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https://www.readbyqxmd.com/read/30117665/pulmonary-sequestration-mimicking-lung-abscess-in-old-age
#1
Yasser A Kamal, Yasser S Mubarak
No abstract text is available yet for this article.
August 17, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/30108386/short-term-outcome-of-clinical-and-histopathologic-variants-of-mesangiocapillary-glomerulonephritis-in-children-a-retrospective-analysis-from-a-tertiary-care-center
#2
Sabeeta Khatri, Irshad Ali Bajeer, Vina Tresa, Seema Hashmi, Muhammed Mubarak, Ali Asghar Lanewala
OBJECTIVE: To study the frequency, clinicopathological features and short-term outcome of mesangiocapillary glomerulonephritis (MCGN) in children at a tertiary care kidney center in Pakistan. METHODS: A descriptive, observational study was conducted at the Paediatric Nephrology Department, Sindh Institute of Urology and Transplantation, Karachi, from January 2011 till December 2015. A review of all paediatric (<18 years) renal biopsies during the study period was performed and cases of MCGN were enrolled...
August 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30092045/correction-a-reassessment-of-the-early-archaeological-record-at-leang-burung-2-a-late-pleistocene-rock-shelter-site-on-the-indonesian-island-of-sulawesi
#3
Adam Brumm, Budianto Hakim, Muhammad Ramli, Maxime Aubert, Gerrit D van den Bergh, Bo Li, Basran Burhan, Andi Muhammad Saiful, Linda Siagian, Ratno Sardi, Andi Jusdi, Abdullah, Andi Pampang Mubarak, Mark W Moore, Richard G Roberts, Jian-Xin Zhao, David McGahan, Brian G Jones, Yinika Perston, Katherine Szabó, M Irfan Mahmud, Kira Westaway, Jatmiko, E Wahyu Saptomo, Sander van der Kaars, Rainer Grün, Rachel Wood, John Dodson, Michael J Morwood
[This corrects the article DOI: 10.1371/journal.pone.0193025.].
2018: PloS One
https://www.readbyqxmd.com/read/30091726/effect-of-caffeine-on-serum-tumour-necrosis-factor-alpha-and-lactate-dehydrogenase-in-wistar-rats-exposed-to-cerebral-ischaemia-reperfusion-injury
#4
Mubarak Muhammad, A B El-Ta'alu, M A Mohammed, I U Yarube, J M Nuhu, I Yusuf, U A Daneji
Caffeine is known to confer neuro-protection via A1 and A2A adenosine receptor antagonism in which adenosine neuro-modulates excitotoxic release of glutamate. Currently, it is unclear whether caffeine modulates inflammation in ischaemic stroke model. The present study examined effects of caffeine following ischaemia-reperfusion injury on neuro-inflammatory tumour necrosis alpha (TNF-α), lactate dehydrogenase (LDH), as well as effect of caffeine against brain ischaemic damage on histology. Thirty three adult male Wistar rats (180-300 g) were used in this study...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30080530/ultrasound-assisted-synthesis-of-two-novel-cubr-diamine-2-%C3%A2-h-2-o-br-complexes-solvatochromism-crystal-structure-physicochemical-hirshfeld-surface-thermal-dna-binding-antitumor-and-antibacterial-activities
#5
Ismail Warad, Firas F Awwadi, Bahaa Abd Al-Ghani, Ashraf Sawafta, Naveen Shivalingegowda, Neartur Krishnappagowda Lokanath, Mohammad S Mubarak, Taibi Ben Hadda, Abdelkader Zarrouk, Fuad Al-Rimawi, Abdallah Bani Odeh, Sameer A Barghouthi
Two new hydrated monocationic Cu(II) complexes with 1,3-propylenediamine and 1,2-ethylenediamine of general formula [CuBr(N-N)2 ·H2 O]Br were prepared. The complexes were identified by means of several spectroscopic tools (Uv-visible, IR and MS), thermally (TG/DTA) and CHN-elemental analysis. The three dimensional structure for complex A and B was provide by X-ray diffraction studies and showed the Cu(II) ion as 4 + 1 + 1 coordinated, four nitrogen atoms of the diamine ligands, one bromide ion and one H2 O semi-coordinated to the Cu(II) center, a typical trans effect is clearly observed in the two complexes...
November 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/30079256/a-case-of-sirenomelia-associated-with-hypoplastic-left-heart-with-a-healthy-co-twin-a-rare-entity
#6
Houda Nasser Al Yaqoubi, Muna Mubarak Al Badi, Farida Mohsin Ambu Saidi, Nasser Shaikhan Taaeeb Al Shafouri
Sirenomelia is a rare developmental malformation and is incompatible to life. The incidence of sirenomelia, as recorded in the literature, is estimated to be approximately between 1.5 and 4.2 per 1,00,000 births. Around 15% of sirenomelia cases are associated with twin pregnancy, most often in monozygotic cases with an incidence of 7%. In monozygotic twins, the risk of sirenomelia is nearly 100-150 times higher as compared to dizygotic twins or singleton pregnancies. Until now, only two cases of sirenomelia associated with hypoplastic left heart have been reported in the literature...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/30076924/molecular-modeling-studies-of-coruscanone-a-core-nucleus-as-potential-antifungal-agents
#7
REVIEW
Haroon Khan, Dima A Sabbah, Muhammad Zafar, Mohammad S Mubarak
Fungal diseases could be serious and, in some cases, life-threatening. Considering the limited availability of antifungal agents in use, and the emergence of multi drug resistance (MDR) in fungal infections, there is a pressing need for the development of novel broad spectrum antifungal drugs with better efficacy. Coruscanone A analogues, natural derivatives which target the fungal lanosterol enzyme, were docked against lanosterol 14 α-demethylase (CYP51A1) that converts lanosterol to 4,4-dimethylcholesta-8,14,24-trien-3β-ol in the ergosterol biosynthesis pathway in order to stabilize the plasma membrane of the fungal species, and hence can be targeted for an effective antifungal therapy...
August 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/30072706/poultry-and-beef-meat-as-potential-seedbeds-for-antimicrobial-resistant-enterotoxigenic-bacillus-species-a-materializing-epidemiological-and-potential-severe-health-hazard
#8
Kamelia M Osman, Anthony D Kappell, Ahmed Orabi, Khalid S Al-Maary, Ayman S Mubarak, Turki M Dawoud, Hassan A Hemeg, Ihab M I Moussa, Ashgan M Hessain, Hend M Y Yousef, Krassimira R Hristova
Although Bacillus cereus is of particular concern in food safety and public health, the role of other Bacillus species was overlooked. Therefore, we investigated the presence of eight enterotoxigenic genes, a hemolytic gene and phenotypic antibiotic resistance profiles of Bacillus species in retail meat samples. From 255 samples, 124 Bacillus isolates were recovered, 27 belonged to B. cereus and 97 were non-B. cereus species. Interestingly, the non-B. cereus isolates carried the virulence genes and exhibited phenotypic virulence characteristics as the B...
August 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30065628/opposite-roles-of-wnt7a-and-sfrp1-in-modulating-proper-development-of-neural-progenitors-in-the-mouse-cerebral-cortex
#9
Nan Miao, Shan Bian, Trevor Lee, Taufif Mubarak, Shiying Huang, Zhihong Wen, Ghulam Hussain, Tao Sun
The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/30060950/c-terminal-phosphorylation-of-spak-and-osr1-kinases-promotes-their-binding-and-activation-by-the-scaffolding-protein-mo25
#10
Youcef Mehellou, Mubarak A Alamri, Binar A Dhiani, Hachemi Kadri
SPAK and OSR1 are two protein kinases that play important roles in regulating the function of numerous ion co-transporters. They are activated by two distinct mechanisms that involve initial phosphorylation at their T-loops by WNK kinases and subsequent binding to a scaffolding protein termed MO25. To understand this latter SPAK and OSR1 regulation mechanism, we herein show that MO25 binding to these two kinases is enhanced by serine phosphorylation in their highly conserved WEWS motif, which is located in their C-terminal domains...
July 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30050438/valproic-acid-induces-endothelial-to-mesenchymal-transition-like-phenotypic-switching
#11
Shamini Murugavel, Antoinette Bugyei-Twum, Pratiek N Matkar, Husain Al-Mubarak, Hao H Chen, Mohamed Adam, Shubha Jain, Tanya Narang, Rawand M Abdin, Mohammad Qadura, Kim A Connelly, Howard Leong-Poi, Krishna K Singh
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is a widely used anticonvulsant drug that is currently undergoing clinical evaluation for anticancer therapy due to its anti-angiogenic potential. Endothelial cells (ECs) can transition into mesenchymal cells and this form of EC plasticity is called endothelial-to-mesenchymal transition (EndMT), which is widely implicated in several pathologies including cancer and organ fibrosis. However, the effect of VPA on EC plasticity and EndMT remains completely unknown...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30042622/thidiazuron-tdz-induced-organogenesis-and-clonal-fidelity-studies-in-haloxylon-persicum-bunge-ex-boiss-buhse-an-endangered-desert-tree-species
#12
Shyam Sreedhara Kurup, Fayas Thayale Purayil, Mubarak Mohammed Sultan Alkhaili, Nadia Hassan Tawfik, Abdul Jaleel Cheruth, Maher Kabshawi, Sreeramanan Subramaniam
Haloxylon persicum (Bunge ex Boiss & Buhse), is one of the hardy woody desert shrubs, which is now endangered and/or nearing extinction. Urban landscape development and overgrazing are the major threats for the erosion of this important plant species. For conserving the species, it is critical to develop an efficient in vitro regeneration protocol for rapid multiplication of large number of regenerants. Leaf explants, cultured on Murashige and Skoog (MS) medium supplemented with different concentrations of thidiazuron (TDZ) (0...
July 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/30039547/anticancer-potential-of-quercetin-a-comprehensive-review
#13
REVIEW
Abdur Rauf, Muhammad Imran, Imtiaz Ali Khan, Mujeeb- Ur-Rehman, Syed Amir Gilani, Zaffar Mehmood, Mohammad S Mubarak
Diet plays a key role to maintaining healthy life. Many natural products present in our diet, such as flavonoids, can prevent the progression of cancer. Quercetin, a distinctive bioactive flavonoid, is a dietary component that has attracted the attention of dietitians and medicinal chemists due to its numerous health-promoting effects. It is an outstanding antioxidant that has a well-documented role in reducing different human cancers. Quercetin exhibits direct proapoptotic effects on tumor cells and thus can inhibit the progress of numerous human cancers...
July 24, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30026033/vaccination-status-of-children-aged-1-4-years-in-afghanistan-and-associated-factors-2015
#14
Luke M Shenton, Abram L Wagner, Bradley F Carlson, Mohammad Yousuf Mubarak, Matthew L Boulton
BACKGROUND: Childhood mortality in Afghanistan fell by half between 1990 and 2015, due in part to the government's commitment to improving pediatric immunization services. Although progress has been made, immunization coverage has nonetheless remained low with only 65% of children receiving the third dose of Diphtheria-Pertussis-Tetanus (DPT3) based on WHO estimates. This study aims to calculate the proportion of Afghan children aged 1-4 years who were fully vaccinated, under-vaccinated, or non-vaccinated with government-recommended Expanded Program on Immunization vaccines and identify predictors related to the family's sociodemographic status and maternal autonomy...
July 17, 2018: Vaccine
https://www.readbyqxmd.com/read/30019987/the-histological-spectrum-of-tubulo-reticular-inclusion-positive-renal-biopsies-a-tertiary-hospital-experience-and-review-of-the-literature
#15
Hala Kfoury, Mohammed Mubarak, Abd Assalam Qannus, Malak Alshareef, Jwaher Alharbi, Hadeel Alghurair, Alanoud Bin Omair, Najd Alshamlan, Lama Raddaoui, Hisham Alkhalidi
AIM: To identify the underlying diseases with TRI-positive kidney biopsies, and describe the histological pattern and spectrum of TRI-positive kidney biopsies. METHODS: A retrospective analysis of all patients' chart that underwent renal biopsy at King Saud University Medical City between 2012 and 2017 was done. Kidney biopsies that indicated a positive result for tubuloreticular inclusions (TRI's) on electron microscopy were reviewed and the underlying disease and histological pattern was extracted...
July 18, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/30019644/novel-benzylidenehydrazide-1-2-3-triazole-conjugates-as-antitubercular-agents-synthesis-and-molecular-docking
#16
Mubarak H Shaikh, Dnyaneshwar D Subhedar, Laxman Nawale, Dhiman Sarkar, Firoz A Kalam Khan, Jaiprakash Sangshetti, Bapurao B Shingate
Novel 1,2,3-triazole based benzylidenehydrazide derivatives were synthesized and evaluated for antitubercular activity against Mycobacterium tuberculosis (MTB) H37Ra, M. bovis BCG and cytotoxic activity. Most of the derivatives exhibited promising in vitro potency against MTB characterized by lower MIC values. Among all the synthesized derivatives, compound 6a and 6j were the most active against active and dormant MTB H37Ra, respectively. Compound 6d was significantly active against dormant and active M. bovis BCG...
July 18, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/30017864/long-term-neurotoxic-effects-of-domoic-acid-on-primary-dopaminergic-neurons
#17
Khaled Radad, Rudolf Moldzio, Mubarak Al-Shraim, Ahmed Al-Emam, Wolf-Dieter Rausch
Domoic acid, an excitatory neurotoxin produced by certain algae, reaches the food chain through accumulation in some sea organisms. To investigate its long-term neurotoxicity on dopaminergic neurons, prepared primary mesencephalic cell cultures were exposed to different concentrations of domoic acid (0.1, 1, 10, 100 μM) on the 8th day in vitro (DIV) for 4 days. On the 12th DIV, culture media were collected for measurement of lactate dehydrogenase and cultured cells were subjected to immunohistochemistry against tyrosine hydroxylase, neuronal nuclear antigen and glial fibrillary acidic protein, and fluorescence staining using H2 DCFDA, JC-1 and Hoechst 33342 dyes...
July 11, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/30009484/protective-and-therapeutic-potential-of-ginger-zingiber-officinale-extract-and-6-gingerol-in-cancer-a-comprehensive-review
#18
REVIEW
Rosália Maria Tôrres de Lima, Antonielly Campinho Dos Reis, Ag-Anne Pereira Melo de Menezes, José Victor de Oliveira Santos, José Williams Gomes de Oliveira Filho, José Roberto de Oliveira Ferreira, Marcus Vinícius Oliveira Barros de Alencar, Ana Maria Oliveira Ferreira da Mata, Ishaq N Khan, Amirul Islam, Shaikh Jamal Uddin, Eunüs S Ali, Muhammad Torequl Islam, Swati Tripathi, Siddhartha Kumar Mishra, Mohammad S Mubarak, Ana Amélia de Carvalho Melo-Cavalcante
Natural dietary agents have attracted considerable attention due to their role in promoting health and reducing the risk of diseases including cancer. Ginger, one of the most ancient known spices, contains bioactive compounds with several health benefits. [6]-Gingerol constitutes the most pharmacologically active among such compounds. The aim of the present work was to review the literature pertaining to the use of ginger extract and [6]-gingerol against tumorigenic and oxidative and inflammatory processes associated with cancer, along with the underlying mechanisms of action involved in signaling pathways...
July 16, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30008308/development-of-a-novel-conjugatable-sunitinib-analogue-validated-through-in-vitro-and-in-vivo-preclinical-settings
#19
Mohamed A El Mubarak, Iliana Leontari, Giannopoulou Efstathia, Eirinaios I Vrettos, Abdul Kadar Shaikh, Siatis E Konstantinos, Charikleia Danika, Haralabos P Kalofonos, Andreas G Tzakos, Gregory B Sivolapenko
Sunitinib is an oral FDA/EMEA approved multi-targeted tyrosine kinase inhibitor. It possesses anti-angiogenic and antitumor activity against a variety of advanced solid tumors. However, its chemical core does not allow a potential linkage to tumor-homing elements that could eventually enhance its potency. Therefore, a novel linkable sunitinib derivative, designated SB1, was rationally designed and synthesized. The pharmaceutical profile of SB1 was explored both in vitro and in vivo. Mass spectrometry and NMR spectroscopy were utilized for characterization, while MTT assays and LC-MS/MS validated protocols were used to explore its antiproliferative effect and stability, respectively...
August 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/30008002/salmonella-brain-abscess-in-an-infant
#20
Mubarak Al-Yaqoobi, Sulien Al-Khalili, Ganpati P Mishra
Brain abscess is a potentially life-threatening condition requiring rapid diagnosis and prompt medical and surgical intervention. Various etiological agents associated with different epidemiological backgrounds are implicated, including Gram-positive and Gram- negative bacterial agents as well as anaerobes. Salmonella is rarely reported to be the cause of this medical condition despite being known to cause invasive infections at extremes of age and the fact that this organism is a common cause of other clinical infectious diseases encountered in immunocompromised and immunocompetent individuals...
July 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
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