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https://www.readbyqxmd.com/read/29352728/differential-proteomic-analysis-of-synovial-fluid-from-hip-arthroplasty-patients-with-a-pseudotumor-vs-periprosthetic-osteolysis
#1
Isabelle Catelas, Eric A Lehoux, Zhibin Ning, Daniel Figeys, Stephen J Baskey, Paul E Beaulé
Adverse tissue reactions to metal implants, including pseudotumors, can compromise implant functionality and survivorship. The identification of specific proteins in the synovial fluid (SF) of hip arthroplasty patients with a pseudotumor may lead to a better understanding of the underlying pathomechanisms. The objective of the present study was to compare the protein content of SF from patients with a short-term metal-on-metal hip implant associated with a pseudotumor and patients with a long-term metal-on-polyethylene hip implant associated with periprosthetic osteolysis...
January 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29350096/%C3%AE-tocopherol-protected-against-cobalt-nanoparticles-and-cocl2-induced-cytotoxicity-and-inflammation-in-balb-3t3-cells
#2
Xin Yan, Yake Liu, Tian Xie, Fan Liu
CONTEXT: Currently, tissue damage induced by cobalt nanoparticles (CoNPs) and cobalt ions (Co2+) are the most serious adverse effect in the patients with metal-on-metal hip prostheses. Therefore, an urgent need exists for the identification of the mechanisms and the development of therapeutic strategies to limit it. OBJECTIVE: We aimed to explore the mechanisms of cytotoxicity of CoNPs and Co2+ and developed strategies to reduce this cytotoxicity with α-tocopherol treatment...
January 19, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29333941/intraoperative-complications-and-mid-term-follow-up-of-large-diameter-head-metal-on-metal-total-hip-arthroplasty-and-hip-resurfacing-arthroplasty
#3
S S A Miettinen, T J Mäkinen, K Mäkelä, H Huhtala, J S Kettunen, V Remes
BACKGROUND AND AIMS: Large-diameter head total hip arthroplasty and hip resurfacing arthroplasty were popular in Finland from 2000 to 2012 for the treatment of hip osteoarthritis. The aim of this retrospective study was to investigate the mid-term survival of large-diameter head total hip arthroplasty patients operated on in three university hospitals and to compare these results to the survival of hip resurfacing arthroplasty patients. MATERIAL AND METHODS: A total of 3860 hip arthroplasties (3029 large-diameter head total hip arthroplasties in 2734 patients and 831 hip resurfacing arthroplasties in 757 patients) were operated on between January 2004 and December 2009...
January 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29305448/is-the-rate-of-revision-of-36-mm-metal-on-metal-total-hip-arthroplasties-with-pinnacle-acetabular-components-related-to-the-year-of-the-initial-operation-an-interrupted-time-series-analysis-using-data-from-the-national-joint-registry-for-england-and-wales
#4
G S Matharu, L P Hunt, D W Murray, P Howard, H G Pandit, A W Blom, B Bolland, A Judge
AIMS: The aim of this study was to determine whether the rates of revision for metal-on-metal (MoM) total hip arthroplasties (THAs) with Pinnacle components varied according to the year of the initial operation, and compare these with the rates of revision for other designs of MoM THA. PATIENTS AND METHODS: Data from the National Joint Registry for England and Wales included 36 mm MoM THAs with Pinnacle acetabular components which were undertaken between 2003 and 2012 with follow-up for at least five years (n = 10 776) and a control group of other MoM THAs (n = 13 817)...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29305447/metal-on-metal-total-hip-arthroplasty-is-not-associated-with-cardiac-disease
#5
L H Goodnough, A Bala, J I Huddleston Iii, S B Goodman, W J Maloney, D F Amanatullah
AIMS: Many case reports and small studies have suggested that cobalt ions are a potential cause of cardiac complications, specifically cardiomyopathy, after metal-on-metal (MoM) total hip arthroplasty (THA). The impact of metal ions on the incidence of cardiac disease after MoM THA has not been evaluated in large studies. The aim of this study was to compare the rate of onset of new cardiac symptoms in patients who have undergone MoM THA with those who have undergone metal-on-polyethylene (MoP) THA...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29305446/the-risk-of-cardiac-failure-following-metal-on-metal-hip-arthroplasty
#6
S A Sabah, J C Moon, S Jenkins-Jones, C Ll Morgan, C J Currie, J M Wilkinson, M Porter, G Captur, J Henckel, N Chaturvedi, P Kay, J A Skinner, A H Hart, C Manisty
AIMS: The aim of this study was to determine whether patients with metal-on-metal (MoM) arthroplasties of the hip have an increased risk of cardiac failure compared with those with alternative types of arthroplasties (non-MoM). PATIENTS AND METHODS: A linkage study between the National Joint Registry, Hospital Episodes Statistics and records of the Office for National Statistics on deaths was undertaken. Patients who underwent elective total hip arthroplasty between January 2003 and December 2014 with no past history of cardiac failure were included and stratified as having either a MoM (n = 53 529) or a non-MoM (n = 482 247) arthroplasty...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29305442/a-new-year-but-the-spectre-of-metal-on-metal-lives-on
#7
EDITORIAL
J A Skinner, F S Haddad
No abstract text is available yet for this article.
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29303467/prospective-randomized-multicenter-study-of-cervical-arthroplasty-versus-anterior-cervical-discectomy-and-fusion-5-year-results-with-a-metal-on-metal-artificial-disc
#8
Domagoj Coric, Richard D Guyer, Pierce D Nunley, David Musante, Cameron Carmody, Charles Gordon, Carl Lauryssen, Margaret O Boltes, Donna D Ohnmeiss
OBJECTIVE Seven cervical total disc replacement (TDR) devices have received FDA approval since 2006. These devices represent a heterogeneous assortment of implants made from various biomaterials with different biomechanical properties. The majority of these devices are composed of metallic endplates with a polymer core. In this prospective, randomized multicenter study, the authors evaluate the safety and efficacy of a metal-on-metal (MoM) TDR (Kineflex|C) versus anterior cervical discectomy and fusion (ACDF) in the treatment of single-level spondylosis with radiculopathy through a long-term (5-year) follow-up...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29280283/pet-ct-to-detect-adverse-reactions-to-metal-debris-in-patients-with-metal-on-metal-hip-arthroplasty-an-exploratory-prospective-study
#9
Erik Aro, Marko Seppänen, Keijo T Mäkelä, Pauliina Luoto, Anne Roivainen, Hannu T Aro
Metal-on-metal (MoM) bearings in total hip arthroplasties and hip resurfacing arthroplasties have recently shown a new type of complication: adverse reactions to metal debris (ARMD). ARMD is characterized by local severe inflammation and tissue necrosis leading to implant failures. The gluteal muscle region is important for the patient outcome after revision surgery. This prospective positron emission tomography/computed tomography (PET/CT) study was undertaken to evaluate the characteristics of 2-deoxy-2-[18 F]fluoro-d-glucose ([18 F]FDG) and [68 Ga]Gallium citrate ([68 Ga]Citrate) PET/CT in ARMD patients...
December 27, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29278375/tribochemical-characterization-and-tribocorrosive-behavior-of-cocrmo-alloys-a-review
#10
REVIEW
Wei Quan Toh, Xipeng Tan, Ayan Bhowmik, Erjia Liu, Shu Beng Tor
Orthopedic implants first started out as an all-metal hip joint replacement. However, poor design and machinability as well as unsatisfactory surface finish subjected the all-metal joint replacement to being superseded by a polyethylene bearing. Continued improvement in manufacturing techniques together with the reality that polyethylene wear debris can cause hazardous reactions in the human body has brought about the revival of metal-on-metal (MOM) hip joints in recent years. This has also led to a relatively new research area that links tribology and corrosion together...
December 26, 2017: Materials
https://www.readbyqxmd.com/read/29276121/a-randomized-seven-year-study-on-performance-of-the-stemmed-metal-m2a-magnum-and-ceramic-c2a-taper-and-the-resurfacing-recap-hip-implants
#11
Arne Borgwardt, Lotte Borgwardt, Bo Zerahn, Henrik Daugaard, Lise Borgwardt, Søren Ribel-Madsen
BACKGROUND: The large-diameter metal-on-metal hip prostheses were expected to have low wear and reduced dislocation rate compared to the traditional metal-on-polyethylene implants. We compare 2 such prostheses, the ReCap resurfacing implant and the M2a-Magnum stemmed implant, with the C2a ceramic-on-ceramic stemmed implant as to clinical performance, serum concentrations of prosthesis metals, and the durability of the implants in a randomized, controlled clinical trial at 7 years of follow-up...
December 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29276120/damage-assessment-of-retrieved-birmingham-monoblock-cups-is-conversion-to-dual-mobility-head-a-viable-revision-option
#12
Trevor C Gascoyne, Brent A Lanting, Kieran J Derksen, Matthew G Teeter, Thomas R Turgeon
BACKGROUND: A novel revision technique for failed hip resurfacings involves retention of the acetabular cup, if well-fixed, which is mated to dual-mobility (DM) prosthesis in a traditional hip replacement configuration. It is unknown whether existing damage on the retained cup will result in unacceptable wear of the DM prosthesis. METHODS: Thirty retrieved Birmingham (Smith & Nephew) monoblock cups were visually scored for damage features and area of coverage. Surface roughness measurements were obtained within each damage feature as well as reference points on each cup...
October 26, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29261128/hard-chrome-coated-and-fullerene-doped-metal-surfaces-in-orthopedic-bearings
#13
Robert Sonntag, Katja Feige, Claudia Beatriz Dos Santos, Jan Philippe Kretzer
Metal-on-metal bearings for total hip replacements have been introduced as an alternative to polyethylene in young and more active patients. These have, however, been shown to be prone to implant malpositioning and have been limited by some specific design features. In that context, coatings present an option to increase wear resistance by keeping the high fracture strength of the metal substrate. A custom-made electroplating setup was designed for the coating of CoCr substrates using (a) an industrial standard chromium electrolyte; (b) a custom-made hexavalent chromium (Cr6+) electrolyte with a reduced chromium trioxide (CrO₃) content, both without solid additives and (c) with the addition of fullerene (C60) nanoparticles; and (d) a trivalent chromium (Cr3+) electrolyte with C60 addition...
December 20, 2017: Materials
https://www.readbyqxmd.com/read/29260384/predictive-factors-for-metal-ion-levels-in-metal-on-metal-total-hip-arthroplasty
#14
Maximilian F Kasparek, Lisa Renner, Martin Faschingbauer, Wenzel Waldstein, Michael Weber, Friedrich Boettner
INTRODUCTION: Although metal-on-metal (MoM) total hip arthroplasty (THA) and hip resurfacings (HR) have similar bearing surfaces and comparable wear rates, metal ion levels and risk of failure are higher for MoM-THA. The mechanism behind the increased metal ion levels in large head MoM-THA is not completely understood. The current study aims to identify predictive factors for increased metal ion levels in unilateral and bilateral large head MoM-THA. MATERIALS AND METHODS: 99 Birmingham modular MoM-THA in 87 patients with metal ion levels at least 36 months after index procedure were analyzed...
December 19, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29244690/aseptic-lymphocyte-dominated-vasculitis-associated-lesion-as-early-as-six-weeks-after-total-hip-replacement-a-case-report
#15
Sajid Khawaja, Graeme Holt, Aman Khan
CASE: A 40-year-old man who underwent total hip replacement on the left side with a metal-on-metal (MOM) implant reported swelling at the operative site within 6 weeks of the arthroplasty. Tissue sampled during the revision arthroplasty showed an aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL). CONCLUSION: ALVAL is a widely recognized complication of MOM hip implants and needs to be considered early, even in completely asymptomatic patients with normal metal ion levels and normal radiographs...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29228956/analysis-of-bearing-wear-whole-blood-and-synovial-fluid-metal-ion-concentrations-and-histopathological-findings-in-patients-with-failed-asr-hip-resurfacings
#16
Lari Lehtovirta, Aleksi Reito, Jyrki Parkkinen, Harry Hothi, Johann Henckel, Alister Hart, Antti Eskelinen
BACKGROUND: Adverse Reaction to Metal Debris (ARMD) is still a major reason for revision surgeries in patients with metal-on-metal (MoM) hip replacements. ARMD consists of a wide range of alterations in periprosthetic tissues, most important of which are metallosis, inflammation, pseudotumors and necrosis. Studies investigating histopathological findings and their association to implant wear or indirect measures of wear have yielded inconsistent results. Therefore, we aimed to investigate bearing surface wear volume, whole blood and synovial fluid metal ion concentrations, histopathological findings in periprosthetic tissues and their associations...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29204485/arthroprosthetic-cobaltism-associated-with-cardiomyopathy
#17
Ryan S Charette, Alexander L Neuwirth, Charles L Nelson
Systemic cobaltism related to metal-on-metal total hip arthroplasty has been published in case reports and series with effects on the cardiac, neurologic, endocrine, and immunologic systems. This case report presents a 46-year-old male who underwent bilateral metal-on-metal total hip arthroplasty and subsequently developed cardiomyopathy requiring left ventricular assist device implantation. Intervention with bilateral revision to non-cobalt-containing implants resulted in improved cardiac function. This case report will alert clinicians to the presentation of this rare but devastating complication while also displaying improvement following revision total hip arthroplasty...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29204484/pseudotumor-in-ceramic-on-metal-total-hip-arthroplasty
#18
Yoni M Blau, Andrew J Meyers, Mauro Giordani, John P Meehan
The increasing demand for total hip arthroplasty (THA) in relatively young, high-demand patients has led to the use of hard-on-hard bearing surfaces. Adverse local tissue reaction/pseudotumor and elevated serum metal ion levels are commonly reported complications encountered in metal-on-metal THA, while audible articulation and rim fracture are reported in ceramic-on-ceramic THA. For this reason, ceramic-on-metal THA was implemented as an ideal hard-on-hard bearing combination. In this report, we describe a case of bilateral simultaneous ceramic-on-metal THA in a 69-year-old woman who presented 7 years postoperatively with unilateral hip pain associated with underlying pseudotumor and elevated serum cobalt and chromium ion levels...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29203637/can-zinc-protect-cells-from-the-cytotoxic-effects-of-cobalt-ions-and-nanoparticles-derived-from-metal-on-metal-joint-arthroplasties
#19
Y Liu, H Zhu, H Hong, W Wang, F Liu
OBJECTIVES: Recently, high failure rates of metal-on-metal (MOM) hip implants have raised concerns of cobalt toxicity. Adverse reactions occur to cobalt nanoparticles (CoNPs) and cobalt ions (Co2+) during wear of MOM hip implants, but the toxic mechanism is not clear. METHODS: To evaluate the protective effect of zinc ions (Zn2+), Balb/3T3 mouse fibroblast cells were pretreated with 50 μM Zn2+ for four hours. The cells were then exposed to different concentrations of CoNPs and Co2+ for four hours, 24 hours and 48 hours...
December 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29201158/biomonitoring-method-for-the-analysis-of-chromium-and-cobalt-in-human-whole-blood-using-inductively-coupled-plasma-kinetic-energy-discrimination-mass-spectrometry-icp-ked-ms
#20
Joaudimir Castro Georgi, Yuliya L Sommer, Cynthia D Ward, Po-Yung Cheng, Robert L Jones, Kathleen L Caldwell
The Centers for Disease Control and Prevention developed a biomonitoring method to rapidly and accurately quantify chromium and cobalt in human whole blood by ICP-MS. Many metal-on-metal hip implants which contain significant amounts of chromium and cobalt are susceptible to metal degradation. This method is used to gather population data about chromium and cobalt exposure of the U.S. population that does not include people that have metal-on-metal hip implants so that reference value can be established for a baseline level in blood...
2017: Analytical Methods: Advancing Methods and Applications
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