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(Boswellia or Frankincense) AND (Nerve or autoimmune or immune* )

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https://www.readbyqxmd.com/read/29969452/combined-acetyl-11-keto-%C3%AE-boswellic-acid-and-radiation-treatment-inhibited-glioblastoma-tumor-cells
#1
Sefora Conti, Akiva Vexler, Liat Edry-Botzer, Lital Kalich-Philosoph, Benjamin W Corn, Natan Shtraus, Yaron Meir, Lior Hagoel, Alexander Shtabsky, Sylvia Marmor, Gideon Earon, Shahar Lev-Ari
Glioblastoma multiforme (GBM) is the most common and most aggressive subtype of malignant gliomas. The current standard of care for newly diagnosed GBM patients involves maximal surgical debulking, followed by radiation therapy and temozolomide chemotherapy. Despite the advances in GBM therapy, its outcome remains poor with a median survival of less than two years. This poor outcome is partly due to the ability of GBM tumors to acquire adaptive resistance to therapy and in particular to radiation. One of the mechanisms contributing to GBM tumor progression and resistance is an aberrant activation of NF-ĸB, a family of inducible transcription factors that play a pivotal role in regulation of many immune, inflammatory and carcinogenic responses...
2018: PloS One
https://www.readbyqxmd.com/read/29784005/cd8-t-cells-mediate-the-antitumor-activity-of-frankincense-and-myrrh-in-hepatocellular-carcinoma
#2
Chun Xu, Xian Lu, Wei Liu, Anxian Chen, Gang Meng, Hailin Zhang, Binghua Li, Yonghui Zhang, Junhua Wu, Jiwu Wei
BACKGROUND: Tumor-promoting inflammation is an emerging hallmark of cancer, which participates in both cancer progression and immune escape. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer with an extremely poor prognosis. Frankincense and myrrh are anti-inflammation agents commonly used in clinic. The purpose of this study is to investigate whether extract of frankincense and myrrh (FM) downregulates inflammatory microenvironment of HCC and thereby restores antitumor immune responses...
May 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29731716/protective-effect-of-casperome-%C3%A2-an-orally-bioavailable-frankincense-extract-on-lipopolysaccharide-induced-systemic-inflammation-in-mice
#3
Konstantin Loeser, Semjon Seemann, Stefanie König, Isabell Lenhardt, Mona Abdel-Tawab, Andreas Koeberle, Oliver Werz, Amelie Lupp
Introduction: Despite recent advances in critical care, sepsis remains a crucial cause of morbidity and mortality in intensive care units. Therefore, the identification of new therapeutic strategies is of great importance. Since ancient times, frankincense is used in traditional medicine for the treatment of chronic inflammatory disorders such as rheumatoid arthritis. Thus, the present study intends to evaluate if Casperome® (Casp), an orally bioavailable soy lecithin-based formulation of standardized frankincense extract, is able to ameliorate systemic effects and organ damages induced by severe systemic inflammation using a murine model of sepsis, i...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29623934/acetyl-11-keto-%C3%AE-boswellic-acid-extracted-from-boswellia-serrata-promotes-schwann-cell-proliferation-and-sciatic-nerve-function-recovery
#4
Xiao-Wen Jiang, Bin-Qing Zhang, Lu Qiao, Lin Liu, Xue-Wei Wang, Wen-Hui Yu
Frankincense can promote blood circulation. Acetyl-11-keto-β-boswellic acid (AKBA) is a small molecule with anti-inflammatory properties that is derived from Boswellia serrata. Here, we hypothesized that it may promote regeneration of injured sciatic nerve. To address this hypothesis, we established a rat model of sciatic nerve injury using a nerve clamping method. Rats were administered AKBA once every 2 days at doses of 1.5, 3, and 6 mg/kg by intraperitoneal injection for 30 days from the 1st day after injury...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29450150/chemical-composition-analysis-and-in-vitro-biological-activities-of-ten-essential-oils-in-human-skin-cells
#5
Xuesheng Han, Cody Beaumont, Nicole Stevens
Research on the biological effects of essential oils on human skin cells is scarce. In the current study, we primarily explored the biological activities of 10 essential oils (nine single and one blend) in a pre-inflamed human dermal fibroblast system that simulated chronic inflammation. We measured levels of proteins critical for inflammation, immune responses, and tissue-remodeling processes. The nine single oils were distilled from Citrus bergamia (bergamot), Coriandrum sativum (cilantro), Pelargonium graveolens (geranium), Helichrysum italicum (helichrysum), Pogostemon cablin (patchouli), Citrus aurantium (petitgrain), Santalum album (sandalwood), Nardostachys jatamansi (spikenard), and Cananga odorata (ylang ylang)...
December 2017: Biochimie open
https://www.readbyqxmd.com/read/29450138/biological-activities-of-frankincense-essential-oil-in-human-dermal-fibroblasts
#6
Xuesheng Han, Damian Rodriguez, Tory L Parker
Although frankincense essential oil (FREO) has become increasingly popular in skin care, research on its biological activities in human skin cells is scarce, if not completely absent. In the current study, we explored the biological activities of FREO in pre-inflamed human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. FREO exhibited robust anti-proliferative activity in these skin cells. It also significantly inhibited collagen III, interferon gamma-induced protein 10, and intracellular cell adhesion molecule 1...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/28386311/antioxidant-and-ex-vivo-immune-system-regulatory-properties-of-boswellia-serrata-extracts
#7
Daniela Beghelli, Gloria Isani, Paola Roncada, Giulia Andreani, Onelia Bistoni, Martina Bertocchi, Giulio Lupidi, Alessia Alunno
Boswellia serrata (BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially available B...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#8
REVIEW
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27671822/boswellic-acids-and-their-role-in-chronic-inflammatory-diseases
#9
REVIEW
H P T Ammon
Boswellic acids, which are pentacyclic triterpenes belong to the active pharmacological compounds of the oleogum resin of different Boswellia species. In the resin, more than 12 different boswellic acids have been identified but only KBA and AKBA received significant pharmacological interest. Biological Activity: In an extract of the resin of Boswellia species multiple factors are responsible for the final outcome of a therapeutic effect, be it synergistic or antagonistic. Moreover, the anti-inflammatory actions of BAs are caused by different mechanisms of action...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27366027/favorable-results-from-the-use-of-herbal-and-plant-products-in-inflammatory-bowel-disease-evidence-from-experimental-animal-studies
#10
REVIEW
John K Triantafillidis, Aikaterini Triantafyllidi, Constantinos Vagianos, Apostolos Papalois
The use of herbal therapy for inflammatory bowel disease is increasing worldwide. The aim of this study was to review the available literature on the efficacy of herbal therapy in experimental colitis. All relevant studies published in Medline and Embase up to June 2015 have been reviewed. The results of bowel histology and serum parameters have been recorded. A satisfactory number of published experimental studies, and a quite large one of both herbal and plant products tested in different studies have been reported...
July 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/27143985/effect-of-frankincense-extract-on-nerve-recovery-in-the-rat-sciatic-nerve-damage-model
#11
Xiaowen Jiang, Jun Ma, Qingwei Wei, Xinxin Feng, Lu Qiao, Lin Liu, Binqing Zhang, Wenhui Yu
This study investigated the effect of frankincense extract on peripheral nerve regeneration in a crush injury rat model. Forty-eight Sprague-Dawley rats were randomly divided into four groups: control and frankincense extract low-, medium-, and high-dose groups. At days 7, 14, 21, and 28 following the surgery, nerve regeneration and functional recovery were evaluated using the sciatic functional index (SFI), expression of GAP-43, and the proliferation of Schwann cells (SCs) in vivo and in vitro. At day 7, the SFI in the frankincense extract high-dose group was significantly improved compared with the control group...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26361729/boswellic-acids-target-the-human-immune-system-modulating-antimicrobial-peptide-ll-37
#12
Arne Henkel, Lars Tausch, Max Pillong, Johann Jauch, Michael Karas, Gisbert Schneider, Oliver Werz
The antimicrobial peptide LL-37 is the sole member of the human cathelicidin family with immune system-modulating properties and roles in autoimmune disease development. Small molecules able to interact with LL-37 and to modulate its functions have not been described yet. Boswellic acids (BAs) are pentacyclic triterpene acids that are bioactive principles of frankincense extracts used as anti-inflammatory remedies. Although various anti-inflammatory modes of action have been proposed for BAs, the pharmacological profile of these compounds is still incompletely understood...
December 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/25830661/herbal-and-plant-therapy-in-patients-with-inflammatory-bowel-disease
#13
REVIEW
Aikaterini Triantafyllidi, Theodoros Xanthos, Apostolos Papalois, John K Triantafillidis
The use of herbal therapy in inflammatory bowel disease (IBD) is increasing worldwide. The aim of this study was to review the literature on the efficacy of herbal therapy in IBD patients. Studies on herbal therapy for IBD published in Medline and Embase were reviewed, and response to treatment and remission rates were recorded. Although the number of the relevant clinical studies is relatively small, it can be assumed that the efficacy of herbal therapies in IBD is promising. The most important clinical trials conducted so far refer to the use of mastic gum, tormentil extracts, wormwood herb, aloe vera, triticum aestivum, germinated barley foodstuff, and boswellia serrata...
April 2015: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/25452227/posttreatment-with-11-keto-%C3%AE-boswellic-acid-ameliorates-cerebral-ischemia-reperfusion-injury-nrf2-ho-1-pathway-as-a-potential-mechanism
#14
Yi Ding, MinChun Chen, MingMing Wang, YuWen Li, AiDong Wen
Oxidative stress is well known to play a pivotal role in cerebral ischemia-reperfusion injury. The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has been considered a potential target for neuroprotection in stroke. 11-Keto-β-boswellic acid (KBA) is a triterpenoid compound from extracts of Boswellia serrata. The aim of the present study was to determine whether KBA, a novel Nrf2 activator, can protect against cerebral ischemic injury. Middle cerebral artery occlusion (MCAO) was operated on male Sprague-Dawley rats...
December 2015: Molecular Neurobiology
https://www.readbyqxmd.com/read/24698440/extract-from-gum-resin-of-boswellia-serrata-decreases-ia-2-antibody-in-a-patient-with-late-onset-autoimmune-diabetes-of-the-adult-lada
#15
E Schrott, S Laufer, M Lämmerhofer, H P T Ammon
No abstract text is available yet for this article.
May 15, 2014: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/24667331/boswellia-serrata-extract-attenuates-inflammatory-mediators-and-oxidative-stress-in-collagen-induced-arthritis
#16
Sadiq Umar, Khalid Umar, Abu Hasnath Md Golam Sarwar, Altaf Khan, Niyaz Ahmad, Sayeed Ahmad, Chandra Kant Katiyar, Syed Akhtar Husain, Haider A Khan
Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to destruction of joints. Current treatment modalities for RA either produce symptomatic relief (NSAIDs) or modify the disease process (DMARDs). Though effective, their use is also limited by their side effects. As a result, the interest in alternative, well tolerated anti-inflammatory remedies has re-emerged. Our aim was to evaluate the antioxidant and antiarthritic activity of Boswellia serrata gum resin extract (BSE) in collagen induced arthritis...
May 15, 2014: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/24469975/boswellic-acids-reduce-th17-differentiation-via-blockade-of-il-1%C3%AE-mediated-irak1-signaling
#17
Klarissa Hanja Stürner, Nina Verse, Sara Yousef, Roland Martin, Mireia Sospedra
Interferon-gamma producing CD4(+) T (Th1) cells and IL-17-producing CD4(+) T (Th17) cells are involved in the pathogenesis of several autoimmune diseases including multiple sclerosis. Therefore, the development of treatment strategies controlling the generation and expansion of these effector cells is of high interest. Frankincense, the resin from trees of the genus Boswellia, and particularly its prominent bioactive compound acetyl-11-keto-β-boswellic acid (AKBA), have potent anti-inflammatory properties...
April 2014: European Journal of Immunology
https://www.readbyqxmd.com/read/22249085/herbal-medicine-in-the-treatment-of-ulcerative-colitis
#18
REVIEW
Fei Ke, Praveen Kumar Yadav, Liu Zhan Ju
Ulcerative colitis (UC) is a refractory, chronic, and nonspecific disease occurred usually in the rectum and the entire colon. The etiopathology is probably related to dysregulation of the mucosal immune response toward the resident bacterial flora together with genetic and environmental factors. Several types of medications are used to control the inflammation or reduce symptoms. Herbal medicine includes a wide range of practices and therapies outside the realms of conventional Western medicine. However, there are limited controlled evidences indicating the efficacy of traditional Chinese medicines, such as aloe vera gel, wheat grass juice, Boswellia serrata, and bovine colostrum enemas in the treatment of UC...
January 2012: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/21831620/prevention-of-multiple-low-dose-streptozotocin-mld-stz-diabetes-in-mice-by-an-extract-from-gum-resin-of-boswellia-serrata-be
#19
Ahmed M Shehata, L Quintanilla-Fend, Sabrina Bettio, C B Singh, H P T Ammon
Type 1-diabetes is an autoimmune disease, where a chronic inflammatory process finally causes β-cell death and insulin deficiency. Extracts from gum resin of Boswellia serrata (BE) have been shown to posses anti-inflammatory properties especially by targeting factors/mediators related to autoimmune diseases. Multiple low dose-streptozotocin (MLD-STZ) treatment is a method to induce diabetes in animals similar to Type 1 diabetes in humans. It was aimed to study whether or not a BE could prevent hyperglycemia, inflammation of pancreatic islets and increase of proinflammatory cytokines in the blood in MLD-STZ treated mice...
September 15, 2011: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/21371582/immunological-adjuvant-effect-of-boswellia-serrata-bos-2000-on-specific-antibody-and-cellular-response-to-ovalbumin-in-mice
#20
Amit Gupta, A Khajuria, J Singh, S Singh, K A Suri, G N Qazi
In this study, the biopolymeric fraction BOS 2000 from Boswellia serrata was evaluated for its potential ability as adjuvants on the immune responses to ovalbumin (OVA) in mice. Balb/c mice were immunized subcutaneously with OVA 100 μg alone or with OVA 100 μg dissolved in saline containing alum (200 μg) or BOS 2000 (10, 20, 40 and 80 μg) on Days 1 and 15. Two weeks later, OVA specific antibodies in serum; concanavalin A (Con A), OVA stimulated splenocyte proliferation, CD4/CD8/CD80/CD86 analysis in spleen cells and its estimation of cytokines (IL-2 and IFN gamma) from cell culture supernatant were measured...
August 2011: International Immunopharmacology
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