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https://www.readbyqxmd.com/read/29219147/mitochondrial-metabolism-and-cancer
#1
REVIEW
Paolo Ettore Porporato, Nicoletta Filigheddu, José Manuel Bravo-San Pedro, Guido Kroemer, Lorenzo Galluzzi
Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view has been instrumental for the development of powerful imaging tools that are still used in the clinics, it is now clear that mitochondria play a key role in oncogenesis. Besides exerting central bioenergetic functions, mitochondria provide indeed building blocks for tumor anabolism, control redox and calcium homeostasis, participate in transcriptional regulation, and govern cell death...
December 8, 2017: Cell Research
https://www.readbyqxmd.com/read/29218858/in-vitro-and-in-vivo-study-of-commercial-calcium-phosphate-cement-hydroset%C3%A2
#2
Niall W Kent, Gordon Blunn, Natalia Karpukhina, Graham Davis, Roberta Ferro de Godoy, Rory M Wilson, Melanie Coathup, Lyris Onwordi, Wen Yu Quak, Robert Hill
The commercial calcium phosphate cement, HydroSet™, was investigated in vitro, studying phase formation, compressive strength and setting time, followed by an ovine in vivo study to measure osseointegration, bone apposition and bone-to-graft contact. The X-ray diffraction and 31 P Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR) results showed the initial formation of octacalcium phosphate and hydroxyapatite at one hour. Over 7 days the octacalcium phosphate transformed to apatite, which was the only crystalline phase of the cement at 28 days...
January 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29212403/-express-a-simple-and-fast-method-to-image-calcium-activity-of-neurons-from-intact-dorsal-root-ganglia-using-fluorescent-chemical-ca2-indicators
#3
Yong Chen, Li-Yen Huang
No abstract text is available yet for this article.
January 1, 2017: Molecular Pain
https://www.readbyqxmd.com/read/29210275/sequestration-of-antimony-on-calcite-observed-by-time-resolved-nanoscale-imaging
#4
Francois Renard, Christine V Putnis, German Montes-Hernandez, Helen E King, Gijs D Breedveld, Gudny Okkenhaug
Antimony, which has damaging effects on the human body and the ecosystem, can be released into soils, ground- and surface waters either from ore minerals that weather in near surface environments, or due to anthropogenic releases from waste rich in antimony, a component used in batteries, electronics, ammunitions, plastics and many other industrial applications. Here, we show that dissolved Sb can interact with calcite, a widespread carbonate mineral, through a coupled dissolution-precipitation mechanism. The process is imaged in-situ, at room temperature, at the nanometer scale by using an atomic force microscope equipped with a flow-through cell...
December 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29210091/clinical-relevance-of-radiographic-linear-branching-mineral-opacities-in-the-canine-liver
#5
M-A Genain, A Barbosa, M Herrtage, P Watson
OBJECTIVES: To assess the prevalence, clinical significance and breed distribution of linear branching mineralisation superimposed on the hepatic radiographic silhouette in dogs. MATERIALS AND METHODS: Retrospective review of radiographs or ultrasound images of dogs showing branching mineralisation in the liver. RESULTS: Over the 30-year review period, 17 cases were identified and the mineralisation had a predominantly ventral distribution...
December 6, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29209189/spike-triggered-regression-for-synaptic-connectivity-reconstruction-in-neuronal-networks
#6
Yaoyu Zhang, Yanyang Xiao, Douglas Zhou, David Cai
How neurons are connected in the brain to perform computation is a key issue in neuroscience. Recently, the development of calcium imaging and multi-electrode array techniques have greatly enhanced our ability to measure the firing activities of neuronal populations at single cell level. Meanwhile, the intracellular recording technique is able to measure subthreshold voltage dynamics of a neuron. Our work addresses the issue of how to combine these measurements to reveal the underlying network structure. We propose the spike-triggered regression (STR) method, which employs both the voltage trace and firing activity of the neuronal population to reconstruct the underlying synaptic connectivity...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29207490/is-trabecular-bone-score-valuable-in-bone-microstructure-assessment-after-gastric-bypass-in-women-with-morbid-obesity
#7
Agustina Pia Marengo, Fernando Guerrero Pérez, Luis San Martín, Rosa Monseny, Anna Casajoana, Rocio Valera, Nuria Virgili, Andreu Simó Servat, Albert Prats, Carmen Gómez-Vaquero, Nuria Vilarrasa
INTRODUCTION: The effects of bariatric surgery on skeletal health raise many concerns. Trabecular bone score (TBS) is obtained through the analysis of lumbar spine dual X-ray absorptiometry (DXA) images and allows an indirect assessment of skeletal microarchitecture (MA). The aim of our study was to evaluate the changes in bone mineral density (BMD) and alterations in bone microarchitecture assessed by TBS in morbidly obese women undergoing Roux-en-Y gastric bypass (RYGB), over a three-year follow-up...
December 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29205875/a-case-report-of-basic-calcium-phosphate-mimicking-septic-arthritis
#8
Queenie Luu, Siroos Nasibi, Praneal Sharma, Andrew Bonura, David Massasso
We report a case of a 53-year-old man who presented with a diagnostic dilemma mimicking septic arthritis. It is important to consider the diagnosis of calcific peri-arthritis clinically and recognize the hallmarks on radiograph and magnetic resonance imaging as this disease process resolves completely with conservative management like in our patient, and does not require operative intervention.
December 4, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29203208/systems-consolidation-revisited-but-not-revised-the-promise-and-limits-of-optogenetics-in-the-study-of-memory
#9
REVIEW
Hardt Oliver, Nadel Lynn
Episodic memories (in humans) and event-like memories (in non-human animals) require the hippocampus for some time after acquisition, but at remote points seem to depend more on cortical areas instead. Systems consolidation refers to the process that promotes this reorganization of memory. Various theoretical frameworks accounting for this process have been proposed, but clear evidence favoring one or another of these positions has been lacking. Addressing this issue, a recent study deployed some of the most advanced neurobiological technologies - optogenetics and calcium imaging - and provided high resolution, precise observations regarding brain systems involved in recent and remote contextual fear memories...
December 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29200901/the-bifunctional-effect-of-propofol-on-thromboxane-agonist-u46619-induced-vasoconstriction-in-isolated-human-pulmonary-artery
#10
Ning Hao, Wang Zhaojun, Sujuan Kuang, Guangyan Zhang, Chunyu Deng, Jue Ma, Jianxiu Cui
Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol on human pulmonary arteries obtained from patients who had undergone surgery. Arterial rings were mounted in a Multi-Myograph system for measurement of isometric forces. U46619 was used to induce sustained contraction of the intrapulmonary arteries, and propofol was then applied (in increments from 10-300 µM)...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29199591/copine-3-as-a-novel-potential-drug-target-for-non-small-cell-lung-carcinoma
#11
Kunnathur Murugesan Sakthivel, Venugopal Vinod Prabhu
Cancer originates from uncontrolled cell division in any part of the body. The universal burden of cancer continues to increase, and its treatment remains ever more challenging. Among several cancers, lung cancer is the second most common, causing 1.6 million deaths worldwide per year. Approximately 85% of lung cancers are non-small-cell lung carcinomas (NSCLCs), which are considerably more difficult to treat than other cancers. Although various imaging, biopsy, and histopathological analyses are widely used, there are no effective or reliable biomarkers for detecting early lung carcinoma, particularly NSCLC...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29196182/peripheral-5-ht3-mediates-mirror-image-pain-by-a-cross-talk-with-acid-sensing-ion-channel-3
#12
Yeu-Shiuan Su, Hao-Ruei Mei, Chun-Hung Wang, Wei-Hsin Sun
Mirror-image pain (MIP), which occurs along with complex regional pain syndrome, rheumatoid arthritis and chronic migraine, is characterized by increased pain sensitivity of healthy body regions other than the actual injured or inflamed sites. A high level of peripheral inflammation may activate central or peripheral glia, triggering mirror-image pain. However, which receptors mediate inflammatory signals to contribute glial activation remains unclear. Intraplantarly injecting mice with 5-hydroxytryptamine (5-HT) or acidic buffer (proton) caused only unilateral hyperalgesia, but co-injection of 5-HT/acid induced bilateral hyperalgesia (MIP)...
November 28, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29195946/rennet-induced-coagulation-properties-of-yak-casein-micelles-a-comparison-with-cow-casein-micelles
#13
Yan Zhang, Yuan Li, Pengjie Wang, Yanbao Tian, Qi Liang, Fazheng Ren
It is essential for yak cheese processing to understand the rennet-induced coagulation properties of gel formation from casein micelles. We have previously discovered that yak milk requires a longer incubation time but forms stronger gels compared with cow milk. In this study, we are aiming to understand the rennet-induced coagulation properties of yak casein micelles comparing with cow casein micelles. Rheological analyses revealed that the gelling times of yak and cow casein micelles were 11.6±0.5 and 8...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29195182/a-mitochondrial-targeting-near-infrared-fluorescent-probe-for-bioimaging-and-evaluating-endogenous-superoxide-anion-changes-during-ischemia-reperfusion-injury
#14
Xiaoyue Han, Rui Wang, Xinyu Song, Fabiao Yu, Changjun Lv, Lingxin Chen
The outburst of superoxide anion (O2-) in mitochondrial during ischemia/reperfusion (I/R) process will cause a series of oxidative damage including polarity loss of mitochondrial membrane potential, overload of secondary cellular calcium, and cascade apoptosis. To monitor the O2- level fluctuations as well as to evaluate the relationship between O2- concentration and the degree of cell apoptosis during I/R process, we propose a ratiometric near-infrared mitochondrial targeting fluorescent probe Mito-Cy-Tfs for the detection of level changes of O2- in cells and in vivo...
November 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/29194598/composition-granular-structure-and-pasting-properties-of-native-starch-extracted-from-plectranthus-edulis-oromo-dinich-tubers
#15
Tom Hellemans, Gifty Abera, Ingrid De Leyn, Paul Van der Meeren, Koen Dewettinck, Mia Eeckhout, Bruno De Meulenaer, Filip Van Bockstaele
Chemical composition, granular morphology and pasting properties of native starch extracted from tubers of Plectranthus edulis were analyzed. Starch was extracted from tubers of 6 accessions collected from 4 different areas in Ethiopia. Particle size analysis (PSA) and cryo-scanning electron microscope (cryo-SEM) imaging were used to examine the granular morphology and visualize the starch paste, respectively. Pasting properties, water absorption, and gelation capacity were compared. A wide range was found for the amylose (14...
December 1, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29192697/mapping-piezoelectric-response-in-nanomaterials-using-a-dedicated-non-destructive-scanning-probe-technique
#16
Yonatan Calahorra, Michael Smith, Anuja Datta, Hadas Benisty, Sohini Kar-Narayan
There has been tremendous interest in piezoelectricity at the nanoscale, for example in nanowires and nanofibers where piezoelectric properties may be enhanced or controllably tuned, thus necessitating robust characterization techniques of piezoelectric response in nanomaterials. Piezo-response force microscopy (PFM) is a well-established scanning probe technique routinely used to image piezoelectric/ferroelectric domains in thin films, however, its applicability to nanoscale objects is limited due to the requirement for physical contact with an atomic force microscope (AFM) tip that may cause dislocation or damage, particularly to soft materials, during scanning...
December 1, 2017: Nanoscale
https://www.readbyqxmd.com/read/29192635/is-hemorrhage-the-reason-in-crimean-congo-hemorrhagic-fever-patients-with-neurological-signs-and-symptomsa
#17
Fatma Aktaş, Zafer Özmen, Ayşegül Altunkaş, Eda Albayrak, Fazilet Duygu, Osman Demir, Zeliha Cansel Özmen
PURPOSE: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease can result in mortality varying from 3.0% to 50.0%. In this study, we wished to discuss computed tomography (CT) findings together with clinical and laboratory findings in patients who had disease-related neurological signs. MATERIALS AND METHODS: The study included patients who were diagnosed with CCHF. Seventeen patients that had neurological signs were enrolled as the patient group. As a control group, 40 patients diagnosed with CCHF and did not have neurological signs were enrolled...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29190464/facile-one-pot-fabrication-of-calcium-phosphate-based-composite-nanoparticles-as-delivery-and-mri-contrast-agents-for-macrophages
#18
Maki Nakamura, Ayako Oyane, Kiyoko Kuroiwa, Yoshiki Shimizu, Alexander Pyatenko, Masaki Misawa, Tomokazu Numano, Hisanori Kosuge
We developed a facile one-pot fabrication process for magnetic iron oxide-calcium phosphate (IO-CaP) composite nanoparticles via coprecipitation in labile supersaturated CaP solutions containing IO nanocrystals. All the source solutions used were clinically approved for injection, including water and magnetic IO nanocrystals (ferucarbotran, used as a negative magnetic resonance imaging (MRI) contrast agent). This ensured that the resulting nanoparticles were pathogen- and endotoxin-free. The dispersants used were clinically approved heparin sodium (heparin) or adenosine triphosphate disodium hydrate (ATP), which were added to the IO-containing labile supersaturated CaP solutions...
November 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29185963/the-therapeutic-nuclear-magnetic-resonance-changes-the-balance-in-intracellular-calcium-and-reduces-the-interleukin-1%C3%AE-induced-increase-of-nf-%C3%AE%C2%BAb-activity-in-chondrocytes
#19
Bibiane Steinecker-Frohnwieser, Werner Kullich, Anda Mann, Hans Georg Kress, Lukas Weigl
OBJECTIVES: Osteoarthritis as the main chronic joint disease is characterised by the destruction of articular cartilage. Developing new, more effective and in particular non-invasive methods to achieve pain reduction of OA patients are of exceptional interest. Clinical observations demonstrated positive effects of therapeutically applied low nuclear magnetic resonance (NMRT) for the treatment of painful disorders of the musculoskeletal system. In this study the cellular mechanism of action of NMRT was examined on chondrocytes...
November 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29185575/osteoinductive-superparamagnetic-fe-nanocrystal-calcium-phosphate-heterostructured-microspheres
#20
So Yeon Park, Sajeesh Kumar Madhurakkat Perikamana, Jong Ho Park, Sung Wng Kim, Heungsoo Shin, Sung Pyo Park, Hyun Suk Jung
Functional magnetic and biocompatible particles are of great interest because of their potential use in various bioapplications such as hyperthermia for cancer treatment, magnetic resonance imaging (MRI) contrast agents and drug delivery. Herein, we introduce a facile method for synthesizing magnetic Fe nanocrystal/Fe-substituted calcium phosphate (Fe/FeCaP) heterostructured microspheres using a two-step procedure: (1) one-pot hydrothermal synthesis to prepare uniform-sized FeCaP microspheres and (2) post-reduction annealing at 600 °C for Fe extraction from FeCaP...
November 29, 2017: Nanoscale
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