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Wafaa S Ramadan, Ghada A Abdel-Hamid, Saleh Al-Karim, Noor Ahmed Mubarak Ben Zakar, M-Zaki Elassouli
The outcomes of compressed spinal cord injury (CSCI) necessitate radical treatment. The therapeutic potential of neuroectodermal stem cells (NESCs) in a rat model of CSCI in acute and subacute stages was assessed. White Wistar rat were divided into control, sham-operated, CSCI untreated model, CSCI grafted with NESCs at 1 day after CSCI, and at 7 days after CSCI. Primary NESC cultures were prepared from brains of embryonic day 10 (E10) mice embryos. NESCs were transplanted at the site of injury using a Hamilton syringe...
December 2018: Journal of Biosciences
Hibah M Aldawsari, Harkiranpreet Kaur Dhaliwal, Bader Mubarak Aljaeid, Nabil A Alhakamy, Zainy Mohammad Banjar, Mansoor M Amiji
Polymeric systems have been extensively studied as polyelectrolyte complexes to enhance the cellular delivery and transfection efficiency of genetic materials, such as plasmid DNA (pDNA). Here, self-assembled nanoparticles were formulated by complexation of hyaluronic acid (HA) conjugated poly(ethylene glycol) (HA-PEG), and poly(ethyleneimine) (HA-PEI), respectively, with pDNA creating relatively small, stable, and multifunctional nanoparticle complex formulations with high transfection efficiency. This formulation strategy offers high gene expression efficiency and negligible cytotoxicity in HeLa and A549 human lung cancer cell lines...
December 10, 2018: Molecular Pharmaceutics
Ahmad Iyad Mubarak, Ajaykumar C Morani, Jessica Samuel, Jia Sun, Wei Wei, Priya R Bhosale
PURPOSE: This study aimed to determine the ability of ultrasound to predict survival and detect more aggressive tumors in women with ovarian masses. MATERIALS AND METHODS: Institutional review board approval was obtained. A total of 167 patients who presented with adnexal mass/masses were included. These were documented as benign or malignant on ultrasound. Age, date of diagnosis and date of death, type of tumor, and tumor marker cancer antigen 125 (CA-125) values were recorded...
December 3, 2018: Ultrasound Quarterly
Wenfeng Gong, Mubarak Taighoon Shah, Sumera Firdous, Brooke A Jarrett, Lawrence H Moulton, William J Moss, Kyla Hayford, Katherine L O'Brien, Subhash Chandir
Background: Household surveys are an essential tool for vaccine coverage monitoring in developing countries, and the World Health Organization (WHO) Expanded Program on Immunization (EPI) cluster survey design has been a default choice for decades. In response to methodological limitations of the traditional EPI sampling, alternative methods have been proposed, based on modern statistical and geographical techniques. This study compared the coverage estimates and the time efficiency of the EPI sampling design and two alternative methods: the compact segment sampling and innovative grid-based geographical information system (GIS) sampling...
November 30, 2018: International Journal of Epidemiology
Khaled Cheaib, Muhammad Qadri Effendy Mubarak, Katell Sénéchal-David, Christian Herrero, Régis Guillot, Martin Clémancey, Jean-Marc Latour, Samuel de Visser, Jean-Pierre Mahy, Frédéric Banse, Frederic Avenier
We demonstrate that the devised incorporation of an alkylamine group into the second coordination sphere of an FeII complex allows to switch its reactivity with H2O2 from the usual formation of FeIII species towards the selective generation of an FeIV-oxo intermediate. The FeIV-oxo was characterized by UV-visible absorption and Mössbauer spectroscopy. Variable temperature kinetic analyses point towards a mechanism where the heterolytic cleavage of the O-O bond is triggered by a proton transfer from the proximal to the distal oxygen atom in the FeII-H2O2 complex with the assistance of the pendant amine...
November 28, 2018: Angewandte Chemie
Min Juey Yee, N M Mubarak, Mohammad Khalid, E C Abdullah, Priyanka Jagadish
Buckypaper (BP)/polymer composites are viewed as a viable option to improve the strain transfer across the buckypaper strain sensor by means of providing better interfacial bonding between the polymer and carbon nanotubes (CNTs). Multiwall carbon nanotubes (MWCNTs) BP/polyvinyl alcohol (PVA) composites were fabricated by a sequence of vacuum filtration and polymer intercalation technique. The optimized conditions for achieving a uniform and stable dispersion of MWCNTs were found to be using ethanol as a dispersion medium, 54 μm ultrasonic amplitude and 40 min sonication time...
November 23, 2018: Scientific Reports
Anderson Wilbur Lopes Andrade, Daiana Dias Ribeiro Figueiredo, Muhammad Torequl Islam, Adriana Maria Viana Nunes, Keylla da Conceição Machado, Katia da Conceição Machado, Shaikh Jamal Uddin, Jamil Ahmed Shilpi, Razina Rouf, Ana Amélia de Carvalho Melo-Cavalcante, Jorge Mauricio David, Mohammad S Mubarak, Jéssica Pereira Costa
Agathisflavone (AGF) is a biflavonoid with a number of important biological and pharmacological activities, such as antioxidant, antimicrobial, and neuroprotective effects. However, its toxicological effects have not been fully investigated. Accordingly, the aim of this study was to investigate the toxicological effects of AGF in mice. For this purpose, the median lethal dose 50% (LD50 ) was determined along with the anatomic and histopathological parameters (weight, alimentation, excretion, biochemical, and hematological) in fertile untouched female Swiss mice...
November 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kandasamy Saravanakumar, Davoodbasha Mubarak Ali, Kandasamy Kathiresan, Myeong-Hyeon Wang
Biopolymers are ubiquitous in biomedical and healthcare application. Its nanocomposites have gained the more attention as antimicrobials, drug carrier, sensors, disease diagnosis, tissue engineering, wound healing and cancer therapy. These biopolymer composites are efficient in holding, protect and releasing the bioactive drugs such as pharmaceutics, nutraceuticals, enzymes and probiotics. Several studies are revealed that polymer based drug delivery system in cancer therapy and microbial treatments so on. However, this mini review emphasized the source, extraction, and characterizations of the biopolymers and their use in the fabrication of various drug or metals based nanocomposites followed by its utilization as drug carrier or drug to treat the various diseases such as antimicrobial infections and cancer...
November 20, 2018: Current Pharmaceutical Design
Sapna Ramkrishna Parab, Mubarak M Khan
Abstract: Cartilage-perichondrium composite graft is used in middle ear surgery for tympanic membrane, ossicular and for soft wall reconstruction. The thickness of the cartilage is thought to interfere with the sound conduction. In our otology practice for tympanic membrane reconstruction, we prefer the sliced cartilage graft to achieve acoustic benefit. At times in the process of slicing, the cartilage gets wasted if not sliced with a precision slicing instrument. We have designed and developed a multi-purpose cartilage slicer for precise reduction of the thickness of the cartilage...
December 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Charles Antwi-Boasiako, Ivy Ekem, Mubarak Abdul-Rahman, Frederika Sey, Alfred Doku, Bartholomew Dzudzor, Gifty B Dankwah, Kate Hagar Otu, John Ahenkorah, Robert Aryee
Background: Effective treatment and management of sickle cell disease (SCD) has been a challenge in Africa over the years. Hematological parameters are very useful profiles in the effective management of the disease. However, there is scarcity of studies on the hematological parameters of SCD in Ghana. This study aimed at determining hematological parameters among SCD patients with vaso-occlusion, those in the steady state as well as healthy controls at a teaching hospital in Ghana. Methodology: This was a cross-sectional study involving a total of 628 subjects, including 148 HbAA controls, 208 HbSS patients in steady state, 82 HbSC patients in steady state, 156 HbSS patients in vaso-occlusive crises (VOC), and 34 HbSC patients in VOC...
2018: Journal of Blood Medicine
Ahmed M Habib, Azhar Hussain, Martin Jarvis, Michael E Cowen, Mubarak A Chaudhry, Mahmoud Loubani, Alex Cale, Dumbor L Ngaage
OBJECTIVES: With an ageing population, increasing numbers of octogenarians are undergoing high-risk cardiac surgery. We examine the changing characteristics and in-hospital outcomes for octogenarians over an 18-year period. METHODS: Clinical data from our prospective database for all octogenarians who had cardiac surgery from March 1999 through May 2016 were reviewed. We examined trends, risk profiles and in-hospital outcomes over 3 eras, namely early (1999-2004), middle (2005-2010) and late (2011-2016)...
November 8, 2018: Interactive Cardiovascular and Thoracic Surgery
Muhammad Imran, Abdur Rauf, Zafar Ali Shah, Farhan Saeed, Ali Imran, Muhammad Umair Arshad, Bashir Ahmad, Sami Bawazeer, Muhammad Atif, Dennis G Peters, Mohammad S Mubarak
Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2)...
November 7, 2018: Phytotherapy Research: PTR
Muhammad F Mubarak, Janak N Shah, John S Bolton, Mona Bansal, Abdul Hamid El Chafic
No abstract text is available yet for this article.
November 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Muhammed Mubarak
No abstract text is available yet for this article.
October 2018: Urology Annals
Mohamed H Mubarak, Othman Sidek, Mohamed R Abdel-Rahman, Mohd Tafir Mustaffa, Ahmad Shukri Mustapa Kamal, Saad M Mukras
Since the 1940s, infrared (IR) detection and imaging at wavelengths in the two atmospheric windows of 3 to 5 and 8 to 14 μm has been extensively researched. Through several generations, these detectors have undergone considerable developments and have found use in various applications in different fields including military, space science, medicine and engineering. For the most recently proposed generation, these detectors are required to achieve high-speed detection with spectral and polarization selectivity while operating at room temperature...
October 31, 2018: Sensors
Dina Rady, Rabab Mubarak, Rehab A Abdel Moneim
Background: Various techniques for tissue engineering have been introduced to aid the regeneration of defective or lost bone tissue. The aim of this study was to compare the in vivo bone-forming potential of bone marrow mesenchymal stem cells (BM-MSCs) and platelet-rich fibrin (PRF) on induced bone defects in rats' tibiae. Methods: In total, one defect of 3-mm diameter was created in each tibia of 36 Wistar male rats. There were two groups: group A, left tibia bone defects that received PRF; and group B, right tibia bone defects of the same animal that received BM-MSCs loaded on a chitosan scaffold...
2018: F1000Research
Charikleia Danika, Mohamed A El Mubarak, Iliana Leontari, Gregory B Sivolapenko
PCK3145 is an anti-metastatic synthetic peptide against prostate cancer. The objective of the study is to develop and validate novel and sensitive methods for the determination of PCK3145 and Pegylated PCK3145 in mouse plasma. An LC-MS/MS method was developed and validated for the determination of PCK3145 giving high sensitivity and linearity in the range of 0.125-4.0 μg/mL. PCK3145 characterised by short half-life, therefore, it was conjugated with the poly ethylene glycol (PEG). However, LC-MS/MS has been more difficult to apply for the quantitative analysis of PEGylated peptides due to the large size...
January 1, 2019: Analytical Biochemistry
Mubarak Ahmed Mashrah, Taghrid Ahmed Al-Dhohrah, Fahmi Ahmed Al-Zubeiry, Lingjian Yan, Faez Saleh Al-Hamed, Xiaopeng Zhao, Chaobin Pan
OBJECTIVE: The primary aim of this meta-analysis was to test the null hypothesis of no difference in facial nerve dysfunction in studies that compared classical antegrade facial nerve dissection (AFND) versus retrograde facial nerve dissection (RFND) during benign parotid surgery. METHODS: A comprehensive search of PubMed, the Cochrane Central Register of Controlled Trials, Scopus, Google Scholar, Science Direct and relevant journals was undertaken up to June 27, 2018...
2018: PloS One
Mubarak Ali, Ishtiaq Ahmed, Saima Nasir, Ivana Duznovic, Christof M Niemeyer, Wolfgang Ensinger
Solid-state nanofluidic pores have been attracting considerable attention of scientific community because of their structural and chemical resemblance with biological ion channels for mimicking biological processes in living systems. Compared to ion channels, synthetic nanopores exhibit high stability, control over pore dimensions (size and geometry) and their surface chemical properties can be tuned on demand. Therefore, they are considered perfect candidates to design and develop nanofluidic sensory devices by introducing a variety of functional moieties on the inner pore surface...
December 18, 2018: Analytica Chimica Acta
Perry Wengrofsky, Ghassan Mubarak, Ahmed Shim, Pramod Theetha Kariyanna, Adam Buzidkowski, Jacob Schwartz, Samy I McFarlane
Marijuana abuse is rapidly growing and currently it is the most coimnon drug of abuse in the United States due to increased legalization for recreational and medicinal use. Delta 9-tetrahydrocannibol, the main psychoactive compound in marijuana, acts via the endocannabinoid system to elicit various cardiovascular physiological effects, and has been associated with many adverse cardiovascular effects such as acute coronary syndrome, arrhythmias, and sudden cardiac death that have previously been reported by our group and others...
2018: American journal of medical case reports
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