Marie-Luise Sellin, Anika Seyfarth-Sehlke, Mahammad Aziz, Christian Fabry, Katrin Wenke, Paul Johan Høl, Ivan Rios-Mondragon, Mihaela Roxana Cimpan, Marcus Frank, Rainer Bader, Anika Jonitz-Heincke
To improve the wear resistance of articulating metallic joint endoprostheses, the surfaces can be coated with titanium niobium nitride (TiNbN). Under poor tribological conditions or malalignment, wear can occur on these implant surfaces in situ. This study investigated the biological response of human osteoblasts to wear particles generated from TiNbN-coated hip implants. Abrasive particles were generated in a hip simulator according to ISO 14242-1/-2 and extracted with Proteinase K. Particle characteristics were evaluated by electron microscopy and energy dispersive x-ray spectroscopy (EDS), inductively coupled plasma mass spectrometry (ICP-MS) and dynamic light scattering (DLS) measurements...
January 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials