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Vera H Buss, Kayla Lee, Mark Naunton, Gregory M Peterson, Sam Kosari
The prolongation of the QT interval is a relatively rare but serious adverse drug reaction. It can lead to torsade de pointes, which is potentially life-threatening. The study's objectives were: determine the use of QT interval-prolonging drugs in an elderly community-dwelling population at risk of medication misadventure and identify recommendations regarding the risk of QT interval prolongation made by pharmacists when performing medication reviews. In a retrospective evaluation, 500 medication review reports from Australian pharmacists were analysed...
December 10, 2018: Journal of Clinical Medicine
Marie-Thérèse Lussier, Fatoumata Binta Diallo, Pierre Pluye, Roland Grad, Andréa Lessard, Caroline Rhéaume, Michel Labrecque
OBJECTIVE: To draw a portrait of drug sample distribution and to assess the concordance between drug samples distributed and the medical problems encountered in the ambulatory primary health care setting. DESIGN: Descriptive cross-sectional survey. A self-administered questionnaire was distributed to all health care professionals (HCPs) in family medicine teaching units (FMTUs) that kept drug samples between February and December 2013. Dispensers were defined as HCPs reporting the use of drug samples...
December 2018: Canadian Family Physician Médecin de Famille Canadien
Christopher W Liu, Anuj Bhatia, Arlene Buzon-Tan, Susan Walker, Dharini Ilangomaran, Jamal Kara, Lakshmikumar Venkatraghavan, Atul J Prabhu
BACKGROUND: The recreational and medical use of cannabinoids has been increasing. While most studies and reviews have focused on the role of cannabinoids in the management of acute pain, no study has examined the postoperative outcomes of surgical candidates who are on cannabinoids preoperatively. This retrospective cohort study examined the impact of preoperative cannabinoid use on postoperative pain scores and pain-related outcomes in patients undergoing major orthopedic surgery. METHODS: Outcomes of patients who had major orthopedic surgery at our hospital between April 1, 2015 and June 30, 2017 were reviewed...
December 7, 2018: Anesthesia and Analgesia
Renata Domagała-Rodacka, Tomasz Rodacki, Danuta Owczarek, Dorota Cibor, Paweł Zagrodzki
INTRODUCTION: The history of using performance-enhancing substances (PES) is long and it goes back to ancient times. At present, PES are employed at all levels of sport competition, starting from Olympic level contestants to individuals recreationally involved in various sports disciplines. PURPOSE: e objective of the study was examining the views on doping in sports in a group of physicians, together with evaluating the frequency of their contacts with this phenomenon, in their professional activities...
2018: Folia Medica Cracoviensia
Ai Shiraishi, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Yuri Tsuji, Makio Yamaga, Hiroaki Koga
AIM: To examine the effects of oral management provided by dental hygienists (DH) on patient outcomes in post-acute rehabilitation. METHODS: We carried out a retrospective cohort study with 1056 patients newly admitted to a post-rehabilitation hospital in Japan. DH care was defined as two or more consecutive instances of oral management provided by a ward DH during hospitalization. The primary outcome was the motor domain of Functional Independence Measure score at discharge...
December 5, 2018: Geriatrics & Gerontology International
Xue-Fei Ding, Tian-Bao Huang, Ying Gao, Sheng-Ming Lu, Hua-Zhi Tao, Jia-Nan Xu, Yao-Zong Xu, Fei Wang, Yu-Quan Zhou, Guang-Chen Zhou, Yang Luan
OBJECTIVE: To evaluate the clinical significance of permanent 125 I prostate brachytherapy in patients with castration-resistant prostate cancer. METHODS: A retrospective study of 45 patients with castration-resistant prostate cancer from the Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China was carried out. Patients were divided into two groups according to different treatments: 21 patients received endocrine therapy alone (control group), and 24 patients underwent brachytherapy combined with endocrine therapy (treatment group)...
December 4, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Makoto Shiragami
We have been studying the way advertisements for medicines have been monitored by the Health, Labour and Welfare Sciences Research Grants. In the last fiscal year, we identified products that were being advertised to general consumers, such as OTC drugs and designated quasi-drugs, and made recommendations to the Ministry of Health, Labour and Welfare on the methods of advertisement. Members of our research group, including physicians, pharmacists, and consumers, pointed out that advertisements for so-called health foods and foods with functional claims were much more unregulated than those for drugs, including OTC drugs...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Todd Yezefski, Ann Schwemm, Michelle Lentz, Katie Hone, Veena Shankaran
High out-of-pocket (OOP) spending on cancer drugs is a known contributor to "financial toxicity" among cancer patients. Many predict that this problem will only worsen as patients continue to bear more responsibility for the cost of their medical care and as the use of oral chemotherapeutic agents increases. Although foundations and pharmaceutical companies offer patient assistance programs (PAPs) to improve drug affordability, the degree to which these programs are used is poorly understood. There are several barriers to the use of PAPs that not only affect access to patients who may benefit but also create limitations on the research and study of these programs...
October 2018: Seminars in Hematology
Joel T Wu, Jennifer B McCormick
Broad dissemination and consumption of false or misleading health information, amplified by the internet, poses risks to public health and problems for both the health care enterprise and the government. In this article, we review government power for, and constitutional limits on, regulating health-related speech, particularly on the internet. We suggest that government regulation can only partially address false or misleading health information dissemination. Drawing on the American Medical Association's Code of Medical Ethics , we argue that health care professionals have responsibilities to convey truthful information to patients, peers, and communities...
November 1, 2018: AMA Journal of Ethics
Vaibhav Wani, Ankur Kulkarni, Bhushan Pustake, Vilas Takate, Parag Wani, Jasraj Singh Sondhi
Introduction: The incidence of childhood malignancy is greatest in the 1st year of life, with the second peak to be found at 2-3 years of age. The aim for the study was to investigate the incidence and nature of oral problems occurring in a population of child cancer patients; the other aim was to assess the dental management of the treatment undergoing children. Materials and Methods: All child patients between 2 and 15 years old were admitted to the medical hospital for the treatment of newly diagnosed oral cancer over a period of 1 year were included in the study...
October 2018: Journal of Cancer Research and Therapeutics
S Sultana, Q H Jaigirdar, M A Islam, A K Azad
Onychomycosis is a common nail problem in our country. Diabetic patients are more prone to develop onychomycosis. Various types of fungi are the causative agents of nail infections. This cross sectional explorative study was designed to find out the pattern of onychomycosis among diabetic and non-diabetic patients attending the out patient Department of Dermatology and Venereology and Endocrinology of Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh from July 2012 to June 2013. Clinically diagnosed patients of onychomycosis with diabetic or non-diabetic were included purposively in this study...
October 2018: Mymensingh Medical Journal: MMJ
Helen Payne, Susan Brooks
Medically unexplained symptoms (MUS) are common and costly in both primary and secondary health care. It is gradually being acknowledged that there needs to be a variety of interventions for patients with MUS to meet the needs of different groups of patients with such chronic long-term symptoms. The proposed intervention described herewith is called The BodyMind Approach (TBMA) and promotes learning for self-management through establishing a dynamic and continuous process of emotional self-regulation. The problem is the mismatch between the patient's mind-set and profile and current interventions...
2018: Frontiers in Psychology
Bram J Mertens, Henk-Frans Kwint, Rob J van Marum, Marcel L Bouvy
Background Automated multidose drug dispensing is used to support patients with their medication management. Though multidose drug dispensing systems are frequently used, little is known about patients' experiences with multidose drug dispensing systems. Objective To explore patients' experiences with the initiation and use of multidose drug dispensing systems. Setting A survey was carried out with patients using multidose drug dispensing systems through three community pharmacies. Method A semi-structured interview protocol was designed based on existing literature and a pilot study...
November 26, 2018: International Journal of Clinical Pharmacy
Ronit Shtrichman, Stefan Conrad, Kai Schimo, Ran Shachar, Ehud Machluf, Enrique Mindal, Howard Epstein, Shirli Epstein, Alan Paz
BACKGROUND: Medication nonadherence is a major problem in health care, imposing poor clinical outcomes and a heavy financial burden on all stakeholders. Current methods of medication adherence assessment are severely limited: they are applied only periodically, do not relate to actual pill intake, and suffer from patient bias due to errors, misunderstanding, or intentional nonadherence. ReX is an innovative medication management system designed to address poor patient adherence and enhance patient engagement with their therapy...
November 26, 2018: JMIR Human Factors
Hyun Soon Kim, Dae Hee Kim, Hai-Jeon Yoon, Woon Jeong Lee, Seon Hee Woo, Seung Pill Choi
Background: Vancomycin-resistant enterococci (VRE) infections have become a major healthcare-associated pathogen problem worldwide. Nosocomial VRE infections could be effectively controlled by screening patients at high risk of harboring VRE and thereby lowering the influx of VRE into healthcare centers. In this study, we evaluated factors associated with VRE colonization in patients transferred to emergency departments, to detect patients at risk for VRE carriage. Methods: This study was conducted in the emergency department of a medical college-affiliated hospital in Korea...
November 26, 2018: Journal of Korean Medical Science
Thierry Hannedouche, Denis Fouque, Dominique Joly
Metabolic complications of chronic kidney disease (CKD) are frequent; the aims of this review are to present a 2018 update for hyperkalemia, hyperphosphatemia and anemia. Hyperkalemia is defined by a plasma level above 5.0 mmol/L, after ruling out pre-analytical problems such as hemolysis. It is frequent in CKD, most often due to drugs and notably renin/ angiotensin blockers. Chronic hyperkalemia is deleterious, with an increased risk of mortality. Therapeutic strategies to decrease the incidence and severity of hyperkalemia are therefore crucial in nephrology: experts recommend to maintain the renin/angiotensin blockers as long as possible, whilst associating diuretics and potassium binders...
November 2018: Néphrologie & Thérapeutique
M J Hajjar-Nejad, Natalia Kubicki, David Morales, Stephen M Kavic
BACKGROUND: Quality improvement (QI) activities are an integral part of residency training. We started the process to implement team-based, multilevel QI project streams within our academic surgical residency by studying resident perceptions. OBJECTIVE: Our residency carried out 6 QI projects in line with the American Council for Graduate Medical Education competencies. A resident survey was completed in 2016 to measure resident perceptions of an individual versus team-based QI project approach...
November 21, 2018: Journal of Surgical Education
Evija Gutmane, Normunds Suna, Anastasija Tomilova, Lelde Liepina, Valdis Folkmanis, Guntis Karelis
Severe alcohol abuse and related medical and social functioning risks, as well as clinically significant depression, are common in patients who are admitted to hospital with alcohol-related seizures (ARS) and significantly affect the quality of life of the patient. Compared with studies involving patients with alcohol dependence, no large-scale studies with the aim of finding the prevalence and severity of depression and its most commonly affected aspects for patients with ARS have been carried out in Latvia yet...
November 20, 2018: Epilepsy & Behavior: E&B
Małgorzata Bulanda, Magdalena Leśniak, Judyta Szałkowska, Weronika Madej, Agata Wojtyna, Maria Czarnobilska, Daniel Bulanda, Ewa Czarnobilska
Anaphylaxis is an increasing problem in public health. The food allergens (mainly milk, eggs, and peanuts) are the most frequent cause of anaphylaxis in children and youth. In order to define the cause of anaphylaxis, skin tests, the determination of the concentration of specific IgE in the blood and basophil activation test are conducted. In vitro tests are preferred due to the risk of allergic response during in vivo tests. Component-resolved diagnosis (CRD) is an additional tool in allergology, recommended in the third level of diagnostics when there are diagnostic doubts after the above mentioned tests have been carried out...
2018: Folia Medica Cracoviensia
Patricia Enel, Frederique Retornaz, Isabelle Ravaux, Jean-Pierre de Jaureguiberry, Patrick Philibert, Thierry Allegre, Stephane Chadapaud, Rolande Cohen-Valensi, Patricia Granet-Brunello, Laurence Pelissier, Gilles Pichancourt, Sylvie Bregigeon, Frank Tollinchi, Albert Darque, Nathalie Petit
Aging persons living with HIV may develop multiple health problems, including comorbidities, and altered physical and mental health, earlier than non-infected people. They may also experience social deprivation. We assessed the prevalence of social deprivation and its relationship with health indicators in older persons living with HIV. An 18-month, multicenter, cross-sectional study was carried out between 2013 and 2014 focusing on patients ≥50-years of age followed-up in 12 dedicated HIV medical hospital units located in the South of France and involved the VISAGE study group...
November 22, 2018: AIDS Care
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