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Acute kidney injury, chronic kidney disease

Hua Liang, Feng Xu, Tao Zhang, Jian Huang, Qingbin Guan, Hanbing Wang, Qiong Huang
Acute kidney injury induced by ischemia-reperfusion injury (IRI) is a high risk factor in the progression towards chronic kidney disease, which is featured by renal interstitial fibrosis. Interleukin (IL)-18 is produced by T cells and macrophages and has been involved in the pathophysiology of IRI. However, the role of IL-18 in IRI-induced renal fibrosis is poorly understood. In the present study, we showed that interleukin (IL)-18 was significantly up-regulated after IRI stress. Mice treated with IL-18 Bp, a natural inhibitor of IL-18, presented less severe fibrotic response in the kidneys following IRI compared with vehicle-treated mice...
July 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Raymond K Hsu, Jonathon D Truwit, Michael A Matthay, Joseph E Levitt, Boyd Taylor Thompson, Kathleen D Liu
Background: Acute kidney injury (AKI) commonly occurs in patients with sepsis and acute respiratory distress syndrome (ARDS). Objective: To investigate whether statin treatment is protective against AKI in sepsis-associated ARDS. Design: Secondary analysis of data from Statins for Acutely Injured Lungs in Sepsis (SAILS), a randomized controlled trial that tested the impact of rosuvastatin therapy on mortality in patients with sepsis-associated ARDS...
2018: Canadian Journal of Kidney Health and Disease
Dhruvkumar M Patel, Mukundkumar V Patel, Kamal H Sharma, Greshaben Rajeshkumar Patel, Manish B Patel, Vipul B Shah
BACKGROUND: Atherosclerosis and coronary plaque destabilization are linked to each other. Infections due to various microbes may trigger acute coronary syndrome (ACS) by systemic inflammation cascade. METHODS: We have evaluated the prevalence of Post chikungunya chronic arthritis (PCCA) among 400 consecutive ACS patients (Case group) and compared with control group subjected to elective surgery by the prospective case-control observational study. Cases were excluded if standard criteria of ACS were not satisfied and in control group if the patient suffered a myocardial infarction (MI) within 28 days of elective surgery...
August 15, 2018: Current Rheumatology Reviews
Mohsen Honarpisheh, Orestes Foresto-Neto, Stefanie Steiger, Franziska Kraft, Paulina Koehler, Ekaterina von Rauchhaupt, Jan Potempa, Karina Adamowicz, Joanna Koziel, Maciej Lech
Acute and chronic kidney injuries are multifactorial traits that involve various risk factors. Experimental animal models are crucial to unravel important aspects of injury and its pathophysiological mechanisms. Translating knowledge obtained from experimental approaches into clinically useful information is difficult; therefore, significant attention needs to be paid to experimental procedures that mimic human disease. Herein, we compared aristolochic acid I (AAI) acute and chronic kidney injury model with unilateral ischemic-reperfusion injury (uIRI), cisplatin (CP)- or folic acid (FA)-induced renal damage...
August 15, 2018: Scientific Reports
Jonatan Barrera-Chimal, Leslie Rocha, Isabel Amador-Martínez, Rosalba Pérez-Villalva, Rafael González, Cesar Cortés-González, Norma Uribe, Victoria Ramírez, Nathan Berman, Gerardo Gamba, Norma A Bobadilla
Background: Acute kidney injury (AKI) is not as harmless as previously thought since it may lead to chronic kidney disease (CKD). Because most of the time ischemic AKI occurs unexpectedly, it is difficult to prevent its occurrence and there are no specific therapeutic approaches to prevent the AKI to CKD transition. We aimed to determine whether mineralocorticoid receptor blockade (MRB) in the first days after ischemia/reperfusion (IR) can prevent progression to CKD. Methods: Four groups of male Wistar rats were included: sham and three groups of bilateral renal ischemia for 45 min, one without treatment and the other two receiving spironolactone for 5 or 10 days, starting 24 h after IR...
August 9, 2018: Nephrology, Dialysis, Transplantation
Maxime Rossi, Sandrine Delbauve, Eric Wespes, Thierry Roumeguère, Oberdan Leo, Véronique Flamand, Alain Le Moine, Jean-Michel Hougardy
Acute kidney injury (AKI) is a major public health concern, which is contributing to serious hospital complications, chronic kidney disease (CKD) and even death. Renal ischemia-reperfusion injury (IRI) remains a leading cause of AKI. The stress-responsive enzyme, heme oxygenase-1 (HO-1) mediates protection against renal IRI and may be preventively induced using hemin prior to renal insult. This HO-1 induction pathway called hemin preconditioning is largely known to be effective. Therefore, HO-1 might be an interesting therapeutic target in case of predictable AKI (e...
August 9, 2018: Biochemical and Biophysical Research Communications
F Dewi, R J Egan, T Abdelrahman, C Morris, M J Stechman, W G Lewis
AIMS: Post-operative acute kidney injury (AKI) is a common and independent mortality risk factor carrying high clinical and economic cost. This study aimed to establish the incidence of AKI in patients undergoing emergency laparotomy (EL), to determine patients' risk profile and consequent mortality. METHODS: Consecutive 239 patients of median age 68 (IQR 51-76) years, undergoing EL in a UK tertiary hospital, were studied. Primary outcome measure was AKI and in-hospital operative mortality...
August 10, 2018: World Journal of Surgery
Bikrant Bihari Lal, Priti Vijay, Vikrant Sood, Rajeev Khanna, Seema Alam
No abstract text is available yet for this article.
August 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
Yuxi Wang, Zhi Zhao, Weiqi Yang, Lin Li, Fengming Zhu, Guangchang Pei, Juan Yang, Han Zhu, Huzi Xu, Meng Wang, Qian Yang, Zhizhi Hu, Pengge Wang, Gang Xu, Rui Zeng, Ying Yao
Tamoxifen is used to activate tamoxifen-dependent Cre recombinase (CreER) to generate time- and tissue-specific genetically mutant mice. However, tamoxifen is also an active estrogen analogue that binds with higher affinity to estrogen receptors and exhibits anti-apoptosis, anti-inflammation, and antifibrotic properties. Renal ischemia reperfusion (I/R) injury is characterized by increased apoptosis and inflammation, so optimal utility of tamoxifen-inducible CreER genetic systems in I/R model is important. The purpose of this study was to optimize the tamoxifen dose and evaluate its safety and tolerability in the development of mouse I/R injury...
2018: American Journal of Translational Research
Luke Maxfield, Aurora Peck, Laura Bond Youngblood
We report a 66-year-old man with a history of congestive heart failure, atrial fibrillation on warfarin therapy and chronic kidney disease that presented with acute dyspnoea. He had multiple palpable purpuric lesions on his bilateral lower extremities. Laboratory findings supported acute anaemia with no obvious bleeding source, supratherapeutic international normalised ratio and acute on chronic kidney injury. Oesophogastroduodenoscopy and colonoscopy initially suggested ischaemic colitis. The patient's legs were treated symptomatically with topical steroids...
August 9, 2018: BMJ Case Reports
Shuang Li, Bingbing Qiu, Hong Lu, Yunshi Lai, Jixing Liu, Jiajun Luo, Fengxin Zhu, Zheng Hu, Miaomiao Zhou, Jianwei Tian, Shouyi Yu, Fan Yi, Jing Nie
AIMS: The risk factors promoting acute kidney injury (AKI) to chronic kidney disease (CKD) progression remains largely unknown. The aim of the present study was to investigate whether hyperhomocysteinemia (Hhcy) accelerates the development of renal fibrosis after AKI. RESULTS: Hhcy aggravated ischemia-reperfusion-induced AKI and the subsequent development of renal fibrotic lesions characterized by excessive extracellular matrix deposition. Mechanistically, the RNA binding protein human antigen R (HuR) bound to the 3'-untranslated region (3'-UTR) of heme oxygenase-1 (HO-1) mRNA...
August 7, 2018: Antioxidants & Redox Signaling
Felix S Seibert, Maximilian Sitz, Jürgen Passfall, Martin Haesner, Peter Laschinski, Martin Buhl, Frederic Bauer, Nina Babel, Nikolaos Pagonas, Timm H Westhoff
BACKGROUND/AIMS: Urinary biomarkers like neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) do not only allow an early diagnosis of acute kidney injury, but also provide prognostic information in this setting. The present prospective study investigates, whether the urinary biomarkers NGAL, KIM-1 and calprotectin have prognostic information in chronic kidney disease (CKD) as well. METHODS: Urinary calprotectin, NGAL and KIM-1 concentrations were assessed in a study population of 143 patients with stable CKD comprising diabetic and hypertensive nephropathy, glomerulonephritis/vasculitis, and autosomal dominant polycystic kidney disease...
August 3, 2018: Kidney & Blood Pressure Research
Sandro Ninni, Claire Seunes, Staniel Ortmans, Stéphanie Mouton, Thomas Modine, Mohamed Koussa, Bruno Jegou, Jean-Louis Edme, Bart Staels, David Montaigne, Augustin Coisne
BACKGROUND: A relevant morning-afternoon variation in ischemia-reperfusion (IR) insult after cardiac surgery has been demonstrated. We speculated that the biorhythm might also impact systemic reactions involved in acute kidney injury (AKI) following cardiac surgery. We aimed at investigating incidence, determinants and prognostic impact of AKI in a large cohort of patients referred for surgical aortic valve replacement (SAVR) according to surgery time-of-day. METHODS: Between 2009 and 2015, we explored consecutive patients referred to our Heart Valve Center (CHU Lille) for first SAVR...
July 19, 2018: International Journal of Cardiology
Anubhav Chakraborty, Pragasam Viswanathan
Over the years, the epigenetic landscape has grown increasingly complex. Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications. However, with the discovery of enzymes involved in the demethylation process, several exciting prospects have emerged that focus on the dynamic regulation of methylation and its crucial role in development and disease. An interplay of the methylation-demethylation machinery controls the process of gene expression. Since acute kidney injury (AKI), a major risk factor for chronic kidney disease and death, is characterised by aberrant expression of genes, understanding the dynamics of methylation and demethylation will provide new insights into the intricacies of the disease...
2018: Analytical Cellular Pathology (Amsterdam)
Sharad Kholia, Maria Beatriz Herrera Sanchez, Massimo Cedrino, Elli Papadimitriou, Marta Tapparo, Maria Chiara Deregibus, Maria Felice Brizzi, Ciro Tetta, Giovanni Camussi
With limited therapeutic intervention in preventing the progression to end-stage renal disease, chronic kidney disease (CKD) remains a global health-care burden. Aristolochic acid (AA) induced nephropathy is a model of CKD characterised by inflammation, tubular injury, and interstitial fibrosis. Human liver stem cell-derived extracellular vesicles (HLSC-EVs) have been reported to exhibit therapeutic properties in various disease models including acute kidney injury. In the present study, we aimed to investigate the effects of HLSC-EVs on tubular regeneration and interstitial fibrosis in an AA-induced mouse model of CKD...
2018: Frontiers in Immunology
Yu-Feng Lin, Likwang Chen, Shuei-Liong Lin, Yu-Chang Yeh, Tao-Min Huang, Yu-Hsiang Chou, Fan-Chi Chang, Yi-Ting Chen, Shao-Yu Yang, Tai-Shuan Lai, Vin-Cent Wu, Tzong-Shinn Chu, Kwan-Dun Wu
OBJECTIVES: Acute kidney disease (AKD), the transition of acute kidney injury to chronic kidney disease, has major clinical significance. Whether mineralocorticoid receptor antagonist will afford target organ protection during this critical stage remains ill-defined. METHODS: Using a population-based cohort database from January 1999 to July 2011, we identified 7252 AKD patients with hypertension, of whom 2255 were treated with mineralocorticoid receptor antagonist (user) and 4997 were treated by other antihypertensive medication (nonuser)...
July 30, 2018: Journal of Hypertension
Zain Ul Abideen, Syed Nayer Mahmud, Mohammad Salih, Ali Arif, Furqan Ali, Amna Rasheed, Muhammad Zafran
Contrast-induced acute kidney injury (CI-AKI) has been studied less extensively in patients with liver cirrhosis (LC). It is unclear whether the presence of severe liver disease is actually a predisposing factor for CI-AKI. Liver cirrhosis is extremely common in Pakistan and is attributed to the high prevalence of chronic viral hepatitis. Patients with LC often undergo contrast-enhanced computed tomograms (CECT) for various diagnostic and therapeutic purposes, and there have been concerns regarding them being at risk for CI-AKI...
May 29, 2018: Curēus
Małgorzata Zalewska-Adamiec, Jolanta Małyszko, Hanna Bachórzewska-Gajewska, Anna Tomaszuk-Kazberuk, Marcin Kożuch, Paweł Kralisz, Sławomir Dobrzycki
Introduction The prognosis of takotsubo syndrome -TTS was recognized as benign, however, in takotsubo patients with chronic kidney disease (CKD), severe complications in the acute phase of the disease, mainly, sudden cardiac arrest are more common. Objectives The aim of the study was to assess the impact of CKD on early and long-term outcomes, including mortality among 95 patients with TTS. Patients and methods All the patients underwent coronary angiography. Clinical, biochemical and other medical data were recorded...
July 27, 2018: Polish Archives of Internal Medicine
Faeq Husain-Syed, Fiorenza Ferrari, Aashish Sharma, Tommaso Hinna Danesi, Pércia Bezerra, Salvador Lopez-Giacoman, Sara Samoni, Massimo de Cal, Valentina Corradi, Grazia Maria Virzì, Silvia De Rosa, María Jimena Muciño Bermejo, Carla Estremadoyro, Gianluca Villa, Jose J Zaragoza, Carlotta Caprara, Alessandra Brocca, Horst-Walter Birk, Hans-Dieter Walmrath, Werner Seeger, Federico Nalesso, Monica Zanella, Alessandra Brendolan, Davide Giavarina, Loris Salvador, Rinaldo Bellomo, Mitchell H Rosner, John A Kellum, Claudio Ronco
Background: Cardiac surgery is a leading cause of acute kidney injury (AKI). Such AKI patients may develop progressive chronic kidney disease (CKD). Others, who appear to have sustained no permanent loss of function (normal serum creatinine), may still lose renal functional reserve (RFR). Methods: We extended the follow-up in the observational 'Preoperative RFR Predicts Risk of AKI after Cardiac Surgery' study from hospital discharge to 3 months after surgery for 86 (78...
July 19, 2018: Nephrology, Dialysis, Transplantation
Katharina Schütte-Nütgen, Maria Edeling, Gudrun Mendl, Michael P Krahn, Bayram Edemir, Thomas Weide, Joachim Kremerskothen, Ulf Michgehl, Hermann Pavenstädt
Reactivation of Notch signaling in kidneys of animal models and patients with chronic kidney disease (CKD) has been shown to contribute to epithelial injury and fibrosis development. Here, we investigated the mechanisms of Notch-induced injury in renal epithelial cells. We performed genome-wide transcriptome analysis to identify Notch target genes using an in vitro system of cultured tubular epithelial cells expressing the intracellular domain of Notch1. One of the top downregulated genes was Disabled-2 ( Dab2)...
July 27, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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