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Mubarak Ali, Ishtiaq Ahmed, Saima Nasir, Ivana Duznovic, Christof M Niemeyer, Wolfgang Ensinger
Solid-state nanofluidic pores have been attracting considerable attention of scientific community because of their structural and chemical resemblance with biological ion channels for mimicking biological processes in living systems. Compared to ion channels, synthetic nanopores exhibit high stability, control over pore dimensions (size and geometry) and their surface chemical properties can be tuned on demand. Therefore, they are considered perfect candidates to design and develop nanofluidic sensory devices by introducing a variety of functional moieties on the inner pore surface...
December 18, 2018: Analytica Chimica Acta
Perry Wengrofsky, Ghassan Mubarak, Ahmed Shim, Pramod Theetha Kariyanna, Adam Buzidkowski, Jacob Schwartz, Samy I McFarlane
Marijuana abuse is rapidly growing and currently it is the most coimnon drug of abuse in the United States due to increased legalization for recreational and medicinal use. Delta 9-tetrahydrocannibol, the main psychoactive compound in marijuana, acts via the endocannabinoid system to elicit various cardiovascular physiological effects, and has been associated with many adverse cardiovascular effects such as acute coronary syndrome, arrhythmias, and sudden cardiac death that have previously been reported by our group and others...
2018: American journal of medical case reports
Keylla da Conceição Machado, Muhammad Torequl Islam, Eunüs S Ali, Razina Rouf, Shaikh Jamal Uddin, Shrabanti Dev, Jamil A Shilpi, Manik Chandra Shill, Hasan Mahmud Reza, Asish Kumar Das, Subrata Shaw, Mohammad S Mubarak, Siddhartha Kumar Mishra, Ana Amelia de Carvalho Melo-Cavalcante
Beta (β)-caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotective, nephroprotective, antimicrobial, and immune-modulatory activity. Recent studies suggest that it also possesses neuroprotective effect. This study reviews published reports pertaining to the neuropharmacological activities of BCAR. Databases such as PubMed, Scopus, MedLine Plus, and Google Scholar with keywords "beta (β)-caryophyllene" and other neurological keywords were searched...
October 3, 2018: Phytotherapy Research: PTR
Fatima Mubarak, Asra Tanwir, Waseem M Nizamani
Intracranial schwannomas account for 8% of all intracranial tumors, out of which 90% are acoustic schwannomas. Other rare varieties include trigeminal melanotic schwannomas that account for 0.2% of all intracranial tumors. Melanotic schwannomas are intracranial tumors that are heavily pigmented due to the presence of melanin. The most common origination of the tumor involves being confined to Meckel's cave, presenting with features of trigeminal neuralgia, neurasthenia, and numbness. We report a case of a 48-year-old male presenting with dysarthria, left-sided hemiparesis, dysphagia, and headache for the past six months...
July 30, 2018: Curēus
Muhammad F Mubarak, Ebubekir S Daglilar, Thom Smilari, Arnab Ray
Background: Renal cell carcinoma (RCC) is responsible for nearly 13,000 deaths in the United States every year, predominantly because of metastasis to other bodily organs. However, metastasis of RCC to the stomach occurs rarely; it presents as solitary or multiple polyps or as ulcers concerning for primary gastric carcinoma. Bleeding from metastasis to the stomach is a rare and underrecognized cause of gastrointestinal bleeding. We describe a case of gastrointestinal bleeding in an elderly female who was found to have a gastric polyp of RCC origin...
2018: Ochsner Journal
Haijun Zhang, Yafei Chang, Longbin Zhang, Seung-Nam Kim, Gaizka Otaegi, Zhen Zhang, Yanzhen Nie, Taufif Mubarak, Cui Li, Cheng-Feng Qin, Zhiheng Xu, Tao Sun
Proper growth of the mammalian cerebral cortex, which is determined by expansion and survival of neural progenitors and mature neurons, is crucial for cognitive functions. Here, we show a role of the dosage of microRNA miR-9 in controlling brain size. Cortical-specific upregulation of miR-9 causes microcephalic defects in mice, due to apoptosis, reduced neural progenitor pool, and decreased neurogenesis. Glial cell-derived neurotrophic factor (GDNF) is a target of miR-9, and protects neural progenitors from miR-9-induced apoptosis...
September 27, 2018: Molecular Neurobiology
Samah A Ata, Kamal I Abu-Dari, Maha F Tutunji, Mohammad S Mubarak
N,N`-Bis[(1,2-didehydro-1-hydroxy-2-thioxopyrid-4-yl)-carbonyl]- L-lysine (HTPL) is a novel newly synthesized compound intended to be used for the chelation of lead in intoxicated animals. Subchronic lead intoxication experiments were carried out on Wistar male rats; these rats were intoxicated with lead and then treated with HTPL. Results were compared with those obtained with known compounds used for lead chelation therapy, such as disodium ethylnediaminetetraacetic acid (CaNa2 EDTA) and meso-2,3-dimercaptosuccininc acid (DMSA), using different routes of administration...
December 2018: Journal of Trace Elements in Medicine and Biology
Antoine Vallatos, Haitham F I Al-Mubarak, James M Mullin, William M Holmes
Phase contrast velocimetry (PCV) has been widely used to investigate flow properties in numerous systems. Several authors have reported errors in velocity measurements and have speculated on the sources, which have ranged from eddy current effects to acceleration artefacts. An often overlooked assumption in the theory of PCV, which may not be met in complex or unsteady flows, is that the intravoxel displacement distributions (propagators) are symmetric. Here, the effect of the higher moments of the displacement distribution (variance, skewness and kurtosis) on the accuracy of PCV is investigated experimentally and theoretically...
September 5, 2018: Journal of Magnetic Resonance
Mohamed A El Mubarak, Evgenios K Stylos, Maria V Chatziathanasiadou, Charikleia Danika, George A Alexiou, Periklis Tsekeris, Alexander Renziehausen, Tim Crook, Nelofer Syed, Gregory B Sivolapenko, Andreas G Tzakos
Temozolomide (TEMODAL™) (TMZ) is an antineoplastic agent that is primarily used for the treatment of glioblastoma and anaplastic gliomas, two aggressive forms of brain cancer. Due to the poor prognosis of brain tumour patients, there is an increasing body of research into improving the stability and delivery of TMZ past the blood brain barrier using carrier molecules. These require accurate determination of TMZ levels for biodistribution and pharmacokinetic evaluation. Unfortunately, current methodologies for the determination of TMZ in human plasma suffer from low reproducibility, recovery, sensitivity or cost ineffective procedures associated with extensive sample cleaning...
September 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
Mahamudul Hasan, M Munirul Islam, Eman Mubarak, Md Ahshanul Haque, Nuzhat Choudhury, Tahmeed Ahmed
Mothers are often responsible for preparing nutritious foods in their households. However, the quality of mother's diets is often neglected, which may affect both mother's and child's nutrition. Because no single food contains all necessary nutrients, diversity in dietary sources is needed to ensure a quality diet. We aimed to study the association between mother's dietary diversity and stunting in children <2 years attending Dhaka Hospital of icddr,b, a diarrhoeal disease hospital in Dhaka, Bangladesh...
September 14, 2018: Maternal & Child Nutrition
Sapna R Parab, Mubarak M Khan, Sneha Kulkarni, Virendra Ghaisas, Prakash Kulkarni
Hearing is one of the most important sense organs for man. Hearing loss is often associated with delayed speech and language development in young children. Early identification and intervention improves the chance a child gets to lesser delays in development and improving the overall quality of life. To find out the prevalence of hearing loss in neonates in the rural taluka of Maval, Pune, Maharashtra, India. Prospective Non Randomized Clinical Study. The study was carried out between April 2012 and April 2015...
September 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Zaki Mubarak, Adintya Humaira, Basri A Gani, Zainal A Muchlisin
Background: Candida albicans is an opportunistic fungus that might infect the oral cavity. Increased colony numbers of C. albicans in the mouth can be caused by multiple factors, such as smoking, weakened immune system, antibiotics use and immune-compromised condition. Smoking can increase expression of virulence factors of C. albicans and make it stronger. One virulence factor of C. albicans is biofilm formation. The ability of creating biofilm makes C. albicans more tolerant to commercial antifungal agents...
2018: F1000Research
Longbin Zhang, Taufif Mubarak, Yase Chen, Trevor Lee, Andrew Pollock, Tao Sun
Brain morphogenesis requires precise regulation of multiple genes to control specification of distinct neural progenitors (NPs) and neuronal production. Dysregulation of these genes results in severe brain malformation such as macrocephaly and microcephaly. Despite studies of the effect of individual pathogenic genes, the counter-balance between multiple factors in controlling brain size remains unclear. Here we show that cortical deletion of Gli3 results in enlarged brain and folding structures in the cortical midline at the postnatal stage, which is mainly caused by the increased percentage of intermediate progenitors (IPs) and newborn neurons...
2018: Frontiers in Cellular Neuroscience
Qurat-Ul-Ain Mubarak, Muhammad Usman Akram, Arslan Shaukat, Farhan Hussain, Sajid Gul Khawaja, Wasi Haider Butt
BACKGROUND AND OBJECTIVE: Accurate localization of heart beats in phonocardiogram (PCG) signal is very crucial for correct segmentation and classification of heart sounds into S1 and S2. This task becomes challenging due to inclusion of noise in acquisition process owing to number of different factors. In this paper we propose a system for heart sound localization and classification into S1 and S2. The proposed system introduces the concept of quality assessment before localization, feature extraction and classification of heart sounds...
October 2018: Computer Methods and Programs in Biomedicine
Subhash Chandir, Danya Arif Siddiqi, Owais Ahmed Hussain, Tahira Niazi, Mubarak Taighoon Shah, Vijay Kumar Dharma, Ali Habib, Aamir Javed Khan
BACKGROUND: Despite the availability of free routine immunizations in low- and middle-income countries, many children are not completely vaccinated, vaccinated late for age, or drop out from the course of the immunization schedule. Without the technology to model and visualize risk of large datasets, vaccinators and policy makers are unable to identify target groups and individuals at high risk of dropping out; thus default rates remain high, preventing universal immunization coverage...
September 4, 2018: JMIR Public Health and Surveillance
Muhammad Torequl Islam, Siddhartha Kumar Mishra, Swati Tripathi, Marcus Vinícius Oliveira Barros de Alencar, João Marcelo de Castro E Sousa, Hercília Maria Lins Rolim, Maria das Graças Freire de Medeiros, Paulo Michel Pinheiro Ferreira, Razina Rouf, Shaikh Jamal Uddin, Mohammad Suleiman Mubarak, Ana Amélia de Carvalho Melo-Cavalcante
Mitochondria are the powerhouse of cells, which upon dysfunctions may lead to several diseases. Mycotoxins are the toxic secondary metabolites from fungi which are capable of causing diseases and death in humans and animals. They have a versatile mechanism of action in biological systems and can be used as lead compounds to treat some diseases including cancer. The present work encompasses analysis on the effects of mycotoxins on mitochondrial dysfunction. Electronic databases such as PubMed, ScienceDirect, Scopus, Web of Science, and Google Scholar were thoroughly searched for up-to-date published information associated with those mycotoxins and their effect on mitochondrial dysfunction...
November 2018: IUBMB Life
Antonio Luiz Gomes, Jana Dimitrova Tchekalarova, Milena Atanasova, Keylla da Conceição Machado, Maria Alexsandra de Sousa Rios, Márcia Fernanda Correia Jardim Paz, Mihnea-Alexandru Găman, Amelia Maria Găman, Santosh Yele, Manik Chandra Shill, Ishaq N Khan, Md Amirul Islam, Eunüs S Ali, Siddhartha K Mishra, Muhammad Torequl Islam, Mohammad S Mubarak, Luciano da Silva Lopes, Ana Amélia de Carvalho Melo-Cavalcante
Epilepsy is a neurological disease affecting people of all ages worldwide. Side effects of antiepileptic drugs and their association with oxidative stress stimulate the search for new drugs, which would be more affordable with fewer adverse effects. Accordingly, the aim of the present work is to evaluate the anticonvulsant effect of anacardic acid (AA), a natural compound extracted from cashew liquid (Anacardium occidentalis), in murine models, as well as its antioxidant actions in Saccharomyces cerevisiae...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Muhammad Torequl Islam, Eunüs S Ali, Shaikh J Uddin, Subrata Shaw, Md Amirul Islam, Md Iqbal Ahmed, Manik Chandra Shill, Utpal Kumar Karmakar, Nagendra Sastry Yarla, Ishaq N Khan, Md Morsaline Billah, Magdalena D Pieczynska, Gokhan Zengin, Clemens Malainer, Ferdinando Nicoletti, Diana Gulei, Ioana Berindan-Neagoe, Apostol Apostolov, Maciej Banach, Andy W K Yeung, Amr El-Demerdash, Jianbo Xiao, Prasanta Dey, Santosh Yele, Artur Jóźwik, Nina Strzałkowska, Joanna Marchewka, Kannan R R Rengasamy, Jarosław Horbańczuk, Mohammad Amjad Kamal, Mohammad S Mubarak, Siddhartha K Mishra, Jamil A Shilpi, Atanas G Atanasov
Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action...
August 18, 2018: Food and Chemical Toxicology
Jimoh Olubanwo Agbaje, Akinyele Olumuyiwa Adisa, Mariya Ivanova Petrova, Adeola Adenike Olusanya, Tolulope Osayomi, Olajumoke Ajibola Effiom, Olujide Oladele Soyele, Olufemi Gbenga Omitola, Adetokunbo Babajide Olawuyi, Robinson Obos Okiti, Thelma Eziafa Saiki, Benjamin Fomete, Adebayo Aremu Ibikunle, Chuckwubuzor Okwuosa, Mofoluwaso Abimbola Olajide, Adeola Mofoluwake Ladeji, Kehinde Emmanuel Adebiyi, Mubarak Mobola Emmanuel, Hammed Sikiru Lawal, Emeke Uwadia, Babatunde Oludare Fakuade, Yusuf Mohammed Abdullahi, Constantinus Politis
OBJECTIVES: Ameloblastoma is a benign, slow-growing, locally invasive epithelial tumor of odontogenic origin, with unlimited growth capacity and a strong tendency to recur. This multicentric study analyzed ameloblastoma diagnosed in Nigeria among different ethnic groups. STUDY DESIGN: This retrospective study included ameloblastoma cases diagnosed from 1964 to 2017 at 10 hospitals or medical centers in Nigeria. Age, sex, tribe, and location of the ameloblastoma in the jaw were analyzed...
July 24, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Yasser A Kamal, Yasser S Mubarak
No abstract text is available yet for this article.
August 17, 2018: ANZ Journal of Surgery
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