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Interval Timing

Hiran Thabrew, Karolina Stasiak, Sarah E Hetrick, Stephen Wong, Jessica H Huss, Sally N Merry
BACKGROUND: Long-term physical conditions affect 10% to 12% of children and adolescents worldwide; these individuals are at greater risk of developing psychological problems, particularly anxiety and depression. Access to face-to-face treatment for such problems is often limited, and available interventions usually have not been tested with this population. As technology improves, e-health interventions (delivered via digital means, such as computers and smart phones and ranging from simple text-based programmes through to multimedia and interactive programmes, serious games, virtual reality and biofeedback programmes) offer a potential solution to address the psychological needs of this group of young people...
August 16, 2018: Cochrane Database of Systematic Reviews
Jennifer K Litton, Hope S Rugo, Johannes Ettl, Sara A Hurvitz, Anthony Gonçalves, Kyung-Hun Lee, Louis Fehrenbacher, Rinat Yerushalmi, Lida A Mina, Miguel Martin, Henri Roché, Young-Hyuck Im, Ruben G W Quek, Denka Markova, Iulia C Tudor, Alison L Hannah, Wolfgang Eiermann, Joanne L Blum
Background The poly(adenosine diphosphate-ribose) inhibitor talazoparib has shown antitumor activity in patients with advanced breast cancer and germline mutations in BRCA1 and BRCA2 ( BRCA1/2). Methods We conducted a randomized, open-label, phase 3 trial in which patients with advanced breast cancer and a germline BRCA1/2 mutation were assigned, in a 2:1 ratio, to receive talazoparib (1 mg once daily) or standard single-agent therapy of the physician's choice (capecitabine, eribulin, gemcitabine, or vinorelbine in continuous 21-day cycles)...
August 15, 2018: New England Journal of Medicine
Laura D Tamayo, Felipe Guhl, Gustavo A Vallejo, Juan David Ramírez
The increase in the global land temperature, expected under predictions of climate change, can directly affect the transmission of some infectious diseases, including Chagas disease, an anthropozoonosis caused by Trypanosoma cruzi and transmitted by arthropod vectors of the subfamily Triatominae. This work seeks to study the effects of temperature on the development of the life cycle, fertility and fecundity of the insect vector Rhodnius prolixus and on the metacyclogenesis of T. cruzi. All of the variables were subjected to 3 temperatures: 26°C, 28°C and 30°C...
August 15, 2018: PLoS Neglected Tropical Diseases
Ju Tian, Xiao Xuan Lei, Li Xuan, Jian Bing Tang, Biao Cheng
BACKGROUND AND OBJECTIVES: Plasma skin regeneration (PSR) and platelet-rich plasma(PRP) have gained popularity in the treatment of acne scars due to their efficacy and improved tolerability. The objective of this investigation was to evaluate the synergistic effect of PRP plus PSR (plasma-combined regeneration technology, PCRT) in managing facial acne scars. METHODS: From March 2015 to June 2017,a total of 25 cases with facial atrophic acne scars were treated with PCRT treatment for three to five times...
August 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Eerik Ee Santala, Antti Rannikko, Teemu J Murtola
Antihypertensive (anti-HT) drugs targeting renin-angiotensin-aldosterone (RAA)- system have been associated with improved prostate cancer (PCa)-specific survival. Challenge is that often multiple drugs are used simultaneously. We evaluated the association between use of anti-HT drugs and PCa survival among 14,422 surgically treated Finnish PCa patients. Information on drug purchases was obtained from a national prescription database. We used Cox regression to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for risk of PCa death and initiation of androgen deprivation therapy (ADT) with adjustment for age, tumor extent, use of statins and for Charlson Comorbidity Index...
August 15, 2018: International Journal of Cancer. Journal International du Cancer
Alexandria C McGrath, Geeta Sandhu, Euan Walpole, Elizabeth McCaffrey, Samantha A Hollingworth
Erlotinib is used to treat non-small-cell lung cancer (NSCLC). Erlotinib was subsidized on the Pharmaceutical Benefits Schedule in Australia for the treatment of advanced stage (IIIB or IV) NSCLC (August 2008). In the pivotal trial supporting initial subsidy, erlotinib increased overall survival (OS) by 2 months compared with placebo (adjusted hazard ratio, 0.70; 95% confidence interval: 0.58-0.85). We examined the effectiveness of erlotinib in a 'real-world' setting by measuring survival outcomes in NSCLC patients treated in two tertiary metropolitan public hospitals in Queensland...
September 2018: Anti-cancer Drugs
Xiansheng Huang, Rong Li, Yunzhi Feng, Yining Wang
To explore the remineralization effect of bioactive glass NovaMin on demineralized dentin specimens, and to study the physical and chemical properties of formed structure at dentin surface.
 Methods: One mm-thickness coronal dentin slices were soaked in ethylene diamine tetraacetic acid (EDTA) for 48 h to prepare the completely demineralized dentin specimens and they were divided into 2 groups: an artificial saliva group (control group) and a NovaMin powder group. The specimens were treated with artificial saliva or NovaMin powder for 2 min (2 times every day), and the interval was 8 hours...
June 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Kei Ichiji, Yusuke Yoshida, Noriyasu Homma, Xiaoyong Zhang, Ivo Bukovsky, Yoshihiro Takai, Makoto Yoshizawa
In radiation therapy, for accurate radiation dose delivery to a target tumor and reduction of the extra exposure of normal tissues, real-time tumor tracking is an important technique typically for a lung cancer treatment since the lung tumor moves with patient's respiration. To observe the tumor motion in real time, X-ray fluoroscopic devices can be employed, and various tracking techniques have been proposed to track the tumor. However, development of an accurate and fast-tracking method for clinical use is still a challenging task since the obscureness can cause the decreased tracking accuracy and additional processing time for improving the accuracy...
August 15, 2018: Physics in Medicine and Biology
Maura Massimino, Francesco Barretta, Piergiorgio Modena, Felice Giangaspero, Luisa Chiapparini, Alessandra Erbetta, Luna Boschetti, Manila Antonelli, Paolo Ferroli, Daniele Bertin, Emilia Pecori, Veronica Biassoni, Maria Luisa Garrè, Elisabetta Schiavello, Iacopo Sardi, Elisabetta Viscardi, Giovanni Scarzello, Maurizio Mascarin, Lucia Quaglietta, Giuseppe Cinalli, Lorenzo Genitori, Paola Peretta, Anna Mussano, Salvina Barra, Angela Mastronuzzi, Carlo Giussani, Carlo Efisio Marras, Rita Balter, Patrizia Bertolini, Assunta Tornesello, Milena La Spina, Francesca Romana Buttarelli, Antonio Ruggiero, Massimo Caldarelli, Geraldina Poggi, Lorenza Gandola
PURPOSE: The aims of patients' radiological surveillance are to: ascertain relapse; apply second-line therapy; accrue patients in phase 1/2 protocols if second-line therapy is not standardized/curative; and assess/treat iatrogenic effects. To lessen the emotional and socioeconomic burdens for patients and families, we ideally need to establish whether scheduled radiological surveillance gives patients a better outcome than waiting for symptoms and signs to appear. METHODS: We analyzed a prospective series of 160 newly-diagnosed and treated pediatric/adolescent patients with intracranial ependymoma, comparing patients with recurrent disease identified on scheduled MRI (the RECPT group; 34 cases) with those showing signs/symptoms of recurrent disease (the SYMPPT group; 16 cases)...
August 14, 2018: Journal of Neuro-oncology
Sarah L Stuebing, Andrew T Marshall, Ashton Triplett, Kimberly Kirkpatrick
Impulsive choice has been implicated in substance abuse, gambling, obesity, and other maladaptive behaviors. Deficits in interval timing may increase impulsive choices, and therefore, could serve as an avenue through which suboptimal impulsive choices can be moderated. Temporal interventions have successfully attenuated impulsive choices in male rats, but the efficacy of a temporal intervention has yet to be assessed in female rats. As such, this experiment examined timing and choice behavior in female rats, and evaluated the ability of a temporal intervention to mitigate impulsive choice behavior...
August 14, 2018: Animal Cognition
Haichun Zhou, Xiaohui Ma, Meijun Sheng, Can Lai, Junfen Fu
BACKGROUND: The magnetic resonance imaging (MRI) characteristics of evolving duodenal hematomas in children are unknown. OBJECTIVE: To describe the MRI changes exhibited by evolving duodenal hematomas and the likely mechanisms behind these changes. MATERIALS AND METHODS: We retrospectively reviewed the MR features of intramural duodenal hematomas (6 lesions, 10 examinations) studied on a 1.5-T MR unit. All patients had clinical histories of blunt abdominal trauma or endoscopic procedures and we were able to determine the time interval between the onset and MR imaging...
August 14, 2018: Pediatric Radiology
Mirta Fiorio, Mehran Emadi Andani, Serena Recchia, Michele Tinazzi
In a recent study, we showed that tactile perception can be enhanced by applying a placebo manipulation consisting of verbal suggestion and conditioning (Fiorio et al., Neuroscience 217:96-104, 2012). Whether this change in perception is related to a better tactile functioning is still unknown. Aim of this study is to investigate whether placebo-induced enhancement of tactile perception results in better somatosensory temporal discrimination threshold (STDT), as a proxy of tactile acuity. To this purpose, a group of subjects (experimental group) was verbally influenced and conditioned about the effect of an inert cream in enhancing tactile perception, while a control group was informed about the real nature of the cream...
August 14, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Xu Cong Ruan, Wai Loong Wong, Hui Qing Yeong, Yong Kuei Timothy Lim
INTRODUCTION: Endometrial carcinoma is the most common gynaecological malignancy. Studies have shown that laparoscopic total hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection was advantageous compared to laparotomy in reducing length of stay and intraoperative blood loss. However, these studies had a predominantly Caucasian population. A comparison study was conducted among the Singapore population to investigate the differences in oncological and surgical outcomes between these two methods...
July 2018: Singapore Medical Journal
Ohhwan Kwon, Jinwoo Jeong, Hyung Bin Kim, In Ho Kwon, Song Yi Park, Ji Eun Kim, Yuri Choi
Objectives: Heart rate variability (HRV) has gained recognition as a noninvasive marker of autonomic activity. HRV is considered a promising tool in various clinical scenarios. The optimal electrocardiogram (ECG) sampling frequency required to ensure sufficient precision of R-R intervals for HRV analysis has not yet been determined. Here, we aimed to determine the acceptable ECG sampling frequency range by analyzing ECG signals from patients who visited an emergency department with the chief complaint of acute intoxication or overdose...
July 2018: Healthcare Informatics Research
Nur Shafika Mohd Sairazi, Kuttulebbai N S Sirajudeen, Mustapha Muzaimi, Swamy Mummedy, Mohd Asnizam Asari, Siti Amrah Sulaiman
The protective effect of tualang honey (TH) on neuroinflammation and caspase-3 activity in rat cerebral cortex, cerebellum, and brainstem after kainic acid- (KA-) induced status epilepticus was investigated. Male Sprague-Dawley rats were pretreated orally with TH (1.0 g/kg body weight) five times at 12 h intervals. KA (15 mg/kg body weight) was injected subcutaneously 30 min after last oral treatment. Rats were sacrificed at 2 h, 24 h, and 48 h after KA administration. Neuroinflammation markers and caspase-3 activity were analyzed in different brain regions 2 h, 24 h, and 48 h after KA administration...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Wei Liu, Qiang Wu, Xiao-Jie Yang, Jing Huang
Objective: To evaluate the trend of change in the efficacy and safety of catheter ablation compared with antiarrhythmic drug therapy (ADT) for rhythm control in patients with atrial fibrillation (AF) over time. Methods: The online databases PubMed and EMBASE were searched for relevant studies. STATA software (version 12.0) was used to perform the meta-analysis and meta-regression. Results: Fifteen randomized controlled trials including 2249 patients with AF were identified...
June 2018: Journal of Geriatric Cardiology: JGC
Maciej Grzybek, Mohammed Alsarraf, Katarzyna Tołkacz, Jolanta Behnke-Borowczyk, Beata Biernat, Joanna Stańczak, Aneta Strachecka, Leszek Guz, Klaudiusz Szczepaniak, Jerzy Paleolog, Jerzy M Behnke, Anna Bajer
Rodents are known to play a significant role as reservoir hosts for TBEV. During three sequential expeditions at 4-year intervals to three ecologically similar study sites in NE Poland, we trapped bank voles (Myodes glareolus) and then tested their blood for the presence of specific antiviral antibodies to TBEV. The strongest effects on seroprevalence were the extrinsic factors, site of capture of voles and year of sampling. Seroprevalence increased markedly with increasing host age, and our analysis revealed significant interactions among these three factors...
August 15, 2018: Emerging Microbes & Infections
Lucia De Martino, Nadya Yousef, Rafik Ben-Ammar, Francesco Raimondi, Shivani Shankar-Aguilera, Daniele De Luca
BACKGROUND AND OBJECTIVES: There are several lung ultrasound scores (LUS) for evaluating lung aeration in critically ill adults with restrictive lung disorders. A modified LUS adapted for neonates correlates well with oxygenation and is able to be used to predict the need for surfactant in preterm neonates with respiratory distress syndrome (RDS). However, no data are available for extremely preterm neonates for whom timely surfactant administration is especially important. We hypothesized that LUS might be reliable in extremely preterm neonates with RDS who are treated with continuous positive airway pressure...
August 14, 2018: Pediatrics
Richard C Blagrove, Kristina M Holding, Stephen D Patterson, Glyn Howatson, Philip R Hayes
OBJECTIVES: To determine the effect of performing depth jumps (DJ) pre-exercise on running economy (RE) and time to exhaustion (TTE) at the speed associated with maximal oxygen uptake (sV˙O2max ) in a group of high-performing junior middle-distance runners. DESIGN: Randomized crossover study. METHODS: Seventeen national- and international-standard male distance runners (17.6±1.2years, 63.4±6.3kg, 1.76±0.06m, 70.7±5.2mLkg-1 min-1 ) completed two trials...
August 3, 2018: Journal of Science and Medicine in Sport
C Teixeira, C Martins, E Dantas, D Trabulo, J Mangualde, R Freire, A L Alves, I Cremers, A P Oliveira
INTRODUCTION AND AIMS: Interval colorectal cancer (iCRC) can occur due to missed lesions or to a newly developed lesion. The present study aimed to assess the iCRC rate and its characteristics in our population and find possible explanations. MATERIALS AND METHODS: A retrospective study was conducted on patients with colorectal cancer (CRC) diagnosed between January 2011 and January 2015 at our department. Demographics, endoscopic data, and tumor characteristics (location, histology, staging) were collected...
August 11, 2018: Revista de Gastroenterología de México
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