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https://www.readbyqxmd.com/read/28032714/n-acetylcysteine-attenuates-cobalt-nanoparticle-induced-cytotoxic-effects-through-inhibition-of-cell-death-reactive-oxygen-species-related-signaling-and-cytokines-expression
#1
Ya-Ke Liu, Hong-Wei Yang, Meng-Hong Wang, Wei Wang, Fan Liu, Hui-Lin Yang
OBJECTIVE: Complex cobalt-chromium alloys, bearing surfaces of the second-generation metal-on-metal (MoM) hip prostheses, are subject to wear and generate cobalt nanoparticles (CoNPs). CoNPs could reduce cellular viability, activate the mitogen-activated protein kinase (MAPK) pathway and increase cell apoptosis via reactive oxygen species (ROS). However, the detailed mechanisms of ROS functioning on CoNP-mediated signaling molecules and cytotoxicity has not yet been fully demonstrated...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28009708/trunnion-corrosion-in-metal-on-polyethylene-total-hip-arthroplasty-a-case-series
#2
Sivashanmugam Raju, Karthikeyan Chinnakkannu, Mohan K Puttaswamy, Matthew J Phillips
INTRODUCTION: Modular total hip arthroplasty implants can help the operating surgeon reproduce the optimum limb length and offset; however, the modularity can lead to fretting and corrosion with associated metal-related problems. Although metal-on-metal bearings are often reported to have problems, recent case reports suggest that the problems can occur with any articulation, usually as a result of problems at the head/neck junction. METHODS: We retrospectively reviewed three cases of a specific implant combination with nontraumatic trunnion failure, with two cases presenting as acute complete dissociation of the femoral head from the neck...
December 22, 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27992643/recall-of-the-asr-xl-head-and-hip-resurfacing-systems
#3
Werner Maurer-Ertl, Joerg Friesenbichler, Lukas A Holzer, Lukas Leitner, Kathrin Ogris, Michael Maier, Andreas Leithner
At the beginning of the 21st century, use of large-diameter, metal-on-metal devices was a popular procedure for hip replacement in young and physically active patients; however, within a few years, the number of revisions increased, resulting in a worldwide recall for the articular surface replacement (ASR) system. Complication rates for the ASR devices implanted at the authors' department are reported, with revision rates of 32% and 30% in the ASR XL Head and ASR Resurfacing groups, respectively. Reasons for revision surgery were serum metal ion elevation, luxation or subluxation, aseptic loosening, soft tissue compromise (adverse reactions to metal debris [ARMD]), and infection...
December 19, 2016: Orthopedics
https://www.readbyqxmd.com/read/27988181/incidence-of-adverse-reactions-to-metal-debris-from-28-mm-metal-on-metal-total-hip-arthroplasties-with-minimum-10-years-of%C3%A2-follow-up-clinical-laboratory-and-ultrasound-assessment-of-44%C3%A2-cases
#4
Béchir Ayoub, Sophie Putman, Pierre Cholewinski, Amandine Paris, Henri Migaud, Julien Girard
BACKGROUND: Total hip arthroplasty with metal-on-metal (MoM) bearings has been suspected to cause adverse reactions to metal debris (ARMD), with the incidence varying greatly by implant type and patient gender. The prevalence of ARMD from small-diameter MoM bearings in women is unknown, especially after 10 years of follow-up (FU). METHODS: Cementless 28-mm MoM total hip arthroplasty bearings (Metasul) were implanted consecutively in 42 active women between 1996 and 2002...
November 15, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27979436/ruminococcus-gnavus-infection-of-a-metal-on-metal-hip-arthroplasty-resembling-a-pseudo-tumour-in-a-72-year-old-woman-with-no-intestinal-symptoms
#5
Belén Fernández-Caso, Diego Domingo García, Laura Cardeñoso Domingo, José Cordero Ampuero
No abstract text is available yet for this article.
December 12, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27979408/aseptic-lymphocytic-dominated-vasculitis-associated-lesions-scores-do-not-correlate-with-metal-ion-levels-or-unreadable-synovial-fluid-white-blood-cell-counts
#6
Darren R Plummer, Paul H Yi, Joshua J Jacobs, Robert M Urban, Mario M Moric, Craig J Della Valle
BACKGROUND: Failed metal-on-metal (MoM) bearings are being increasingly encountered with little information to guide evaluation for aseptic lymphocytic-dominated vasculitis-associated lesions (ALVAL). It is often assumed that elevated metal ion levels correlate with the occurrence of ALVAL. Our purpose was to determine the utility of the erythrocyte sedimentation rate, C-reactive protein, synovial white blood cell count, differential (%PMN), and serum metal ion levels in diagnosing ALVAL...
November 22, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27977422/metallosis-identified-via-intraoperative-cell-salvage
#7
Lauren M Parker, Mark H Yazer, Jonathan H Waters
Intraoperative cell salvage, whereby shed surgical blood is recovered for autologous reinfusion, is frequently used during hip arthroplasty because of the potential for significant blood loss. The following cases describe 2 instances in which chromium and cobalt particles from patients' metal-on-metal hip implants were identified within the blood recovery system. Results of heavy metal testing during the second case suggest that the use of a leukocyte reduction filter effectively reduces metal concentrations to below normal circulating levels...
December 12, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27955657/adverse-reactions-to-metal-debris-occur-with-all-types-of-hip-replacement-not-just-metal-on-metal-hips-a-retrospective-observational-study-of-3340-revisions-for-adverse-reactions-to-metal-debris-from-the-national-joint-registry-for-england-wales-northern-ireland
#8
Gulraj S Matharu, Hemant G Pandit, David W Murray, Andrew Judge
BACKGROUND: Adverse reactions to metal debris (ARMD) have resulted in the high short-term failure rates observed with metal-on-metal hip replacements. ARMD has recently been reported in non-metal-on-metal total hip replacements (non-MoM THRs) in a number of small cohort studies. However the true magnitude of this complication in non-MoM THRs remains unknown. We used a nationwide database to determine the risk of ARMD revision in all non-MoM THRs, and compared patient and surgical factors associated with ARMD revision between non-MoM and MoM hips...
December 13, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27911456/mid-term-results-of-recap-magnum-taperloc-metal-on-metal-total-hip-arthroplasty-with-mean-follow-up-of-7-1-years
#9
Antonios A Koutalos, Aristotelis Kourtis, Ian C Clarke, Evert J Smith
INTRODUCTION: Despite enthusiasm for metal-on-metal bearings, disappointing short- to mid-term outcomes has all but halted the use of this bearing articulation. This review presents mid-term results for the ReCap Magnum total hip replacement. PATIENTS AND METHODS: This prospective study evaluated 79 ReCap/Magnum/Taperloc total hip replacements with mean follow-up of 7.1 (range 3.7-9.2) years. 43 were female and 36 male. Metal ions were measured and radiographic measurement included a 'margin of safety' angle to quantify risk of edge loading...
December 2, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27888094/nano-analyses-of-wear-particles-from-metal-on-metal-and-non-metal-on-metal-dual-modular-neck-hip-arthroplasty
#10
Zhidao Xia, Benjamin F Ricciardi, Zhao Liu, Christopher von Ruhland, Mike Ward, Alex Lord, Louise Hughes, Steven R Goldring, Edward Purdue, David Murray, Giorgio Perino
Increased failure rates due to metallic wear particle-associated adverse local tissue reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty. Retrieved periprosthetic tissue of 53 cases with corrosion/conventional metallic wear particles from 285 revision operations for ALTR was selected for nano-analyses. Three major classes of hip implants associated with ALTR, metal-on-metal hip resurfacing arthroplasty (MoM HRA) and large head total hip replacement (MoM LHTHA) and non-metal-on-metal dual modular neck total hip replacement (Non-MoM DMNTHA) were included...
November 22, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27874913/metal-on-metal-total-hip-arthroplasty-quality-of-online-patient-information
#11
Geoff Crozier-Shaw, Joseph M Queally, John F Quinlan
Metal-on-metal total hip arthroplasty (THA) has generated much attention in the media because of early failure of certain implant systems. This study assessed the quality, accuracy, and readability of online information on metal-on-metal THA. The search terms "metal-on-metal hip replacement" and "metal hip replacement" were entered into the 3 most popular search engines. Information quality was assessed with the DISCERN score and a specific metal-on-metal THA content score. Accuracy of information was assessed with a customized score...
November 22, 2016: Orthopedics
https://www.readbyqxmd.com/read/27857822/revision-of-metal-on-metal-hip-arthroplasty-with-well-fixed-and-positioned-acetabular-component-using-a-dual-mobility-head-and-review-of-literature
#12
Guillem Figueras, Ramón Vives Planell, Ramón Serra Fernàndez, Joan Camí Biayna
BACKGROUND: As a consequence of use of metal-on-metal hip arthroplasties some patients have precised revision for pain or metal hipersensivity reactions among other causes. We propose to salvage monoblock acetabular component and femoral component using a dual-mobility head and perform a lower morbidity operation in young patients preserving host bone stock in cases with well fixed and positioned components. OBJECTIVE: (1) What clinical problems have been reported in patients with Metal-on-metal hip arthroplasties? (2) Could the tribocorrosion potentially cause a fracture of neck femoral component? (3) Can be the dual-mobility head a recourse in metal-on-metal hip revision? METHODS: Ten patients were revised for pain or/and raised Cobalt/Chromium levels between August 2012 and December 2015...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27857480/differences-in-concentration-of-metal-debris-in-blood-serum-and-plasma-samples-of-patients-with-metal-on-metal-hip-resurfacing-arthroplasty
#13
M Khan, J H Kuiper, Christine Sieniawska, J B Richardson
BACKGROUND/AIMS: Cobalt and chromium are released from MOM hips and their precise nature (ions/particles) is not known. Their distribution in serum, plasma, and whole blood may help to determine their nature. METHODS: We measured cobalt and chromium concentrations in plasma, serum, and whole blood samples of patients with resurfacing MOM hips. RESULTS: We found that chromium concentration was highest in plasma, followed by serum and whole blood...
December 2016: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27852907/scoring-the-current-risk-stratification-guidelines-in-follow-up-evaluation-of-patients-after-metal-on-metal-hip-arthroplasty-a-proposal-for-a-metal-on-metal-risk-score-supporting-clinical-decision-making
#14
Daniel K Hussey, Rami Madanat, Gabrielle S Donahue, Ola Rolfson, Charles R Bragdon, Orhun K Muratoglu, Henrik Malchau
BACKGROUND: In the follow-up evaluation of patients with metal-on-metal (MoM) hip replacements, current evidence suggests that orthopaedic surgeons should avoid reliance on any single investigative tool. Current risk stratification guidelines can be difficult to interpret because they do not provide guidance when there are several risk factors in different groups (high and low risk). To improve the clinical utility of risk stratification guidelines, we designed a scoring system to assess the risk of revision...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27844400/editor-s-spotlight-take-5-poor-survivorship-and-frequent-complications-at-a-median-of-10-years-after-metal-on-metal-hip-resurfacing-revision
#15
Seth S Leopold
No abstract text is available yet for this article.
November 14, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27835611/effect-of-cobalt-mediated-toll-like-receptor-4-activation-on-inflammatory-responses-in-endothelial-cells
#16
Sami A Anjum, Helen Lawrence, James P Holland, John A Kirby, David J Deehan, Alison J Tyson-Capper
Cobalt-containing metal-on-metal hip replacements are associated with adverse reactions to metal debris (ARMD), including inflammatory pseudotumours, osteolysis, and aseptic implant loosening. The exact cellular and molecular mechanisms leading to these responses are unknown. Cobaltions (Co2+) activate human Toll-like receptor 4 (TLR4), an innate immune receptor responsible for inflammatory responses to Gram negative bacterial lipopolysaccharide (LPS).We investigated the effect of Co2+-mediated TLR4 activation on human microvascular endothelial cells (HMEC-1), focusing on the secretion of key inflammatory cytokines and expression of adhesion molecules...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27834460/a-randomised-controlled-clinical-study-on-total-hip-arthroplasty-using-4-different-bearings-results-after-10-years
#17
Arne Borgwardt, Bo Zerahn, Sandra D Fabricius, Tine H Bertelsen, Henrik Daugaard, Søren Ribel-Madsen
PURPOSE: To compare 4 different bearings in total hip arthroplasty (THA) in a randomised controlled clinical study on clinical performance. METHODS: 393 patients with osteoarthritis of the hip or avascular necrosis were included and allocated to 1 of the head-and-cup couples zirconia-on-polyethylene (group A), metal-on-metal (group B), zirconia-on-polyethylene with the liner moulded into the shell (group C), or alumina-on-alumina (group D). In the individual case the surgeon could choose other implants if indicated...
November 3, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27829734/601-metal-on-metal-total-hip-replacements-with-36%C3%A2-mm-heads-a-5-minimum-year-follow-up-levels-of-armd-remain-low-despite-a-comprehensive-screening-program
#18
Amit Atrey, Alister Hart, Nasir Hussain, Jonathon Waite, Andrew J Shepherd, Steve Young
BACKGROUND: We conducted a retrospective study to assess the clinical outcome, failure rate, and reason for failure of a large consecutive series of 36 mm MoM Corail/Pinnacle total hip replacements (THRs). METHODS: Between 2006 and 2011, 601 consecutive 36 mm MoM THRs were performed (585 patients). Patients were followed according to the UK Medicines and Healthcare Products Regulatory Agency (MHRA) guidelines. All patients were accounted for and 469 patients (78%) were clinically and radiographically assessed...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27821101/factors-associated-with-symptomatic-pseudotumors-following-metal-on-metal-total-hip-arthroplasty
#19
Masahiro Hasegawa, Yohei Naito, Toshio Yamaguchi, Shinichi Miyazaki, Hiroki Wakabayashi, Akihiro Sudo
BACKGROUND: Pseudotumors associated with metal-on-metal hips can be symptomatic or asymptomatic. The purpose of this study was to identify the characteristics of pseudotumors associated with pain. METHODS: A total of 239 large-diameter, metal-on-metal total hip arthroplasties (THAs) were performed in 222 patients. Screening for pseudotumors was performed using magnetic resonance imaging (MRI) in all patients who underwent metal-on-metal THA, and 57 patients with 62 affected hips showed pseudotumors...
November 7, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27817993/patient-reported-outcomes-after-revision-of-metal-on-metal-total-bearings-in-total-hip-arthroplasty
#20
Ana Mata-Fink, Daniel J Philipson, Benjamin J Keeney, Dipak B Ramkumar, Wayne E Moschetti, Ivan M Tomek
BACKGROUND: Failure of metal-on-metal (MOM) total hip arthroplasty (THA) bearings is often accompanied by an aggressive local reaction associated with destruction of bone, muscle, and other soft tissues around the hip. Little is known about whether patient-reported physical and mental function following revision THA in MOM patients is compromised by this soft tissue damage, and whether revision of MOM THA is comparable with revision of hard-on-soft bearings such as metal-on-polyethylene (MOP)...
October 11, 2016: Journal of Arthroplasty
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