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Katerina Saltiki, George Simeakis, Elli Anagnostou, Evangelia Zapanti, Eleni Anastasiou, Maria Alevizaki
BACKGROUND: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic MTC (spMTC). METHODS: A total of 273 MTCs (familial: n = 110 [40.3%], males: 38.5%) were followed for 1-35 years (median 5.0 years). Fifty one of the familial cases were operated because of positive findings at genetic screening. Disease extent at diagnosis and follow-up was recorded. RESULTS: Mean age at diagnosis was: fMTC = 33...
December 11, 2018: Head & Neck
Martha-Spyridoula Katsarou, Aikaterini Karathanasopoulou, Angeliki Andrianopoulou, Vasileios Desiniotis, Efthymios Tzinis, Efthimios Dimitrakis, Maria Lagiou, Evangelia Charmandari, Michael Aschner, Aristeidis M Tsatsakis, George P Chrousos, Nikolaos Drakoulis
Genetic polymorphisms in β1 -, β2 - and β3 -adrenergic receptors (β-ARs) have been associated with chronic non-communicable disorders, such as cardiovascular diseases, asthma, chronic obstructive pulmonary disease (COPD) and obesity, as well as β-agonists and antagonists response and toxicity. The purpose of this study was to determine the frequency distribution of ADRB1 genetic variants Ser49Gly and Arg389Gly, ADRB2 variants Gly16Arg and Gln27Glu, ADRB3 variant Trp64Arg in a Southeastern European Caucasian (SEC) population sample and to establish a comparison with existing data from other human populations...
2018: Frontiers in Genetics
Vassiliki Kotoula, Kalliopi Tsakiri, Georgia-Angeliki Koliou, Georgios Lazaridis, Kyriaki Papadopoulou, Eleni Giannoulatou, Ioannis Tikas, Christos Christodoulou, Kyriakos Chatzopoulos, Mattheos Bobos, George Pentheroudakis, Eleftheria Tsolaki, Anna Batistatou, Athanassios Kotsakis, Angelos Koutras, Helena Linardou, Evangelia Razis, Eleni Res, Dimitrios Pectasides, George Fountzilas
BACKGROUND: We examined tumor genotype characteristics of human epidermal growth factor receptor 2 (HER2)-positive relapsed (R-) and de novo (dn-) metastatic breast cancer (MBC) in trastuzumab-treated patients who were previously not exposed to this agent. MATERIALS AND METHODS: We analyzed genotypes obtained upon deep sequencing from 113 HER2-positive primary tumors from 69 patients with R-MBC and 44 patients with dn-MBC. RESULTS: Mutations were observed in 90 (79...
November 5, 2018: Clinical Breast Cancer
Eleni Orfanoudaki, Maria Gazouli, Kalliopi Foteinogiannopoulou, Eirini Theodoraki, Evangelia Legaki, Ioannis Romanos, Ioannis Mouzas, Ioannis E Koutroubakis
BACKGROUND: Infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATIs) have been suggested as useful markers for the optimization of treatment in inflammatory bowel disease (IBD). We aimed to estimate the patterns over time of IFX-TLs and ATIs in IBD patients on maintenance treatment with IFX. METHODS: Two different measurements of IFX-TLs and ATIs were performed (ELISA; Eagle BioSciences) at a 10-month interval using serum samples of consecutive patients on maintenance treatment with IFX...
December 12, 2018: European Journal of Gastroenterology & Hepatology
Marij Gielen, Geja J Hageman, Evangelia E Antoniou, Katarina Nordfjall, Massimo Mangino, Muthuswamy Balasubramanyam, Tim de Meyer, Audrey E Hendricks, Erik J Giltay, Steven C Hunt, Jennifer A Nettleton, Klelia D Salpea, Vanessa A Diaz, Ramin Farzaneh-Far, Gil Atzmon, Sarah E Harris, Lifang Hou, David Gilley, Iiris Hovatta, Jeremy D Kark, Hisham Nassar, David J Kurz, Karen A Mather, Peter Willeit, Yun-Ling Zheng, Sofia Pavanello, Ellen W Demerath, Line Rode, Daniel Bunout, Andrew Steptoe, Lisa Boardman, Amelia Marti, Belinda Needham, Wei Zheng, Rosalind Ramsey-Goldman, Andrew J Pellatt, Jaakko Kaprio, Jonathan N Hofmann, Christian Gieger, Giuseppe Paolisso, Jacob B H Hjelmborg, Lisa Mirabello, Teresa Seeman, Jason Wong, Pim van der Harst, Linda Broer, Florian Kronenberg, Barbara Kollerits, Timo Strandberg, Dan T A Eisenberg, Catherine Duggan, Josine E Verhoeven, Roxanne Schaakxs, Raffaela Zannolli, Rosana M R Dos Reis, Fadi J Charchar, Maciej Tomaszewski, Ute Mons, Ilja Demuth, Andrea Elena Iglesias Molli, Guo Cheng, Dmytro Krasnienkov, Bianca D'Antono, Marek Kasielski, Barry J McDonnell, Richard Paul Ebstein, Kristina Sundquist, Guillaume Pare, Michael Chong, Maurice P Zeegers
Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes...
September 1, 2018: American Journal of Clinical Nutrition
Evangelia Theochari, Hannah Cock, Dora Lozsadi, Clare Galtrey, Jan Arevalo, Marco Mula
This is a case series of 25 patients with drug-resistant epilepsy and psychiatric comorbidities who started on brivaracetam (BRV) at St George's University Hospitals and Frimley Health in London. Median BRV dose was 150 mg for a median follow-up period of 8 months. Twenty had focal epilepsy, four had generalized epilepsies, and one had unclassified epilepsy; 76% had mood disorders (either depression or bipolar disorder), 12% intellectual disabilities with autism spectrum disorder and challenging behavior, and 12% psychoses...
December 7, 2018: Epilepsy & Behavior: E&B
Anastasia Polytarchou, Georgia Katsouli, Marina Tsaoussoglou, Evangelia Charmandari, Christina Kanaka-Gantenbein, George Chrousos, Athanasios G Kaditis
OBJECTIVE: Children with Prader-Willi syndrome (PWS) have a high prevalence of obstructive sleep apnea syndrome (OSAS). In most typically developing children with OSAS, more obstructive apneas and hypopneas occur during rapid eye movement (REM) than during non-REM (NREM) sleep. It was hypothesized that patients with PWS are even more prone to obstructive events in REM sleep than otherwise healthy subjects with OSAS. METHODS: Polysomnographic data of patients with PWS and of typically developing children (controls) with OSAS (apnea-hypopnea index [AHI] > 1 episode/h) were analyzed...
October 28, 2018: Sleep Medicine
Petros Tzimas, Evangelia Samara, Anastasios Petrou, Anastasios Korompilias, Athanasios Chalkias, Georgios Papadopoulos
BACKGROUND: Hip fracture is common and morbid in elderly patients. Postoperative cognitive dysfunction (POCD) is also very common in these subjects undergoing surgery with an incidence which exceeds 40% in some reports. To date, the evidence is ambiguous as to whether anesthetic technique may affect the patients' outcome as far as postoperative cognitive function is concerned. OBJECTIVE: The aim of this study was to compare the effect of general and subarachnoid (spinal) anesthesia on the development of POCD up to 30 days after surgery in elderly patients undergoing hip fracture surgery...
December 2018: Injury
Theodore G Papaioannou, Evangelos Oikonomou, George Lazaros, Evangelia Christoforatou, Georgia Vogiatzi, Sotiris Tsalamandris, Christos Chasikidis, Aimilios Kalambogias, Timoleon Mavratzas, Eythymia Stofa, Vasiliki-Chara Mystakidi, George Latsios, Spyridon Deftereos, Dimitris Tousoulis
BACKGROUND: The 2017 ACC/AHA blood pressure (BP) guidelines generated controversies due to the new proposed BP cut-off values defining hypertension. We aimed to assess aortic stiffness of subjects who are reclassified as stage 1 hypertensive according to the new guidelines and compare them with the subjects of "elevated BP" category. PATIENTS AND METHODS: Data from the "Corinthia" study, an observational, cross-sectional survey of 2,043 participants were analyzed...
December 10, 2018: VASA. Zeitschrift Für Gefässkrankheiten
Angelos Koutras, Georgios Lazaridis, Georgia-Angeliki Koliou, George Kouvatseas, Christos Christodoulou, Dimitrios Pectasides, Vassiliki Kotoula, Anna Batistatou, Mattheos Bobos, Eleftheria Tsolaki, Kyriaki Papadopoulou, George Pentheroudakis, Pavlos Papakostas, Stavroula Pervana, Kalliopi Petraki, Sofia Chrisafi, Evangelia Razis, Amanda Psyrri, Dimitrios Bafaloukos, Konstantine T Kalogeras, Haralambos P Kalofonos, George Fountzilas
In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic breast cancer treated with trastuzumab-based regimens and evaluated their prognostic value. Formalin-fixed paraffin-embedded tumor tissue samples were collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories. We evaluated gene amplification, copy number variations (CNVs), mRNA and protein expression of all four HER family members...
2018: PloS One
Ioannis Patoulias, Maria Kalogirou, Evangelia Rachmani, Kyriakos Chatzopoulos, Thomas Feidantsis, Dimitrios Patoulias
Meckel's diverticulum represents a remnant of the proximal end of the omphalomesenteric duct, which constitutes a connection between the middle intestine and the vitelline vesicle. It is the most common congenital anomaly of the gastrointestinal tract and is found in approximately 0.3-2% of the general population. Complications such as hemorrhage, bowel obstruction, inflammation, perforation, intussusception, volvulus and malignant transformation develop in only 4-4.8% of all patients, with most cases presenting in childhood, while relative risk decreases during life...
2018: Folia Medica Cracoviensia
Aleka Kyriakopoulou, Evangelia Meimeti, Ioannis Moisoglou, Anna Psarrou, Xeni Provatopoulou, Georgios Dounias
Introduction: Acute leukemia, accounting for 20% of all cancers diagnosed in individuals younger than 19 years old, is the most prevalent childhood malignancy. Among environmental risk factors, parental occupational exposures have attracted scientific interest as potential predisposing factors for childhood leukemia. The role of parental occupational exposure to social contacts, harmful chemicals, electromagnetic fields and ionizing radiation has been investigated with conflicting and inconsistent results...
October 2018: Materia Socio-medica
Vasiliki Kalogera, Dimitrios Galopoulos, Gerasimos Eleftheriotis, Evangelia Meimeti, Ioannis Malios, Georgios Marathonitis, Chariclia Loupa
Introduction: Oxcarbazepine is a carbamazepine pre-drug with less drug interactions. Its adverse effects, including hyponatremia, somnolence and ataxia, are dose dependent. Olanzapine is an atypical antipsychotic drug most commonly used to manage psychoses and symptoms of irritability and aggressive behavior. Main side effects include extrapyramidal and anticholinergic symptoms, weight gain, and hyperglycemia. Case Report: In this manuscript a case of oxcarbazepine and olanzapine intoxication is discussed...
October 2018: Medical Archives
Evangelos Oikonomou, Sotiris Tsalamandris, Dimitris Karlis, Gerasimos Siasos, Christina Chrysohoou, Georgia Vogiatzi, Stathis Dimitropoulos, Georgios Charalambous, Evangelia Kouskouni, Dimitris Tousoulis
AIM: The NGAL is a biomarker of renal injury associated with the progression of heart failure (HF). We examine the association of NGAL with Galectin-3 in patients with chronic HF. METHODS: We consecutively enrolled 115 subjects with stable ischemic HF of reduced ejection fraction. Serum levels of Galectin-3, b-type natriuretic peptide and NGAL were measured. RESULTS: NGAL levels were positively correlated with Galectin-3 (rho = 0.26; p = 0...
December 4, 2018: Biomarkers in Medicine
Dimitra Savvaki, Eleftheria Taousani, Dimitrios G Goulis, Efrosini Tsirou, Evangelia Voziki, Helen Douda, Nikolaos Nikolettos, Savvas P Tokmakidis
OBJECTIVE: Τo summarize and present the main guidelines for exercise during normal pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM). METHODS: Relevant guidelines were retrieved through the electronic databases PubMed (MEDLINE), CENTRAL (Cochrane), and Embase; reference sections of the retrieved publications; proceedings of the main congresses in the field; and websites of relevant organizations published during the years 2000-2018. RESULTS: All guidelines recommend aerobic training from 60 to 150 min/week, with an upper limit of 30 min/day...
December 3, 2018: Hormones: International Journal of Endocrinology and Metabolism
Evangelia-Nefeli Athanasopoulou, Nikolaos Nianias, Quy Khac Ong, Francesco Stellacci
Surface coatings are becoming an integral part of materials. In recent years, molecular coatings have found larger acceptance and uses. Among them, self-assembled monolayers (SAMs) are attractive due to their inherent versatility, manufacturability, and scale up ease. Understanding their structure-properties relationships in realistic conditions remains a major challenge. Here we present a methodology based on simultaneous topographical and nanomechanical characterization of SAMs using a commercially available setup for bimodal atomic force microscopy (AFM)...
December 3, 2018: Nanoscale
Stamatia Theodoridou, Nikolaos Prapas, Angeliki Balassopoulou, Effrossyni Boutou, Timoleon-Achilleas Vyzantiadis, Despoina Adamidou, Evangelia-Eleni Delaki, Eleni Yfanti, Marina Economou, Αikaterini Teli, Olga Karakasidou, Evangelia Skatharoudi, Theodoros Theodoridis, Ersi Voskaridou
Hemoglobinopathies constitute the most frequent monogenic disorders worldwide and in Greece. In Greece, carrier frequency is estimated at about 8.0%, resulting in a heavy disease burden in the past. Therefore, the implementation of a national prevention program of the disease was an urgent necessity. Moreover, due to migration flow from different geographic areas in the last two decades, the observed spectrum of underlying mutations was expanded, leading to the adaptation of diagnostic approaches. We report the results of the National Thalassaemia Prevention Programme in Northern Greece, over a 15-year period (2001-2015)...
December 3, 2018: Hemoglobin
Sadaf Fatima Jafri, Evangelia S Koumousi, Marie-Anne Arrio, Amélie Juhin, Dmitri Mitcov, Mathieu Rouzieres, Pierre Dechambenoit, Dongfeng Li, Edwige Otero, Fabrice Wilhelm, Andrei Rogalev, Loïc Joly, Jean-Paul Kappler, Christophe Cartier Dit Moulin, Corine Mathoniere, Rodolphe Clérac, Philippe Sainctavit
Molecular complexes based on Prussian Blue Analogues have recently attracted considerable interest for their unique bistable properties combined to ultimately reduced dimensions. Here, we investigate the first dinuclear FeCo complex exhibiting both thermal and photomagnetic bistability in solid state. Through an experimental and theoretical approach combining local techniques - X-ray Absorption Spectroscopy (XAS), X-ray Magnetic Circular Dichroism (XMCD) and Ligand Field Multiplet calculations, we were able to evidence the changes occuring at the atomic scale in the electronic and magnetic properties...
December 2, 2018: Journal of the American Chemical Society
Ioanna Dagla, Evangelia Karkoula, Eirini Baira, Anthony Tsarbopoulos, Evagelos Gikas
Colistin is a multicomponent polypeptide antibiotic consisting mainly of colistin A and colistin B, produced by selected strains of Bacillus polymyxa var. Colistinus. Only recently, the prodrug of colistin, colistimethate sodium, is widely used as last resort antibiotic for infections caused by resistant gram-negative bacteria. Colistin having been discovered several years ago, has not subjected to the drug development and regulatory approval processes that are applied today. However, pharmacological and pharmacokinetic information are necessary for its optimal use thus, during the last decades several studies are carried out in order to shed light on this issue...
November 19, 2018: Journal of Pharmaceutical and Biomedical Analysis
Iordanis Papadopoulos, Evangelia Bountouvi, Achilleas Attilakos, Evangelia Gole, Argirios Dinopoulos, Melpomeni Peppa, Polyxeni Nikolaidou, Anna Papadopoulou
Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal-recessive disorder, characterized by severe osteoporosis and early-onset blindness. Loss of function mutations in the gene encoding low-density lipoprotein receptor-related protein 5 (LRP5) have been established as the genetic defect of the disease. We report the clinical and genetic evaluation of ten OPPG cases in eight related nuclear families and their close relatives. Bone mineral density (BMD) in OPPG patients was assessed by dual-energy X-ray absorptiometry (DXA)...
November 29, 2018: European Journal of Pediatrics
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