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Amulya Nidhi Shrivastava, Antoine Triller, Ronald Melki
Neuronal Na+ /K+ -ATPase is responsible for the maintenance of ionic gradient across plasma membrane. In doing so, in a healthy brain, Na+ /K+ -ATPase activity accounts for nearly half of total brain energy consumption. The α3-subunit containing Na+ /K+ -ATPase expression is restricted to neurons. Heterozygous mutations within α3-subunit leads to Rapid-onset Dystonia Parkinsonism, Alternating Hemiplegia of Childhood and other neurological and neuropsychiatric disorders. Additionally, proteins such as α-synuclein, amyloid-β, and SOD1 whose aggregation is associated to neurodegenerative diseases directly bind and impair α3-Na+ /K+ -ATPase activity...
December 11, 2018: Neuropharmacology
Stacy M Scofield-Kaplan, Sagar Y Patel, Ronald Mancini
Reconstruction of the orbital rim and floor following tumor excision is traditionally performed with bone grafts, vascularized grafts, or free flaps. The authors describe a case of an osteosarcoma of the maxillary sinus and a second case of an ossifying fibroma of the orbital floor, both of which required reconstruction of the orbital floor and rim. In both of these cases, reconstruction of the orbital floor and rim was performed with a titanium implant whose anterior portion was bent inferiorly to recreate the orbital rim...
December 7, 2018: Ophthalmic Plastic and Reconstructive Surgery
Mark S Komrad, Ronald W Pies, Annette L Hanson, Cynthia M A Geppert
No abstract text is available yet for this article.
November 27, 2018: Journal of Clinical Psychiatry
James A Naifeh, Robert J Ursano, Ronald C Kessler, Alan M Zaslavsky, Matthew K Nock, Catherine L Dempsey, Danielle Bartolanzo, Tsz Hin Hinz Ng, Pablo A Aliaga, Kelly L Zuromski, Hieu M Dinh, Carol S Fullerton, Tzu-Cheg Kao, Holly B Herberman Mash, Nancy A Sampson, Gary H Wynn, Murray B Stein
BACKGROUND: Most people with suicide ideation (SI) do not attempt suicide (SA). Understanding the transition from current/recent SI to SA is important for mental health care. Our objective was to identify characteristics that differentiate SA from 30-day SI among representative U.S. Army soldiers. METHODS: Using a unique case-control design, soldiers recently hospitalized for SA (n = 132) and representative soldiers from the same four communities (n = 10,193) were administered the same questionnaire...
December 14, 2018: Depression and Anxiety
Brian S Eastwood, Bryan M Hooks, Ronald F Paletzki, Nathan J O'Connor, Jacob R Glaser, Charles R Gerfen
Advances in molecular neuroanatomical tools have expanded the ability to map in detail connections of specific neuron subtypes in the context of behaviorally driven patterns of neuronal activity. Analysis of such data across the whole mouse brain, registered to a reference atlas, aids in understanding the functional organization of brain circuits related to behavior. A process is described to image mouse brain sections labeled with standard histochemical techniques, reconstruct those images into a whole brain image volume and register those images to the Allen Mouse Brain Common Coordinate Framework...
December 14, 2018: Journal of Comparative Neurology
Artem M Morozov, Ronald A Sherman
The 21st century is seeing a resurgence in the use of maggot therapy-using the physical and biochemical benefits of fly larvae to debride and heal chronic, problematic wounds. Maggots are repulsive to many people, and this could interfere with the acceptance of this modality. Before instituting a maggot therapy programme at our institution, we sought to better understand the psychological barriers that may exist among patients in the Tver region of Russia. Between 2014 and 2016, all patients with arterial insufficiency and trophic ulcers at City Clinical Hospital No...
December 13, 2018: International Wound Journal
Mark Lenz, Jana Schwinn, Ladina Hofmann-Fliri, Ronald Schwyn, Matthias Knobe, Kajetan Klos, Heike Kielstein, Gunther O Hofmann, Boyko Gueorguiev
Migration profile of helical blades differs from conventional screw design. Tip-apex distance (TAD) greater than 25mm is associated with early failure in hip screws. This study investigates the effect of a reduced TAD on helical blade fixation. Six pairs of human cadaveric femoral heads were used. Bone mineral density (BMD) was determined by pQCT. Local bone quality was evaluated by breakaway torque. Helical blades were implanted with TAD of 20mm (normal) and 6mm (reduced). Specimens were cyclically tested under progressively increasing physiologic loading at 2Hz with starting peak force of 1'000N, increasing by 0...
December 13, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Lana Sanford, Janelle Molloy, Sameera Kumar, Marcus Randall, Ronald McGarry, Damodar Pokhrel
PURPOSE/OBJECTIVES: To evaluate the plan quality and treatment delivery efficiency of single-isocenter/two-lesions volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT). MATERIALS/METHODS: Eight consecutive patients with two peripherally located early stage nonsmall-cell-lung cancer (NSCLC) lung lesions underwent single-isocenter highly conformal noncoplanar VMAT SBRT treatment in our institution. A single-isocenter was placed between the two lesions...
December 8, 2018: Journal of Applied Clinical Medical Physics
Neville Firth, Slade O Jensen, Stephen M Kwong, Ronald A Skurray, Joshua P Ramsay
Strains of Staphylococcus aureus , and to a lesser extent other staphylococcal species, are a significant cause of morbidity and mortality. An important factor in the notoriety of these organisms stems from their frequent resistance to many antimicrobial agents used for chemotherapy. This review catalogues the variety of mobile genetic elements that have been identified in staphylococci, with a primary focus on those associated with the recruitment and spread of antimicrobial resistance genes. These include plasmids, transposable elements such as insertion sequences and transposons, and integrative elements including ICE and SCC elements...
November 2018: Microbiology Spectrum
Kiara Alvarez, Mirko Fillbrunn, Jennifer Greif Green, James S Jackson, Ronald C Kessler, Katie A McLaughlin, Ekaterina Sadikova, Nancy A Sampson, Margarita Alegría
PURPOSE: There has been no comprehensive examination of how race/ethnicity and nativity intersect in explaining differences in lifetime prevalence of mental disorders among Asian, Black, Latino, and White adults. This study aims to estimate racial/ethnic differences in lifetime risk of mental disorders and examine how group differences vary by nativity. METHODS: Survival models were used to estimate racial/ethnic and nativity differences in lifetime risk of DSM-IV anxiety, mood, and substance use disorders in a nationally representative sample of over 20,000 respondents to four US surveys...
December 13, 2018: Social Psychiatry and Psychiatric Epidemiology
Joseph L Laratta, Jamal N Shillingford, Joshua S Meredith, Lawrence G Lenke, Ronald A Lehman, Jeffrey L Gum
Achieving fixation and fusion across the lumbosacral junction has been a challenge for spinal deformity surgeons ever since the development of instrumentation. The S2 alar-iliac (S2AI) trajectory has been introduced as a method of pelvic fixation to decrease strain on S1 screws. The S2AI screws differ in several ways from traditional iliac screws. The trajectory of these screws helps avoid the use of offset connectors due to the screws alignment with the proximal pedicle screw instrumentation. Current literature shows that S2AI screws are effective with low complication rates, but the path of these screws is intimately associated with major neural and vascular structures...
September 2018: Journal of Spine Surgery (Hong Kong)
Ronald H L Li, Fern Tablin
Sepsis is the leading cause of critical illness and mortality in human beings and animals. Neutrophils are the primary effector cells of innate immunity during sepsis. Besides degranulation and phagocytosis, neutrophils also release neutrophil extracellular traps (NETs), composed of cell-free DNA, histones, and antimicrobial proteins. Although NETs have protective roles in the initial stages of sepsis, excessive NET formation has been found to induce thrombosis and multiple organ failure in murine sepsis models...
2018: Frontiers in Veterinary Science
Doris Höflmayer, Eray Öztürk, Cornelia Schroeder, Claudia Hube-Magg, Niclas C Blessin, Ronald Simon, Dagmar S Lang, Emily Neubauer, Cosima Göbel, Marie-Christine Heinrich, Christoph Fraune, Katharina Möller, Moritz Armbrust, Morton Freytag, Andrea Hinsch, Clara Lühr, Magdalena Noack, Viktor Reiswich, Sören Weidemann, Maximilian Bockhorn, Daniel Perez, Jakob R Izbicki, Guido Sauter, Frank Jacobsen
Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3-negative...
December 2018: Oncology Letters
Ronald Kiguba, Helen B Ndagije, Victoria Nambasa, Sheila M Bird
Introduction: Developing countries can improve their pharmacovigilance systems by analysing their own medication safety data. Objective: The aims of this study were to characterize Uganda's reported adverse drug reaction (ADR) onsets in 2012-2015 that were registered on VigiBase® by 31 December 2017, to document delays in international visibility and the influence of covariates on this delay from ADR onsets in 2013 + 2014, to examine data quality, and to illustrate analytical approaches for safety data, particularly for patients receiving antiretroviral therapy (ART)...
2018: Pharmaceutical Medicine
Adaani Frost, David Badesch, J Simon R Gibbs, Deepa Gopalan, Dinesh Khanna, Alessandra Manes, Ronald Oudiz, Toru Satoh, Fernando Torres, Adam Torbicki
A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or complicated patients and patients with confounding comorbidities. New recommendations for screening high-risk groups are given, and current diagnostic tools and emerging diagnostic technologies are reviewed.
December 13, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Michael S Khodadoust, Niclas Olsson, Binbin Chen, Brian Sworder, Tanaya Shree, Chih Long Liu, Lichao Zhang, Debra K Czerwinski, Mark M Davis, Ronald Levy, Joshua E Elias, Ash A Alizadeh
No abstract text is available yet for this article.
December 13, 2018: Blood
Rachel Langevin, Martine Hébert, Sébastien J Bergeron, Manon Duchesne, Yves Lambert, Ronald Chartrand, Jean-Yves Frappier
OBJECTIVE: The objective this study was to investigate the relative contributions of gender, common mental health symptoms, and experiences of interpersonal violence to the presence of sleep disturbances in Youth in Care under Child Welfare Society admitted to residential facilities. METHODS: A sample of 315 teenagers (14-18 years old) completed a self-reported questionnaire upon admission, followed by a medical consultation with a nurse and a physician. Information regarding experiences of interpersonal violence, mental health symptoms, and sleep disturbances was collected using a standardized questionnaire...
November 23, 2018: Sleep Medicine
Shahrzad Mavandadi, Laura O Wray, Ronald W Toseland
This study examined the psychometric properties of the Self-Appraisal of Change Scale, a measure designed to capture domains that are subjectively relevant to caregivers, associated with overall well-being, and amenable to change upon engaging in an intervention. Data from 107 caregivers of veterans with dementia enrolled in a randomized controlled trial of a telephone-delivered caregiver psychoeducation and support group program (the Telehealth Education Program (TEP)) were analyzed. The TEP, which was delivered by master's prepared social workers and a nurse dementia care manager, targeted caregivers' dementia-related knowledge, attitudes, and self-management skills...
December 13, 2018: Journal of Gerontological Social Work
Michel Villatoro-Villar, Michael S Bold, Kenneth J Warrington, Cynthia S Crowson, Gaurav Goyal, Mithun Shah, Ronald S Go, Matthew J Koster
Erdheim-Chester disease (ECD) is a rare histiocytosis of the "L" (Langerhans) group with multisystem involvement that can affect the large and medium-sized arteries mimicking vasculitis. Aortic involvement is common but the frequency and outcome of aortic branch vessel abnormalities are less well described.Patients with ECD were retrospectively identified. Images containing information of arterial involvement within 6 months of diagnosis were considered baseline and compared to last follow-up studies...
December 2018: Medicine (Baltimore)
Urshila Durani, Ronald S Go, Neil E Kay
Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and treatment of these autoimmune disorders, specifically in the setting of B-cell malignancies. AIHA and ITP are classically associated with chronic lymphocytic leukemia (CLL) but have also been reported in plasmacytic and lymphoproliferative disorders. AIHA includes both warm AIHA and cold agglutinin disease, the latter of which is strongly associated with Waldenström macroglobulinemia...
October 2018: Clinical Advances in Hematology & Oncology: H&O
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