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Castells, Maria

Valéry Bocquet, Jessica Barré, Sophie Couffignal, Marylène d'Incau, Charles Delagardelle, Georges Michel, Marc Schlesser, Saverio Stranges, Andrea Kuemmerle, Maria Ruiz-Castell
BACKGROUND: The European Health Examination Survey in Luxembourg (EHES-LUX) is a population based survey performed from 2013 to 2015 with the aim to establish baseline information on the general health status of the Luxembourg population aged 25 to 64 years. The paper introduces the study design, recruitment method and representativeness of the sample, and summarizes the sociodemographic characteristics of participants and the prevalence of major health outcomes. METHODS: EHES-LUX is based on a random sample representative of the population of Luxembourg based on gender, age and district of residence...
October 11, 2018: BMC Public Health
Velia Margarita Cárdenas Villarreal, Rosario Edith Ortiz Félix, Ernesto Cortés-Castell, Patricia Edina Miranda Félix, Milton Carlos Guevara Valtier, María Mercedes Rizo-Baeza
INTRODUCTION: despite the fact that childhood obesity is a serious health problem, little is known about its related factors in early childhood. OBJECTIVE: to evaluate which maternal, cognitive and infant factors influence the infant's energy intake and if these influence their nutritional status before the year. METHODS: descriptive study of correlation. Two hundred and sixty-seven dyads (mother/child) participated. The questionnaires consisted of four instruments for the cognitive variables of the mother (maternal self-efficacy, attitude in the diet, perception of signs of hunger, satiety and weight of the child), energy intake through a 24-hour reminder and sociodemographic and anthropometric data of the mother and child, through which maternal body mass index (BMI) and Z-score of infant weight/height have been calculated...
October 5, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Mauro Pagani, Sevim Bavbek, Adile Berna Dursun, Patrizia Bonadonna, Maria Caralli, Josefina Cernadas, Gabriele Cortellini, Maria Teresa Costantino, Asli Gelincik, Giuseppe Lucchini, Mariana Castells
BACKGROUND: Immediate hypersensitivity reactions (HSRs) to taxanes have been increasing in recent years, but the importance of skin tests in allergological work-up has not been established. OBJECTIVE: In our study we tried to evaluate the role of prick and intradermal tests in the diagnosis of HSRs to paclitaxel and docetaxel. METHODS: In this multicenter prospective study we enrolled patients with immediate HSRs reactions to the aforesaid agents...
October 4, 2018: Journal of Allergy and Clinical Immunology in Practice
Carmelo García-Monzón, Petar D Petrov, Esther Rey, Patricia Marañón, Elvira Del Pozo-Maroto, Carla Guzmán, Javier Rodríguez de Cía, Alfonso J Casado-Collado, Javier Vargas-Castrillón, Alicia Saez, María E Miquilena-Colina, Oreste Lo Iacono, José Vicente Castell, Águeda González-Rodríguez, Ramiro Jover
Hepatic vitamin D receptor (VDR) expression is increased in patients with non-alcoholic fatty liver (NAFL) and is required for liver steatosis in an NAFL mouse model. However, how hepatocyte VDR is involved in setting up steatosis remains unclear. We transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid. The mRNA levels of hepatic VDR- and vitamin D -related genes (cytochrome P450 (CYP) 2R1, CYP27A1, and CYP3A4) were higher in NAFL patients compared to NL subjects...
September 21, 2018: American Journal of Pathology
Liseth Rivero-Sánchez, Jaume Grau, Josep María Augé, Lorena Moreno, Angels Pozo, Anna Serradesanferm, Mireia Díaz, Sabela Carballal, Ariadna Sánchez, Leticia Moreira, Francesc Balaguer, Maria Pellisé, Antoni Castells
Background and study aims  Colorectal cancer (CRC) risk after a positive fecal immunochemical test (FIT) and negative colonoscopy is unknown. We aimed to ascertain the cumulative incidence of post-colonoscopy colorectal cancer (PCCRC) and the manifestation of other lesions that could explain the test positivity in individuals with a negative colonoscopy in a population screening program. Patients and method  Observational study in participants from the first round of a CRC screening program (2010 - 2012) with positive-FIT (≥ 20 μg/g of feces) and negative colonoscopy (without neoplasia)...
September 2018: Endoscopy International Open
Esther Román-Conejos, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, Manuel Sánchez-Molla, María Mercedes Rizo-Baeza, Vicente Francisco Gil-Guillén, Ernesto Cortés-Castell
No validated screening method currently exists for Chronic Obstructive Pulmonary Disease (COPD) in smokers. Therefore, we constructed a predictive model with simple parameters that can be applied for COPD screening to detect fixed airflow limitation. This observational cross-sectional study included a random sample of 222 smokers with no previous diagnosis of COPD undertaken in a Spanish region in 2014-2016. The main variable was fixed airflow limitation by spirometry. The secondary variables (COPD factors) were: age, gender, smoking (pack-years and Fagerström test), body mass index, educational level, respiratory symptoms and exacerbations...
September 6, 2018: Scientific Reports
Oscar Murcia, Míriam Juárez, María Rodríguez-Soler, Eva Hernández-Illán, Mar Giner-Calabuig, Miren Alustiza, Cecilia Egoavil, Adela Castillejo, Cristina Alenda, Víctor Barberá, Carolina Mangas-Sanjuan, Ana Yuste, Luís Bujanda, Joan Clofent, Montserrat Andreu, Antoni Castells, Xavier Llor, Pedro Zapater, Rodrigo Jover
OBJECTIVE: The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to chemotherapy. DESIGN: This retrospective observational study included a population-based cohort of 878 CRC patients. We classified tumours into five different subtypes based on BRAF and KRAS mutation, CIMP status, and MSI...
2018: PloS One
Paulina Torres-Castro, Mar Abril-Gil, María J Rodríguez-Lagunas, Margarida Castell, Francisco J Pérez-Cano, Àngels Franch
Breast milk, due to its large number of nutrients and bioactive factors, contributes to optimal development and immune maturation in early life. In this study, we aimed to assess the influence of some growth factors present in breast milk, such as transforming growth factor-β2 (TGF-β2), epidermal growth factor (EGF), and fibroblast growth factor 21 (FGF21), on the immune response development. Newborn Wistar rats were supplemented daily with TGF-β2, EGF, or FGF21, throughout the suckling period. At day 14 and 21 of life, lymphocytes from mesenteric lymph nodes (MLNs) were isolated, immunophenotyped, and cultured to evaluate their ability to proliferate and release cytokines...
August 27, 2018: Nutrients
Andrea Burón, Francesc Macià, Montserrat Andreu, Maria Pellisé, Xavier Castells, Jaume Grau
INTRODUCTION AND OBJECTIVE: The sensitivity of colorectal cancer screening programmes determines their effectiveness and is directly related to the interval cancer (IC). This study describes the frequency and characteristics of the IC of the Programme of Barcelona, Spain, and analyses its relationship with the quantitative value of the screening test (FIT). MATERIAL AND METHODS: ICs after negative FIT of the first two rounds of the Programme (2010-2013) were included, observation period until July 2017...
August 23, 2018: Medicina Clínica
María Pilar de Lara-Castells, Alexander O Mitrushchenkov
A first-principles study of the spectroscopy of a single hydrogen molecule rotating inside and outside of carbon nanotubes is presented. Density functional theory (DFT)-based symmetry-adapted perturbation theory (SAPT) is applied to analyze the influence of the rotation in the dispersionless and dispersion energy contributions to the adsorbate-nanotube interaction. A potential model for the H2-nanotube interaction is proposed and applied to derive the molecular energy levels of the rotating hydrogen molecule...
August 17, 2018: Physical Chemistry Chemical Physics: PCCP
Eytan Ben-Ami, Maria C Castells, Nathan T Connell, Anna E Rutherford, Katherine A Thornton
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, potentially life-threatening drug-induced hypersensitivity reaction, characterized by cutaneous eruptions, fever, diffuse lymphadenopathy, along with hypereosinophilia, and elevated liver function tests, which in severe cases may lead to fulminant hepatic failure and death. Although DRESS syndrome has been associated with over 50 different drugs including imatinib, it has never been reported in association with imatinib treatment in solid tumors...
October 2018: Anti-cancer Drugs
Daniel Rodríguez-Alcalde, Sabela Carballal, Leticia Moreira, Luis Hernández, Lorena Rodríguez-Alonso, Francisco Rodríguez-Moranta, Victoria Gonzalo, Luis Bujanda, Xavier Bessa, Carmen Poves, Joaquín Cubiella, Inés Castro, Mariano González, Eloísa Moya, Susana Oquiñena, Joan Clofent, Enrique Quintero, Pilar Esteban, Virginia Piñol, Francisco Javier Fernández, Rodrigo Jover, Lucía Cid, Esteve Saperas, María López-Cerón, Miriam Cuatrecasas, Jorge López-Vicente, Liseth Rivero-Sánchez, Gerhard Jung, María Vila-Casadesús, Ariadna Sánchez, Antoni Castells, María Pellisé, Francesc Balaguer
BACKGROUND:  Serrated polyposis syndrome (SPS) has been associated with an increased risk of colorectal cancer (CRC). Accordingly, intensive surveillance with annual colonoscopy is advised. The aim of this multicenter study was to describe the risk of advanced lesions in SPS patients undergoing surveillance, and to identify risk factors that could guide the prevention strategy. METHODS:  From March 2013 to April 2015, 296 patients who fulfilled criteria I and/or III for SPS were retrospectively recruited at 18 centers...
August 1, 2018: Endoscopy
Rocío Casañas, Victoria-Mailen Arfuch, Pere Castellví, Juan-José Gil, Maria Torres, Angela Pujol, Gemma Castells, Mercè Teixidó, Maria Teresa San-Emeterio, Hernán María Sampietro, Aleix Caussa, Jordi Alonso, Lluís Lalucat-Jo
BACKGROUND: One half of adults who develop any mental disorder do so during adolescence. Previous literature showed that Mental Health Literacy (MHL) interventions impact mental health knowledge, reduce the associated stigma, and promote help-seeking among the adolescent population. However, evidence for the effectiveness and cost-effectiveness of these programmes remains inconclusive. The aim of this paper is to present a study protocol that evaluates the effectiveness of the " EspaiJove...
July 31, 2018: BMC Public Health
Cristina Ornelas, Joana Caiado, Alcinda Campos Melo, Manuel Pereira Barbosa, Mariana C Castells, Maria Conceição Pereira Dos Santos
Cytostatics, mainly oxaliplatin, are widely used to treat oncological diseases. There has been an increase in hypersensitivity reactions to these drugs, mostly IgE-mediated. Skin tests are the main diagnostic method used but they may induce irritant local reactions and contamination by health care professionals. The main goals of this work were to evaluate the contribution of the basophil activation test (BAT) as a diagnostic tool for hypersensitivity reactions to oxaliplatin, and to compare the expression of CD63 and CD203c molecules...
July 24, 2018: International Archives of Allergy and Immunology
Rosa Puigpinós-Riera, Adán Castillo Gómez, Anabel Romero Morales, Marta Aller, Xavier Castells, María Sala
OBJECTIVE: To describe and analyse the factors associated with the use of health services (emergency departments, admissions and primary care) in women survivors of breast cancer diagnosed or treated in four university hospitals of Barcelona (Spain) between 2003 and 2013, within the framework of the Cohort DAMA project. METHOD: Descriptive design nested in a mixed cohort (Cohort Dama). We obtained sociodemographic information and information on the use of health services through a questionnaire, and on the tumour from the clinical history...
July 18, 2018: Gaceta Sanitaria
Hanna Tolonen, Päivikki Koponen, Ala'a Al-Kerwi, Nada Capkova, Simona Giampaoli, Jennifer Mindell, Laura Paalanen, Maria Ruiz-Castell, Antonia Trichopoulou, Kari Kuulasmaa
Background: Representative and reliable data on health and health determinants of the population and population sub-groups are needed for evidence-informed policy making; planning and evaluation of prevention programmes; and research. Health examination surveys (HESs) including questionnaires, objective health measurements and analysis of biological samples, provide information on many health indicators that are available not at all or less reliably or completely through administrative registers or health interview surveys...
2018: Archives of Public Health, Archives Belges de Santé Publique
Ana Gutiérrez-Hervás, Ernesto Cortés-Castell, Mercedes Juste-Ruíz, Antonio Palazón-Bru, Vicente Gil-Guillén, María Mercedes Rizo-Baeza
INTRODUCTION: interpretation of accelerometer-derived physical activity in preschool children is confounded by differences in cut-off points. AIM: the purpose of this study was to analyze physical activity in 2-to-7-year-old children to establish reference values for daily activity. METHODS: observational study in children aged 2-7 years, without chronic diseases and whose parents provided informed consent. The main variable was physical activity, measured continuously over 120 hours (three workdays and two weekend days) by accelerometer...
June 27, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
María Pilar de Lara-Castells, Carlos Cabrillo, David A Micha, Alexander O Mitrushchenkov, Tijo Vazhappilly
A first-principles study of the stability and optical response of subnanometer silver clusters Agn (n ≤ 5) on a TiO2(110) surface is presented. First, the adequacy of the vdW-corrected DFT-D3 approach is assessed using the domain-based pair natural orbital correlation DLPNO-CCSD(T) calculations along with the Symmetry-Adapted Perturbation Theory [SAPT(DFT)] applied to a cluster model. Next, using the DFT-D3 treatment with a periodic slab model, we analyze the interaction energies of the atomic silver clusters with the TiO2(110) surface...
July 18, 2018: Physical Chemistry Chemical Physics: PCCP
Christian Manzardo, Maria C Londoño, LLuís Castells, Milagros Testillano, José Luis Montero, Judit Peñafiel, Marta Subirana, Ana Moreno, Victoria Aguilera, María Luisa González-Diéguez, Jorge Calvo-Pulido, Xavier Xiol, Magdalena Salcedo, Valentin Cuervas-Mons, José Manuel Sousa, Francisco Suarez, Trinidad Serrano, Jose Ignacio Herrero, Miguel Jiménez, José R Fernandez, Carlos Giménez, Santos Del Campo, Juan I Esteban-Mur, Gonzalo Crespo, Asunción Moreno, Gloria de la Rosa, Antoni Rimola, Jose M Miro
Direct-acting antivirals have proved to be highly efficacious and safe in monoinfected liver transplant (LT) recipients who experience recurrence of hepatitis C virus (HCV) infection. However, there is a lack of data on effectiveness and tolerability of these regimens in HCV/HIV-coinfected patients who experience recurrence of HCV infection after LT. In this prospective, multicenter cohort study, the outcomes of 47 HCV/HIV-coinfected LT patients who received DAA therapy (with or without ribavirin [RBV]) were compared with those of a matched cohort of 148 HCV-monoinfected LT recipients who received similar treatment...
October 2018: American Journal of Transplantation
Maria Del Mar Rigo-Adrover, Kees van Limpt, Karen Knipping, Johan Garssen, Jan Knol, Adele Costabile, Àngels Franch, Margarida Castell, Francisco José Pérez-Cano
Rotavirus (RV) causes morbidity and mortality among infants worldwide, and there is evidence that probiotics and prebiotics can have a positive influence against infective processes such as that due to RV. The aim of this study was to evidence a preventive role of one prebiotic mixture (of short-chain galactooligosaccharide/long-chain fructooligosaccharide), the probiotic Bifidobacterium breve M-16V and the combination of the prebiotic and the probiotic, as a synbiotic, in a suckling rat double-RV infection model...
2018: Frontiers in Immunology
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