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https://www.readbyqxmd.com/read/30304806/controversial-impact-of-sirtuins-in-chronic-non-transmissible-diseases-and-rehabilitation-medicine
#1
REVIEW
Alessia Mongelli, Carlo Gaetano
A large body of evidence reports about the positive effects of physical activity in pathophysiological conditions associated with aging. Physical exercise, alone or in combination with other medical therapies, unquestionably causes reduction of symptoms in chronic non-transmissible diseases often leading to significant amelioration or complete healing. The molecular basis of this exciting outcome-however, remain largely obscure. Epigenetics, exploring at the interface between environmental signals and the remodeling of chromatin structure, promises to shed light on this intriguing matter possibly contributing to the identification of novel therapeutic targets...
October 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30298020/fibrogenic-secretome-of-sirtuin-1-deficient-endothelial-cells-wnt-notch-and-glycocalyx-rheostat
#2
REVIEW
Mark Lipphardt, Hassan Dihazi, Gerhard A Müller, Michael S Goligorsky
Sirtuins (SIRT) are ubiquitous histone and protein deacetylases and a member of this family, SIRT1, is the best-studied one. Its functions in endothelial cells encompass branching angiogenesis, activation of endothelial nitric oxide synthase, regulation of proapoptotic and proinflammatory pathways, among others. Defective SIRT1 activity has been described in various cardiovascular, renal diseases and in aging-associated conditions. Therefore, understanding of SIRT1-deficient, endothelial dysfunctional phenotype has much to offer clinically...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30189861/elevated-contextual-fear-memory-by-sirt6-depletion-in-excitatory-neurons-of-mouse-forebrain
#3
Hyopil Kim, Hyun-Seok Kim, Bong-Kiun Kaang
A class of NAD-dependent protein deacetylases, the Sirtuin (SIRT) family of proteins is involved in aging, cell survival, and neurodegeneration. Recently, SIRT proteins, including SIRT6, have been reported to be important in learning and memory. However, the role of SIRT6 in excitatory brain neurons in cognitive behaviors is not well characterized. We investigated how cognitive behaviors are affected by genetic SIRT6 depletion in excitatory neurons in the mouse forebrain. We generated a conditional knockout (cKO) mouse line by mating two transgenic lines, Floxed SIRT6 and CaMKIIa-Cre...
September 6, 2018: Molecular Brain
https://www.readbyqxmd.com/read/30132522/moderate-calorie-restriction-attenuates-age%C3%A2-associated-alterations-and-improves-cardiac-function-by-increasing-sirt1-and-sirt3-expression
#4
Wei Yu, Jinjin Qin, Chunjuan Chen, Yucai Fu, Wei Wang
Calorie restriction (CR) extends the lifespan of mammals and improves cardiac function by attenuation of age‑associated alterations. Sirtuins (SIRT) are involved in these mechanisms, however, the extent to which CR affects cardiac function and sirtuin expression remains unknown. Therefore, the present study aimed to determine to what extent CR affects cardiac function and sirtuin expression. A total of 60 female Sprague‑Dawley rats were randomly divided into four groups, including normal control (NC), 25% calorie restriction (25% CR), 45% calorie restriction (45% CR) and high‑fat diet (HF)...
August 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30131769/inverse-association-of-circulating-sirt1-and-adiposity-a-study-on-underweight-normal-weight-and-obese-patients
#5
Stefania Mariani, Maria R di Giorgio, Paolo Martini, Agnese Persichetti, Giuseppe Barbaro, Sabrina Basciani, Savina Contini, Eleonora Poggiogalle, Antonio Sarnicola, Alfredo Genco, Carla Lubrano, Aldo Rosano, Lorenzo M Donini, Andrea Lenzi, Lucio Gnessi
Context: Sirtuins (SIRTs) are NAD+-dependent deacetylases, cellular sensors to detect energy availability, and modulate metabolic processes. SIRT1, the most studied family member, influences a number of tissues including adipose tissue. Expression and activity of SIRT1 reduce with weight gain and increase in conditions of starvation. Objective: To focus on SIRT1 plasma concentrations in different conditions of adiposity and to correlate SIRT1 with fat content and distribution, energy homeostasis and inflammation in under-weight, normal-weight, and obese individuals...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30131726/acetylation-of-mitochondrial-proteins-in-the-heart-the-role-of-sirt3
#6
REVIEW
Rebecca M Parodi-Rullán, Xavier R Chapa-Dubocq, Sabzali Javadov
A growing number of studies have demonstrated the role of post-translational modifications of proteins, particularly acetylation, in human diseases including neurodegenerative and cardiovascular diseases, diabetes, cancer, and in aging. Acetylation of mitochondrial proteins has been shown to be involved in the pathogenesis of cardiac diseases such as myocardial infarction (ischemia-reperfusion) and heart failure. Indeed, over 60% of mitochondrial proteins contain acetylation sites, and most of these proteins are involved in mitochondrial bioenergetics...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30104552/effects-of-rhizome-extract-of-dioscorea-batatas-and-its-active-compound-allantoin-on-the-regulation-of-myoblast-differentiation-and-mitochondrial-biogenesis-in-c2c12-myotubes
#7
Junnan Ma, Seok Yong Kang, Xianglong Meng, An Na Kang, Jong Hun Park, Yong-Ki Park, Hyo Won Jung
With the aging process, a loss of skeletal muscle mass and dysfunction related to metabolic syndrome is observed in older people. Yams are commonly use in functional foods and medications with various effects. The present study was conducted to investigate the effects of rhizome extract of Dioscorea batatas (Dioscoreae Rhizoma, Chinese yam) and its bioactive compound, allantoin, on myoblast differentiation and mitochondrial biogenesis in skeletal muscle cells. Yams were extracted in water and allantoin was analyzed by high performance liquid chromatography (HPLC)...
August 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30082184/clinical-utility-of-one-month-imaging-following-selective-internal-radiation-therapy
#8
S Young, A Taylor, J Golzarian, S Flanagan, D D'Souza, T Sanghvi
PURPOSE: The goal of this retrospective review was to determine the clinical relevance of one-month post-treatment imaging in the selective internal radiation therapy (SIRT) patient population by reporting the incidence of change in clinical management. MATERIALS AND METHODS: Between January 2012 and January 2016, 85 patients underwent 109 SIRT treatments for either primary or secondary hepatic malignancies. There were 59 men and 26 women with a mean age of 62.4 years (range: 39-89 years)...
August 3, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29971668/exercise-training-protects-against-aging-induced-cognitive-dysfunction-via-activation-of-the-hippocampal-pgc-1%C3%AE-fndc5-bdnf-pathway
#9
Muaz Belviranlı, Nilsel Okudan
This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats (P < 0...
September 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29937556/the-role-of-forkhead-box-class-o3a-and-sirt1-gene-variants-in-early-onset-psoriasis
#10
Suzan Demir Pektas, Gursoy Dogan, Tuba Gokdogan Edgunlu, Sevim Karakas-Celik, Esra Ermis, Nilgun Solak Tekin
Background: Psoriasis is a chronic inflammatory skin disorder, which is characterized by a heightened immunological response. Although the immunogenetics of this chronic inflammatory disorder is poorly understood, its expression is known to be dependent on proinflammatory cytokines. It is known that two distinct subtypes of chronic plaque psoriasis: Early-onset psoriasis (EOP) before the age of 40 years and late-onset psoriasis after the age of 40 years. Forkhead box class O3A (FOXO3A) is a transcription factor, which plays an important role in cell-cycle regulation, apoptosis, oxidative stress, and DNA repair...
May 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29849892/short-duration-swimming-exercise-after-myocardial-infarction-attenuates-cardiac-dysfunction-and-regulates-mitochondrial-quality-control-in-aged-mice
#11
Dajun Zhao, Yang Sun, Yanzhen Tan, Zhengbin Zhang, Zuoxu Hou, Chao Gao, Pan Feng, Xing Zhang, Wei Yi, Feng Gao
Background: Exercise benefits to cardiac rehabilitation (CR) following stable myocardial infarction (MI). The suitable exercise duration for aged patients with coronary heart disease (CHD) remains controversial, and the underlying molecular mechanism is still unclear. Methods and Results: 18-Month-old mice after stable MI were randomly submitted to different durations of exercise, including 15 and 60 min swimming training (ST) once per day, five times a week for 8 weeks...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29802939/depressed-mitochondrial-function-and-electron-transport-complex-ii-mediated-h-2-o-2-production-in-the-cortex-of-type-1-diabetic-rodents
#12
Subir Roy Chowdhury, Jelena Djordjevic, Ella Thomson, Darrell R Smith, Benedict C Albensi, Paul Fernyhough
AIMS: Abnormalities in mitochondrial function under diabetic conditions can lead to deficits in function of cortical neurons and their support cells exhibiting a pivotal role in the pathogenesis of several neurodegenerative disorders, including Alzheimer's disease. We aimed to assess mitochondrial respiration rates and membrane potential or H2 O2 generation simultaneously and expression of proteins involved in mitochondrial dynamics, ROS scavenging and AMPK/SIRT/PGC-1α pathway activity in cortex under diabetic conditions...
May 23, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29745797/reversing-age-associated-arterial-dysfunction-insight-from-preclinical-models
#13
Venkateswara Reddy Gogulamudi, Jinjin Cai, Lisa A Lesniewski
Cardiovascular diseases (CVDs) remain the leading causes of death in the US, and advancing age is a primary risk factor. Impaired endothelium dependent dilation and increased stiffening of the arteries with aging are independent predictors of CVD. Increased tissue and systemic oxidative stress and inflammation underlie this age-associated arterial dysfunction. Calorie restriction (CR) is the most powerful intervention known to increase lifespan and improve age-related phenotypes, including arterial dysfunction...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29693113/role-of-sirtuin-1-in-the-pathogenesis-of-ocular-disease-review
#14
REVIEW
Mengwen Zhou, Jing Luo, Huiming Zhang
Sirtuin (SIRT)1, a member of the SIRT family, is a highly conserved NAD+‑dependent histone deacetylase, which has a regulatory role in numerous physiological and pathological processes by removing acetyl groups from various proteins. SIRT1 controls the activity of numerous transcription factors and cofactors, which impacts the downstream gene expression, and eventually alleviates oxidative stress and associated damage. Numerous studies have revealed that dysfunction of SIRT1 is linked with ocular diseases, including cataract, age‑associated macular degeneration, diabetic retinopathy and glaucoma, while ectopic upregulation of SIRT1 protects against various ocular diseases...
July 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29686722/energy-restriction-exercise-and-atorvastatin-treatment-improve-endothelial-dysfunction-and-inhibit-mirna-155-in-the-erectile-tissue-of-the-aged-rat
#15
B Rocha, A R Rodrigues, I Tomada, M J Martins, J T Guimarães, A M Gouveia, H Almeida, D Neves
Background: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet pattern, exercise and atorvastatin modulate the expression of eNOS, inducible NOS (iNOS), endothelin-1, sirtuins (SIRT) and microRNA-155 in the erectile tissue of high-fat fed aged rats...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29659739/physical-exercise-improves-aging-related-changes-in-angiotensin-igf-1-sirt-1-sirt3-and-vegf-in-the-substantia-nigra
#16
Ana Muñoz, Clynton L Corrêa, Andrea Lopez-Lopez, Maria A Costa-Besada, Carmen Diaz-Ruiz, Jose L Labandeira-Garcia
Dysregulation of tissue renin-angiotensin system (RAS) is involved in oxidative and inflammatory processes observed in major aging-related diseases, including neurodegenerative diseases such as Parkinson´s disease (PD). Physical exercise has beneficial effects against aging-related changes, dopaminergic neuron vulnerability and PD progression. The present study indicates that sedentary aged rats have an increase in activity of the nigral angiotensin (Ang) II/Ang type 1 receptor (AT1) axis (i.e. the pro-oxidative pro-inflammatory arm), and a decrease in the activity of the RAS protective arm (i...
April 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29657112/high-expression-of-cpt1b-in-skeletal-muscle-in-metabolically-healthy-older-subjects
#17
C Bétry, E Meugnier, M Pflieger, G Grenet, S Hercberg, P Galan, E Kesse-Guyot, H Vidal, M Laville
AIM: Ageing is often associated with metabolic abnormalities such as insulin resistance, although some people remain metabolically healthy throughout their lives. The aim of this study was to gain more insight into metabolic health with increasing age. METHODS: Two groups of robust and of frail subjects, respectively, were identified based on a composite ageing indicator and recruited from the French SU.VI.MAX 2 cohort of older disease-free subjects. In all, 14 men and 12 women, aged 67±4 years, with similar anthropometric and metabolic characteristics at baseline (BMI: 24...
February 12, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29579543/igfbp-3-plays-an-important-role-in-senescence-as-an-aging-marker
#18
Sugyeong Hong, Moon-Moo Kim
Aging study requires aging markers to measure the degree of aging process. The aging markers such as senescence associated-β-galactosidase (SA-β-gal), lipofuscin, telomere, p53 and p16 have been known in aging study until now. Therefore, we investigated the role of genes and proteins related to aging in young, senescent and H2 O2 -induced old cells to develop a novel aging marker involved in aging mechanism. After cellular aging was compared in young, senescent and H2 O2 -induced old cells using SA-β-galactosidase staining assay, the expression level of genes and proteins in senescent and H2 O2 -induced old cells were compared and analyzed with those of young cells using RT-PCR, western blot and immunofluorescence staining...
April 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29570854/daily-melatonin-protects-the-endothelial-lineage-and-functional-integrity-against-the-aging-process-oxidative-stress-and-toxic-environment-and-restores-blood-flow-in-critical-limb-ischemia-area-in-mice
#19
Fan-Yen Lee, Cheuk-Kwan Sun, Pei-Hsun Sung, Kuan-Hung Chen, Sarah Chua, Jiunn-Jye Sheu, Sheng-Ying Chung, Han-Tan Chai, Yi-Ling Chen, Tien-Hung Huang, Chi-Ruei Huang, Yi-Chen Li, Chi-Wen Luo, Hon-Kan Yip
We tested the hypothesis that daily melatonin treatment protects endothelial lineage and functional integrity against the aging process, oxidative stress/endothelial denudation (ED), and toxic environment and restored blood flow in murine critical limb ischemia (CLI). In vitro study using HUVECs, in vivo models (ie, CLI through left femoral artery ligation and ED through carotid artery wire injury), and model of lipopolysaccharide-induced aortic injury in young (3 months old) and aged (8 months old) mice were used to elucidate effects of melatonin treatment on vascular endothelial integrity...
September 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29550994/sirtuins-and-accelerated-aging-in-scleroderma
#20
REVIEW
Anne E Wyman, Sergei P Atamas
PURPOSE OF REVIEW: Premature activation of aging-associated molecular mechanisms is emerging as an important contributor to many diseases, including scleroderma. Among central regulators of the aging process are a group of histone deacetylases called sirtuins (SIRTs). Recent findings implicate these molecules as pathophysiological players in scleroderma skin and lung fibrosis. The goal of this article is to review recent studies on the involvement of SIRTs in scleroderma from the perspective of aging-related molecular mechanisms...
March 17, 2018: Current Rheumatology Reports
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