keyword
MENU ▼
Read by QxMD icon Read
search

Vancomycin AND outcome AND Mortality

keyword
https://www.readbyqxmd.com/read/30113856/efficacy-of-vancomycin-on-gram-positive-bacterial-infection-in-elderly-critical-patients-and-risk-factors-associated-with-nephrotoxicity
#1
Min Huang, Hao Wu, Jing Zhou, Min Xu, Suming Zhou
BACKGROUND: Vancomycin is widely used for infections caused by gram-positive bacteria, but little attention has been paid to vancomycin in the treatment of critically ill patients aged ≥80 years. The aim of the current study was to investigate the efficacy of vancomycin and risk factors associated with nephrotoxicity of vancomycin in elderly critically ill patients. METHODS: A retrospective study was performed in a 14-bed medical-surgical geriatric ICU between January 2007 and June 2014...
August 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/30103003/comparative-incidence-and-excess-risk-of-acute-kidney-injury-in-hospitalized-patients-receiving-vancomycin-and-piperacillin-tazobactam-in-combination-or-as-monotherapy
#2
Joseph J Carreno, Tori Smiraglia, Christopher Hunter, Ellis Tobin, Ben Lomaestro
INTRODUCTION: Combination therapy with vancomycin and piperacillin-tazobactam has been associated with increased risk of acute kidney injury (AKI) as compared to monotherapy. This study was conducted to assess the comparative incidence of AKI due to combination therapy in patients receiving vancomycin and piperacillin-tazobactam in combination or as monotherapy. METHODS: Retrospective, matched, cohort study of patients receiving vancomycin and piperacillin-tazobactam in combination or as monotherapy...
August 10, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/30048534/cost-effectiveness-analysis-of-ribotype-guided-fecal-microbiota-transplantation-in-chinese-patients-with-severe-clostridium-difficile-infection
#3
Minghuan Jiang, Nok-Hang Leung, Margaret Ip, Joyce H S You
BACKGROUND: Clostridium difficile infection (CDI) caused by ribotype 002 strain is associated with poor outcomes in Chinese patients. Fecal microbiota transplantation (FMT) is an effective but costly treatment for CDI. We aimed to examine potential cost-effectiveness of ribotype-guided FMT in Chinese patients with severe CDI. METHODS: A decision-analytic model was designed to simulate outcomes of ribotype 002-guided FMT versus vancomycin treatment in Chinese patients with severe CDI in the hospital setting...
2018: PloS One
https://www.readbyqxmd.com/read/30025222/does-antibiotic-choice-for-the-treatment-of-suspected-late-onset-sepsis-in-premature-infants-determine-the-risk-of-developing-necrotising-enterocolitis-a-systematic-review
#4
REVIEW
Josephine V Seale, Richard A Hutchinson, Paul F Fleming, Ajay Sinha, Stephen T Kempley, Shahid M Husain, Michael R Millar
BACKGROUND: Necrotising enterocolitis (NEC) is a significant cause of infant morbidity and mortality, disproportionately affecting those of extreme prematurity and/or very low birth weight. A number of risk factors have been identified, including an association between the use of antibiotics, and the subsequent development of NEC. AIM: This review sought to address whether the choice of antibiotic(s) used to treat infants with suspected late-onset sepsis (LOS) influences the risk of developing NEC...
July 2, 2018: Early Human Development
https://www.readbyqxmd.com/read/30011107/fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-in-patients-with-solid-organ-transplants-an-institutional-experience-and-review-of-the-literature
#5
Steven C Lin, Carolyn D Alonso, Alan C Moss
Clostridium difficile, an anaerobic gram-positive, spore-forming bacillus, has become the most common cause of nosocomial infectious diarrhea, and is associated with increased mortality in all populations. Patients who have received solid organ transplants (SOT) are at increased risk of Clostridium difficile infection (CDI) and CDI recurrence (rCDI). This may be related to chronic immunosuppression, frequent antibiotic exposure, and increased or prolonged hospitalizations. Increased morbidity and mortality from CDI is well-described in SOT patients...
July 16, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29948742/appropriateness-of-vancomycin-therapeutic-drug-monitoring-and-its-outcomes-among-non-dialysis-patients-in-a-tertiary-hospital-in-singapore
#6
Jun Jie Benjamin Seng, Mei Hui Amanda Yong, Zi Xin Peh, Jie Lin Soong, Mooi Heong Tan
Background Vancomycin therapeutic drug monitoring (TDM) is commonly performed to ensure safe and effective use of the antibiotic. Aim of Study To evaluate appropriateness of vancomycin TDM and its outcomes in Singapore General Hospital. Method A retrospective, cross-sectional study was conducted between 1 January 2014 and 28 February 2014 involving patients who received ≥ 1 dose of intravenous vancomycin with TDM. Patient demographics and relevant vancomycin TDM data were collected from medical records...
June 12, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29941432/the-evolving-epidemiology-of-clostridium-difficile-infection-in-canadian-hospitals-during-a-postepidemic-period-2009-2015
#7
Kevin C Katz, George R Golding, Kelly Baekyung Choi, Linda Pelude, Kanchana R Amaratunga, Monica Taljaard, Stephanie Alexandre, Jun Chen Collet, Ian Davis, Tim Du, Gerald A Evans, Charles Frenette, Denise Gravel, Susy Hota, Pamela Kibsey, Joanne M Langley, Bonita E Lee, Camille Lemieux, Yves Longtin, Dominik Mertz, Lorraine Maze Dit Mieusement, Jessica Minion, Dorothy L Moore, Michael R Mulvey, Susan Richardson, Michelle Science, Andrew E Simor, Paula Stagg, Kathryn N Suh, Geoffrey Taylor, Alice Wong, Nisha Thampi
BACKGROUND: The clinical and molecular epidemiology of health care-associated Clostridium difficile infection in nonepidemic settings across Canada has evolved since the first report of the virulent North American pulsed-field gel electrophoresis type 1 (NAP1) strain more than 15 years ago. The objective of this national, multicentre study was to describe the evolving epidemiology and molecular characteristics of health care-associated C. difficile infection in Canada during a post-NAP1-epidemic period, particularly patient outcomes associated with the NAP1 strain...
June 25, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29926235/impact-of-superimposed-clostridium-difficile-infection-in-crohn-s-or-ulcerative-colitis-flares-in-the-outpatient-setting
#8
Patrícia Guedes Garcia, Liliana Andrade Chebli, Tarsila Campanha da Rocha Ribeiro, Pedro Duarte Gaburri, Fabio Heleno de Lima Pace, Kátia Valéria Bastos Dias Barbosa, Lívia Almeida Costa, William de Almeida Cruz, Isabelle Carvalho de Assis, Bernardo Rodriguez Mendes Moraes, Alexandre Zanini, Julio Maria Fonseca Chebli
PURPOSE: The prospective assessment of Clostridium difficile infection (CDI) impact in inflammatory bowel disease (IBD) flare in outpatient setting has been poorly investigated. We aimed to evaluate the prevalence and the associated factors with CDI in IBD outpatients presenting colitis flares as well as the outcomes following treatment. METHODS: In this prospective cohort study, conducted from October, 2014, to July, 2016, 120 IBD patients (55% presenting colitis flare) and 40 non-IBD controls were assessed for CDI...
June 21, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29913285/epidemiology-and-clinical-outcomes-of-viral-central-nervous-system-infections
#9
Fatma Ben Abid, Mohammed Abukhattab, Hafedh Ghazouani, Obada Khalil, Ahmed Gohar, Hussam Al Soub, Muna Al Maslamani, Abdullatif Al Khal, Eman Al Masalamani, Said Al Dhahry, Samar Hashim, Faraj Howadi, Adeel A Butt
BACKGROUND: Central nervous system (CNS) viral infections are an important cause of morbidity and mortality. No data are available regarding their epidemiology in Qatar. DESIGN: We retrospectively evaluated all cerebrospinal fluid findings from January 2011-March 2015 at Hamad Medical Corporation. Those with abnormal CSF finding were included in our study. We excluded those with missing medical records, no clinical evidence of viral CNS infection, or proven bacterial, fungal or tuberculosis CNS infection...
August 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29909051/early-prophylactic-antibiotics-for-severe-acute-pancreatitis-a-population-based-cohort-study-using-a-nationwide-database-in-japan
#10
Kazuhiko Nakaharai, Kojiro Morita, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
OBJECTIVES: Previous studies evaluating the clinical benefits of prophylactic antibiotics for severe acute pancreatitis (SAP) have generated inconsistent results due to heterogeneities among the study settings. We determined if early prophylactic antibiotics improved the outcomes of SAP patients using a study designed to overcome these previous methodological weaknesses. METHODS: We conducted a retrospective cohort study of SAP patients discharged between July 2010 and March 2016, using a Japanese nationwide inpatient database...
June 13, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29893805/vancomycin-monotherapy-may-be-insufficient-to-treat-methicillin-resistant-staphylococcus-aureus-coinfection-in-children-with-influenza-related-critical-illness
#11
Adrienne G Randolph, Ruifei Xu, Tanya Novak, Margaret M Newhams, Juliane Bubeck Wardenburg, Scott L Weiss, Ronald C Sanders, Neal J Thomas, Mark W Hall, Keiko M Tarquinio, Natalie Cvijanovich, Rainer G Gedeit, Edward J Truemper, Barry Markovitz, Mary E Hartman, Kate G Ackerman, John S Giuliano, Steven L Shein, Kristin Moffitt
Background: Respiratory coinfection with influenza virus and methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening necrotizing pneumonia in children. Sporadic incidence precludes evaluation of antimicrobial efficacy. We assessed the clinical characteristics and outcomes of critically ill children with influenza-MRSA respiratory coinfection and evaluated antibiotic use. Methods: We prospectively enrolled children (<18 years) with influenza infection and acute respiratory failure across 34 pediatric intensive care units Nov 2008 to May 2016...
June 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29804104/new-threats-from-an-old-foe-methicillin-resistant-staphylococcus-aureus-infections-in-neonates
#12
REVIEW
Ying Dong, Kirsten Glaser, Christian P Speer
Methicillin-resistant Staphylococcus aureus (MRSA) is a ubiquitous human inhabitant and one of the important pathogens of neonatal infections. MRSA is associated with significant mortality and morbidity, especially in very immature preterm neonates. Moreover, MRSA may be implicated in adverse long-term neonatal outcomes, posing a substantial disease burden. Recent advances in molecular microbiology have shed light on the evolution of MRSA population structure and virulence factors, which may contribute to MRSA epidemic waves worldwide...
2018: Neonatology
https://www.readbyqxmd.com/read/29777150/risk-factors-of-treatment-failure-and-30-day-mortality-in-patients-with-bacteremia-due-to-mrsa-with-reduced-vancomycin-susceptibility
#13
Chien-Chang Yang, Cheng-Len Sy, Yhu-Chering Huang, Shian-Sen Shie, Jwu-Ching Shu, Pang-Hsin Hsieh, Ching-Hsi Hsiao, Chih-Jung Chen
Bacteremia caused by MRSA with reduced vancomycin susceptibility (MRSA-RVS) frequently resulted in treatment failure and mortality. The relation of bacterial factors and unfavorable outcomes remains controversial. We retrospectively reviewed clinical data of patients with bacteremia caused by MRSA with vancomycin MIC = 2 mg/L from 2009 to 2012. The significance of bacterial genotypes, agr function and heterogeneous vancomycin-intermediate S. aureus (hIVSA) phenotype in predicting outcomes were determined after clinical covariates adjustment with multivariate analysis...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765236/methicillin-resistant-staphylococcus-aureus-bacteremia-among-liver-transplant-recipients-epidemiology-and-associated-risk-factors-for-morbidity-and-mortality
#14
REVIEW
Taohua Liu, Yuezhong Zhang, Qiquan Wan
Bacteremia due to Staphylococcus aureus , especially methicillin-resistant S. aureus (MRSA), complicates the clinical course of liver transplantation and is associated with high morbidity and mortality. Intravascular catheters had been reported to be the most frequent source of MRSA bacteremia. Among bacteremic liver recipients, 26.3%-100% of S. aureus were MRSA. Previous studies identified pre-transplant and post-transplant acquired S. aureus carriage, greater severity of liver disease, hepatocellular carcinoma and infection with immuno-modulatory viruses as predictors of S...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29758367/clinical-and-neurosurgical-management-of-cranial-machete-injuries-the-experience-of-a-tertiary-referral-center-in-nicaragua
#15
Luis Zapata, Ernest J Wright, Peter Nakaji
BACKGROUND: The neurosurgical literature rarely describes managing open head injuries caused by machetes, although this is a common head injury in developing countries. We present our experience managing cranial machete injuries in Nicaragua over a 5-year period. METHODS: A retrospective chart review identified patients admitted to a neurosurgery service for cranial machete injury. RESULTS: Among 51 patients studied, the majority (n = 42, 82%) presented with mild neurologic deficits (Glasgow Coma Scale score ≥14)...
August 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29750765/ideal-and-actual-impact-of-rapid-diagnostic-testing-and-antibiotic-stewardship-on-antibiotic-prescribing-and-clinical-outcomes-in-children-with-positive-blood-cultures
#16
Caroline H Reuter, Hannah L Palac, Larry K Kociolek, Xiaotian T Zheng, Yusuf Y Chao, Rupal Patel, Sameer J Patel
BACKGROUND: Implementing matrix assisted laser desorption ionization time of flight (MALDI-TOF) and multiplex PCR (mPCR) has been associated with decreased mortality and hospital length of stay in adults, but the impact in pediatrics is less understood. METHODS: This pre-post quasi-experimental study compared antibiotic prescribing for positive blood cultures in patients ≤21 years collected in 2012 (pre-intervention) and in 2015 (after MALDI-TOF/mPCR). Time to effective and optimal antimicrobial therapy were evaluated using Cox proportional hazards regression...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29746941/10-year-trends-in-vancomycin-resistant-enterococci-among-allogeneic-hematopoietic-cell-transplant-recipients
#17
Trenton J MacAllister, Erica Stohs, Catherine Liu, Andrew Bryan, Estella Whimbey, Amanda Phipps, Steven A Pergam
OBJECTIVES: We examined VRE colonization, bacteremia (VREB) incidence and outcomes within 100 days of allogeneic hematopoietic cell transplantation (HCT). METHODS: HCT recipients screened for VRE were assessed, and colonization and VREB incidence compared over time using linear regression. Cox proportional hazards models were constructed to assess the relationship between mortality, pre-HCT colonization, and underlying disease. RESULTS: Of 1492 HCT recipients, 204 (14%) patients were colonized pre-HCT, while 90 (6%) acquired colonization post-HCT...
July 2018: Journal of Infection
https://www.readbyqxmd.com/read/29734957/hospital-level-variability-in-broad-spectrum-antibiotic-use-for-children-with-acute-leukemia-undergoing-hematopoietic-cell-transplantation
#18
Caitlin W Elgarten, Staci D Arnold, Yimei Li, Yuan-Shung V Huang, Marcie L Riches, Jeffrey S Gerber, Richard Aplenc, Wael Saber, Brian T Fisher
OBJECTIVETo explore the prevalence and drivers of hospital-level variability in antibiotic utilization among hematopoietic cell transplant (HCT) recipients to inform antimicrobial stewardship initiatives.DESIGNRetrospective cohort study using data merged from the Pediatric Health Information System and the Center for International Blood and Marrow Transplant Research.SETTINGThe study included 27 transplant centers in freestanding children's hospitals.METHODSThe primary outcome was days of broad-spectrum antibiotic use in the interval from day of HCT through neutrophil engraftment...
July 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29721739/evaluation-of-a-pharmacy-driven-methicillin-resistant-staphylococcus-aureus-surveillance-protocol-in-pneumonia
#19
Sarah Dunaway, Kara W Orwig, Zachary Q Arbogast, Zachary L Myers, James A Sizemore, Stephanie E Giancola
Background Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of pneumonia and clinicians must determine when empiric antimicrobial therapy directed toward MRSA is needed. Objective To evaluate the effect of a pharmacy-driven protocol utilizing the nasal swab MRSA polymerase chain reaction (PCR) test to discontinue vancomycin on duration of vancomycin therapy and clinical outcomes in patients with suspected community-acquired pneumonia (CAP) or healthcare-associated pneumonia (HCAP). Setting A teaching hospital in Huntington, WV, USA...
June 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29705860/bloodstream-infections-in-haematological-cancer-patients-colonized-by-multidrug-resistant-bacteria
#20
C Cattaneo, R Di Blasi, C Skert, A Candoni, B Martino, N Di Renzo, M Delia, S Ballanti, F Marchesi, V Mancini, E Orciuolo, S Cesaro, L Prezioso, R Fanci, G Nadali, A Chierichini, L Facchini, M Picardi, M Malagola, V Orlando, E M Trecarichi, M Tumbarello, F Aversa, G Rossi, L Pagano
Infections by multidrug-resistant (MDR) bacteria are a worrisome phenomenon in hematological patients. Data on the incidence of MDR colonization and related bloodstream infections (BSIs) in haematological patients are scarce. A multicentric prospective observational study was planned in 18 haematological institutions during a 6-month period. All patients showing MDR rectal colonization as well as occurrence of BSI at admission were recorded. One-hundred forty-four patients with MDR colonization were observed (6...
April 28, 2018: Annals of Hematology
keyword
keyword
165174
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"