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Serotonine Bone

Amal M Mahfoz
Sensory contact model (SCM) permits the evolution of diverse psychopathological states by the repeated antagonistic interactions between male mice. Biphenyl dimethyl dicarboxylate (DDB) is used as a hepatoprotective agent. The present work aimed to study the possible effects of DDB on social behavior developed by SCM by studying its effects on the transformation process to aggressive and submissive behaviors. Besides, measuring behavioral changes using the open field test (OFT) and the elevated plus maze test (EPM), neurochemical parameters [serotonin (5HT), norepqinephrine (NE), and dopamine(DA)], and immunological changes (total leucocyte count, differential leucocytic count, and evaluation of bone marrow lymphocytes count and viability assessment)...
November 28, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Samantha R Weaver, Hannah P Fricke, Cynthia Xie, Robert J Aiello, Julia F Charles, Laura L Hernandez
Long-term effects of breastfeeding on maternal bone are not fully understood. Excessive maternal bone loss stimulated by serotonin signaling during lactation may increase bone fragility later in life. We hypothesized inhibiting non-neuronal serotonin activity by feeding a small molecule inhibitor of the rate-limiting enzyme in serotonin synthesis (tryptophan hydroxylase 1; TPH1) would preserve maternal bone post-weaning without affecting neonatal bone. Small molecule TPH1 inhibitor LP778902 (~100 mg/kg) or control chow was fed to C57BL/6 dams throughout pregnancy and lactation and blood collected on days 1 and 21 of lactation...
October 23, 2018: American Journal of Physiology. Endocrinology and Metabolism
Vivianne Chappuis, Gustavo Avila-Ortiz, Mauricio G Araújo, Alberto Monje
OBJECTIVES: The aim of this systematic review was to investigate the association between the intake of systemic medications that may affect bone metabolism and their subsequent impact on implant failures. MATERIAL AND METHODS: Electronic and manual literature searches were conducted. Implant failure (IF) was the primary outcome, while biological/mechanical and the causes/timing associated with IF were set as secondary outcomes. Meta-analyses for the binary outcome IF and odds ratio were performed to investigate the association with medications...
October 2018: Clinical Oral Implants Research
Ronald E Jung, Bilal Al-Nawas, Mauricio Araujo, Gustavo Avila-Ortiz, Stephen Barter, Nadine Brodala, Vivianne Chappuis, Bo Chen, Andre De Souza, Ricardo Faria Almeida, Stefan Fickl, Gary Finelle, Jeffrey Ganeles, Hadi Gholami, Christoph Hammerle, Simon Jensen, Asbjørn Jokstad, Hideaki Katsuyama, Johannes Kleinheinz, Chatchai Kunavisarut, Nikos Mardas, Alberto Monje, Panos Papaspyridakos, Michael Payer, Eik Schiegnitz, Ralf Smeets, Martina Stefanini, Christiaan Ten Bruggenkate, Konstantinos Vazouras, Hans-Peter Weber, Dieter Weingart, Péter Windisch
OBJECTIVES: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient-reported outcomes in implant dentistry. Focused questions on (a) short posterior dental implants (≤6 mm), (b) narrow diameter implants, (c) implant design (tapered compared to a non-tapered implant design), and (d) medication-related dental implant failures were addressed. MATERIALS AND METHODS: Four systematic reviews were prepared in advance of the Consensus Conference and were discussed among the participants of Group 1...
October 2018: Clinical Oral Implants Research
L Abu Nada, A Al Subaie, A Mansour, X Wu, M N Abdallah, H Al-Waeli, A Ersheidat, L S Stone, M Murshed, F Tamimi
AIM: Selective Serotonin Reuptake Inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. MATERIALS AND METHODS: On a total of 24 Sprague-Dawley rats, a custom-made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia...
October 5, 2018: Journal of Clinical Periodontology
Khac-Dung Nguyen, Bahador Bagheri, Haleh Bagheri
Drug-induced bone loss remains the major cause of vertebral and hip fractures and significantly associated to morbidity and mortality. This article will review the common drugs identified as the causes of bone loss and the risk factors and management in European countries. Areas covered: Beyond glucorticoid - the most cause of osteoporosis, many different drugs could cause harmful skeletal disorders. The antiepileptics, hormonal therapy, GnRH antagonists, aromatase inhibitors are well-known cause of bone loss...
October 2018: Expert Opinion on Drug Safety
Hui-Hui Xiao, Tung-Ting Sham, Chi-On Chan, Meng-Heng Li, Xi Chen, Qing-Chang Wu, Daniel Kam-Wah Mok, Xin-Sheng Yao, Man-Sau Wong
The lignan-rich fraction (SWR) of Sambucus Williamsii Ramulus, a folk herbal medicine in China for treatment of bone diseases, has previously reported to exert protective effects on bone without exerting uterotrophic effects in ovariectomized (OVX) mice. The aim of the present study was to identify the potential metabolites and the associated metabolic pathways that contribute to the beneficial effects of SWR on bone in vivo . Aged female Sprague Dawley rats (9 months old) were either sham-operated or ovariectomized for 12 weeks, before receiving treatment for another 12 weeks with the following treatment groups ( n = 12 each): vehicle (Sham), vehicle (OVX), Premarin (130 μg/kg) or low (57 mg/kg), medium (114 mg/kg), and high (228 mg/kg) doses of SWR...
2018: Frontiers in Pharmacology
Jian Zhang, Yanqin Lu, Yanzhou Wang, Xiuzhi Ren, Jinxiang Han
Intestinal microbial flora, known as the second gene pool of the human body, play an important role in immune function, nutrient uptake, and various activities of host cells, as well as in human disease. Intestinal microorganisms are involved in a variety of mechanisms that affect bone health. Gut microbes are closely related to genetic variation, and gene regulation plays an important part in the development of bone-related diseases such as osteoporosis. Intestinal microorganisms can disrupt the balance between bone formation and resorption by indirectly stimulating or inhibiting osteoblasts and osteoclasts...
August 2018: Intractable & Rare Diseases Research
Kristian H Mikkelsen, Tina Vilsbøll, Jens J Holst, Bolette Hartmann, Filip K Knop, Morten Frost
BACKGROUND: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown...
September 4, 2018: BMC Endocrine Disorders
R Nicole Howie, Samuel Herberg, Emily Durham, Zachary Grey, Grace Bennfors, Mohammed Elsalanty, Amanda C LaRue, William D Hill, James J Cray
Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors (SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients' ability to heal after sustaining trauma...
September 3, 2018: International Journal of Oral Science
Vanessa de J R De-Paula, Andrea S Forlenza, Orestes V Forlenza
Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as glucose and bone metabolism, inflammation and immune response, peripheral (enteric) and central neurotransmission. For that reason, recent studies proposed that abnormalities in gut microbiota may play a role in systemic and central nervous system (CNS) conditions...
August 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Anne Baudry, Benoit Schneider, Jean-Marie Launay, Odile Kellermann
Genetic and pharmacological studies provided evidence that serotonin (5-HT) is an important signaling molecule for the development and the maintenance of mineralized tissues. However, how 5-HT takes part to the homeostasis of teeth and bone remains elusive. In the dental field, a major breakthrough comes from the identification of 5-HT but also dopamine (DA) as "damage" signals necessary for stem cell-based tooth repair. Pulpal stem cells express the overall functions of 5-HT and DA neurons including a definite set of functional 5-HT/DA receptors that render cells responsive for circulating bioamines...
August 2, 2018: Biochimie
Deepa, Karishma Mujawar, Komal Dhillon, Premraj Jadhav, Indrani Das, Youginder K Singla
AIM: Dental implants are the preferred treatment modality in the present edentulous era. Selective serotonin reuptake inhibitors (SSRIs) have detrimental effect on bone density. The present study was conducted to determine the effect of SSRIs on the success rate of dental implants. MATERIALS AND METHODS: The present study was conducted on 352 patients of both genders with 680 dental implants. History of depression and SSRI medication was retrieved. Patients were divided into two groups...
July 1, 2018: Journal of Contemporary Dental Practice
Craig K Docherty, Katie Yates Harvey, Kirsty M Mair, Sinead Griffin, Nina Denver, Margaret R MacLean
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by increased pulmonary vascular resistance and pulmonary artery remodelling as result of increased vascular tone and vascular cell proliferation, respectively. Eventually, this leads to right heart failure. Heritable PAH is caused by a mutation in the bone morphogenetic protein receptor-II (BMPR-II). Female susceptibility to PAH has been known for some time, and most recent figures show a female-to-male ratio of 4:1. Variations in the female sex hormone estrogen and estrogen metabolism modify FPAH risk, and penetrance of the disease in BMPR-II mutation carriers is increased in females...
2018: Advances in Experimental Medicine and Biology
B Lavoie, J A Roberts, M M Haag, S N Spohn, K G Margolis, K A Sharkey, J B Lian, G M Mawe
Osteoporosis and bone fractures occur at higher frequency in patients with inflammatory bowel disease (IBD), and decreased bone mass is observed in animal models of colitis. Another consistent feature of colitis is increased serotonin (5-HT) availability in the intestinal mucosa. Since gut-derived 5-HT can decrease bone mass, via activation of 5-HT1B receptors on pre-osteoblasts, we tested the hypothesis that 5-HT contributes to bone loss in colitis. Colitis was chronically induced in mice by adding dextran sodium sulfate (DSS) to their drinking water for 21 days...
July 17, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Bhumija Gupta, Aneesha Acharya, Shilpa Singh, Stefania Brazzoli, Mohamed Ghorab, Shaima Malik, George Pelekos, Emile Rossouw
OBJECTIVES: To assess the influence of selective serotonin reuptake inhibitor (SSRI) use on jawbone and bone mineral density by retrospective analysis of panoramic radiographs. METHODS: Radiographic and clinical records were sourced from the Division of Orthodontics and TMJD, Eastman Institute for Oral Health, University of Rochester. Randomly selected adults (20-65 years) were categorized into: "Active" (with history of SSRI use of >6 months) and a "Control" group...
September 4, 2018: Dento Maxillo Facial Radiology
Julietta Ursula Schweiger, Ulrich Schweiger, Michael Hüppe, Kai G Kahl, Wiebke Greggersen, Kamila Jauch-Chara, Eva Fassbinder
Antidepressive agents are one of the fastest-growing classes of prescribed drugs. However, the effects of antidepressive agents on bone density are controversial. The aim of this meta-analysis is to evaluate the state of research on the relationship between the use of tricyclic antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRIs) and bone mineral density (BMD) in women. The database searched was Pubmed. The meta-analysis included human studies in women fulfilling the following criteria: (i) an assessment of bone mineral density in the lumbar spine, the femoral neck or the total hip; (ii) a comparison of the BMD of depressed individuals using antidepressive agents (SSRIs or TCAs), and a control group that did not use antidepressive agents; (iii) measurement of BMD using dual-energy X-ray absorptiometry (DXA); and (iv) calculations of the mean BMD and standard deviation or standard error...
June 30, 2018: International Journal of Environmental Research and Public Health
Dimitrios Agas, Giovanna Lacava, Maria Giovanna Sabbieti
Bone is a multifaceted dynamic tissue, involved in mobility, mineral metabolism, and mesenchymal or stromal and hematopoietic progenitor or stem cells breading. Recently, an endocrine role has been attributed to bone due to its ability to produce at least two hormones (osteocalcin and fibroblast growth factor 23) and to participate directly or indirectly in leptin, insulin, estrogens, and serotonin signaling; regulation; and action. Also, bearing in mind the enormous amounts of substances secreted by the different bone marrow cell types, it becomes understandable the contribution of bone tissue to systemic homeostasis...
January 2018: Journal of Cellular Physiology
Suhrid Banskota, Jean-Eric Ghia, Waliul I Khan
Serotonin (5-hydroxytryptamine or 5-HT) once most extensively studied as a neurotransmitter of the central nervous system, is seen to be predominantly secreted in the gut. About 95% of 5-HT is estimated to be found in gut mainly within the enterochromaffin cells whereas about 5% is found in the brain. 5-HT is an important enteric signaling molecule and is well known for playing a key role in sensory-motor and secretory functions in the gut. In recent times, studies uncovering various new functions of gut-derived 5-HT indicate that many more are yet to be discovered in coming days...
June 14, 2018: Biochimie
Samantha R Weaver, Hannah P Fricke, Cynthia Xie, Robert J Lipinski, Chad M Vezina, Julia F Charles, Laura L Hernandez
Selective serotonin reuptake inhibitors (SSRIs) have been linked to osteopenia and fracture risk; however, their long-term impact on bone health is not well understood. SSRIs are widely prescribed to pregnant and breastfeeding women who might be at particular risk of bone pathology because lactation is associated with considerable maternal bone loss. We used microCT and molecular approaches to test whether the SSRI fluoxetine, administered to C57BL/6 mice from conception through the end of lactation, causes persistent maternal bone loss...
August 1, 2018: Endocrinology
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