keyword
https://read.qxmd.com/read/38528036/single-cell-rna-sequencing-unveils-tumor-heterogeneity-and-immune-microenvironment-between-subungual-and-plantar-melanoma
#21
JOURNAL ARTICLE
Panpan Wang, Yangyang Ma, Yige Zhao, Yong Li, Chenyu Tang, Shiwen Wang, Sha Jin, Jiaqi Wang, Mengyan Zhu, Bo Xie, Ping Wang
Acral melanoma (AM) is a subtype of melanoma with high prevalence in East Asians. AM is characterized by greater aggressiveness and lower survival rates. However, there are still fewer studies on immune mechanisms of AM especially subungual melanoma (SM) versus non-subungual melanoma (NSM). In order to explore tumor heterogeneity and immune microenvironment in different subtypes of AM, we applied single-cell RNA sequencing to 24,789 single cells isolated from the SM and plantar melanoma (PM) patients. Aspects of tumor heterogeneity, melanocytes from PM and SM had significant differences in gene expression, CNV and pathways in which tumor-associated such as NF-kb and Wnt were involved...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527290/the-kir2dl-family-serves-as-prognostic-biomarkers-and-correlates-with-immune-infiltrates-in-acute-myeloid-leukaemia
#22
JOURNAL ARTICLE
Wenling Liu, Mingming Zhu, Ganggang Li, Yaming Xi
Acute myeloid leukaemia (AML) is a prevalent haematological malignancy in which various immune and stromal cells in the bone marrow microenvironment have instrumental roles and substantially influence its progression. KIR2DL is a member of the immunoglobulin-like receptor family and a natural killer (NK) cell surface-specific receptor. However, its impact on immune infiltration regarding AML has not been addressed. We aimed to explore molecular markers associated with the immune microenvironment and prognosis of AML with a particular focus on KIR2DL family members...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38526656/electrospun-nanofibrous-mats-loaded-with-gemcitabine-and-cisplatin-suppress-bladder-tumor-growth-by-improving-the-tumor-immune-microenvironment
#23
JOURNAL ARTICLE
Jing Wang, Yisheng Yin, Xiang Ren, Shaogang Wang, Yunpeng Zhu
The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues...
March 25, 2024: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/38526604/bioinformatics-based-screening-and-analysis-of-the-key-genes-involved-in-the-influence-of-antiangiogenesis-on-myeloid-derived-suppressor-cells-and-their-effects-on-the-immune-microenvironment
#24
JOURNAL ARTICLE
XiangFei Zhao, RuGang Zhao, JuYi Wen, Xia Zhang, ShanShan Wu, Juan Fang, JunPeng Ma, LiPin Gao, Yi Hu
This study aimed to screen differentially expressed genes (DEGs) involved in the influence of antiangiogenic therapy on myeloid-derived suppressor cell (MDSC) infiltration and investigate their mechanisms of action. Data on DEGs after the action of antiangiogenic drugs in a pan-cancer context were obtained from the Gene Expression Omnibus (GEO) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the clusterProfiler package in R software...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38526307/brain-delivery-of-biomimetic-phosphorus-dendrimer-antibody-nanocomplexes-for-enhanced-glioma-immunotherapy-via-immune-modulation-of-t-cells-and-natural-killer-cells
#25
JOURNAL ARTICLE
Yamin Peng, Mengsi Zhan, Andrii Karpus, Yu Zou, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi, Mingwu Shen
Fully mobilizing the activities of multiple immune cells is crucial to achieve the desired tumor immunotherapeutic efficacy yet still remains challenging. Herein, we report a nanomedicine formulation based on phosphorus dendrimer (termed AK128)/programmed cell death protein 1 antibody (aPD1) nanocomplexes (NCs) that are camouflaged with M1-type macrophage cell membranes (M1m) for enhanced immunotherapy of orthotopic glioma. The constructed AK128-aPD1@M1m NCs with a mean particle size of 160.3 nm possess good stability and cytocompatibility...
March 25, 2024: ACS Nano
https://read.qxmd.com/read/38526128/the-%C3%AF-3-polyunsaturated-fatty-acid-docosahexaenoic-acid-enhances-nk-cell-antitumor-effector-functions
#26
JOURNAL ARTICLE
Shuting Wu, Hongyan Peng, Songyang Li, Lanlan Huang, Xiangyu Wang, Yana Li, Yongjie Liu, Peiwen Xiong, Qinglan Yang, Kunpeng Tian, Weiru Wu, Rongxi Pu, Xiulan Lu, Zhenghui Xiao, Jian Yang, Zhaoyang Zhong, Yuan Gao, Yafei Deng, Youcai Deng
ω-3 polyunsaturated fatty acids (PUFAs) are known to directly repress tumour development and progression. In this study, we explored whether docosahexaenoic acid (DHA), a type of ω-3 PUFA, had an immunomodulatory role in promoting tumour growth in immunocompetent mice. The number of natural killer (NK) cells but not the number of T or B cells was decreased by DHA supplementation in various tissues under physiological conditions. Although the frequency and number of NK cells were comparable, IFN-γ production by NK cells in both the spleen and lung was increased in DHA-supplemented mice in the mouse B16F10 melanoma tumour model...
March 25, 2024: Cancer Immunology Research
https://read.qxmd.com/read/38525901/decreased-ldhb-expression-in-breast-tumor-cells-causes-nk-cell-activation-and-promotes-tumor-progression
#27
JOURNAL ARTICLE
Zhihong Luo, Xiaohua Huang, Xinyi Xu, Kefeng Wei, Yi Zheng, Ke Gong, Wenhua Li
OBJECTIVE: Abnormal metabolism is the underlying reason for breast cancer progression. Decreased lactate dehydrogenase B ( LDHB ) has been detected in breast cancer but the function of LDHB remains unknown. METHODS: Western blot was used to analyze LDHB expression in breast cancer cells. The impact of LDHB on tumor cell migration and invasion was determined using Transwell assays, wound healing assays, and a mouse lung metastasis model. Subcutaneous tumor formation, a natural killer (NK) cell cytotoxicity assay, and flow cytometry evaluated NK cell activation...
March 25, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38525442/impacts-of-cryopreservation-on-phenotype-and-functionality-of-mononuclear-cells-in-peripheral-blood-and-ascites
#28
JOURNAL ARTICLE
Jie Zhang, Zhongnan Yin, Zhaoyuan Liang, Yang Bai, Ting Zhang, Jianling Yang, Xianlong Li, Lixiang Xue
BACKGROUND: Mononuclear cells in peripheral blood and ascites are important clinical resources commonly used in translational and basic research. However, the impact of different cryopreservation durations and extra freeze-thaw cycles on the number and function of mononuclear cells is unknown. METHODS: Peripheral blood samples ( n = 21) and ascites samples ( n = 8) were collected from healthy volunteers and ovarian cancer patients. Mononuclear cells were isolated, frozen, and thawed at 6 and 12 months...
February 2024: Journal of Translational Internal Medicine
https://read.qxmd.com/read/38525441/the-role-of-tim3-nk-and-tim3-nk-cells-in-the-immune-pathogenesis-of-severe-aplastic-anemia
#29
JOURNAL ARTICLE
Shaoxue Ding, Tian Zhang, Yingying Lei, Chunyan Liu, Zhaoyun Liu, Rong Fu
BACKGROUND: Natural killer (NK) cells play important immunoregulatory roles in the immune pathogenesis of severe aplastic anemia (SAA). Our previous research showed that SAA caused a decrease in T cell immunoglobulin mucin-3 (TIM3) expression on NK cells. Here we investigated the expression of surface receptors, and the cytotoxicity of peripheral TIM3+ NK and TIM3- NK cells in patients with SAA. METHODS: The expressions of surface receptors and cytoplasmic protein of TIM3+ NK and TIM3- NK cells from peripheral blood were detected by FCM...
February 2024: Journal of Translational Internal Medicine
https://read.qxmd.com/read/38525380/exploring-nk-cell-receptor-dynamics-in-paediatric-leukaemias-implications-for-immunotherapy-and-prognosis
#30
JOURNAL ARTICLE
Cui Tu, Irina Buckle, Ingrid Leal Rojas, Gustavo Rodrigues Rossi, David P Sester, Andrew S Moore, Kristen Radford, Camille Guillerey, Fernando Souza-Fonseca-Guimaraes
OBJECTIVES: Immunotherapies targeting natural killer (NK) cell receptors have shown promise against leukaemia. Unfortunately, cancer immunosuppressive mechanisms that alter NK cell phenotype prevent such approaches from being successful. The study utilises advanced cytometry to examine how cancer immunosuppressive pathways affect NK cell phenotypic changes in clinical samples. METHODS: In this study, we conducted a high-dimensional examination of the cell surface expression of 16 NK cell receptors in paediatric patients with acute myeloid leukaemia and acute lymphoblastic leukaemia, as well as in samples of non-age matched adult peripheral blood (APB) and umbilical cord blood (UCB)...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38525109/b-cell-pathway-dual-inhibition-for-systemic-lupus-erythematosus-a-prospective-single-arm-cohort-study-of-telitacicept
#31
JOURNAL ARTICLE
Lanlan Ji, Yan Geng, Xiaohui Zhang, Xuerong Deng, Zhibo Song, Meng Tan, Ying Tan, Chenxue Qu, Zhuoli Zhang
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with B-cell hyperactivity. Telitacicept is a transmembrane activator, calcium modulator, and cyclophilin ligand interactor-Fc fusion protein, which can neutralize both B-cell lymphocyte stimulator and a proliferation-inducing ligand. Patients with active SLE who received telitacicept were prospectively followed at month 1, 3, 6, 9, and 12 after telitacicept initiation. Thirty-seven participants were involved and followed for 6...
April 2024: MedComm
https://read.qxmd.com/read/38524535/exploring-cellular-immunotherapy-platforms-in-multiple-myeloma
#32
REVIEW
Manh-Cuong Vo, Sung-Hoon Jung, Van-Tan Nguyen, Van-Dinh-Huan Tran, Nodirjon Ruzimurodov, Sang Ki Kim, Xuan-Hung Nguyen, Mihee Kim, Ga-Young Song, Seo-Yeon Ahn, Jae-Sook Ahn, Deok-Hwan Yang, Hyeoung-Joon Kim, Je-Jung Lee
Despite major advances in therapeutic platforms, most patients with multiple myeloma (MM) eventually relapse and succumb to the disease. Among the novel therapeutic options developed over the past decade, genetically engineered T cells have a great deal of potential. Cellular immunotherapies, including chimeric antigen receptor (CAR) T cells, are rapidly becoming an effective therapeutic modality for MM. Marrow-infiltrating lymphocytes (MILs) derived from the bone marrow of patients with MM are a novel source of T cells for adoptive T-cell therapy, which robustly and specifically target myeloma cells...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38523995/nasal-type-natural-killer-t-cell-lymphoma-with-inaugural-testicular-presentation-in-a-young-patient
#33
Oumayma Mnafe, Eddou Hicham
Nasal-type natural killer/T-cell lymphoma is a rare non-Hodgkin's malignant lymphoma. A distinct clinicopathological entity associated with the Epstein-Barr virus, it typically presents with otorhinolaryngeal symptomatology. We report a rare case of a 24-year-old patient with nasal-type lymphoma with an atypical inaugural testicular presentation associated with the discovery of bilateral adrenal involvement.
February 2024: Curēus
https://read.qxmd.com/read/38523872/late-stage-ovarian-cancer-with-systemic-multiple-metastases-shows-marked-shrinkage-using-a-combination-of-wilms-tumor-antigen-1-wt1-dendritic-cell-vaccine-natural-killer-nk-cell-therapy-and-nivolumab
#34
Hisashi Nagai, Ryusuke Karube
A patient with bilateral ovarian cancer, peritoneal dissemination, and multiple liver and lung metastases was found with a sudden accumulation of ascites six months after delivery. Chemotherapy was started, but the prognosis was judged to be poor, so immuno-cell therapy was combined with chemotherapy. After multiple cycles of Wilms' tumor antigen 1 (WT1) dendritic cell vaccine therapy and highly activated natural killer (NK) cell therapy, the patient showed a disappearance of ascites and a remarkable reduction of multiple cancers in the whole body...
March 2024: Curēus
https://read.qxmd.com/read/38523646/insights-into-the-glioblastoma-tumor-microenvironment-current-and-emerging-therapeutic-approaches
#35
REVIEW
Dev Kumar Tripathy, Lakshmi Priya Panda, Suryanarayan Biswal, Kalpana Barhwal
Glioblastoma (GB) is an intrusive and recurrent primary brain tumor with low survivability. The heterogeneity of the tumor microenvironment plays a crucial role in the stemness and proliferation of GB. The tumor microenvironment induces tumor heterogeneity of cancer cells by facilitating clonal evolution and promoting multidrug resistance, leading to cancer cell progression and metastasis. It also plays an important role in angiogenesis to nourish the hypoxic tumor environment. There is a strong interaction of neoplastic cells with their surrounding microenvironment that comprise several immune and non-immune cellular components...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38522775/pharmacological-suppression-of-hhla2-glycosylation-restores-anti-tumor-immunity-in-colorectal-cancer
#36
JOURNAL ARTICLE
Dongze Zhang, Jinjing Xie, Fangxin Sun, Ruyan Xu, Wenjun Liu, Jia Xu, Xue Huang, Guangbo Zhang
Immunotherapy aimed at inhibiting the negative co-stimulatory molecule programmed cell death receptor-1 has limited effectiveness, with clinical response rates remaining below 10%-15%. Therefore, new immune checkpoints need to be explored. Our study focused on human endogenous retrovirus H long terminal repeat-associating protein 2 (HHLA2), a highly glycosylated member of the B7 family that is widely expressed in colorectal cancer. HHLA2 expression negatively correlates with the prognosis of colorectal cancer...
March 22, 2024: Cancer Letters
https://read.qxmd.com/read/38521829/utilizing-machine-learning-to-identify-biomarkers-of-endoplasmic-reticulum-stress-and-analyze-immune-cell-infiltration-in-parkinson-s-disease
#37
JOURNAL ARTICLE
Guang Yang, Bing Zhang, Chun Yang Xu, Jia Wen Wu, Yi Zhang, Yue Yu, Xiao Gang He, Jun Dou
The neurodegenerative disorder known as Parkinson's disease (PD) affects many people. The objective of this investigation was to examine the relationship between immune system infiltration, ATP-binding cassette transporter subfamily A member 7 (ABCA7) and TBL2 as well as potential therapeutic targets for the identification of PD associated to endoplasmic reticulum (ER) stress. First, we obtained PD data through GEO and divided it into two sets: a training set (GSE8397) plus a set for validation (GSE7621). Functional enrichment analysis was performed on a set of DEGs that overlapped with genes involved in endoplasmic reticulum stress...
March 23, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38521068/the-central-role-of-natural-killer-cells-in-mediating-acute-myocarditis-after-mrna-covid-19-vaccination
#38
JOURNAL ARTICLE
Hing Wai Tsang, Mike Yat Wah Kwan, Gilbert T Chua, Sabrina Siu Ling Tsao, Joshua Sung Chih Wong, Keith Tsz Suen Tung, Godfrey Chi Fung Chan, Kelvin Kai Wang To, Ian Chi Kei Wong, Wing Hang Leung, Patrick Ip
BACKGROUND: Vaccine-related acute myocarditis is recognized as a rare and specific vaccine complication following mRNA-based COVID-19 vaccinations. The precise mechanisms remain unclear. We hypothesized that natural killer (NK) cells play a central role in its pathogenesis. METHODS: Samples from 60 adolescents with vaccine-related myocarditis were analyzed, including pro-inflammatory cytokines, cardiac troponin T, genotyping, and immunophenotyping of the corresponding activation subsets of NK cells, monocytes, and T cells...
March 15, 2024: Med
https://read.qxmd.com/read/38520980/simultaneous-disturbance-of-nhe1-and-loxl2-decreases-tumorigenicity-of-head-and-neck-squamous-cell-carcinoma
#39
JOURNAL ARTICLE
Yuji Hayashi, Shoko Miyoshi, Itaru Watanabe, Nagomi Yano, Kodai Nagashio, Mihiro Kaneko, Teppei Kaminota, Tomoyoshi Sanada, Yuki Hosokawa, Takashi Kitani, Sohei Mitani, Mohammed E Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato
OBJECTIVE: Although there have been brilliant advancements in the practical application of therapies targeting immune checkpoints, achieving success in targeting the microenvironment remains elusive. In this study, we aimed to address this gap by focusing on Na+ / H+ exchanger 1 (NHE1) and Lysyl Oxidase Like 2 (LOXL2), which are upregulated in head and neck squamous cell carcinoma (HNSCC) cells. METHODS: The malignancy of a metastatic human HNSCC cell line was assessed in a mouse tongue cancer xenograft model by knocking down (KD) NHE1, responsible for regulating intracellular pH, and LOXL2, responsible for extracellular matrix (ECM) reorganization via cross-linking of ECM proteins...
March 22, 2024: Auris, Nasus, Larynx
https://read.qxmd.com/read/38519469/bet-inhibitors-drive-natural-killer-activation-in-non-small-cell-lung-cancer-via-brd4-and-smad3
#40
JOURNAL ARTICLE
Francesca Reggiani, Giovanna Talarico, Giulia Gobbi, Elisabetta Sauta, Federica Torricelli, Veronica Manicardi, Eleonora Zanetti, Stefania Orecchioni, Paolo Falvo, Simonetta Piana, Filippo Lococo, Massimiliano Paci, Francesco Bertolini, Alessia Ciarrocchi, Valentina Sancisi
Non-small-cell lung carcinoma (NSCLC) is the most common lung cancer and one of the pioneer tumors in which immunotherapy has radically changed patients' outcomes. However, several issues are emerging and their implementation is required to optimize immunotherapy-based protocols. In this work, we investigate the ability of the Bromodomain and Extra-Terminal protein inhibitors (BETi) to stimulate a proficient anti-tumor immune response toward NSCLC. By using in vitro, ex-vivo, and in vivo models, we demonstrate that these epigenetic drugs specifically enhance Natural Killer (NK) cell cytotoxicity...
March 22, 2024: Nature Communications
keyword
keyword
1651
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.