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Evangelia Pardali, Lena-Maria Makowski, Merle Leffers, Andreas Borgscheiper, Johannes Waltenberger
Type 2 diabetes mellitus (T2DM) is a cardiovascular risk factor which leads to atherosclerosis, an inflammatory disease characterized by the infiltration of mononuclear cells in the vessel. Bone morphogenetic protein (BMP)-2 is a cytokine which has been recently shown to be elevated in atherosclerosis and T2DM and to contribute to vascular inflammation. However, the role of BMP-2 in the regulation of mononuclear cell function remains to be established. Herein, we demonstrate that BMP-2 induced human monocyte chemotaxis via phosphoinositide 3 kinase and mitogen-activated protein kinases...
August 13, 2018: Journal of Cellular and Molecular Medicine
Evangelia Zampeli, Haralampos M Moutsopoulos
A 46-year-old lady was referred to us for evaluation of possible psoriatic arthritis. Four weeks before she had developed psoriasiform lesions of the palms and soles as well as knee pain, while for the past two months she was also complaining of dysuria. Clinical examination revealed mild arthritis of the left knee and brown vesiculo-pustular waxy lesions of the palms (Figure 1A), soles and heels (Figure 1B), which fused together into crusty plaques on an erythematous base. This article is protected by copyright...
August 12, 2018: Arthritis & Rheumatology
Christopher Adlbrecht, Alejandro Blanco-Verea, María C Bouzas-Mosquera, María Brion, Martin Burtscher, Federico Carbone, Ting-Ting Chang, Evangelia Charmandari, Jaw-Wen Chen, Liane Correia-Costa, Robin P F Dullaart, Makarios Eleftheriades, Beatriz Fernandez-Fernandez, Georg Goliasch, Thomas Gremmel, Menno Evert Groeneveld, Alexandrino Henrique, Martin Huelsmann, Christian Jung, Michael Lichtenauer, Fabrizio Montecucco, Nicolas C Nicolaides, Alexander Niessner, Carlos Palmeira, Markus Pirklbauer, Maria Dolores Sanchez-Niño, Alexandros Sotiriadis, Teresa Sousa, Patrick Sulzgruber, André P van Beek, Nicola Veronese, Max-Paul Winter, Kak Khee Yeung
Following the publication of our study [1] no biochemical data derived from adolescent marathon runners have been made available. However, there are two potentially relevant investigations including adult runners. Shin and colleagues demonstrated different effects depending on the running distance, i.e. marathon, 100 km and 308 km [2]. Hepatic function was more impaired after completing 308 km (low intensity, long duration) compared to marathon or 100 km, but renal dysfunction was more pronounced after marathon and especially after 100 km (higher intensity and shorter duration)...
August 12, 2018: European Journal of Clinical Investigation
Chrysoula-Christina Emmanouil, Panagiota Pervanidou, Evangelia Charmandari, Christina Darviri, George P Chrousos
OBJECTIVE: Our study aimed to evaluate the effectiveness of an 8-week stress management intervention program that included progressive muscle relaxation, diaphragmatic breathing, guided imagery, and cognitive restructuring in obese Greek children and adolescents. DESIGN: Thirty-six patients were prospectively recruited to participate in this randomized controlled study. Of these, 16 participants formed the intervention group and 20 participants the control group...
August 11, 2018: Hormones: International Journal of Endocrinology and Metabolism
Konstantinos Assimakopoulos, Katerina Karaivazoglou, Evangelia-Eirini Tsermpini, Georgia Diamantopoulou, Christos Triantos
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent medical condition, which may lead to severe complications including cirrhosis and hepatocellular carcinoma. Its chronic course and its association with obesity and diabetes mellitus augment the long-term impact of NAFLD on patients' health and quality of life (QoL) and put great strain on healthcare systems worldwide. Research is growingly focusing on NAFLD patients' QoL in an attempt to describe the full spectrum of disease burden and tackle its future consequences...
September 2018: Journal of Psychosomatic Research
Panayiotis Bilalis, Dimitrios Skoulas, Anastasios Karatzas, John Marakis, Athanasios Stamogiannos, Chrisida Tsimblouli, Evangelia Sereti, Efstratios Stratikos, Konstantinos Dimas, Dimitris Vlassopoulos, Hermis Iatrou
A novel, multifunctional hydrogel that exhibits a unique set of properties for the effective treatment of pancreatic cancer (PC) is presented. The material is comprised of a pentablock terpolypeptide of the type PLys-b-(PHIS-co-PBLG)-PLys-b-(PHIS-co-PBLG)-b-PLys which is a non-cytotoxic polymer. It can be implanted via the least invasive route and selectively delivers gemcitabine to efficiently treat PC. Simply mixing the novel terpolypeptide with an aqueous solution of gemcitabine within a syringe results in the facile formation of a hydrogel that has the ability to become liquid under the shear rate of the plunger...
August 10, 2018: Biomacromolecules
Evangelia Pappa, Constantinos Papadopoulos, Philippe Grimbert, Pascal Laforêt, Guillaume Bassez
Vascular involvement in Late Onset Pompe Disease, glycogen storage disease type II characterized by limb-girdle muscle and diaphragmatic weakness, is well documented. Abnormalities of posterior cerebral circulation have mostly been reported, whereas there are also cases of associated extracerebral arteriopathy. We report the case of a 42-year-old man diagnosed with LOPD a year after renal infarct due to renal artery fibromuscular dysplasia. We propose that the association of LOPD and arteriopathy should always be considered in clinical practice...
September 2018: Molecular Genetics and Metabolism Reports
Anastasia Bougea, Leonidas Stefanis, George P Paraskevas, Evangelia Emmanouilidou, Efthimia Efthymiopoulou, Kostas Vekrelis, Elisabeth Kapaki
INTRODUCTION: Given the overlapping of neuropathological, neurochemical and neuropsychiatric profiles of Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), their differential diagnosis is challenging. Specific neuropsychiatric features or biomarkers, such as cerebrospinal fluid (CSF) α-Synuclein (α-Syn), may aid in differential diagnosis. This study aims to compare the neuropsychiatric and CSF α-Syn profiles in these conditions, and to investigate the possible association between CSF α-Syn levels and neuropsychiatric symptoms...
August 6, 2018: Journal of Neurology
Kyriakos Souliotis, Lily-Evangelia Peppou, Chara Tzavara, Eirini Agapidaki, Dimitrios Varvaras, Oreste Buonomo, Dominique Debiais, Stanimir Hasurdjiev, Francois Sarkozy
OBJECTIVES: Even though patient involvement in health policy decision-making is well documented, studies evaluating the degree and impact of this participation are scarce. This is even more conspicuous in the case of cancer. There is evidence showing that patients with the same type of cancer and at the same stage of the disease will receive different treatments in different countries. Therefore, it is crucial to assess the degree of patient participation in health policy decision-making across Europe, as it may result in health inequalities across countries...
August 5, 2018: BMJ Open
Evangelia-Georgia Kostaki, Timokratis Karamitros, Garyfallia Stefanou, Ioannis Mamais, Konstantinos Angelis, Angelos Hatzakis, Anna Kramvis, Dimitrios Paraskevis
Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe...
August 7, 2018: ELife
Garyfalia Karponi, Penelope-Georgia Papayanni, Fani Zervou, Asimina Bouinta, Achilles Anagnostopoulos, Evangelia Yannaki
Stable gene marking and effective engraftment of gene-modified CD34+ hematopoietic stem cells is a prerequisite for gene therapy success, but may be challenged by the inevitable cryopreservation of the final product, prior to extensive quality assurance testing. We investigated the β-globin gene transfer potency in fresh and cryopreserved CD34+ cells from mobilized patients with β-thalassemia, as well as the qualitative impact of repeated freeze/thaw cycles on the functionality of cultured and unmanipulated CD34+ cells in terms of engrafting capacity in a xenotransplantation model, under partial myeloablation...
August 4, 2018: Human Gene Therapy Methods
Dušica Simijonović, Evangelia-Eirini Vlachou, Zorica D Petrović, Dimitra J Hadjipavlou-Litina, Κonstantinos E Litinas, Nevena Stanković, Nezrina Mihović, Milan P Mladenović
Dicoumarol derivatives were synthesized in the InCl3 catalyzed pseudo three-component reactions of 4-hydroxycoumarin with aromatic aldehydes in excellent yields. The reactions were performed in water under microwave irradiation. All synthesized compounds were characterized using NMR, IR, and UV-Vis spectroscopy, as well as with TD-DFT. Obtained dicoumarols were subjected to evaluation of their in vitro lipid peroxidation and soybean lipoxygenase inhibition activities. It was shown that five of ten examined compounds (3e, 3h, 3b, 3d, 3f) possess significant potential of antilipid peroxidation (84-97%), and that compounds 3b, 3e, 3h provided the highest soybean lipoxygenase (LOX-Ib) inhibition (IC50  = 52...
July 20, 2018: Bioorganic Chemistry
Antonios N Gargalionis, Lina S Malakou, Christos Adamopoulos, Christina Piperi, Irini Theochari, Marjan Nokhbehsaim, James Deschner, Georgios Kokkalis, Penelope Korkolopoulou, Evangelia Papadavid, Athanasios G Papavassiliou, Efthimia K Basdra
Psoriatic plaques tend to localize to the knees and elbows, areas that are particularly subject to mechanical stress resulting from bending and friction. Moreover, plaques often develop at sites of mechanical trauma or injury (Koebner phenomenon). Nevertheless, mechanotransduction has never been linked to psoriasis. Polycystins (polycystin-1, PC1; polycystin-2, PC2) are mechanosensitive molecules that function as key regulators of cellular mechanosensitivity and mechanotransduction. The aim of this in vitro study was to investigate the role of polycystins in the development of psoriasis...
August 2, 2018: Biochimica et Biophysica Acta
Kees de Hoogh, Jie Chen, John Gulliver, Barbara Hoffmann, Ole Hertel, Matthias Ketzel, Mariska Bauwelinck, Aaron van Donkelaar, Ulla A Hvidtfeldt, Klea Katsouyanni, Jochem Klompmaker, Randal V Martin, Evangelia Samoli, Per E Schwartz, Massimo Stafoggia, Tom Bellander, Maciej Strak, Kathrin Wolf, Danielle Vienneau, Bert Brunekreef, Gerard Hoek
BACKGROUND: In order to investigate associations between air pollution and adverse health effects consistent fine spatial air pollution surfaces are needed across large areas to provide cohorts with comparable exposures. The aim of this paper is to develop and evaluate fine spatial scale land use regression models for four major health relevant air pollutants (PM2.5 , NO2 , BC, O3 ) across Europe. METHODS: We developed West-European land use regression models (LUR) for 2010 estimating annual mean PM2...
July 31, 2018: Environment International
Stuart Wilson, Evangelia Bassiou, Aysel Denli, Lynsey C Dolan, Matthew Watson
We tested the hypothesis that the social act of moving through space with others-collective directional movement-is associated with greater levels of group cohesion compared to static activities. We asked participants to imagine participating in activities as part of a same-sex group and found that imagining going on a journey is associated with higher levels of expected cohesion compared to imagining attending a meeting (Study 1) or an event (Study 2). Study 3 replicates the main effect using different manipulations and finds that it persists regardless of whether the imagined group were friends or strangers...
July 2018: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
Chantell Farias, Roman Lyman, Cecilia Hemingway, Huong Chau, Anne Mahacek, Evangelia Bouzos, Maryam Mobed-Miremadi
Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ± 24.5 µm) post-extrusion through a three-dimensional (3D) printed methacrylate-based custom hollow microneedle assembly (circular array of 13 conical frusta) fabricated using stereolithography. With a jetting reliability of 80%, the solvent-sterilized device with a root mean square roughness of 158 nm at the extrusion nozzle tip (d = 325 μm) was operated at a flowrate of 12 mL/min...
July 31, 2018: Bioengineering
Evangelia Flampouri, Dimitra Theodosi-Palimeri, Spyridon Kintzios
In this paper we report the effects of the complex III inhibitor, strobilurin fungicide kresoxim-methyl, on the cellular homeostasis of a mammalian cancerous neural cell line. We examined whether exposure to subcytotoxic concentrations of kresoxim-methyl induce cellular and biochemical mechanisms of toxicity on the murine neuroblastoma N2a cells. Results revealed elevation of mitochondrial superoxide generation, decrease in mitochondrial transmembrane potential, losses on GPx enzyme activity, along with increased nitrite release...
July 31, 2018: Toxicology Mechanisms and Methods
Carlos Carballo, Evangelia G Chronopoulou, Sofia Letsiou, Claudia Maya, Nikolaos E Labrou, Carlos Infante, Deborah M Power, Manuel Manchado
The microalgae are an important source of bioactive molecules including β-glucans that can be used as immunostimulants in aquaculture. In the present study, the antioxidant capacity, cytotoxicity and immunomodulatory activity of a chrysolaminarin-enriched extract obtained from the diatom Phaeodactylum tricornutum was evaluated. The extract showed a higher total antioxidant activity as determined by ORAC and FRAP assays and a lower DPPH scavenging activity than particulate yeast-β-glucan. The cytotoxicity test indicated that extract concentrations higher than 0...
July 28, 2018: Fish & Shellfish Immunology
Evangelos Karagiannis, Michail Michailidis, Georgia Tanou, Martina Samiotaki, Katerina Karamanoli, Evangelia Avramidou, Ioannis Ganopoulos, Panagiotis Madesis, Athanassios Molassiotis
Superficial scald is a major physiological disorder of apple fruit (Malus domestica Borkh.) characterized by skin browning following cold storage; however, knowledge regarding the downstream processes that modulate scald phenomenon is unclear. To gain insight into the mechanisms underlying scald resistance, 'Granny Smith' apples after harvest were treated with diphenylamine (DPA) or 1-methylcyclopropene (1-MCP), then cold stored (0 °C for 3 months) and subsequently were ripened at room temperature (20 °C for 8 days)...
July 30, 2018: Scientific Reports
Evangelia Vamvaka, Gemma Farré, Luis M Molinos-Albert, Abbey Evans, Anna Canela-Xandri, Richard M Twyman, Jorge Carrillo, Raziel A Ordóñez, Robin J Shattock, Barry R O'Keefe, Bonaventura Clotet, Julian Blanco, Gurdev S Khush, Paul Christou, Teresa Capell
The transmission of HIV can be prevented by the application of neutralizing monoclonal antibodies and lectins. Traditional recombinant protein manufacturing platforms lack sufficient capacity and are too expensive for developing countries, which suffer the greatest disease burden. Plants offer an inexpensive and scalable alternative manufacturing platform that can produce multiple components in a single plant, which is important because multiple components are required to avoid the rapid emergence of HIV-1 strains resistant to single microbicides...
July 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
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