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https://www.readbyqxmd.com/read/29045957/-clinical-characteristics-of-neonatal-fungal-sepsis-in-neonatal-intensive-care-unit
#1
X Zhang, X F Ru, Y Wang, X Li, T Sang, Q Feng
OBJECTIVE: To study the characteristics of neonatal fungal sepsis and the difference between bacterial sepsis and fungal sepsis. To improve the understanding of neonatal fungal sepsis. METHODS: Clinical data of neonatal fungal sepsis in neonatal intensive care unit (NICU) were collected from 2011 to 2016 in Peking University first Hospital. The clinical characteristics were analyzed retrospectively. The difference between neonatal fungal sepsis and bacterial sepsis was also analyzed...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045642/patient-and-tumor-characteristics-and-their-influence-on-early-therapy-persistence-with-letrozole-in-postmenopausal-patients-with-early-breast-cancer
#2
N Nabieva, S Kellner, T Fehm, L Häberle, J de Waal, M Rezai, B Baier, G Baake, H-C Kolberg, M Guggenberger, M Warm, N Harbeck, R Wuerstlein, J-U Deuker, P Dall, B Richter, G Wachsmann, C Brucker, J W Siebers, N Fersis, T Kuhn, C Wolf, H-W Vollert, G-P Breitbach, W Janni, R Landthaler, A Kohls, D Rezek, T Noesselt, G Fischer, S Henschen, T Praetz, V Heyl, T Kühn, T Krauss, C Thomssen, A Hohn, H Tesch, C Mundhenke, A Hein, C Rauh, C M Bayer, A Jacob, K Schmidt, E Belleville, S Y Brucker, S Kümmel, M W Beckmann, D Wallwiener, P Hadji, P A Fasching
Background: Patients' compliance and persistence with endocrine treatment has a significant effect on the prognosis in early breast cancer (EBC). The purpose of this analysis was to identify possible reasons for non-persistence, defined as premature cessation of therapy, on the basis of patient and tumor characteristics in individuals receiving adjuvant treatment with letrozole. Patients and methods: The EvAluate-TM Study is a prospective, multicenter, noninterventional study in which treatment with the aromatase inhibitor letrozole was evaluated in postmenopausal women with hormone receptor-positive EBC in the early therapy phase...
October 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045560/inflammatory-gastrointestinal-diseases-associated-with-pd-1-blockade-antibodies
#3
M Collins, Jm Michot, Fx Danlos, C Mussini, E Soularue, C Mateus, D Loirat, A Buisson, I Rosa, O Lambotte, S Laghouati, N Chaput, C Coutzac, Al Voisin, Jc Soria, A Marabelle, S Champiat, C Robert, F Carbonnel
Background: Immune check-point blockade agents have shown clinical activity in cancer patients but are associated with immune-related adverse events that could limit their development. The aim of this study was to describe the gastrointestinal immune-related adverse events (GI-irAE) in patients with cancer treated with anti-PD-1. Methods: this is a retrospective study of consecutive adult patients who had a suspected GI-irAE due to anti-PD-1 antibodies between 2013 and 2016...
October 3, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045282/prediction-model-for-wait-times-in-cardiac-transplantation
#4
David L Joyce, Brian D Lahr, Lyle D Joyce, Sudhir S Kushwaha, Richard C Daly
Wait times have increased for patients approved for heart transplants. We reviewed United Network for Organ Sharing (UNOS) data for 14,242 patients listed for isolated heart transplant (2009-2013) to develop a risk score model for timing left ventricular assist device (LVAD) implantation in bridge-to-transplant patients. We used a multivariable Cox proportional hazards regression model with subsequent bootstrap resampling for internal validation to develop a scoring system that combined risk factors, weighted by the corresponding regression coefficients, to define an individual's risk score...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29045229/case-247-jersey-finger-of-the-fifth-finger
#5
Viviane Marie Créteur, Pierre François Durieux, Nicolas Cuylits
History A 34-year-old man without underlying medical conditions came to the emergency department for evaluation of persistent pain over the volar portion of his right fifth finger after a fall during a football match 3 days before. At physical examination, the injured finger was swollen and purple. Passive and active flexion of the proximal and distal interphalangeal joints were compromised, without interphalangeal instability. Radiography was performed in the emergency department, and the patient was released with a diagnosis of a fifth digit sprain...
November 2017: Radiology
https://www.readbyqxmd.com/read/29044819/repeated-sleep-quality-assessment-and-use-of-sleep-promoting-interventions-in-icu
#6
Ashika Menear, Rosalind Elliott, Leanne M Aitken, Sara Lal, Sharon McKinley
To describe sleep quality using repeated subjective assessment and the ongoing use of sleep-promoting interventions in intensive care. It is well known that the critically ill experience sleep disruption while receiving treatment in the intensive care unit. Both the measurement and promotion of sleep is challenging in the complex environment of intensive care unit. Repeated subjective assessment of patients' sleep in the intensive care unit and use of sleep-promoting interventions has not been widely reported...
October 16, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/29044763/theta-band-oscillations-reflect-more-than-entrainment-behavioral-and-neural-evidence-demonstrate-an-active-chunking-process
#7
Xiangbin Teng, Xing Tian, Keith Doelling, David Poeppel
Parsing continuous acoustic streams into perceptual units is fundamental to auditory perception. Previous studies have uncovered a cortical entrainment mechanism in the delta and theta bands (~1-8 Hz) that correlates with formation of perceptual units in speech, music, and other quasi-rhythmic stimuli. Whether cortical oscillations in the delta-theta bands are passively entrained by regular acoustic patterns or play an active role in parsing the acoustic stream is debated. Here we investigate cortical oscillations using novel stimuli with 1/f modulation spectra...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29044643/fidaxomicin-versus-vancomycin-as-a-first-line-treatment-for-clostridium-difficile-associated-diarrhea-cdad-in-specific-patient-populations-a-pharmacoeconomic-evaluation
#8
Kelly R Reveles, Jennifer L Backo, Frank A Corvino, Marko Zivkovic, Kelly C Broderick
OBJECTIVES: The reduction in recurrent Clostridium difficile-associated diarrhea (CDAD) with fidaxomicin therapy may reduce hospital readmissions and lead to lower overall CDAD costs. However, studies assessing the cost-effectiveness of fidaxomicin as first-line therapy from the United States (US) hospital perspective are lacking. This study evaluated the costs associated with utilizing fidaxomicin or vancomycin as a first-line therapy for CDAD in specific patient populations from a US hospital perspective...
October 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29044303/immediate-postoperative-of-bariatric-surgery-in-the-intensive-care-unit-versus-an-inpatient-unit-a-retrospective-study-with-828-patients
#9
Guilherme Loures de Araújo Penna, Igor Pedreira Vaz, Eduardo Côrtes Fonseca, Marcelo Kalichsztein, Gustavo Freitas Nobre
OBJECTIVE: To compare the incidence of complications and the duration of hospitalization of patients undergoing bariatric surgery admitted to the intensive care unit or a post-surgical hospitalization unit. METHODS: This retrospective observational study included 828 patients admitted between January 2010 and February 2015 during the immediate postoperative period of bariatric surgery in a hospital. Data were collected via electronic medical records. The Mann-Whitney test was used to compare continuous variables, and the chi-square was used to compare categorical variables...
July 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29044014/-anaphylaxis-and-allergic-reactions-during-surgery-and-medical-procedures
#10
Blas J Larrauri, María Gabriela Torre, Eloísa Malbrán, María Cecilia Juri, Diego S Fernández Romero, Alejandro Malbrán
Anaphylaxis during anesthesia is an unpredictable, severe, and rare reaction. It has an incidence of 1/10 000 to 1/20 000 surgeries. In most series, the responsible drugs include neuromuscular blocking agents, latex, or antibiotics. The frequency and etiology of systemic allergic reactions in other medical procedures are largely unknown. The identification of responsible drugs of anaphylaxis is a complex task, requiring testing of all medications and substances used during surgery. We describe our experience in a retrospective study of 15 patients...
2017: Medicina
https://www.readbyqxmd.com/read/29043830/red-blood-cell-phenotype-prevalence-in-blood-donors-who-self-identify-as-hispanic
#11
Chelsea A Sheppard, Nicole L Bolen, Beth Eades, Gorka Ochoa-Garay, Mark H Yazer
Molecular genotyping platforms provide a quick, high-throughput method for identifying red blood cell units for patients on extended phenotype-matching protocols, such as those with sickle cell disease or thalassemia. Most of the antigen prevalence data reported are for non-Hispanic populations. Therefore, this study sought to determine the phenotype prevalence in a single blood center's Hispanic population and to compare those results with previously reported rates in non-Hispanic donor populations. We performed a retrospective review of all serologic and molecular typing from donors who self-reported as Hispanic...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29043695/-vascular-anomalies-in-the-neonatal-period
#12
M Bejarano, F Vicario, A Soria, F J Parri, A Albert
OBJECTIVE: Vascular anomalies in the neonatal period are a diagnostic challenge for the lack of evident signs, symptoms and follow-up, and the convenience of restricting aggressive diagnostic tests. The aim of this work is to review the characteristics of neonatal cases presented to our Vascular Anomalies Unit in the last 5 years. MATERIALS AND METHODS: All cases of suspected vascular anomaly presented to our unit before 1 month of age between 2010 and 2015 were reviewed, diagnostic tests and treatments carried out with chronology were analyzed...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29043573/structural-and-physiological-responses-of-halodule-wrightii-to-ocean-acidification
#13
Geniane Schneider, Paulo Antunes Horta, Emiliano Nicolas Calderon, Clovis Castro, Adalto Bianchini, Camilla Reis Augusto da Silva, Isabel Brandalise, José Bonomi Barufi, João Silva, Ana Claudia Rodrigues
Coastal areas face high variability of seawater pH. Ocean acidification (OA) and local stressors are enhancing this variability, which poses a threat to marine life. However, these organisms present potential phenotypic plasticity that can offer physiological and structural tools to survive in these extreme conditions. In this study, we evaluated the effects of elevated CO2 levels and consequent pH reduction on the physiology, anatomy and ultrastructure of the seagrass Halodule wrightii. A mesocosm study was conducted in an open system during a 30-day experiment, where different concentrations of CO2 were simulated following the natural variability observed in coastal reef systems...
October 18, 2017: Protoplasma
https://www.readbyqxmd.com/read/29043338/solvent-driven-azide-induced-mononuclear-discrete-versus-one-dimensional-polymeric-aromatic-m%C3%A3-bius-cadmium-ii-complexes-of-an-n6-tetradentate-helical-ligand
#14
Farhad Akbari Afkhami, Ghodrat Mahmoudi, Atash V Gurbanov, Fedor I Zubkov, Fengrui Qu, Arunava Gupta, Damir A Safin
We report the synthesis and structural characterization of a heteroleptic mononuclear discrete complex [Cd(N3)2(L)(MeOH)]·MeOH (1·MeOH) and a one-dimensional coordination polymer of the composition [Cd3(N3)6(L)]n (2), fabricated from Cd(NO3)2·4H2O and the helical organic ligand benzilbis((pyridin-2-yl)methylidenehydrazone) (L) in the presence of two equivalents of NaN3. The formation of different structures is driven by the solvent. The former complex is formed in the presence of MeOH, while the latter complex is formed in EtOH...
October 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29043326/symmetrical-or-non-symmetrical-luminescent-turnstiles-based-on-hydroquinone-stators-and-rotors-bearing-pyridyl-or-p-dimethylaminopyridyl-coordinating-units
#15
Bérangère Godde, Abdelaziz Jouaiti, Audrey Fluck, Nathalie Kyritsakas, Matteo Mauro, Mir Wais Hosseini
The design and synthesis of a novel family of molecular turnstiles T1-T5 were achieved. All five turnstiles are based on a stator and a rotor covalently interconnected. While turnstiles T1-T2 are based on a symmetric stator equipped with two coordinating pyridyl units and a rotor bearing either a pyridyl or p-dimethylaminopyridyl coordinating moiety, the two non-symmetric turnstiles T4 and T5 are based on a stator bearing only a single pyridyl unit and the same rotor as T1 and T2 mentioned above. The switching between the open (T1-T5) and the closed (T-M) states of the turnstiles by metal cations (M = Ag(+) or Pd(2+)) was investigated in solution by using 1D and 2D NMR techniques...
October 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29043311/strain-induced-atomic-structure-at-the-ir-doped-laalo3-srtio3-interface
#16
M Lee, R Arras, B Warot-Fonrose, T Hungria, M Lippmaa, H Daimon, M J Casanove
The structure of Ir-doped LaAlO3/SrTiO3(001) interfaces was investigated on the atomic scale using probe-corrected transmission electron microscopy in high-angle annular dark-field scanning mode (HAADF-STEM) and electron energy loss spectroscopy (EELS), combined with first-principles calculations. We report the evolution of the strain state experimentally measured in a 5 unit-cell thick LaAlO3 film as a function of the Ir concentration in the topmost SrTiO3 layer. It is shown that the LaAlO3 layers remain fully elastically strained up to 3% of Ir doping, whereas a higher doping level seems to promote strain relaxation through enhanced cationic interdiffusion...
October 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29043063/a-survey-of-working-conditions-within-biomedical-research-in-the-united-kingdom
#17
Nick Riddiford
Background: Many recent articles have presented a bleak view of career prospects in biomedical research in the US. Too many PhDs and postdocs are trained for too few research positions, creating a "holding-tank" of experienced senior postdocs who are unable to get a permanent position. Coupled with relatively low salaries and the high levels of pressure to publish in top-tier academic journals, this has created a toxic environment that is perhaps responsible for a recently observed decline in biomedical postdocs in the US, the so-called "postdocalypse"...
2017: F1000Research
https://www.readbyqxmd.com/read/29042851/implementing-information-and-communication-technology-to-support-community-aged-care-service-integration-lessons-from-an-australian-aged-care-provider
#18
Heather E Douglas, Andrew Georgiou, Amina Tariq, Mirela Prgomet, Andrew Warland, Pauline Armour, Johanna I Westbrook
INTRODUCTION: There is limited evidence of the benefits of information and communication technology (ICT) to support integrated aged care services. OBJECTIVES: We undertook a case study to describe carelink+, a centralised client service management ICT system implemented by a large aged and community care service provider, Uniting. We sought to explicate the care-related information exchange processes associated with carelink+ and identify lessons for organisations attempting to use ICT to support service integration...
April 10, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/29042462/infrequent-provision-of-palliative-care-to-patients-with-dialysis-requiring-aki
#19
Kelly Chong, Samuel A Silver, Jin Long, Yuanchao Zheng, V Shane Pankratz, Mark L Unruh, Glenn M Chertow
BACKGROUND AND OBJECTIVES: The use of palliative care in AKI is not well described. We sought to better understand palliative care practice patterns for hospitalized patients with AKI requiring dialysis in the United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the 2012 National Inpatient Sample, we identified patients with AKI and palliative care encounters using validated International Classification of Diseases, Ninth Revision, Clinical Modification codes...
October 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29042433/serotonin-decreases-the-gain-of-visual-responses-in-awake-macaque-v1
#20
Lenka Seillier, Corinna Lorenz, Katsuhisa Kawaguchi, Torben Ott, Andreas Nieder, Paria Pourriahi, Hendrikje Nienborg
Serotonin (5HT) is an important neuromodulator in the brain implicated in affective and cognitive functions but its role even for basic cortical processes is controversial. For example, in the mammalian primary visual cortex heterogenous serotonergic modulation has been observed in anesthetized animals. Here, we combined extracellular single unit recordings with iontophoresis in awake animals. We examined the role of serotonin on well-defined tuning properties (orientation, spatial frequency, contrast and size) in the primary visual cortex (V1) of two male macaque monkeys...
October 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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