALS AND METHODS: NB cells were treated with nicotinamide (NAM), a non-specific SIRT inhibitor, SIRT-targeted short hairpin RNAs, and retinoic acid to assess cell growth and differentiation. RESULTS: SIRTs are involved in proliferation and differentiation using NAM in BE(2)-C cells...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29302794/evaluation-of-the-neuroprotective-effect-of-sirt3-in-experimental-stroke
#19
Rajkumar Verma, Rodney M Ritzel, Joshua Crapser, Brett D Friedler, Louise D McCullough
Sirtuins (Sirt) are a family of NAD+ dependent histone deacetylase (HDAC) proteins implicated in aging, cell cycle regulation, and metabolism. These proteins are involved in the epigenetic modification of neuromodulatory proteins after strokevia acetylation/deacetylation. The specific role of Sirt3, a mitochondrial sirtuin, in post-stroke injury has been relatively unexplored. Using male Sirt3 knockout (KO) mice and wild-type littermates (WT), we show that Sirt3 KO mice show significant neuroprotection at 3 days after ischemia/reperfusion (I/R) or stroke injury...
January 4, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29280055/sirtuin-1-chromatin-binding-dynamics-points-to-a-common-mechanism-regulating-inflammatory-targets-in-siv-infection-and-in-the-aging-brain
#20
Nikki Bortell, Liana Basova, Julia A Najera, Brenda Morsey, Howard S Fox, Maria Cecilia Garibaldi Marcondes
Microglia and macrophages are the main non-neuronal subsets of myeloid origin in the brain, and are critical regulators in neurodegenerative disorders, where inflammation is a key factor. Since HIV infection results in neurological perturbations that are similar to those in aging, we examined microglial and infiltrating myeloid subsets in the search for changes that might resemble the ones in aging. For that, we used the SIV infection in rhesus macaques to model neuroAIDS. We found that Sirt-1, a molecule that impacts survival and health in many models, was decreased in cell preparations containing a majority of microglia and myeloid cells from the brain of infected macaques...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
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